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Molecular Neurodegeneration

Ausgabe 1/2021

Inhalt (84 Artikel)

Induction of autophagy mitigates TDP-43 pathology and translational repression of neurofilament mRNAs in mouse models of ALS/FTD

  • Open Access
  • Research article

Sunny Kumar, Daniel Phaneuf, Pierre Cordeau Jr., Hejer Boutej, Jasna Kriz, Jean-Pierre Julien

Methods to investigate intrathecal adaptive immunity in neurodegeneration

  • Open Access
  • Methodology

Hamilton Oh, Olivia Leventhal, Divya Channappa, Victor W. Henderson, Tony Wyss-Coray, Benoit Lehallier, David Gate

Comprehensive metabolic profiling of Parkinson’s disease by liquid chromatography-mass spectrometry

  • Open Access
  • Research article

Yaping Shao, Tianbai Li, Zheyi Liu, Xiaolin Wang, Xiaojiao Xu, Song Li, Guowang Xu, Weidong Le

Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer’s disease neuropathology

  • Open Access
  • Research article

Fading Chen, Dan B. Swartzlander, Anamitra Ghosh, John D. Fryer, Baiping Wang, Hui Zheng

Relationships of gut microbiota, short-chain fatty acids, inflammation, and the gut barrier in Parkinson’s disease

  • Open Access
  • Research article

Velma T. E. Aho, Madelyn C. Houser, Pedro A. B. Pereira, Jianjun Chang, Knut Rudi, Lars Paulin, Vicki Hertzberg, Petri Auvinen, Malú G. Tansey, Filip Scheperjans

Increased serum QUIN/KYNA is a reliable biomarker of post-stroke cognitive decline

  • Open Access
  • Research article

Adrien Cogo, Gabrielle Mangin, Benjamin Maïer, Jacques Callebert, Mikael Mazighi, Hughes Chabriat, Jean-Marie Launay, Gilles Huberfeld, Nathalie Kubis

Remodeling Alzheimer-amyloidosis models by seeding

  • Open Access
  • Review

Brittany S. Ulm, David R. Borchelt, Brenda D. Moore

Deletion of Socs3 in LysM+ cells and Cx3cr1 resulted in age-dependent development of retinal microgliopathy

  • Open Access
  • Research article

Xuan Du, Rosana Penalva, Karis Little, Adrien Kissenpfennig, Mei Chen, Heping Xu

Prion protein oligomers cause neuronal cytoskeletal damage in rapidly progressive Alzheimer’s disease

  • Open Access
  • Research article

Mohsin Shafiq, Saima Zafar, Neelam Younas, Aneeqa Noor, Berta Puig, Hermann Clemens Altmeppen, Matthias Schmitz, Jakob Matschke, Isidre Ferrer, Markus Glatzel, Inga Zerr

Dominant mutations in MIEF1 affect mitochondrial dynamics and cause a singular late onset optic neuropathy

  • Open Access
  • Short report

Majida Charif, Yvette C. Wong, Soojin Kim, Agnès Guichet, Catherine Vignal, Xavier Zanlonghi, Philippe Bensaid, Vincent Procaccio, Dominique Bonneau, Patrizia Amati-Bonneau, Pascal Reynier, Dimitri Krainc, Guy Lenaers

Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction

  • Open Access
  • Research article

Emma M. Perkins, Karen Burr, Poulomi Banerjee, Arpan R. Mehta, Owen Dando, Bhuvaneish T. Selvaraj, Daumante Suminaite, Jyoti Nanda, Christopher M. Henstridge, Thomas H. Gillingwater, Giles E. Hardingham, David J. A. Wyllie, Siddharthan Chandran, Matthew R. Livesey

Enhancing GABAergic signaling ameliorates aberrant gamma oscillations of olfactory bulb in AD mouse models

  • Open Access
  • Research article

Ming Chen, Yunan Chen, Qingwei Huo, Lei Wang, Shuyi Tan, Afzal Misrani, Jinxiang Jiang, Jian Chen, Shiyuan Chen, Jiawei Zhang, Sidra Tabassum, Jichen Wang, Xi Chen, Cheng Long, Li Yang

Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer’s disease

  • Open Access
  • Research article

Vicente Roca-Agujetas, Elisabet Barbero-Camps, Cristina de Dios, Petar Podlesniy, Xenia Abadin, Albert Morales, Montserrat Marí, Ramon Trullàs, Anna Colell

High dose expression of heme oxigenase-1 induces retinal degeneration through ER stress-related DDIT3

  • Open Access
  • Research article

Huirong Li, Bo Liu, Lili Lian, Jiajia Zhou, Shengjin Xiang, Yifan Zhai, Yu Chen, Xiaoyin Ma, Wencan Wu, Ling Hou

Preclinical modeling of chronic inhibition of the Parkinson’s disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo

  • Open Access
  • Research article

Jillian H. Kluss, Melissa Conti Mazza, Yan Li, Claudia Manzoni, Patrick A. Lewis, Mark R. Cookson, Adamantios Mamais

Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model

  • Open Access
  • Research article

Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C. Saido, Seiko Ikezu, Tsuneya Ikezu

The CD33 short isoform is a gain-of-function variant that enhances Aβ1–42 phagocytosis in microglia

  • Open Access
  • Research article

Abhishek Bhattacherjee, Jaesoo Jung, Sameera Zia, Madelene Ho, Ghazaleh Eskandari-Sedighi, Chris D. St. Laurent, Kelli A. McCord, Arjun Bains, Gaurav Sidhu, Susmita Sarkar, Jason R. Plemel, Matthew S. Macauley

Fred W. van Leeuwen (1949–2021)

  • Open Access
  • Obituary

Bert M. Verheijen, Aaron Ciechanover

TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation

  • Open Access
  • Review

Lorenza Magno, Tom D. Bunney, Emma Mead, Fredrik Svensson, Magda N. Bictash

Adiponectin-mimetic novel nonapeptide rescues aberrant neuronal metabolic-associated memory deficits in Alzheimer’s disease

  • Open Access
  • Research article

Tahir Ali, Shafiq Ur Rehman, Amjad Khan, Haroon Badshah, Noman Bin Abid, Min Woo Kim, Myeung Hoon Jo, Seung Soo Chung, Hyoung-gon Lee, Bart P. F. Rutten, Myeong Ok Kim

Correction to: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model

  • Open Access
  • Correction

Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C. Saido, Seiko Ikezu, Tsuneya Ikezu

AIF3 splicing switch triggers neurodegeneration

  • Open Access
  • Research article

Shuiqiao Liu, Mi Zhou, Zhi Ruan, Yanan Wang, Calvin Chang, Masayuki Sasaki, Veena Rajaram, Andrew Lemoff, Kalyani Nambiar, Jennifer E. Wang, Kimmo J. Hatanpaa, Weibo Luo, Ted M. Dawson, Valina L. Dawson, Yingfei Wang

RETRACTED ARTICLE: Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4

  • Open Access
  • Research article

Shaowei Wang, Boyang Li, Victoria Solomon, Alfred Fonteh, Stanley I. Rapoport, David A. Bennett, Zoe Arvanitakis, Helena C. Chui, Carol Miller, Patrick M. Sullivan, Hoau-Yan Wang, Hussein N. Yassine

Mitochondrial complex I abnormalities is associated with tau and clinical symptoms in mild Alzheimer’s disease

  • Open Access
  • Research article

Tatsuhiro Terada, Joseph Therriault, Min Su Peter Kang, Melissa Savard, Tharick Ali Pascoal, Firoza Lussier, Cecile Tissot, Yi-Ting Wang, Andrea Benedet, Takashi Matsudaira, Tomoyasu Bunai, Tomokazu Obi, Hideo Tsukada, Yasuomi Ouchi, Pedro Rosa-Neto

Protective genes and pathways in Alzheimer’s disease: moving towards precision interventions

  • Open Access
  • Review

Mabel Seto, Rebecca L. Weiner, Logan Dumitrescu, Timothy J. Hohman

A blood-based diagnostic test incorporating plasma Aβ42/40 ratio, ApoE proteotype, and age accurately identifies brain amyloid status: findings from a multi cohort validity analysis

  • Open Access
  • Research article

Tim West, Kristopher M. Kirmess, Matthew R. Meyer, Mary S. Holubasch, Stephanie S. Knapik, Yan Hu, John H. Contois, Erin N. Jackson, Scott E. Harpstrite, Randall J. Bateman, David M. Holtzman, Philip B. Verghese, Ilana Fogelman, Joel B. Braunstein, Kevin E. Yarasheski

Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson’s disease brain

  • Open Access
  • Research article

Lilah Toker, Gia T. Tran, Janani Sundaresan, Ole-Bjørn Tysnes, Guido Alves, Kristoffer Haugarvoll, Gonzalo S. Nido, Christian Dölle, Charalampos Tzoulis

Modulating innate immune activation states impacts the efficacy of specific Aβ immunotherapy

  • Open Access
  • Research article

Yona Levites, Cory Funk, Xue Wang, Paramita Chakrabarty, Karen N. McFarland, Baxter Bramblett, Veronica O’Neal, Xufei Liu, Thomas Ladd, Max Robinson, Mariet Allen, Minerva M. Carrasquillo, Dennis Dickson, Pedro Cruz, Danny Ryu, Hong-Dong Li, Nathan D. Price, NIlüfer Ertekin-Taner, Todd E. Golde

Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo

  • Open Access
  • Research article

Souvarish Sarkar, Farah Bardai, Abby L. Olsen, Kelly M. Lohr, Ying-Yi Zhang, Mel B. Feany

Parkinson mice show functional and molecular changes in the gut long before motoric disease onset

  • Open Access
  • Research article

Manuela Gries, Anne Christmann, Steven Schulte, Maximilian Weyland, Stephanie Rommel, Monika Martin, Marko Baller, Ralph Röth, Stefanie Schmitteckert, Marcus Unger, Yang Liu, Frederik Sommer, Timo Mühlhaus, Michael Schroda, Jean-Pierre Timmermans, Isabel Pintelon, Gudrun A. Rappold, Markus Britschgi, Hilal Lashuel, Michael D. Menger, Matthias W. Laschke, Beate Niesler, Karl-Herbert Schäfer

Identification of sixteen novel candidate genes for late onset Parkinson’s disease

  • Open Access
  • Research article

Alessandro Gialluisi, Mafalda Giovanna Reccia, Nicola Modugno, Teresa Nutile, Alessia Lombardi, Luca Giovanni Di Giovannantonio, Sara Pietracupa, Daniela Ruggiero, Simona Scala, Stefano Gambardella, Alastair J. Noyce, Rauan Kaiyrzhanov, Ben Middlehurst, Demis A. Kia, Manuela Tan, Henry Houlden, Huw R. Morris, Helene Plun-Favreau, Peter Holmans, John Hardy, Daniah Trabzuni, John Quinn, Vivien Bubb, Kin Y. Mok, Kerri J. Kinghorn, Kimberley Billingsley, Nicholas W. Wood, Patrick Lewis, Sebastian Schreglmann, Ruth Lovering, Lea R’Bibo, Claudia Manzoni, Mie Rizig, Mina Ryten, Sebastian Guelfi, Valentina Escott-Price, Viorica Chelban, Thomas Foltynie, Nigel Williams, Karen E. Morrison, Carl Clarke, Alexis Brice, Fabrice Danjou, Suzanne Lesage, Jean-Christophe Corvol, Maria Martinez, Claudia Schulte, Kathrin Brockmann, Javier Simón-Sánchez, Peter Heutink, Patrizia Rizzu, Manu Sharma, Thomas Gasser, Mark R. Cookson, Sara Bandres-Ciga, Cornelis Blauwendraat, David W. Craig, Derek Narendra, Faraz Faghri, J. Raphael Gibbs, Dena G. Hernandez, Kendall Van Keuren-Jensen, Joshua M. Shulman, Hirotaka Iwaki, Hampton L. Leonard, Mike A. Nalls, Laurie Robak, Jose Bras, Rita Guerreiro, Steven Lubbe, Steven Finkbeiner, Niccolo E. Mencacci, Codrin Lungu, Andrew B. Singleton, Sonja W. Scholz, Xylena Reed, Roy N. Alcalay, Ziv Gan-Or, Guy A. Rouleau, Lynne Krohn, Lynne Krohn, Jacobus J. van Hilten, Johan Marinus, Astrid D. Adarmes-Gómez, Miquel Aguilar, Ignacio Alvarez, Victoria Alvarez, Francisco Javier Barrero, Jesús Alberto Bergareche Yarza, Inmaculada Bernal-Bernal, Marta Blazquez, Marta Bonilla-Toribio, Juan A. Botía, María Teresa Boungiorno, Dolores Buiza-Rueda, Fátima Carrillo, Mario Carrión-Claro, Debora Cerdan, Jordi Clarimón, Yaroslau Compta, Monica Diez-Fairen, Oriol Dols-Icardo, Jacinto Duarte, Raquel Duran, Francisco Escamilla-Sevilla, Mario Ezquerra, Cici Feliz, Manel Fernández, Rubén Fernández-Santiago, Ciara Garcia, Pedro García-Ruiz, Pilar Gómez-Garre, Maria Jose Gomez Heredia, Isabel Gonzalez-Aramburu, Ana Gorostidi Pagola, Janet Hoenicka, Jon Infante, Silvia Jesús, Adriano Jimenez-Escrig, Jaime Kulisevsky, Miguel A. Labrador-Espinosa, Jose Luis Lopez-Sendon, Adolfo López de Munain Arregui, Daniel Macias, Irene Martínez Torres, Juan Marín, Maria Jose Marti, Juan Carlos Martínez-Castrillo, Carlota Méndez-del-Barrio, Manuel Menéndez González, Marina Mata, Adolfo Mínguez, Pablo Mir, Elisabet Mondragon Rezola, Esteban Muñoz, Javier Pagonabarraga, Pau Pastor, Francisco Perez Errazquin, Teresa Periñán-Tocino, Javier Ruiz-Martínez, Clara Ruz, Antonio Sanchez Rodriguez, María Sierra, Esther Suarez-Sanmartin, Cesar Tabernero, Juan Pablo Tartari, Cristina Tejera-Parrado, Eduard Tolosa, Francesc Valldeoriola, Laura Vargas-González, Lydia Vela, Francisco Vives, Alexander Zimprich, Lasse Pihlstrom, Mathias Toft, Sulev Koks, Pille Taba, Sharon Hassin-Baer, Kari Majamaa, Ari Siitonen, Njideka U. Okubadejo, Oluwadamilola O. Ojo, Rauan Kaiyrzhanov, Chingiz Shashkin, Nazira Zharkynbekova, Vadim Akhmetzhanov, Akbota Aitkulova, Elena Zholdybayeva, Zharkyn Zharmukhanov, Gulnaz Kaishybayeva, Altynay Karimova, Dinara Sadykova, Licia Iacoviello, Fernando Gianfrancesco, Dario Acampora, Maurizio D’Esposito, Antonio Simeone, Marina Ciullo, Teresa Esposito

Neuroprotection by WldS depends on retinal ganglion cell type and age in glaucoma

  • Open Access
  • Research article

Michael L. Risner, Silvia Pasini, Nolan R. McGrady, Karis B. D’Alessandro, Vincent Yao, Melissa L. Cooper, David J. Calkins

Key role of the CCR2-CCL2 axis in disease modification in a mouse model of tauopathy

  • Open Access
  • Research article

Hila Ben-Yehuda, Michal Arad, Javier María Peralta Ramos, Efrat Sharon, Giulia Castellani, Shir Ferrera, Liora Cahalon, Sarah Phoebeluc Colaiuta, Tomer-Meir Salame, Michal Schwartz

A proteomic network approach resolves stage-specific molecular phenotypes in chronic traumatic encephalopathy

  • Open Access
  • Research article

Laura Gutierrez-Quiceno, Eric B. Dammer, Ashlyn Grace Johnson, James A. Webster, Rhythm Shah, Duc Duong, Luming Yin, Nicholas T. Seyfried, Victor E. Alvarez, Thor D. Stein, Ann C. McKee, Chadwick M. Hales

Pharmacological rescue of cognitive function in a mouse model of chemobrain

  • Open Access
  • Research article

Lien D. Nguyen, Tom T. Fischer, Barbara E. Ehrlich

Correction to: A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles

  • Open Access
  • Correction

Jian-Guo Li, Jin Chiu, Mercy Ramanjulu, Benjamin E. Blass, Domenico Praticò

AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma

  • Open Access
  • Research article

Nicolas Belforte, Jessica Agostinone, Luis Alarcon-Martinez, Deborah Villafranca-Baughman, Florence Dotigny, Jorge L. Cueva Vargas, Adriana Di Polo

Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer’s disease brains

  • Open Access
  • Research article

Md Golam Sharoar, Sarah Palko, Yingying Ge, Takaomi C. Saido, Riqiang Yan

SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer’s disease

  • Open Access
  • Research article

Maria Bichmann, Nuria Prat Oriol, Ebru Ercan-Herbst, David C. Schöndorf, Borja Gomez Ramos, Vera Schwärzler, Marie Neu, Annabelle Schlüter, Xue Wang, Liang Jin, Chenqi Hu, Yu Tian, Janina S. Ried, Per Haberkant, Laura Gasparini, Dagmar E. Ehrnhoefer

Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microglia

  • Open Access
  • Research article

Diana P. Benitez, Shenyi Jiang, Jack Wood, Rui Wang, Chloe M. Hall, Carlijn Peerboom, Natalie Wong, Katie M. Stringer, Karina S. Vitanova, Victoria C. Smith, Dhaval Joshi, Takashi Saito, Takaomi C. Saido, John Hardy, Jörg Hanrieder, Bart De Strooper, Dervis A. Salih, Takshashila Tripathi, Frances A. Edwards, Damian M. Cummings

Post-infection cognitive impairments in a cohort of elderly patients with COVID-19

Yu-Hui Liu, Ye-Ran Wang, Qing-Hua Wang, Yang Chen, Xian Chen, Ying Li, Yuan Cen, Cheng Xu, Tian Hu, Xu-Dong Liu, Ling-Li Yang, Si-Jing Li, Xue-Fei Liu, Chun-Mei Liu, Jie Zhu, Wei Li, Li-Li Zhang, Juan Liu, Yan-Jiang Wang

The informed road map to prevention of Alzheimer Disease: A call to arms

  • Open Access
  • Review

Eric McDade, Jorge J. Llibre-Guerra, David M. Holtzman, John C. Morris, Randall J. Bateman

Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer’s disease

  • Open Access
  • Short report

Christel Claes, Emma Pascal Danhash, Jonathan Hasselmann, Jean Paul Chadarevian, Sepideh Kiani Shabestari, Whitney E. England, Tau En Lim, Jorge Luis Silva Hidalgo, Robert C. Spitale, Hayk Davtyan, Mathew Blurton-Jones

Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration

  • Open Access
  • Research article

Swetha Mohan, Paul J. Sampognaro, Andrea R. Argouarch, Jason C. Maynard, Mackenzie Welch, Anand Patwardhan, Emma C. Courtney, Jiasheng Zhang, Amanda Mason, Kathy H. Li, Eric J. Huang, William W. Seeley, Bruce L. Miller, Alma Burlingame, Mathew P. Jacobson, Aimee W. Kao

Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis

  • Open Access
  • Research article

Laura Pasetto, Stefano Callegaro, Alessandro Corbelli, Fabio Fiordaliso, Deborah Ferrara, Laura Brunelli, Giovanna Sestito, Roberta Pastorelli, Elisa Bianchi, Marina Cretich, Marcella Chiari, Cristina Potrich, Cristina Moglia, Massimo Corbo, Gianni Sorarù, Christian Lunetta, Andrea Calvo, Adriano Chiò, Gabriele Mora, Maria Pennuto, Alessandro Quattrone, Francesco Rinaldi, Vito Giuseppe D’Agostino, Manuela Basso, Valentina Bonetto

SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

  • Open Access
  • Research article

Lydia M. Castelli, Luisa Cutillo, Cleide Dos Santos Souza, Alvaro Sanchez-Martinez, Ilaria Granata, Ya-Hui Lin, Monika A. Myszczynska, Paul R. Heath, Matthew R. Livesey, Ke Ning, Mimoun Azzouz, Pamela J. Shaw, Mario R. Guarracino, Alexander J. Whitworth, Laura Ferraiuolo, Marta Milo, Guillaume M. Hautbergue

Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures

  • Open Access
  • Research article

Melanie Barth, Mehtap Bacioglu, Niklas Schwarz, Renata Novotny, Janine Brandes, Marc Welzer, Sonia Mazzitelli, Lisa M. Häsler, Manuel Schweighauser, Thomas V. Wuttke, Deborah Kronenberg-Versteeg, Karina Fog, Malene Ambjørn, Ania Alik, Ronald Melki, Philipp J. Kahle, Derya R. Shimshek, Henner Koch, Mathias Jucker, Gaye Tanriöver

Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discovery

  • Open Access
  • Review

Bing Bai, David Vanderwall, Yuxin Li, Xusheng Wang, Suresh Poudel, Hong Wang, Kaushik Kumar Dey, Ping-Chung Chen, Ka Yang, Junmin Peng

Vesicle trafficking and pathways to neurodegeneration

  • Open Access
  • Meeting report

Craig Blackstone, Fiona Elwood, Helene Plun-Favreau, Patrick A. Lewis

Cellular and pathological heterogeneity of primary tauopathies

  • Open Access
  • Review

Dah-eun Chloe Chung, Shanu Roemer, Leonard Petrucelli, Dennis W. Dickson

Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer’s disease brains

  • Open Access
  • Research article

Julio Barrera, Lingyun Song, Julia E. Gamache, Melanie E. Garrett, Alexias Safi, Young Yun, Ivana Premasinghe, Daniel Sprague, Danielle Chipman, Jeffrey Li, Hélène Fradin, Karen Soldano, Raluca Gordân, Allison E. Ashley-Koch, Gregory E. Crawford, Ornit Chiba-Falek

Functional microRNA targetome undergoes degeneration-induced shift in the retina

  • Open Access
  • Research article

Joshua A. Chu-Tan, Adrian V. Cioanca, Zhi-Ping Feng, Yvette Wooff, Ulrike Schumann, Riemke Aggio-Bruce, Hardip Patel, Matt Rutar, Katherine Hannan, Konstantin Panov, Jan Provis, Riccardo Natoli

Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation

  • Open Access
  • Research article

Inmaculada Sanjuan-Ruiz, Noé Govea-Perez, Melissa McAlonis-Downes, Stéphane Dieterle, Salim Megat, Sylvie Dirrig-Grosch, Gina Picchiarelli, Diana Piol, Qiang Zhu, Brian Myers, Chao-Zong Lee, Don W Cleveland, Clotilde Lagier-Tourenne, Sandrine Da Cruz, Luc Dupuis

APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis

  • Open Access
  • Research article

Brandon C. Farmer, Holden C. Williams, Nicholas A. Devanney, Margaret A. Piron, Grant K. Nation, David J. Carter, Adeline E. Walsh, Rebika Khanal, Lyndsay E. A. Young, Jude C. Kluemper, Gabriela Hernandez, Elizabeth J. Allenger, Rachel Mooney, Lesley R. Golden, Cathryn T. Smith, J. Anthony Brandon, Vedant A. Gupta, Philip A. Kern, Matthew S. Gentry, Josh M. Morganti, Ramon C. Sun, Lance A. Johnson

Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model

  • Open Access
  • Research article

Grace M. Lloyd, Jess-Karan S. Dhillon, Kimberly-Marie M. Gorion, Cara Riffe, Susan E. Fromholt, Yuxing Xia, Benoit I. Giasson, David R. Borchelt

Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer’s disease-like neuroinflammation and cognitive impairment

  • Open Access
  • Research article

Shulan Qiu, Juan Pablo Palavicini, Jianing Wang, Nancy S. Gonzalez, Sijia He, Elizabeth Dustin, Cheng Zou, Lin Ding, Anindita Bhattacharjee, Candice E. Van Skike, Veronica Galvan, Jeffrey L. Dupree, Xianlin Han

Nuclear dynamics and stress responses in Alzheimer’s disease

  • Open Access
  • Review

Artemis Iatrou, Eric M. Clark, Yanling Wang

Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing

  • Open Access
  • Research article

Qingyang Zhang, Juan Zhang, Jin Ye, Xiaohui Li, Hongda Liu, Xiaolin Ma, Chao Wang, Keqiang He, Wei Zhang, Ji Yuan, Yingjun Zhao, Huaxi Xu, Qiang Liu

Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques

  • Open Access
  • Methodology

Pranav Preman, Julia TCW, Sara Calafate, An Snellinx, Maria Alfonso-Triguero, Nikky Corthout, Sebastian Munck, Dietmar Rudolf Thal, Alison M Goate, Bart De Strooper, Amaia M Arranz

The TGFβ/Notch axis facilitates Müller cell-to-epithelial transition to ultimately form a chronic glial scar

  • Open Access
  • Research article

Federica Maria Conedera, Ana Maria Quintela Pousa, Nadia Mercader, Markus Tschopp, Volker Enzmann

METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer’s disease through aberrant cell cycle events

  • Open Access
  • Research article

Fanpeng Zhao, Ying Xu, Shichao Gao, Lixia Qin, Quillan Austria, Sandra L. Siedlak, Kinga Pajdzik, Qing Dai, Chuan He, Wenzhang Wang, James M. O’Donnell, Beisha Tang, Xiongwei Zhu

Correction to: Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discovery

  • Open Access
  • Correction

Bing Bai, David Vanderwall, Yuxin Li, Xusheng Wang, Suresh Poudel, Hong Wang, Kaushik Kumar Dey, Ping-Chung Chen, Ka Yang, Junmin Peng

Synaptic dysfunction of Aldh1a1 neurons in the ventral tegmental area causes impulsive behaviors

  • Open Access
  • Research article

Xinyan Li, Wenting Chen, Xian Huang, Wei Jing, Tongmei Zhang, Quntao Yu, Hongyan Yu, Hao Li, Qing Tian, Yumei Ding, Youming Lu

Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer’s disease brain

  • Open Access
  • Research article

Hans-Ulrich Klein, Caroline Trumpff, Hyun-Sik Yang, Annie J. Lee, Martin Picard, David A. Bennett, Philip L. De Jager

The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives

  • Open Access
  • Perspective

Hannah Walgrave, Lujia Zhou, Bart De Strooper, Evgenia Salta

Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans

  • Open Access
  • Research article

Kevin S. Chen, Krystal Menezes, Jarlath B. Rodgers, Darren M. O’Hara, Nhat Tran, Kazuko Fujisawa, Seiya Ishikura, Shahin Khodaei, Hien Chau, Anna Cranston, Minesh Kapadia, Grishma Pawar, Susan Ping, Aldis Krizus, Alix Lacoste, Scott Spangler, Naomi P. Visanji, Connie Marras, Nour K. Majbour, Omar M. A. El-Agnaf, Andres M. Lozano, Joseph Culotti, Satoshi Suo, William S. Ryu, Suneil K. Kalia, Lorraine V. Kalia

CCR5 antagonist reduces HIV-induced amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations in HIV-infected hu-PBL-NSG mice

  • Open Access
  • Research article

Biju Bhargavan, Shawna M. Woollard, Jo Ellyn McMillan, Georgette D. Kanmogne

A panel of CSF proteins separates genetic frontotemporal dementia from presymptomatic mutation carriers: a GENFI study

  • Open Access
  • Research article

Sofia Bergström, Linn Öijerstedt, Julia Remnestål, Jennie Olofsson, Abbe Ullgren, Harro Seelaar, John C. van Swieten, Matthis Synofzik, Raquel Sanchez-Valle, Fermin Moreno, Elizabeth Finger, Mario Masellis, Carmela Tartaglia, Rik Vandenberghe, Robert Laforce, Daniela Galimberti, Barbara Borroni, Chris R. Butler, Alexander Gerhard, Simon Ducharme, Jonathan D. Rohrer, Anna Månberg, Caroline Graff, Peter Nilsson, Lize Jiskoot, James B. Rowe, Alexandre de Mendonça, Fabrizio Tagliavini, Isabel Santana, Isabelle Le Ber, Johannes Levin, Adrian Danek, Markus Otto, Giovanni Frisoni, Roberta Ghidoni, Sandro Sorbi, Florence Pasquier, Vesna Jelic, Christin Andersson, Sónia Afonso, Maria Rosario Almeida, Sarah Anderl-Straub, Anna Antonell, Silvana Archetti, Andrea Arighi, Mircea Balasa, Myriam Barandiaran, Nuria Bargalló, Robart Bartha, Benjamin Bender, Alberto Benussi, Luisa Benussi, Valentina Bessi, Giuliano Binetti, Sandra Black, Martina Bocchetta, Sergi Borrego-Ecija, Jose Bras, Rose Bruffaerts, Marta Cañada, Valentina Cantoni, Paola Caroppo, David Cash, Miguel Castelo-Branco, Rhian Convery, Thomas Cope, Giuseppe Di Fede, Alina Díez, Diana Duro, Chiara Fenoglio, Camilla Ferrari, Catarina B. Ferreira, Nick Fox, Morris Freedman, Giorgio Fumagalli, Alazne Gabilondo, Roberto Gasparotti, Serge Gauthier, Stefano Gazzina, Giorgio Giaccone, Ana Gorostidi, Caroline Greaves, Rita Guerreiro, Carolin Heller, Tobias Hoegen, Begoña Indakoetxea, Lize Jiskoot, Hans-Otto Karnath, Ron Keren, Tobias Langheinrich, Maria João Leitão, Albert Lladó, Gemma Lombardi, Sandra Loosli, Carolina Maruta, Simon Mead, Lieke Meeter, Gabriel Miltenberger, Rick van Minkelen, Sara Mitchell, Katrina Moore, Benedetta Nacmias, Jennifer Nicholas, Jaume Olives, Sebastien Ourselin, Alessandro Padovani, Jessica Panman, Janne M. Papma, Georgia Peakman, Michela Pievani, Yolande Pijnenburg, Cristina Polito, Enrico Premi, Sara Prioni, Catharina Prix, Rosa Rademakers, Veronica Redaelli, Tim Rittman, Ekaterina Rogaeva, Pedro Rosa-Neto, Giacomina Rossi, Martin Rosser, Beatriz Santiago, Elio Scarpini, Sonja Schönecker, Elisa Semler, Rachelle Shafei, Christen Shoesmith, Miguel Tábuas-Pereira, Mikel Tainta, Ricardo Taipa, David Tang-Wai, David L. Thomas, Paul Thompson, Håkan Thonberg, Carolyn Timberlake, Pietro Tiraboschi, Emily Todd, Philip Van Damme, Mathieu Vandenbulcke, Michele Veldsman, Ana Verdelho, Jorge Villanua, Jason Warren, Carlo Wilke, Ione Woollacott, Elisabeth Wlasich, Henrik Zetterberg, Miren Zulaica

MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration

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  • Research article

Thomas Wallach, Zoé J. Mossmann, Michal Szczepek, Max Wetzel, Rui Machado, Martin Raden, Milad Miladi, Gunnar Kleinau, Christina Krüger, Paul Dembny, Drew Adler, Yuanyuan Zhai, Victor Kumbol, Omar Dzaye, Jutta Schüler, Matthias Futschik, Rolf Backofen, Patrick Scheerer, Seija Lehnardt

Basal lamina changes in neurodegenerative disorders

  • Open Access
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Benjamin Nguyen, Gregory Bix, Yao Yao

Discrimination of MSA-P and MSA-C by RT-QuIC analysis of olfactory mucosa: the first assessment of assay reproducibility between two specialized laboratories

  • Open Access
  • Research article

Connor Bargar, Chiara Maria Giulia De Luca, Grazia Devigili, Antonio Emanuele Elia, Roberto Cilia, Sara Maria Portaleone, Wen Wang, Irene Tramacere, Edoardo Bistaffa, Federico Angelo Cazzaniga, Giovanni Felisati, Giuseppe Legname, Alessio Di Fonzo, Rong Xu, Steven Alexander Gunzler, Giorgio Giaccone, Roberto Eleopra, Shu Guang Chen, Fabio Moda

Neuropathology and molecular diagnosis of Synucleinopathies

  • Open Access
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Shunsuke Koga, Hiroaki Sekiya, Naveen Kondru, Owen A. Ross, Dennis W. Dickson

TDP-43 Pathology in Alzheimer’s Disease

  • Open Access
  • Review

Axel Meneses, Shunsuke Koga, Justin O’Leary, Dennis W. Dickson, Guojun Bu, Na Zhao

Kompaktes Leitlinien-Wissen Neurologie (Link öffnet in neuem Fenster)

Mit medbee Pocketcards schnell und sicher entscheiden.
Leitlinien-Wissen kostenlos und immer griffbereit auf ihrem Desktop, Handy oder Tablet.

Neu im Fachgebiet Neurologie

Als Kind pummelig, als Erwachsener geistig weniger flexibel

Wer bereits in der Kindheit oder Jugend ein ungünstiges kardiovaskuläres Risikoprofil aufweist, muss im jungen Erwachsenenalter mit kognitiven Nachteilen rechnen.

Gesunder Lebensstil bei Parkinson essenziell

Wie sehr Menschen mit Parkinson von körperlicher Aktivität, mediterraner Ernährung und Entspannungsübungen profitieren, zeigt ein Review im Fachblatt „Lancet“. Betroffene können mit entsprechenden Maßnahmen eine deutlich verbesserte Lebensqualität erreichen.

RNA-basierte CAR-T-Zell-Therapie hält Myasthenie in Schach

Eine gegen BCMA gerichtete Therapie mit CAR-T-Zellen kann eine schwere Myasthenia gravis über ein Jahr hinweg gut kontrollieren. Der RNA-basierte Ansatz verursacht zudem kaum Nebenwirkungen, erfordert aber sechs wöchentliche Infusionen.

Demenzrisiko: Keine Angst vor fettem Käse!

  • 14.01.2026
  • Demenz
  • Nachrichten

Wer sich täglich ein Stück fetten Käse gönnt oder auf fette Sahne schwört, darf sich über ein vermindertes Demenzrisiko freuen. Dass Milchfett vor Demenz schützt, lässt sich daraus allerdings nicht unbedingt schließen.

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Bildnachweise
Die Leitlinien für Ärztinnen und Ärzte, Untersuchung eines adipösen Kindes/© Colourbox (Symbolbild mit Fotomodell), Senior mit Parkinson hält den Löffel mit zwei Händen/© MarianVejcik / Getty Images / iStock (Symbolbild mit Fotomodell), Störung der Lidhebung bei Myasthenia gravis/© Alessandro Grandini / stock.adobe.com (Symbolbild mit Fotomodell), Person hält ein Glas Milch in beiden Händen/© Africa Studio / stock.adobe.com (Symbolbild mit Fotomodell)