Skip to main content
Erschienen in: International Journal of Colorectal Disease 7/2021

17.02.2021 | Review

The effect of vitamin D on the occurrence and development of colorectal cancer: a systematic review and meta-analysis

verfasst von: Yunbao Xu, Mingxia Qian, Jiaze Hong, Derry Minyao Ng, Tong Yang, Liuhong Xu, Xia Ye

Erschienen in: International Journal of Colorectal Disease | Ausgabe 7/2021

Einloggen, um Zugang zu erhalten

Abstract

Purpose

There has been a lot of controversies about the correlation between vitamin D and colorectal cancer (CRC). In this meta-analysis, we purposed to explore the relationship between vitamin D and the incidence of CRC/the prognosis of CRC.

Methods

A systematic search for articles in databases (Pubmed, Web of Science, EBSCO and Cochrane Library) was terminated in April 2020. The primary outcomes were the incidence rate of CRC and the long-term survival of patients with CRC.

Results

According to the estimated pooled OR from 21 eligible studies, covering 904,152 people, the use of vitamin D was inversely associated with the incidence of CRC [OR = 0.87, (0.82–0.92)]. Among the four studies included in this meta-analysis, covering 7486 patients, compared the overall survival (OS) of CRC between the vitamin D users and the non-users. Based on the estimated pooled HR, vitamin D potentially improved the long-term survival of CRC patients [HR = 0.91, (0.83–0.98)].

Conclusion

This meta-analysis demonstrates that vitamin D not only has a positive impact on the incidence of CRC from either the dietary or supplemental sources but also benefits clinical outcomes and improves the long-term survival of CRC patients. However, further studies are recommended to clarify the above phenomena.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68(6):394–424CrossRefPubMed Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68(6):394–424CrossRefPubMed
2.
Zurück zum Zitat Boyle P, Zaridze D, Smans M (1985) Descriptive epidemiology of colorectal cancer. Int J Cancer 36(1):9–18PubMed Boyle P, Zaridze D, Smans M (1985) Descriptive epidemiology of colorectal cancer. Int J Cancer 36(1):9–18PubMed
3.
Zurück zum Zitat Haenszel W, Berg J, Segi M, Kurihara M, Locke FB (1973) Large-bowel cancer in Hawaiian Japanese. J Natl Cancer Inst 51(6):1765–1779PubMed Haenszel W, Berg J, Segi M, Kurihara M, Locke FB (1973) Large-bowel cancer in Hawaiian Japanese. J Natl Cancer Inst 51(6):1765–1779PubMed
4.
Zurück zum Zitat Lipkin M, Reddy B, Newmark H, Lamprecht SA (1999) Dietary factors in human colorectal cancer. Annu Rev Nutr 19:545–586 Lipkin M, Reddy B, Newmark H, Lamprecht SA (1999) Dietary factors in human colorectal cancer. Annu Rev Nutr 19:545–586
5.
Zurück zum Zitat Kulda V (2012) Vitamin D metabolism. Vnitr Lek 58(5):400–404PubMed Kulda V (2012) Vitamin D metabolism. Vnitr Lek 58(5):400–404PubMed
6.
Zurück zum Zitat Ahmad I, Trikudanathan G, Feinn R, Anderson J, Nicholson M, Lowe S, Levine JB (2016) Low serum vitamin D: A surrogate marker for advanced colon adenoma? J Clin Gastroenterol 50(8):644–648PubMed Ahmad I, Trikudanathan G, Feinn R, Anderson J, Nicholson M, Lowe S, Levine JB (2016) Low serum vitamin D: A surrogate marker for advanced colon adenoma? J Clin Gastroenterol 50(8):644–648PubMed
7.
Zurück zum Zitat Arai H, Miyamoto KI, Yoshida M, Yamamoto H, Taketani Y, Morita K, Kubota M, Yoshida S, Ikeda M, Watabe F, Kanemasa Y, Takeda E (2001) The polymorphism in the caudal-related homeodomain protein Cdx-2 binding element in the human vitamin D receptor gene. J Bone Miner Res 16(7):1256–1264PubMed Arai H, Miyamoto KI, Yoshida M, Yamamoto H, Taketani Y, Morita K, Kubota M, Yoshida S, Ikeda M, Watabe F, Kanemasa Y, Takeda E (2001) The polymorphism in the caudal-related homeodomain protein Cdx-2 binding element in the human vitamin D receptor gene. J Bone Miner Res 16(7):1256–1264PubMed
8.
Zurück zum Zitat Jeffery LE, Henley P, Marium N, Filer A, Sansom DM, Hewison M, Raza K (2018) Decreased sensitivity to 1,25-dihydroxyvitamin D3 in T cells from the rheumatoid joint. J Autoimmun 88:50–60PubMedPubMedCentral Jeffery LE, Henley P, Marium N, Filer A, Sansom DM, Hewison M, Raza K (2018) Decreased sensitivity to 1,25-dihydroxyvitamin D3 in T cells from the rheumatoid joint. J Autoimmun 88:50–60PubMedPubMedCentral
9.
Zurück zum Zitat Barbáchano A, Fernández-Barral A, Ferrer-Mayorga G, Costales-Carrera A, Larriba MJ, Muñoz A (2017) Endocrinology C: The endocrine vitamin D system in the gut. Mol Cell Endocrinol 453:79–87PubMed Barbáchano A, Fernández-Barral A, Ferrer-Mayorga G, Costales-Carrera A, Larriba MJ, Muñoz A (2017) Endocrinology C: The endocrine vitamin D system in the gut. Mol Cell Endocrinol 453:79–87PubMed
10.
Zurück zum Zitat Theodoratou E, Tzoulaki I, Zgaga L, Ioannidis JP (2014) Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. BMJ 348:g2035PubMedPubMedCentral Theodoratou E, Tzoulaki I, Zgaga L, Ioannidis JP (2014) Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. BMJ 348:g2035PubMedPubMedCentral
11.
Zurück zum Zitat Autier P, Boniol M, Pizot C, Mullie P (2014) Vitamin D status and ill health: a systematic review. Lancet Diabetes Endocrinol 2(1):76–89PubMed Autier P, Boniol M, Pizot C, Mullie P (2014) Vitamin D status and ill health: a systematic review. Lancet Diabetes Endocrinol 2(1):76–89PubMed
12.
Zurück zum Zitat Fleet JC, DeSmet M, Johnson R, Li Y (2012) Vitamin D and cancer: a review of molecular mechanisms. Biochem J 441(1):61–76PubMed Fleet JC, DeSmet M, Johnson R, Li Y (2012) Vitamin D and cancer: a review of molecular mechanisms. Biochem J 441(1):61–76PubMed
13.
Zurück zum Zitat Barbáchano A, Larriba MJ, Ferrer-Mayorga G, González-Sancho JM, Muñoz A (2018) Vitamin D and colon cancer. Health Disease and Therapeutics 2:837–862 Barbáchano A, Larriba MJ, Ferrer-Mayorga G, González-Sancho JM, Muñoz A (2018) Vitamin D and colon cancer. Health Disease and Therapeutics 2:837–862
14.
Zurück zum Zitat Martínez M, Giovannucci E, Colditz G, Stampfer M, Hunter D, Speizer F, Wing A, Willett WC (1996) Calcium, vitamin D, and the occurrence of colorectal cancer among women. J Natl Cancer Inst 88(19):1375–1382PubMed Martínez M, Giovannucci E, Colditz G, Stampfer M, Hunter D, Speizer F, Wing A, Willett WC (1996) Calcium, vitamin D, and the occurrence of colorectal cancer among women. J Natl Cancer Inst 88(19):1375–1382PubMed
15.
Zurück zum Zitat Pritchard R, Baron J, Gerhardsson de Verdier M (1996) Dietary calcium, vitamin D, and the risk of colorectal cancer in Stockholm, Sweden. Cancer Epidemiol Biomarkers Prev 5(11):897–900PubMed Pritchard R, Baron J, Gerhardsson de Verdier M (1996) Dietary calcium, vitamin D, and the risk of colorectal cancer in Stockholm, Sweden. Cancer Epidemiol Biomarkers Prev 5(11):897–900PubMed
16.
Zurück zum Zitat Antunac Golubic Z, Barsic I, Librenjak N, Plestina S (2018) Vitamin D supplementation and survival in metastatic colorectal cancer. Nutr Cancer 70(3):413–417PubMed Antunac Golubic Z, Barsic I, Librenjak N, Plestina S (2018) Vitamin D supplementation and survival in metastatic colorectal cancer. Nutr Cancer 70(3):413–417PubMed
17.
Zurück zum Zitat Jeffreys M, Redaniel MT, Martin RM (2015) The effect of pre-diagnostic vitamin D supplementation on cancer survival in women: a cohort study within the UK Clinical Practice Research Datalink. BMC Cancer 15:670PubMedPubMedCentral Jeffreys M, Redaniel MT, Martin RM (2015) The effect of pre-diagnostic vitamin D supplementation on cancer survival in women: a cohort study within the UK Clinical Practice Research Datalink. BMC Cancer 15:670PubMedPubMedCentral
18.
Zurück zum Zitat Lewis C, Xun P, He K (2016) Vitamin D supplementation and quality of life following diagnosis in stage II colorectal cancer patients: a 24-month prospective study. Support Care Cancer 24(4):1655–1661PubMed Lewis C, Xun P, He K (2016) Vitamin D supplementation and quality of life following diagnosis in stage II colorectal cancer patients: a 24-month prospective study. Support Care Cancer 24(4):1655–1661PubMed
19.
Zurück zum Zitat Yang B, McCullough ML, Gapstur SM, Jacobs EJ, Bostick RM, Fedirko V, Flanders WD, Campbell PT (2014) Calcium, vitamin D, dairy products, and mortality among colorectal cancer survivors: the Cancer Prevention Study-II Nutrition Cohort. J Clin Oncol 32(22):2335–2343PubMed Yang B, McCullough ML, Gapstur SM, Jacobs EJ, Bostick RM, Fedirko V, Flanders WD, Campbell PT (2014) Calcium, vitamin D, dairy products, and mortality among colorectal cancer survivors: the Cancer Prevention Study-II Nutrition Cohort. J Clin Oncol 32(22):2335–2343PubMed
20.
Zurück zum Zitat Gu L, Khadaroo PA, Chen L, Li X, Zhu H, Zhong X, Pan J, Chen M (2019) Comparison of long-term outcomes of endoscopic submucosal dissection and surgery for early gastric cancer: A systematic review and meta-analysis. J Gastrointest Surg 23(7):1493–1501PubMed Gu L, Khadaroo PA, Chen L, Li X, Zhu H, Zhong X, Pan J, Chen M (2019) Comparison of long-term outcomes of endoscopic submucosal dissection and surgery for early gastric cancer: A systematic review and meta-analysis. J Gastrointest Surg 23(7):1493–1501PubMed
21.
Zurück zum Zitat Kearney J, Giovannucci E, Rimm E, Ascherio A, Stampfer M, Colditz G, Wing A, Kampman E, Willett WC (1996) Calcium, vitamin D, and dairy foods and the occurrence of colon cancer in men. Am J Epidemiol 143(9):907–917PubMed Kearney J, Giovannucci E, Rimm E, Ascherio A, Stampfer M, Colditz G, Wing A, Kampman E, Willett WC (1996) Calcium, vitamin D, and dairy foods and the occurrence of colon cancer in men. Am J Epidemiol 143(9):907–917PubMed
22.
Zurück zum Zitat Boutron M, Faivre J, Marteau P, Couillault C, Senesse P, Quipourt V (1996) Calcium, phosphorus, vitamin D, dairy products and colorectal carcinogenesis: a French case-control study. Br J Cancer 74(1):145–151PubMedPubMedCentral Boutron M, Faivre J, Marteau P, Couillault C, Senesse P, Quipourt V (1996) Calcium, phosphorus, vitamin D, dairy products and colorectal carcinogenesis: a French case-control study. Br J Cancer 74(1):145–151PubMedPubMedCentral
23.
Zurück zum Zitat Marcus PM, Newcomb PA (1998) The association of calcium and vitamin D, and colon and rectal cancer in Wisconsin women. Int J Epidemiol 27(5):788–793PubMed Marcus PM, Newcomb PA (1998) The association of calcium and vitamin D, and colon and rectal cancer in Wisconsin women. Int J Epidemiol 27(5):788–793PubMed
24.
Zurück zum Zitat Järvinen R, Knekt P, Hakulinen T, Aromaa A (2001) Prospective study on milk products, calcium and cancers of the colon and rectum. Eur J Clin Nutr 55(11):1000–1007PubMed Järvinen R, Knekt P, Hakulinen T, Aromaa A (2001) Prospective study on milk products, calcium and cancers of the colon and rectum. Eur J Clin Nutr 55(11):1000–1007PubMed
25.
Zurück zum Zitat Kampman E, Slattery M, Caan B, Potter JD (2000) Calcium, vitamin D, sunshine exposure, dairy products and colon cancer risk (United States). Cancer Causes Control 11(5):459–466PubMed Kampman E, Slattery M, Caan B, Potter JD (2000) Calcium, vitamin D, sunshine exposure, dairy products and colon cancer risk (United States). Cancer Causes Control 11(5):459–466PubMed
26.
Zurück zum Zitat McCullough M, Robertson A, Rodriguez C, Jacobs E, Chao A, Carolyn J, Calle E, Willett W, Thun MJ (2003) Calcium, vitamin D, dairy products, and risk of colorectal cancer in the Cancer Prevention Study II Nutrition Cohort (United States). J Clin Oncol 14(1):1–12 McCullough M, Robertson A, Rodriguez C, Jacobs E, Chao A, Carolyn J, Calle E, Willett W, Thun MJ (2003) Calcium, vitamin D, dairy products, and risk of colorectal cancer in the Cancer Prevention Study II Nutrition Cohort (United States). J Clin Oncol 14(1):1–12
27.
Zurück zum Zitat Slattery M, Neuhausen S, Hoffman M, Caan B, Curtin K, Ma K, Samowitz W (2004) Dietary calcium, vitamin D, VDR genotypes and colorectal cancer. Int J Cancer 111(5):750–756PubMed Slattery M, Neuhausen S, Hoffman M, Caan B, Curtin K, Ma K, Samowitz W (2004) Dietary calcium, vitamin D, VDR genotypes and colorectal cancer. Int J Cancer 111(5):750–756PubMed
28.
Zurück zum Zitat Terry P, Baron J, Bergkvist L, Holmberg L, Wolk A (2002) Cancer: Dietary calcium and vitamin D intake and risk of colorectal cancer: a prospective cohort study in women. Nutr Cancer 43(1):39–46PubMed Terry P, Baron J, Bergkvist L, Holmberg L, Wolk A (2002) Cancer: Dietary calcium and vitamin D intake and risk of colorectal cancer: a prospective cohort study in women. Nutr Cancer 43(1):39–46PubMed
29.
Zurück zum Zitat Kesse E, Boutron-Ruault M, Norat T, Riboli E, Clavel-Chapelon F (2005) Dietary calcium, phosphorus, vitamin D, dairy products and the risk of colorectal adenoma and cancer among French women of the E3N-EPIC prospective study. Int J Cancer 117(1):137–144PubMed Kesse E, Boutron-Ruault M, Norat T, Riboli E, Clavel-Chapelon F (2005) Dietary calcium, phosphorus, vitamin D, dairy products and the risk of colorectal adenoma and cancer among French women of the E3N-EPIC prospective study. Int J Cancer 117(1):137–144PubMed
30.
Zurück zum Zitat Lin J, Zhang S, Cook N, Manson J, Lee I, Buring JE (2005) Intakes of calcium and vitamin D and risk of colorectal cancer in women. Am J Epidemiol 161(8):755–764PubMed Lin J, Zhang S, Cook N, Manson J, Lee I, Buring JE (2005) Intakes of calcium and vitamin D and risk of colorectal cancer in women. Am J Epidemiol 161(8):755–764PubMed
31.
Zurück zum Zitat Lipworth L, Bender T, Rossi M, Bosetti C, Negri E, Talamini R, Giacosa A, Franceschi S, McLaughlin J, La Vecchia CJN et al (2009) Dietary vitamin D intake and cancers of the colon and rectum: a case-control study in Italy. Nutr Cancer 61(1):70–75PubMed Lipworth L, Bender T, Rossi M, Bosetti C, Negri E, Talamini R, Giacosa A, Franceschi S, McLaughlin J, La Vecchia CJN et al (2009) Dietary vitamin D intake and cancers of the colon and rectum: a case-control study in Italy. Nutr Cancer 61(1):70–75PubMed
32.
Zurück zum Zitat Park S, Murphy S, Wilkens L, Nomura A, Henderson B, Kolonel LN (2007) Calcium and vitamin D intake and risk of colorectal cancer: the Multiethnic Cohort Study. Am J Epidemiol 165(7):784–793PubMed Park S, Murphy S, Wilkens L, Nomura A, Henderson B, Kolonel LN (2007) Calcium and vitamin D intake and risk of colorectal cancer: the Multiethnic Cohort Study. Am J Epidemiol 165(7):784–793PubMed
33.
Zurück zum Zitat Wactawski-Wende J, Kotchen J, Anderson G, Assaf A, Brunner R, O'Sullivan M, Margolis K, Ockene J, Phillips L, Pottern L et al (2006) Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med 354(7):684–696PubMed Wactawski-Wende J, Kotchen J, Anderson G, Assaf A, Brunner R, O'Sullivan M, Margolis K, Ockene J, Phillips L, Pottern L et al (2006) Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med 354(7):684–696PubMed
34.
Zurück zum Zitat Banqué M, Raidó B, Masuet C, Ramon JM (2012) Food groups and nutrient intake and risk of colorectal cancer: a hospital-based case-control study in Spain. Nutr Cancer 64(3):386–392PubMed Banqué M, Raidó B, Masuet C, Ramon JM (2012) Food groups and nutrient intake and risk of colorectal cancer: a hospital-based case-control study in Spain. Nutr Cancer 64(3):386–392PubMed
35.
Zurück zum Zitat Hosseinzadeh P, Javanbakht M, Alemrajabi M, Gholami A, Amirkalali B, Sohrabi M, Zamani F (2019) The association of dietary intake of calcium and vitamin D to colorectal cancer risk among Iranian population. Asian Pac J Cancer Prev 20(9):2825–2830PubMedPubMedCentral Hosseinzadeh P, Javanbakht M, Alemrajabi M, Gholami A, Amirkalali B, Sohrabi M, Zamani F (2019) The association of dietary intake of calcium and vitamin D to colorectal cancer risk among Iranian population. Asian Pac J Cancer Prev 20(9):2825–2830PubMedPubMedCentral
36.
Zurück zum Zitat Manson J, Cook N, Lee I, Christen W, Bassuk S, Mora S, Gibson H, Gordon D, Copeland T, D'Agostino D et al (2019) Vitamin D supplements and prevention of cancer and cardiovascular disease. N Engl J Med 380(1):33–44PubMed Manson J, Cook N, Lee I, Christen W, Bassuk S, Mora S, Gibson H, Gordon D, Copeland T, D'Agostino D et al (2019) Vitamin D supplements and prevention of cancer and cardiovascular disease. N Engl J Med 380(1):33–44PubMed
37.
Zurück zum Zitat Sun Z, Wang P, Roebothan B, Cotterchio M, Green R, Buehler S, Zhao J, Squires J, Zhao J, Zhu Y et al (2011) Calcium and vitamin D and risk of colorectal cancer: results from a large population-based case-control study in Newfoundland and Labrador and Ontario. Can J Public Health 102(5):382–389PubMedPubMedCentral Sun Z, Wang P, Roebothan B, Cotterchio M, Green R, Buehler S, Zhao J, Squires J, Zhao J, Zhu Y et al (2011) Calcium and vitamin D and risk of colorectal cancer: results from a large population-based case-control study in Newfoundland and Labrador and Ontario. Can J Public Health 102(5):382–389PubMedPubMedCentral
38.
Zurück zum Zitat Um C, Prizment A, Hong C, Lazovich D, Bostick RM (2019) Associations of calcium, vitamin D, and dairy product intakes with colorectal cancer risk among older women: the Iowa women's health study. Nutr Cancer 71(5):739–748PubMed Um C, Prizment A, Hong C, Lazovich D, Bostick RM (2019) Associations of calcium, vitamin D, and dairy product intakes with colorectal cancer risk among older women: the Iowa women's health study. Nutr Cancer 71(5):739–748PubMed
39.
Zurück zum Zitat Vallès X, Alonso M, López-Caleya J, Díez-Obrero V, Dierssen-Sotos T, Lope V, Molina-Barceló A, Chirlaque M, Jiménez-Moleón J, Fernández Tardón G et al (2018) Colorectal cancer, sun exposure and dietary vitamin D and calcium intake in the MCC-Spain study. Environ Int 121:428–434PubMed Vallès X, Alonso M, López-Caleya J, Díez-Obrero V, Dierssen-Sotos T, Lope V, Molina-Barceló A, Chirlaque M, Jiménez-Moleón J, Fernández Tardón G et al (2018) Colorectal cancer, sun exposure and dietary vitamin D and calcium intake in the MCC-Spain study. Environ Int 121:428–434PubMed
40.
Zurück zum Zitat Hartman TJ, Albert PS, Snyder K, Slattery ML, Caan B, Paskett E, Iber F, Kikendall JW, Marshall J, Shike M, Weissfeld J, Brewer B, Schatzkin A, Lanza E, Polyp Prevention Study Group (2005) The association of calcium and vitamin D with risk of colorectal adenomas. J Nutr 135(2):252–259PubMed Hartman TJ, Albert PS, Snyder K, Slattery ML, Caan B, Paskett E, Iber F, Kikendall JW, Marshall J, Shike M, Weissfeld J, Brewer B, Schatzkin A, Lanza E, Polyp Prevention Study Group (2005) The association of calcium and vitamin D with risk of colorectal adenomas. J Nutr 135(2):252–259PubMed
41.
Zurück zum Zitat Baron JA, Barry EL, Mott LA, Rees JR, Sandler RS, Snover DC, Bostick RM, Ivanova A, Cole BF, Ahnen DJ, Beck GJ, Bresalier RS, Burke CA, Church TR, Cruz-Correa M, Figueiredo JC, Goodman M, Kim AS, Robertson DJ, Rothstein R, Shaukat A, Seabrook ME, Summers RW (2015) A trial of calcium and vitamin D for the prevention of colorectal adenomas. N Engl J Med 373(16):1519–1530PubMedPubMedCentral Baron JA, Barry EL, Mott LA, Rees JR, Sandler RS, Snover DC, Bostick RM, Ivanova A, Cole BF, Ahnen DJ, Beck GJ, Bresalier RS, Burke CA, Church TR, Cruz-Correa M, Figueiredo JC, Goodman M, Kim AS, Robertson DJ, Rothstein R, Shaukat A, Seabrook ME, Summers RW (2015) A trial of calcium and vitamin D for the prevention of colorectal adenomas. N Engl J Med 373(16):1519–1530PubMedPubMedCentral
42.
Zurück zum Zitat Crockett SD, Barry EL, Mott LA, Ahnen DJ, Robertson DJ, Anderson JC, Wallace K, Burke CA, Bresalier RS, Figueiredo JC, Snover DC, Baron JA (2019) Calcium and vitamin D supplementation and increased risk of serrated polyps: results from a randomised clinical trial. Gut 68(3):475–486PubMed Crockett SD, Barry EL, Mott LA, Ahnen DJ, Robertson DJ, Anderson JC, Wallace K, Burke CA, Bresalier RS, Figueiredo JC, Snover DC, Baron JA (2019) Calcium and vitamin D supplementation and increased risk of serrated polyps: results from a randomised clinical trial. Gut 68(3):475–486PubMed
43.
Zurück zum Zitat Huang D, Lei S, Wu Y, Weng M, Zhou Y, Xu J, Xia D, Xu E, Lai M, Zhang H (2020) Additively protective effects of vitamin D and calcium against colorectal adenoma incidence, malignant transformation and progression: a systematic review and meta-analysis. Clin Nutr 39(8):2525–2538PubMed Huang D, Lei S, Wu Y, Weng M, Zhou Y, Xu J, Xia D, Xu E, Lai M, Zhang H (2020) Additively protective effects of vitamin D and calcium against colorectal adenoma incidence, malignant transformation and progression: a systematic review and meta-analysis. Clin Nutr 39(8):2525–2538PubMed
44.
Zurück zum Zitat Wei MY, Garland CF, Gorham ED, Mohr SB, Giovannucci E (2008) Vitamin D and prevention of colorectal adenoma: a meta-analysis. Cancer Epidemiol Biomark Prev 17(11):2958–2969 Wei MY, Garland CF, Gorham ED, Mohr SB, Giovannucci E (2008) Vitamin D and prevention of colorectal adenoma: a meta-analysis. Cancer Epidemiol Biomark Prev 17(11):2958–2969
45.
Zurück zum Zitat Newmark HL, Lipkin M (1992) Calcium, vitamin D, and colon cancer. Cancer Res 52(7 Suppl):2067s–2070sPubMed Newmark HL, Lipkin M (1992) Calcium, vitamin D, and colon cancer. Cancer Res 52(7 Suppl):2067s–2070sPubMed
46.
Zurück zum Zitat Lamprecht SA, Lipkin M (2003) Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms. Nat Rev Cancer 3(8):601–614PubMed Lamprecht SA, Lipkin M (2003) Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms. Nat Rev Cancer 3(8):601–614PubMed
47.
Zurück zum Zitat Dusso AS, Brown AJ, Slatopolsky E (2005) Vitamin D. Am J Physiol Ren Physiol 289(1):F8–F28 Dusso AS, Brown AJ, Slatopolsky E (2005) Vitamin D. Am J Physiol Ren Physiol 289(1):F8–F28
48.
Zurück zum Zitat Cross HS, Nittke T, Kallay E (2011) Colonic vitamin D metabolism: implications for the pathogenesis of inflammatory bowel disease and colorectal cancer. Mol Cell Endocrinol 347(1-2):70–79PubMed Cross HS, Nittke T, Kallay E (2011) Colonic vitamin D metabolism: implications for the pathogenesis of inflammatory bowel disease and colorectal cancer. Mol Cell Endocrinol 347(1-2):70–79PubMed
49.
Zurück zum Zitat Meeker S, Seamons A, Paik J, Treuting P, Brabb T, Grady W, Maggio-Price LJ (2014) Increased dietary vitamin D suppresses MAPK signaling, colitis, and colon cancer. Cancer Res 74(16):4398–4408PubMedPubMedCentral Meeker S, Seamons A, Paik J, Treuting P, Brabb T, Grady W, Maggio-Price LJ (2014) Increased dietary vitamin D suppresses MAPK signaling, colitis, and colon cancer. Cancer Res 74(16):4398–4408PubMedPubMedCentral
50.
Zurück zum Zitat Ricca C, Aillon A, Viano M, Bergandi L, Aldieri E, Silvagno F (2019) Vitamin D inhibits the epithelial-mesenchymal transition by a negative feedback regulation of TGF-β activity. J Steroid Biochem Mol Biol 187:97–105PubMed Ricca C, Aillon A, Viano M, Bergandi L, Aldieri E, Silvagno F (2019) Vitamin D inhibits the epithelial-mesenchymal transition by a negative feedback regulation of TGF-β activity. J Steroid Biochem Mol Biol 187:97–105PubMed
51.
Zurück zum Zitat Vaughan-Shaw PG, Buijs LF, Blackmur JP, Theodoratou E, Zgaga L, Din FVN, Farrington SM, Dunlop MG (2020) The effect of vitamin D supplementation on survival in patients with colorectal cancer: systematic review and meta-analysis of randomised controlled trials. Br J Cancer 123:1705–1712PubMedPubMedCentral Vaughan-Shaw PG, Buijs LF, Blackmur JP, Theodoratou E, Zgaga L, Din FVN, Farrington SM, Dunlop MG (2020) The effect of vitamin D supplementation on survival in patients with colorectal cancer: systematic review and meta-analysis of randomised controlled trials. Br J Cancer 123:1705–1712PubMedPubMedCentral
52.
Zurück zum Zitat Wranicz J, Szostak-Wegierek D (2014) Health outcomes of vitamin D. Part II. Role in prevention of diseases. Rocz Panstw Zakl Hig 65(4):273–279PubMed Wranicz J, Szostak-Wegierek D (2014) Health outcomes of vitamin D. Part II. Role in prevention of diseases. Rocz Panstw Zakl Hig 65(4):273–279PubMed
53.
Zurück zum Zitat Wu S, Feng B, Li K, Zhu X, Liang S, Liu X, Han S, Wang B, Wu K, Miao D, Liang J, Fan D (2012) Fish consumption and colorectal cancer risk in humans: a systematic review and meta-analysis. Am J Med 125(6):551–559 e555PubMed Wu S, Feng B, Li K, Zhu X, Liang S, Liu X, Han S, Wang B, Wu K, Miao D, Liang J, Fan D (2012) Fish consumption and colorectal cancer risk in humans: a systematic review and meta-analysis. Am J Med 125(6):551–559 e555PubMed
54.
Zurück zum Zitat Holick M, Binkley N, Bischoff-Ferrari H, Gordon C, Hanley D, Heaney R, Murad M, Weaver C (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96(7):1911–1930PubMed Holick M, Binkley N, Bischoff-Ferrari H, Gordon C, Hanley D, Heaney R, Murad M, Weaver C (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96(7):1911–1930PubMed
55.
Zurück zum Zitat Lampe JW, Fredstrom SB, Slavin JL, Potter JD (1993) Sex differences in colonic function: a randomised trial. Gut 34(4):531–536PubMedPubMedCentral Lampe JW, Fredstrom SB, Slavin JL, Potter JD (1993) Sex differences in colonic function: a randomised trial. Gut 34(4):531–536PubMedPubMedCentral
56.
Zurück zum Zitat Speer G, Cseh K, Winkler G, Takacs I, Barna I, Nagy Z, Lakatos P (2001) Oestrogen and vitamin D receptor (VDR) genotypes and the expression of ErbB-2 and EGF receptor in human rectal cancers. Eur J Cancer 37(12):1463–1468PubMed Speer G, Cseh K, Winkler G, Takacs I, Barna I, Nagy Z, Lakatos P (2001) Oestrogen and vitamin D receptor (VDR) genotypes and the expression of ErbB-2 and EGF receptor in human rectal cancers. Eur J Cancer 37(12):1463–1468PubMed
57.
Zurück zum Zitat Gilad LA, Bresler T, Gnainsky J, Smirnoff P, Schwartz B (2005) Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells. J Endocrinol 185(3):577–592PubMed Gilad LA, Bresler T, Gnainsky J, Smirnoff P, Schwartz B (2005) Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells. J Endocrinol 185(3):577–592PubMed
58.
Zurück zum Zitat Iacopetta B (2002) Are there two sides to colorectal cancer? Int J Cancer 101(5):403–408PubMed Iacopetta B (2002) Are there two sides to colorectal cancer? Int J Cancer 101(5):403–408PubMed
59.
Zurück zum Zitat Gorham E, Garland C, Garland F, Grant W, Mohr S, Lipkin M, Newmark H, Giovannucci E, Wei M, Holick MF (2007) Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. Am J Prev Med 32(3):210–216PubMed Gorham E, Garland C, Garland F, Grant W, Mohr S, Lipkin M, Newmark H, Giovannucci E, Wei M, Holick MF (2007) Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. Am J Prev Med 32(3):210–216PubMed
60.
Zurück zum Zitat Sy A, JEK B (2013) Association between serum vitamin D levels and colonic carcinomatous polyps. J Gastrointest Cancer 44(4):481–485PubMed Sy A, JEK B (2013) Association between serum vitamin D levels and colonic carcinomatous polyps. J Gastrointest Cancer 44(4):481–485PubMed
61.
Zurück zum Zitat Sellers TA, Bazyk AE, Bostick RM, Kushi LH, Olson JE, Anderson KE, Lazovich D, Folsom AR (1998) Diet and risk of colon cancer in a large prospective study of older women: an analysis stratified on family history (Iowa, United States). Cancer Causes Control 9(4):357–367PubMed Sellers TA, Bazyk AE, Bostick RM, Kushi LH, Olson JE, Anderson KE, Lazovich D, Folsom AR (1998) Diet and risk of colon cancer in a large prospective study of older women: an analysis stratified on family history (Iowa, United States). Cancer Causes Control 9(4):357–367PubMed
62.
Zurück zum Zitat Peters U, Hayes RB, Chatterjee N, Shao W, Schoen RE, Pinsky P, Hollis BW, McGlynn KA, Prostate LC (2004) Ovarian Cancer Screening Project T: Circulating vitamin D metabolites, polymorphism in vitamin D receptor, and colorectal adenoma risk. Cancer Epidemiol Biomark Prev 13(4):546–552 Peters U, Hayes RB, Chatterjee N, Shao W, Schoen RE, Pinsky P, Hollis BW, McGlynn KA, Prostate LC (2004) Ovarian Cancer Screening Project T: Circulating vitamin D metabolites, polymorphism in vitamin D receptor, and colorectal adenoma risk. Cancer Epidemiol Biomark Prev 13(4):546–552
63.
Zurück zum Zitat Fakih M, Trump D, Johnson C, Tian L, Muindi J, Sunga AY (2009) Chemotherapy is linked to severe vitamin D deficiency in patients with colorectal cancer. Int J Colorectal Dis 24(2):219–224PubMed Fakih M, Trump D, Johnson C, Tian L, Muindi J, Sunga AY (2009) Chemotherapy is linked to severe vitamin D deficiency in patients with colorectal cancer. Int J Colorectal Dis 24(2):219–224PubMed
64.
Zurück zum Zitat Moan J, Porojnicu A, Lagunova Z, Berg J, Dahlback A (2007) Colon cancer: prognosis for different latitudes, age groups and seasons in Norway. J Photochem Photobiol B 89:148–155PubMed Moan J, Porojnicu A, Lagunova Z, Berg J, Dahlback A (2007) Colon cancer: prognosis for different latitudes, age groups and seasons in Norway. J Photochem Photobiol B 89:148–155PubMed
65.
Zurück zum Zitat Mezawa H, Sugiura T, Watanabe M, Norizoe C, Takahashi D, Shimojima A, Tamez S, Tsutsumi Y, Yanaga K, Urashima M (2010) Serum vitamin D levels and survival of patients with colorectal cancer: post-hoc analysis of a prospective cohort study. BMC Cancer 10:347PubMedPubMedCentral Mezawa H, Sugiura T, Watanabe M, Norizoe C, Takahashi D, Shimojima A, Tamez S, Tsutsumi Y, Yanaga K, Urashima M (2010) Serum vitamin D levels and survival of patients with colorectal cancer: post-hoc analysis of a prospective cohort study. BMC Cancer 10:347PubMedPubMedCentral
66.
Zurück zum Zitat Heaney R, Davies K, Chen T, Holick M, Barger-Lux MJ (2003) Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 77(1):204–210PubMed Heaney R, Davies K, Chen T, Holick M, Barger-Lux MJ (2003) Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 77(1):204–210PubMed
67.
Zurück zum Zitat Huncharek M, Muscat J, Kupelnick B (2009) Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies. Nutr Cancer 61(1):47–69PubMed Huncharek M, Muscat J, Kupelnick B (2009) Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies. Nutr Cancer 61(1):47–69PubMed
Metadaten
Titel
The effect of vitamin D on the occurrence and development of colorectal cancer: a systematic review and meta-analysis
verfasst von
Yunbao Xu
Mingxia Qian
Jiaze Hong
Derry Minyao Ng
Tong Yang
Liuhong Xu
Xia Ye
Publikationsdatum
17.02.2021
Verlag
Springer Berlin Heidelberg
Erschienen in
International Journal of Colorectal Disease / Ausgabe 7/2021
Print ISSN: 0179-1958
Elektronische ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-021-03879-w

Weitere Artikel der Ausgabe 7/2021

International Journal of Colorectal Disease 7/2021 Zur Ausgabe

Häusliche Gewalt in der orthopädischen Notaufnahme oft nicht erkannt

28.05.2024 Häusliche Gewalt Nachrichten

In der Notaufnahme wird die Chance, Opfer von häuslicher Gewalt zu identifizieren, von Orthopäden und Orthopädinnen offenbar zu wenig genutzt. Darauf deuten die Ergebnisse einer Fragebogenstudie an der Sahlgrenska-Universität in Schweden hin.

Fehlerkultur in der Medizin – Offenheit zählt!

28.05.2024 Fehlerkultur Podcast

Darüber reden und aus Fehlern lernen, sollte das Motto in der Medizin lauten. Und zwar nicht nur im Sinne der Patientensicherheit. Eine negative Fehlerkultur kann auch die Behandelnden ernsthaft krank machen, warnt Prof. Dr. Reinhard Strametz. Ein Plädoyer und ein Leitfaden für den offenen Umgang mit kritischen Ereignissen in Medizin und Pflege.

Mehr Frauen im OP – weniger postoperative Komplikationen

21.05.2024 Allgemeine Chirurgie Nachrichten

Ein Frauenanteil von mindestens einem Drittel im ärztlichen Op.-Team war in einer großen retrospektiven Studie aus Kanada mit einer signifikanten Reduktion der postoperativen Morbidität assoziiert.

TAVI versus Klappenchirurgie: Neue Vergleichsstudie sorgt für Erstaunen

21.05.2024 TAVI Nachrichten

Bei schwerer Aortenstenose und obstruktiver KHK empfehlen die Leitlinien derzeit eine chirurgische Kombi-Behandlung aus Klappenersatz plus Bypass-OP. Diese Empfehlung wird allerdings jetzt durch eine aktuelle Studie infrage gestellt – mit überraschender Deutlichkeit.

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom BDC Leitlinien Webinare
CME: 2 Punkte

Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur BDC Leitlinien Webinare
CME: 2 Punkte

Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis BDC Leitlinien Webinare
CME: 2 Punkte

Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.