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Die Anaesthesiologie

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01.01.2009 | Klinische Pharmakologie

Sugammadex

Neues pharmakologisches Konzept zur Antagonisierung von Rocuronium und Vecuronium

verfasst von: Dr. H.J. Sparr, L.H. Booij, T. Fuchs-Buder

Erschienen in: Die Anaesthesiologie | Ausgabe 1/2009

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Zusammenfassung

Bisher standen lediglich Acetylcholinesterasehemmer wie z. B. Neostigmin zur Antagonisierung neuromuskulärer Restblockaden zur Verfügung. Mit dem modifizierten γ-Zyklodextrin Sugammadex gibt es zumindest für aminosteroidale Muskelrelaxanzien zukünftig eine Alternative. Es handelt sich bei dieser Substanz um eine ringförmige Zuckerverbindung, die eine stabile Einschlussverbindung mit aminosteroidalen Muskelrelaxanzien, insbesondere Rocuronium und Vecuronium, bildet. Dieser Wirkmechanismus unterscheidet sich somit grundsätzlich von dem der Acetylcholinesterasehemmer. Die nachfolgende Übersichtsarbeit fasst die bisherigen Untersuchungen im Rahmen des Zulassungsverfahrens zusammen. Insbesondere wird auf die Wirksamkeit, Nebenwirkungen und neue anästhesiologische Konzepte, die durch Sugammadex möglich sind, eingegangen.

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Titel: Sugammadex
Neues pharmakologisches Konzept zur Antagonisierung von Rocuronium und Vecuronium
verfasst von: Dr. H.J. Sparr
L.H. Booij
T. Fuchs-Buder
Publikationsdatum: 01.01.2009
Verlag: Springer-Verlag
Erschienen in: Die Anaesthesiologie / Ausgabe 1/2009
Print ISSN: 2731-6858
Elektronische ISSN: 2731-6866
DOI: https://doi.org/10.1007/s00101-008-1455-2

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Sugammadex

Neues pharmakologisches Konzept zur Antagonisierung von Rocuronium und Vecuronium

Zusammenfassung

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