Erschienen in:
01.06.2014 | Case Reports / Case Series
Reversal of a rocuronium-induced grade IV anaphylaxis via early injection of a large dose of sugammadex
verfasst von:
Benjamin Conte, MD, Lana Zoric, MD, Gerard Bonada, MD, Bertrand Debaene, MD, PhD, Jacques Ripart, MD, PhD
Erschienen in:
Canadian Journal of Anesthesia/Journal canadien d'anesthésie
|
Ausgabe 6/2014
Einloggen, um Zugang zu erhalten
Abstract
Aim
To report rapid recovery from grade IV rocuronium-induced anaphylaxis with a large dose of sugammadex administered early after the onset of symptoms.
Clinical features
A 22-yr-old female without relevant medical history developed an anaphylactic reaction within three minutes of rocuronium injection at induction of anesthesia for a routine cholecystectomy. During the first six minutes, she was unresponsive to usual treatment and her condition evolved to a grade IV anaphylaxis reaction despite a cumulated dose of epinephrine 0.7 mg. Sugammadex 14 mg·kg−1, injected six minutes after rocuronium, resulted in total resolution of all manifestations of anaphylaxis within three minutes. The patient was discharged from hospital the next day. Allergy investigations confirmed rocuronium as the cause of anaphylaxis.
Conclusion
Very early administration of a large dose of sugammadex may be an effective treatment for rocuronium-induced anaphylaxis.