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Erschienen in:

14.12.2017

RNA interference-based therapy and its delivery systems

verfasst von: Xiuhui Chen, Lingegowda S. Mangala, Cristian Rodriguez-Aguayo, Xianchao Kong, Gabriel Lopez-Berestein, Anil K. Sood

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 1/2018

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Abstract

RNA interference (RNAi) is considered a highly specific approach for gene silencing and holds tremendous potential for treatment of various pathologic conditions such as cardiovascular diseases, viral infections, and cancer. Although gene silencing approaches such as RNAi are widely used in preclinical models, the clinical application of RNAi is challenging primarily because of the difficulty in achieving successful systemic delivery. Effective delivery systems are essential to enable the full therapeutic potential of RNAi. An ideal nanocarrier not only addresses the challenges of delivering naked siRNA/miRNA, including its chemically unstable features, extracellular and intracellular barriers, and innate immune stimulation, but also offers “smart” targeted delivery. Over the past decade, great efforts have been undertaken to develop RNAi delivery systems that overcome these obstacles. This review presents an update on current progress in the therapeutic application of RNAi with a focus on cancer therapy and strategies for optimizing delivery systems, such as lipid-based nanoparticles.

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Titel: RNA interference-based therapy and its delivery systems
verfasst von: Xiuhui Chen
Lingegowda S. Mangala
Cristian Rodriguez-Aguayo
Xianchao Kong
Gabriel Lopez-Berestein
Anil K. Sood
Publikationsdatum: 14.12.2017
Verlag: Springer US
Erschienen in: Cancer and Metastasis Reviews / Ausgabe 1/2018
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-017-9717-6

Springer Medizin

RNA interference-based therapy and its delivery systems

Abstract

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Abstract

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