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09.08.2018 | Original Article

PLP1 and CNTN1 gene variation modulates the microstructure of human white matter in the corpus callosum

verfasst von: Catrona Anderson, Wanda M. Gerding, Christoph Fraenz, Caroline Schlüter, Patrick Friedrich, Maximilian Raane, Larissa Arning, Jörg T. Epplen, Onur Güntürkün, Christian Beste, Erhan Genç, Sebastian Ocklenburg

Erschienen in: Brain Structure and Function | Ausgabe 8/2018

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Abstract

The corpus callosum is the brain’s largest commissural fiber tract and is crucial for interhemispheric integration of neural information. Despite the high relevance of the corpus callosum for several cognitive systems, the molecular determinants of callosal microstructure are largely unknown. Recently, it was shown that genetic variations in the myelin-related proteolipid 1 gene PLP1 and the axon guidance related contactin 1 gene CNTN1 were associated with differences in interhemispheric integration at the behavioral level. Here, we used an innovative new diffusion neuroimaging technique called neurite orientation dispersion and density imaging (NODDI) to quantify axonal morphology in subsections of the corpus callosum and link them to genetic variation in PLP1 and CNTN1. In a cohort of 263 healthy human adults, we found that polymorphisms in both PLP1 and CNTN1 were significantly associated with callosal microstructure. Importantly, we found a double dissociation between gene function and neuroimaging variables. Our results suggest that genetic variation in the myelin-related gene PLP1 impacts white matter microstructure in the corpus callosum, possibly by affecting myelin structure. In contrast, genetic variation in the axon guidance related gene CNTN1 impacts axon density in the corpus callosum. These findings suggest that PLP1 and CNTN1 gene variations modulate specific aspects of callosal microstructure that are in line with their gene function.

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Titel: PLP1 and CNTN1 gene variation modulates the microstructure of human white matter in the corpus callosum
verfasst von: Catrona Anderson
Wanda M. Gerding
Christoph Fraenz
Caroline Schlüter
Patrick Friedrich
Maximilian Raane
Larissa Arning
Jörg T. Epplen
Onur Güntürkün
Christian Beste
Erhan Genç
Sebastian Ocklenburg
Publikationsdatum: 09.08.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Brain Structure and Function / Ausgabe 8/2018
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-018-1729-7

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PLP1 and CNTN1 gene variation modulates the microstructure of human white matter in the corpus callosum

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