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International Urogynecology Journal
Erschienen in: International Urogynecology Journal 5/2013

01.05.2013 | Original Article

Tissue engineering as a potential alternative or adjunct to surgical reconstruction in treating pelvic organ prolapse

verfasst von: M. Boennelycke, S. Gras, G. Lose

Erschienen in: International Urogynecology Journal | Ausgabe 5/2013

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Abstract

Introduction and hypothesis

Cell-based tissue engineering strategies could potentially provide attractive alternatives to surgical reconstruction of native tissue or the use of surgical implants in treating pelvic organ prolapse (POP).

Methods

Based on a search in PubMed, this review focuses on candidate cell types, scaffolds, and trophic factors used in studies examining cell-based tissue engineering strategies to treat POP, stress urinary incontinence (SUI), and the closely related field of hernias.

Results

In contrast to the field of SUI, the use of cell-based tissue engineering strategies to treat POP are very sparsely explored, and only preclinical studies exist.

Conclusion

The available evidence suggests that the use of autologous muscle-derived cells, fibroblasts, or mesenchymal stem cells seeded on biocompatible, degradable, and potentially growth-promoting scaffolds could be an alternative to surgical reconstruction of native tissue or the use of conventional implants in treating POP. However, the vagina is a complex organ with great demands of functionality, and the perfect match of scaffold, cell, and trophic factor has yet to be found and tested in preclinical studies. Important issues such as safety and economy must also be addressed before this approach is ready for clinical studies.
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Metadaten
Titel
Tissue engineering as a potential alternative or adjunct to surgical reconstruction in treating pelvic organ prolapse
verfasst von
M. Boennelycke
S. Gras
G. Lose
Publikationsdatum
01.05.2013
Verlag
Springer-Verlag
Erschienen in
International Urogynecology Journal / Ausgabe 5/2013
Print ISSN: 0937-3462
Elektronische ISSN: 1433-3023
DOI
https://doi.org/10.1007/s00192-012-1927-4

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