Introduction
Methods
Immunohistochemistry
Antibody | Clonality | Dilution | Retrieval | Supplier |
---|---|---|---|---|
DOG 1 | Mouse monoclonal | 1:250 | EDTA | Dako®, Cambridgeshire, UK |
S100 | Rabbit polyclonal | 1:2,000 | EDTA | Dako®, Cambridgeshire, UK |
SMA | Mouse monoclonal | 1:75 | Citrate | Dako®, Cambridgeshire, UK |
P63 | Mouse monoclonal | 1:25 | EDTA | Dako®, Cambridgeshire, UK |
CK 14 | Mouse monoclonal | 1:20 | Citrate | Abcam®, Cambridge, UK |
Calponin | Rabbit monoclonal | 1:100 | Citrate | EP798Y, Abcam®, Cambridge, UK |
Results
DOG-1
Site | Cases | +ve | Pattern |
---|---|---|---|
Normal gland | 10 | 10/10 | Acini & ducts—luminal |
Acinic cell carcinoma | 15 | 14/15 | Diffuse luminal in acini and small ducts |
Secretory carcinoma | 9 | 3/9 | Negative or weak/focal luminal in microcystic areas |
Pleomorphic adenoma | 49 | 14/49 | Focal luminal or myoepithelial (5/14) |
Ca ex PA | 11 | 4/11 | Luminal and/or myoepithelial cells (2/4) |
Myoepithelioma | 6 | 0/6 | N/A |
Myoepithelial carcinoma | 2 | 0/2 | N/A |
Adenoid cystic carcinoma | 20 | 6/20 | Weak abluminal + luminal |
Polymorphous adenocarcinoma | 6 | 4/6 | Focal luminal |
Basal cell adenoma | 14 | 5/14 | Luminal or abluminal/myoepithelial—variable (5/5) |
Canalicular adenoma | 19 | 0/19 | N/A |
Mucoepidermoid carcinoma | 11 | 8/11 | Luminal + mucous cell brush borders |
Oncocytoma | 2 | 0/2 | N/A |
Adenocarcinoma NOS | 4 | 0/4 | N/A |
Basal cell adenocarcinoma | 2 | 0/2 | N/A |
Salivary duct carcinoma | 3 | 1/3 | Myoepithelial cells (1/1) |
Papillary cystadenocarcinoma | 1 | 1/1 | Abluminal/myoepithelial cells (1/1) |
Total | 184 | 70 |