Adenocarcinomas of the oral cavity are rare neoplasms, and only four cases of primary colonic adenocarcinoma of the tongue have ever been described in literature. Very few information about chemotherapy sensitiveness of this type of neoplasia is available, with only one regimen that showed some activity in a metastatic patient.
We describe the case of a patient bearing a metastatic colonic adenocarcinoma of the tongue submitted to a first-line chemotherapy with oxaliplatin, 5-fluorouracil and folinic acid (FOLFOX regimen). After chemotherapy the patient obtained the complete disappearance of the primitive neoplasia located in the body of the tongue, and a tumor size reduction > 50% of liver and lung metastases.
This case demonstrated the activity of the combination of oxaliplatin and 5-fluorouracil in this very rare neoplasia. The FOLFOX regimen might be considered either in advanced and especially in the neoadjuvant setting, when the reduction of the primary tumor is highly needed.
Slova D, Paniz Mondolfi A, Moisini I, Levi G, Urken M, Zevallos J, et al. Colonic-type adenocarcinoma of the base of the tongue: a case report of a rare neoplasm. Head and Neck Pathol. 2012;6:250–4. CrossRef
Price KA, Cohen EE. Current treatment options for metastatic head and neck cancer. Curr Treat Options in Oncol. 2012;13:35–46. CrossRef
- FOLFOX activity in a rare case of metastatic colonic adenocarcinoma of the tongue: a case report
Maria P. Brizzi
Giorgio V. Scagliotti
- BioMed Central
Neu im Fachgebiet Onkologie
RMN scan of the oral cavity with a bulky, solid, infiltrating lesion/© Zichi et al., e.Med Kampagnen-Visual, Mail Icon II