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12.08.2019 | Primäre Immundefekte | CME

Immundefekte bei chronischer Rhinosinusitis

Eine bedeutende und oft unterschätzte Ursache

verfasst von: Prof. Dr. med. L. Klimek, A. Chaker, C. Matthias, A. Sperl, P. Gevaert, P. Hellings, B. Wollenberg, M. Koennecke, J. Hagemann, J. Eckrich, S. Becker

Erschienen in: HNO | Ausgabe 9/2019

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Zusammenfassung

Hintergrund

Die chronische Rhinosinusitis (CRS) gehört zu den häufigsten chronischen Erkrankungen überhaupt. Die Prävalenz von Immundefekten ist bei diesen Patienten höher als in der Normalbevölkerung.

Methodik

Es wurden eine selektive Literaturrecherche in Pubmed und Medline für den Zeitraum 2008 bis 2018 durchgeführt und zusätzlich die aktuellen Publikationen nicht in Literaturdatenbanken verfügbarer deutschsprachiger Zeitschriften analysiert.

Ergebnisse

Diagnostisch sind Anamnese und körperliche Untersuchung in Bezug auf den Immundefekt, laborchemische Untersuchungen sowie die Antikörperreaktion auf Polysaccharidimpfstoffe und Antigene zielführend. Therapeutisch stehen Antibiotika, Impfungen und Immunglobulinersatz zur Verfügung. Unabhängig davon sollte eine funktionelle Nasennebenhöhlenchirurgie gemäß Leitlinie durchgeführt werden.

Schlussfolgerungen

Bei Patienten mit CRS, die auf eine konservative und chirurgische Behandlung nicht adäquat ansprechen, sollte dem Verdacht auf einen zugrunde liegenden Immundefekt nachgegangen werden.

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Titel: Immundefekte bei chronischer Rhinosinusitis
Eine bedeutende und oft unterschätzte Ursache
verfasst von: Prof. Dr. med. L. Klimek
A. Chaker
C. Matthias
A. Sperl
P. Gevaert
P. Hellings
B. Wollenberg
M. Koennecke
J. Hagemann
J. Eckrich
S. Becker
Publikationsdatum: 12.08.2019
Verlag: Springer Medizin
Schlagwörter: Primäre Immundefekte
Sekundäre Immundefekte
Antibiotika
Rhinosinusitis
Immundefekte
Humorale Immundefekte
Impfungen
Erschienen in: HNO / Ausgabe 9/2019
Print ISSN: 0017-6192
Elektronische ISSN: 1433-0458
DOI: https://doi.org/10.1007/s00106-019-0719-2

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Immundefekte bei chronischer Rhinosinusitis

Eine bedeutende und oft unterschätzte Ursache