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International Journal of Colorectal Disease

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01.12.2023 | REVIEW

The role of viruses in human acute appendicitis: a systematic literature review

verfasst von: Saber Soltani, Mina Mobini Kesheh, Goli Siri, Samireh Faramarzi, Ramin Shahbahrami, Mojtaba Didehdar, Yousef Erfani, Abbas Farahani

Erschienen in: International Journal of Colorectal Disease | Ausgabe 1/2023

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Abstract

Background

There have been debates about the human appendix function, and while previous research suggested it might be a vestigial organ with no functional significance, recent studies have pointed out that it might have an important role in the immune system. Acute appendicitis (AA) is a common cause of emergency abdominal surgery in the world. Some epidemiologic investigations have found an association between appendicitis and viral infections. In this study, we have reviewed systematically articles to discover viral infections that cause appendicitis and find any possible correlations between the two.

Methods

This systematic review was performed by searching among electronic databases including Web of Science, PubMed, Scopus, and EMBASE on viruses and appendicitis topics.

Results

Conducted search leads to 983 results in all databases after the duplicate removal and screening by title, abstract, and full-text based on inclusion criteria lead to 19 studies. There were several assays to detect the viruses, which are thought to be AA causative agents. RT-PCR and immunoassays were the mainstay methods to detect the probable cause.

Conclusion

Investigations suggested that some viruses including measles virus (MV), influenza virus, dengue fever virus (DFV), human immunodeficiency virus (HIV), human herpesviruses, rotavirus, and adenovirus are associated with acute appendicitis. Despite the available reports, the specific mechanisms behind the relationship between acute appendicitis and viral infections are yet to be understood. Therefore, further investigations are necessary to find out the pathogenesis and pathophysiology of viral complications in appendicitis.

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Titel: The role of viruses in human acute appendicitis: a systematic literature review
verfasst von: Saber Soltani
Mina Mobini Kesheh
Goli Siri
Samireh Faramarzi
Ramin Shahbahrami
Mojtaba Didehdar
Yousef Erfani
Abbas Farahani
Publikationsdatum: 01.12.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: International Journal of Colorectal Disease / Ausgabe 1/2023
Print ISSN: 0179-1958
Elektronische ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-023-04391-z

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The role of viruses in human acute appendicitis: a systematic literature review

Abstract

Background

Methods

Results

Conclusion

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