Ausgabe 1/2022
Inhalt (202 Artikel)
Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline
Raúl González-Domínguez, Pol Castellano-Escuder, Sophie Lefèvre-Arbogast, Dorrain Y. Low, Andrea Du Preez, Silvie R. Ruigrok, Hyunah Lee, Catherine Helmer, Mercè Pallàs, Mireia Urpi-Sarda, Alex Sánchez-Pla, Aniko Korosi, Paul J. Lucassen, Ludwig Aigner, Claudine Manach, Sandrine Thuret, Cécilia Samieri, Cristina Andres-Lacueva
Mild behavioral impairment: measurement and clinical correlates of a novel marker of preclinical Alzheimer’s disease
Byron Creese, Zahinoor Ismail
Antiherpetic drugs: a potential way to prevent Alzheimer’s disease?
Morgane Linard, Julien Bezin, Emilie Hucteau, Pierre Joly, Isabelle Garrigue, Jean-François Dartigues, Antoine Pariente, Catherine Helmer
Optimal transport- and kernel-based early detection of mild cognitive impairment patients based on magnetic resonance and positron emission tomography images
Ziyu Liu, Travis S. Johnson, Wei Shao, Min Zhang, Jie Zhang, Kun Huang
Plasma MCP-1 and changes on cognitive function in community-dwelling older adults
Juan Luis Sanchez-Sanchez, Kelly V. Giudici, Sophie Guyonnet, Julien Delrieu, Yan Li, Randall J. Bateman, Angelo Parini, Bruno Vellas, Philipe de Souto Barreto, Bruno Vellas, Sophie Guyonnet, Isabelle Carrié, Lauréane Brigitte, Catherine Faisant, Françoise Lala, Julien Delrieu, Hélène Villars, Emeline Combrouze, Carole Badufle, Audrey Zueras, Sandrine Andrieu, Christelle Cantet, Christophe Morin, Gabor Abellan Van Kan, Charlotte Dupuy, Yves Rolland, Céline Caillaud, Pierre-Jean Ousset, Françoise Lala, Sherry Willis, Sylvie Belleville, Brigitte Gilbert, Francine Fontaine, Jean-François Dartigues, Isabelle Marcet, Fleur Delva, Alexandra Foubert, Sandrine Cerda, Marie-Noëlle-Cuffi, Corinne Costes, Olivier Rouaud, Patrick Manckoundia, Valérie Quipourt, Sophie Marilier, Evelyne Franon, Lawrence Bories, Marie-Laure Pader, Marie-France Basset, Bruno Lapoujade, Valérie Faure, Michael Li Yung Tong, Christine Malick-Loiseau, Evelyne Cazaban-Campistron, Françoise Desclaux, Colette Blatge, Thierry Dantoine, Cécile Laubarie-Mouret, Isabelle Saulnier, Jean-Pierre Clément, Marie-Agnès Picat, Laurence Bernard-Bourzeix, Stéphanie Willebois, Iléana Désormais, Noëlle Cardinaud, Marc Bonnefoy, Pierre Livet, Pascale Rebaudet, Claire Gédéon, Catherine Burdet, Flavien Terracol, Alain Pesce, Stéphanie Roth, Sylvie Chaillou, Sandrine Louchart, Kristel Sudres, Nicolas Lebrun, Nadège Barro-Belaygues, Jacques Touchon, Karim Bennys, Audrey Gabelle, Aurélia Romano, Lynda Touati, Cécilia Marelli, Cécile Pays, Philippe Robert, Franck Le Duff, Claire Gervais, Sébastien Gonfrier, Yannick Gasnier, Serge Bordes, Danièle Begorre, Christian Carpuat, Khaled Khales, Jean-François Lefebvre, Samira Misbah El Idrissi, Pierre Skolil, Jean-Pierre Salles, Carole Dufouil, Stéphane Lehéricy, Marie Chupin, Jean-François Mangin, Ali Bouhayia, Michèle Allard, Frédéric Ricolfi, Dominique Dubois, Marie Paule Bonceour Martel, François Cotton, Alain Bonafé, Stéphane Chanalet, Françoise Hugon, Fabrice Bonneville, Christophe Cognard, François Chollet, Pierre Payoux, Thierry Voisin, Sophie Peiffer, Anne Hitzel, Michel Zanca, Jacques Monteil, Jacques Darcourt, Laurent Molinier, Hélène Derumeaux, Nadège Costa, Bertrand Perret, Claire Vinel, Sylvie Caspar-Bauguil, Pascale Olivier-Abbal, Nicola Coley
Serum neurofilament light chain level as a predictor of cognitive stage transition
Eun-Hye Lee, Hyuk Sung Kwon, Seong-Ho Koh, Seong Hye Choi, Jeong-Hwa Jin, Jee Hyang Jeong, Jae-Won Jang, Kyung Won Park, Eun-Joo Kim, Hee Jin Kim, Jin Yong Hong, Soo Jin Yoon, Bora Yoon, Ju-Hee Kang, Jong-Min Lee, Hyun-Hee Park, Jungsoon Ha
Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer’s disease
Jiansong Fang, Pengyue Zhang, Quan Wang, Chien-Wei Chiang, Yadi Zhou, Yuan Hou, Jielin Xu, Rui Chen, Bin Zhang, Stephen J. Lewis, James B. Leverenz, Andrew A. Pieper, Bingshan Li, Lang Li, Jeffrey Cummings, Feixiong Cheng
MIND diet and the risk of dementia: a population-based study
Tosca O. E. de Crom, Sanne S. Mooldijk, M. Kamran Ikram, M. Arfan Ikram, Trudy Voortman
Plasma Lipocalin 2 in Alzheimer’s disease: potential utility in the differential diagnosis and relationship with other biomarkers
Peter Hermann, Anna Villar-Piqué, Matthias Schmitz, Christian Schmidt, Daniela Varges, Stefan Goebel, Timothy Bunck, Hanna Lindemann, Carla Bogner, Isabel Santana, Inês Baldeiras, Joachim Riggert, Inga Zerr, Franc Llorens
Cognitive composites for genetic frontotemporal dementia: GENFI-Cog
Jackie M. Poos, Katrina M. Moore, Jennifer Nicholas, Lucy L. Russell, Georgia Peakman, Rhian S. Convery, Lize C. Jiskoot, Emma van der Ende, Esther van den Berg, Janne M. Papma, Harro Seelaar, Yolande A. L. Pijnenburg, Fermin Moreno, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce, Mario Masellis, Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B. Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre de Mendonça, Pietro Tiraboschi, Isabel Santana, Simon Ducharme, Chris Butler, Alexander Gerhard, Johannes Levin, Adrian Danek, Markus Otto, Isabel Le Ber, Florence Pasquier, John C. van Swieten, Jonathan D. Rohrer, Arabella Bouzigues, Martin N. Rossor, Nick C. Fox, Jason D. Warren, Martina Bocchetta, Imogen J. Swift, Rachelle Shafei, Carolin Heller, Emily Todd, David Cash, Ione Woollacott, Henrik Zetterberg, Annabel Nelson, Rita Guerreiro, Jose Bras, David L. Thomas, Simon Mead, Lieke Meeter, Jessica Panman, Rick van Minkelen, Myriam Barandiaran, Begoña Indakoetxea, Alazne Gabilondo, Mikel Tainta, Ana Gorostidi, Miren Zulaica, Alina Díez, Jorge Villanua, Sergi Borrego-Ecija, Jaume Olives, Albert Lladó, Mircea Balasa, Anna Antonell, Nuria Bargallo, Enrico Premi, Stefano Gazzina, Roberto Gasparotti, Silvana Archetti, Sandra Black, Sara Mitchell, Ekaterina Rogaeva, Morris Freedman, Ron Keren, David Tang-Wai, Hakan Thonberg, Linn Öijerstedt, Christin Andersson, Vesna Jelic, Andrea Arighi, Chiara Fenoglio, Elio Scarpini, Giorgio Fumagalli, Thomas Cope, Carolyn Timberlake, Timothy Rittman, Christen Shoesmith, Robart Bartha, Rosa Rademakers, Carlo Wilke, Hans-Otto Karnarth, Benjamin Bender, Rose Bruffaerts, Philip Vandamme, Mathieu Vandenbulcke, Catarina B. Ferreira, Gabriel Miltenberger, Carolina Maruta, Ana Verdelho, Sónia Afonso, Ricardo Taipa, Paola Caroppo, Giuseppe Di Fede, Giorgio Giaccone, Sara Prioni, Veronica Redaelli, Giacomina Rossi, Diana Duro, Maria Rosario Almeida, Miguel Castelo-Branco, Maria João Leitão, Miguel Tabuas-Pereira, Beatriz Santiago, Serge Gauthier, Pedro Rosa-Neto, Michele Veldsman, Paul Thompson, Tobias Langheinrich, Catharina Prix, Tobias Hoegen, Elisabeth Wlasich, Sandra Loosli, Sonja Schonecker, Sarah Anderl-Straub, Jolina Lombardi, Nuria Bargalló, Alberto Benussi, Valentina Cantoni, Maxime Bertoux, Anne Bertrand, Alexis Brice, Agnès Camuzat, Olivier Colliot, Sabrina Sayah, Aurélie Funkiewiez, Daisy Rinaldi, Gemma Lombardi, Benedetta Nacmias, Dario Saracino, Valentina Bessi, Camilla Ferrari, Marta Cañada, Vincent Deramecourt, Gregory Kuchcinski, Thibaud Lebouvier, Sebastien Ourselin, Cristina Polito, Adeline Rollin
The behavioral variant of Alzheimer’s disease does not show a selective loss of Von Economo and phylogenetically related neurons in the anterior cingulate cortex
E. H. Singleton, Y. A. L. Pijnenburg, P. Gami-Patel, B. D. C. Boon, F. Bouwman, J. M. Papma, H. Seelaar, P. Scheltens, L. T. Grinberg, S. Spina, A. L. Nana, G. D. Rabinovici, W. W. Seeley, R. Ossenkoppele, A. A. Dijkstra
Complaints of daytime sleepiness, insomnia, hypnotic use, and risk of dementia: a prospective cohort study in the elderly
Clémence Cavaillès, Claudine Berr, Catherine Helmer, Audrey Gabelle, Isabelle Jaussent, Yves Dauvilliers
Correction to: BMI1 is associated with CSF amyloid-β and rates of cognitive decline in Alzheimer’s disease
Jun Pyo Kim, Bo-Hyun Kim, Paula J. Bice, Sang Won Seo, David A. Bennett, Andrew J. Saykin, Kwangsik Nho
Parsing heterogeneity within dementia with Lewy bodies using clustering of biological, clinical, and demographic data
Carla Abdelnour, Daniel Ferreira, Marleen van de Beek, Nira Cedres, Ketil Oppedal, Lena Cavallin, Frédéric Blanc, Olivier Bousiges, Lars-Olof Wahlund, Andrea Pilotto, Alessandro Padovani, Mercè Boada, Javier Pagonabarraga, Jaime Kulisevsky, Dag Aarsland, Afina W. Lemstra, Eric Westman
A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro
Isabelle Aillaud, Senthilvelrajan Kaniyappan, Ram Reddy Chandupatla, Lisa Marie Ramirez, Sewar Alkhashrom, Jutta Eichler, Anselm H. C. Horn, Markus Zweckstetter, Eckhard Mandelkow, Heinrich Sticht, Susanne Aileen Funke
Model-based stratification of progression along the Alzheimer disease continuum highlights the centrality of biomarker synergies
Muhammad Usman Sadiq, Kichang Kwak, Eran Dayan
Mendelian randomization highlights significant difference and genetic heterogeneity in clinically diagnosed Alzheimer’s disease GWAS and self-report proxy phenotype GWAX
Haijie Liu, Yang Hu, Yan Zhang, Haihua Zhang, Shan Gao, Longcai Wang, Tao Wang, Zhifa Han, Bao-liang Sun, Guiyou Liu
Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review
Ayda Rostamzadeh, Anna Kahlert, Franziska Kalthegener, Frank Jessen
Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer’s disease
James C. Dodge, Thomas J. Tamsett, Christopher M. Treleaven, Tatyana V. Taksir, Peter Piepenhagen, S. Pablo Sardi, Seng H. Cheng, Lamya S. Shihabuddin
The Aβ1–42/Aβ1–40 ratio in CSF is more strongly associated to tau markers and clinical progression than Aβ1–42 alone
Constance Delaby, Teresa Estellés, Nuole Zhu, Javier Arranz, Isabel Barroeta, María Carmona-Iragui, Ignacio Illán-Gala, Miguel Ángel Santos-Santos, Miren Altuna, Isabel Sala, M. Belén Sánchez-Saudinós, Laura Videla, Sílvia Valldeneu, Andrea Subirana, Mireia Tondo, Francisco Blanco-Vaca, Sylvain Lehmann, Olivia Belbin, Rafael Blesa, Juan Fortea, Alberto Lleó, Daniel Alcolea
Detection of plasma Aβ seeding activity by a newly developed analyzer for diagnosis of Alzheimer’s disease
Jianping Jia, Tingting Li, Jianwei Yang, Baian Chen, Wei Qin, Cuibai Wei, Yang Song, Qigeng Wang, Yan Li, Longfei Jia
Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping
Michael E. Belloy, Sarah J. Eger, Yann Le Guen, Vincent Damotte, Shahzad Ahmad, M. Arfan Ikram, Alfredo Ramirez, Anthoula C. Tsolaki, Giacomina Rossi, Iris E. Jansen, Itziar de Rojas, Kayenat Parveen, Kristel Sleegers, Martin Ingelsson, Mikko Hiltunen, Najaf Amin, Ole Andreassen, Pascual Sánchez-Juan, Patrick Kehoe, Philippe Amouyel, Rebecca Sims, Ruth Frikke-Schmidt, Wiesje M. van der Flier, Jean-Charles Lambert, Zihuai He, Summer S. Han, Valerio Napolioni, Michael D. Greicius
Altered central and blood glutathione in Alzheimer’s disease and mild cognitive impairment: a meta-analysis
Jinghan Jenny Chen, Mathura Thiyagarajah, Jianmeng Song, Clara Chen, Nathan Herrmann, Damien Gallagher, Mark J. Rapoport, Sandra E. Black, Joel Ramirez, Ana C. Andreazza, Paul Oh, Susan Marzolini, Simon J. Graham, Krista L. Lanctôt
Correction to: Self-Administered Gerocognitive Examination: longitudinal cohort testing for the early detection of dementia conversion
Douglas W. Scharre, Shu ing Chang, Haikady N. Nagaraja, Natalie C. Wheeler, Maria Kataki
Cholinergic receptor binding in unimpaired older adults, mild cognitive impairment, and Alzheimer’s disease dementia
David L. Sultzer, Aaron C. Lim, Hailey L. Gordon, Brandon C. Yarns, Rebecca J. Melrose
The accuracy and robustness of plasma biomarker models for amyloid PET positivity
Andréa L. Benedet, Wagner S. Brum, Oskar Hansson, Thomas K. Karikari, Eduardo R. Zimmer, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton
Cortical microstructure in primary progressive aphasia: a multicenter study
Ignacio Illán-Gala, Victor Montal, Sergi Borrego-Écija, Maria Luisa Mandelli, Neus Falgàs, Ariane E. Welch, Jordi Pegueroles, Miguel Santos-Santos, Alexandre Bejanin, Daniel Alcolea, Oriol Dols-Icardo, Olivia Belbin, Mª. Belén Sánchez-Saudinós, Nuria Bargalló, Sofía González-Ortiz, Albert Lladó, Rafael Blesa, Bradford C. Dickerson, Howard J. Rosen, Bruce L. Miller, Alberto Lleó, Maria Luisa Gorno-Tempini, Raquel Sánchez-Valle, Juan Fortea
A comparison between tau and amyloid-β cerebrospinal fluid biomarkers in chronic traumatic encephalopathy and Alzheimer disease
Katherine W. Turk, Alexandra Geada, Victor E. Alvarez, Weiming Xia, Jonathan D. Cherry, Raymond Nicks, Gaoyuan Meng, Sarah Daley, Yorghos Tripodis, Bertrand R. Huber, Andrew E. Budson, Brigid Dwyer, Neil W. Kowall, Robert C. Cantu, Lee E. Goldstein, Douglas I. Katz, Robert A. Stern, Michael L. Alosco, Jesse Mez, Ann C. McKee, Thor D. Stein
Association of peripheral immunity with cognition, neuroimaging, and Alzheimer’s pathology
Jia-Hui Hou, Ya-Nan Ou, Wei Xu, Peng-Fei Zhang, Lan Tan, Jin-Tai Yu
Blood and brain transcriptome analysis reveals APOE genotype-mediated and immune-related pathways involved in Alzheimer disease
Rebecca Panitch, Junming Hu, Weiming Xia, David A. Bennett, Thor D. Stein, Lindsay A. Farrer, Gyungah R. Jun
Considerations regarding a diagnosis of Alzheimer’s disease before dementia: a systematic review
Jetske van der Schaar, Leonie N. C. Visser, Femke H. Bouwman, Johannes C. F. Ket, Philip Scheltens, Annelien L. Bredenoord, Wiesje M. van der Flier
Intracranial internal carotid artery calcification is not predictive of future cognitive decline
Farzaneh Rahmani, Marina Nguyen, Charles D. Chen, Nicole McKay, Aylin Dincer, Nelly Joseph-Mathurin, Gengsheng Chen, Jingxia Liu, Hilary L. P. Orlowski, John C. Morris, Tammie L. S. Benzinger
Amyloid PET imaging and dementias: potential applications in detecting and quantifying early white matter damage
Anna M. Pietroboni, Annalisa Colombi, Tiziana Carandini, Luca Sacchi, Chiara Fenoglio, Giorgio Marotta, Andrea Arighi, Milena A. De Riz, Giorgio G. Fumagalli, Massimo Castellani, Marco Bozzali, Elio Scarpini, Daniela Galimberti
Economic and caregiver impact of Alzheimer’s disease across the disease spectrum: a cohort study
Virginie Dauphinot, Michele Potashman, Mihaela Levitchi-Benea, Ray Su, Ivana Rubino, Pierre Krolak-Salmon
Combination of gut microbiota and plasma amyloid-β as a potential index for identifying preclinical Alzheimer’s disease: a cross-sectional analysis from the SILCODE study
Can Sheng, Kun Yang, Beiqi He, Wenying Du, Yanning Cai, Ying Han
Relationship of sex differences in cortical thickness and memory among cognitively healthy subjects and individuals with mild cognitive impairment and Alzheimer disease
Filippo Cieri, Xiaowei Zhuang, Dietmar Cordes, Nikki Kaplan, Jeffery Cummings, Jessica Caldwell
Serum Thioredoxin-80 is associated with age, ApoE4, and neuropathological biomarkers in Alzheimer’s disease: a potential early sign of AD
Julen Goikolea, Gorka Gerenu, Makrina Daniilidou, Francesca Mangialasche, Patrizia Mecocci, Tiia Ngandu, Juha Rinne, Alina Solomon, Miia Kivipelto, Angel Cedazo-Minguez, Anna Sandebring-Matton, Silvia Maioli
Sensitive and reproducible MEG resting-state metrics of functional connectivity in Alzheimer’s disease
Deborah N. Schoonhoven, Casper T. Briels, Arjan Hillebrand, Philip Scheltens, Cornelis J. Stam, Alida A. Gouw
Novel diagnostic tools for identifying cognitive impairment using olfactory-stimulated functional near-infrared spectroscopy: patient-level, single-group, diagnostic trial
Jaewon Kim, Dong Keon Yon, Kyu Yeong Choi, Jang Jae Lee, Namwoo Kim, Kun Ho Lee, Jae Gwan Kim
Pilot study of repeated blood-brain barrier disruption in patients with mild Alzheimer’s disease with an implantable ultrasound device
Stéphane Epelbaum, Ninon Burgos, Michael Canney, Dawn Matthews, Marion Houot, Mathieu D. Santin, Carole Desseaux, Guillaume Bouchoux, Sebastian Stroer, Cyril Martin, Marie-Odile Habert, Marcel Levy, Aicha Bah, Karine Martin, Benoît Delatour, Maximilien Riche, Bruno Dubois, Lisa Belin, Alexandre Carpentier
A multi-regression framework to improve diagnostic ability of optical coherence tomography retinal biomarkers to discriminate mild cognitive impairment and Alzheimer’s disease
Jacqueline Chua, Chi Li, Lucius Kang Hua Ho, Damon Wong, Bingyao Tan, Xinwen Yao, Alfred Gan, Florian Schwarzhans, Gerhard Garhöfer, Chelvin C. A. Sng, Saima Hilal, Narayanaswamy Venketasubramanian, Carol Y. Cheung, Georg Fischer, Clemens Vass, Tien Yin Wong, Christopher Li-Hsian Chen, Leopold Schmetterer
Correction to: Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of Alzheimer’s amyloidosis
Panchanan Maiti, Zackary Bowers, Ali Bourcier-Schultz, Jarod Morse, Gary L. Dunbar
Automatized FACEmemory® scoring is related to Alzheimer’s disease phenotype and biomarkers in early-onset mild cognitive impairment: the BIOFACE cohort
Montserrat Alegret, Oscar Sotolongo-Grau, Ester Esteban de Antonio, Alba Pérez-Cordón, Adelina Orellana, Ana Espinosa, Silvia Gil, Daniel Jiménez, Gemma Ortega, Angela Sanabria, Natalia Roberto, Isabel Hernández, Maitee Rosende-Roca, Juan Pablo Tartari, Emilio Alarcon-Martin, Itziar de Rojas, Laura Montrreal, Xavier Morató, Amanda Cano, Dorene M. Rentz, Lluís Tárraga, Agustín Ruiz, Sergi Valero, Marta Marquié, Mercè Boada
Correction to: Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review
Ayda Rostamzadeh, Anna Kahlert, Franziska Kalthegener, Frank Jessen
A deep learning MRI approach outperforms other biomarkers of prodromal Alzheimer’s disease
Xinyang Feng, Frank A. Provenzano, Scott A. Small
Combining plasma phospho-tau and accessible measures to evaluate progression to Alzheimer’s dementia in mild cognitive impairment patients
Alexa Pichet Binette, Sebastian Palmqvist, Divya Bali, Gill Farrar, Christopher J. Buckley, David A. Wolk, Henrik Zetterberg, Kaj Blennow, Shorena Janelidze, Oskar Hansson
APOE ε4, Alzheimer’s disease neuropathology and sleep disturbance, in individuals with and without dementia
Jonathan Blackman, Seth Love, Lindsey Sinclair, Richard Cain, Elizabeth Coulthard
Sex differences in neuropsychiatric symptoms in Alzheimer’s disease dementia: a meta-analysis
Willem S. Eikelboom, Michel Pan, Rik Ossenkoppele, Michiel Coesmans, Jennifer R. Gatchel, Zahinoor Ismail, Krista L. Lanctôt, Corinne E. Fischer, Moyra E. Mortby, Esther van den Berg, Janne M. Papma
What’s the cut-point?: a systematic investigation of tau PET thresholding methods
Alexandra J. Weigand, Anne Maass, Graham L. Eglit, Mark W. Bondi
Emotional prosody recognition is impaired in Alzheimer’s disease
Jana Amlerova, Jan Laczó, Zuzana Nedelska, Martina Laczó, Martin Vyhnálek, Bing Zhang, Kateřina Sheardova, Francesco Angelucci, Ross Andel, Jakub Hort
Mesial temporal tau in amyloid-β-negative cognitively normal older persons
Natasha Krishnadas, Vincent Doré, Colin Groot, Fiona Lamb, Pierrick Bourgeat, Samantha C. Burnham, Kun Huang, Anita M. Y. Goh, Colin L. Masters, Victor L. Villemagne, Christopher C. Rowe
Reconfigured metabolism brain network in asymptomatic microtubule-associated protein tau mutation carriers: a graph theoretical analysis
Li Liu, Min Chu, Binbin Nie, Lin Liu, Kexin Xie, Yue Cui, Yu Kong, Zhongyun Chen, Haitian Nan, Kewei Chen, Pedro Rosa-Neto, Liyong Wu
Chemical genetic activation of the cholinergic basal forebrain hippocampal circuit rescues memory loss in Alzheimer’s disease
Weilin Liu, Jianhong Li, Minguang Yang, Xiaohua Ke, Yaling Dai, Huawei Lin, Sinuo Wang, Lidian Chen, Jing Tao
Meaningful benefits: a framework to assess disease-modifying therapies in preclinical and early Alzheimer’s disease
Sheila Seleri Assunção, Reisa A. Sperling, Craig Ritchie, Diana R. Kerwin, Paul S. Aisen, Claire Lansdall, Alireza Atri, Jeffrey Cummings
Comparison and aggregation of event sequences across ten cohorts to describe the consensus biomarker evolution in Alzheimer’s disease
Sepehr Golriz Khatami, Yasamin Salimi, Martin Hofmann-Apitius, Neil P. Oxtoby, Colin Birkenbihl
Glucose metabolism and AD: evidence for a potential diabetes type 3
Andrea González, Camila Calfío, Macarena Churruca, Ricardo B. Maccioni
The retinal ganglion cell layer reflects neurodegenerative changes in cognitively unimpaired individuals
Alicia López-de-Eguileta, Sara López-García, Carmen Lage, Ana Pozueta, María García-Martínez, Martha Kazimierczak, María Bravo, Juan Irure, Marcos López-Hoyos, Pedro Muñoz-Cacho, Noelia Rodríguez-Perez, Diana Tordesillas-Gutiérrez, Alexander Goikoetxea, Claudia Nebot, Eloy Rodríguez-Rodríguez, Alfonso Casado, Pascual Sánchez-Juan
Increased levels of the synaptic proteins PSD-95, SNAP-25, and neurogranin in the cerebrospinal fluid of patients with Alzheimer’s disease
Pia Kivisäkk, Becky C. Carlyle, Thadryan Sweeney, James P. Quinn, Christopher E. Ramirez, Bianca A. Trombetta, Muriel Mendes, Mary Brock, Carrie Rubel, Julie Czerkowicz, Danielle Graham, Steven E. Arnold
Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice
Matthew Simon, Marie Xun Wang, Ozama Ismail, Molly Braun, Abigail G. Schindler, Jesica Reemmer, Zhongya Wang, Mariya A. Haveliwala, Ryan P. O’Boyle, Warren Y. Han, Natalie Roese, Marjorie Grafe, Randall Woltjer, Detlev Boison, Jeffrey J. Iliff
The cerebrospinal fluid biomarker ratio Aβ42/40 identifies amyloid positron emission tomography positivity better than Aβ42 alone in a heterogeneous memory clinic cohort
Michaela Amft, Marion Ortner, Udo Eichenlaub, Oliver Goldhardt, Janine Diehl-Schmid, Dennis M. Hedderich, Igor Yakushev, Timo Grimmer
Cerebrospinal fluid lactate levels along the Alzheimer’s disease continuum and associations with blood-brain barrier integrity, age, cognition, and biomarkers
Paul Theo Zebhauser, Achim Berthele, Oliver Goldhardt, Janine Diehl-Schmid, Josef Priller, Marion Ortner, Timo Grimmer
Comparative analysis of machine learning algorithms for multi-syndrome classification of neurodegenerative syndromes
Leonie Lampe, Sebastian Niehaus, Hans-Jürgen Huppertz, Alberto Merola, Janis Reinelt, Karsten Mueller, Sarah Anderl-Straub, Klaus Fassbender, Klaus Fliessbach, Holger Jahn, Johannes Kornhuber, Martin Lauer, Johannes Prudlo, Anja Schneider, Matthis Synofzik, Adrian Danek, Janine Diehl-Schmid, Markus Otto, Arno Villringer, Karl Egger, Elke Hattingen, Rüdiger Hilker-Roggendorf, Alfons Schnitzler, Martin Südmeyer, Wolfgang Oertel, Jan Kassubek, Günter Höglinger, Matthias L. Schroeter
Subclinical carotid artery atherosclerosis and cognitive function in older adults
Felice Lin, Judy Pa, Roksana Karim, Howard N. Hodis, S. Duke Han, Victor W. Henderson, Jan A. St. John, Wendy J. Mack
The course of primary progressive aphasia diagnosis: a cross-sectional study
A. Mouton, A. Plonka, R. Fabre, T. M. Tran, P. Robert, J. Macoir, V. Manera, A. Gros
Diagnostic value of serum versus plasma phospho-tau for Alzheimer’s disease
Przemysław R. Kac, Fernando Gonzalez-Ortiz, Joel Simrén, Nele Dewit, Eugeen Vanmechelen, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton, Thomas K. Karikari
β-Amyloid in blood neuronal-derived extracellular vesicles is elevated in cognitively normal adults at risk of Alzheimer’s disease and predicts cerebral amyloidosis
Tao-Ran Li, Yun-Xia Yao, Xue-Yan Jiang, Qiu-Yue Dong, Xian-Feng Yu, Ting Wang, Yan-Ning Cai, Ying Han
Diagnostic and prognostic performance to detect Alzheimer’s disease and clinical progression of a novel assay for plasma p-tau217
Colin Groot, Claudia Cicognola, Divya Bali, Gallen Triana-Baltzer, Jeffrey L. Dage, Michael J. Pontecorvo, Hartmuth C. Kolb, Rik Ossenkoppele, Shorena Janelidze, Oskar Hansson
Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort
Leslie Grasset, Cécile Proust-Lima, Jean-François Mangin, Marie-Odile Habert, Bruno Dubois, Claire Paquet, Olivier Hanon, Audrey Gabelle, Mathieu Ceccaldi, Cédric Annweiler, Renaud David, Therese Jonveaux, Catherine Belin, Adrien Julian, Isabelle Rouch-Leroyer, Jérémie Pariente, Maxime Locatelli, Marie Chupin, Geneviève Chêne, Carole Dufouil
ADataViewer: exploring semantically harmonized Alzheimer’s disease cohort datasets
Yasamin Salimi, Daniel Domingo-Fernández, Carlos Bobis-Álvarez, Martin Hofmann-Apitius, Colin Birkenbihl
Correction: A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer’s disease with lecanemab, an anti-Aβ protofibril antibody
Chad J. Swanson, Yong Zhang, Shobha Dhadda, Jinping Wang, June Kaplow, Robert Y. K. Lai, Lars Lannfelt, Heather Bradley, Martin Rabe, Akihiko Koyama, Larisa Reyderman, Donald A. Berry, Scott Berry, Robert Gordon, Lynn D. Kramer, Jeffrey L. Cummings
Plasma neuregulin 1 as a synaptic biomarker in Alzheimer’s disease: a discovery cohort study
Agathe Vrillon, François Mouton-Liger, Matthieu Martinet, Emmanuel Cognat, Claire Hourregue, Julien Dumurgier, Elodie Bouaziz-Amar, Ann Brinkmalm, Kaj Blennow, Henrik Zetterberg, Jacques Hugon, Claire Paquet
Dynamic functional connectivity patterns associated with dementia risk
Sophie Dautricourt, Julie Gonneaud, Brigitte Landeau, Vince D. Calhoun, Robin de Flores, Géraldine Poisnel, Salma Bougacha, Valentin Ourry, Edelweiss Touron, Elizabeth Kuhn, Harriet Demintz-King, Natalie L. Marchant, Denis Vivien, Vincent de la Sayette, Antoine Lutz, Gaël Chételat, Eider M. Arenaza-Urquijo, Florence Allais, Claire André, Julien Asselineau, Alexandre Bejanin, Pierre Champetier, Gaël Chételat, Anne Chocat, Sophie Dautricourt, Robin de Flores, Marion Delarue, Stéphanie Egret, Francesca Felisatti, Eglantine Ferrand Devouge, Eric Frison, Julie Gonneaud, Marc Heidmann, Thien Huong Tran, Elizabeth Kuhn, Gwendoline le Du, Brigitte Landeau, Valérie Lefranc, Antoine Lutz, Florence Mezenge, Inès Moulinet, Valentin Ourry, Cassandre Palix, Léo Paly, Géraldine Poisnel, Anne Quillard, Géraldine Rauchs, Stéphane Rehel, Florence Requier, Edelweiss Touron, Denis Vivien, Caitlin Ware, Sebastian Baez Lugo, Olga Klimecki, Patrik Vuilleumier, Thorsten Barnhofer, Fabienne Collette, Eric Salmon, Vincent de la Sayette, Pascal Delamillieure, Martine Batchelor, Axel Beaugonin, Francis Gheysen, Harriet Demnitz-King, Natalie Marchant, Tim Whitfield, Corinne Schimmer, Miranka Wirth
The role of basket trials in drug development for neurodegenerative disorders
Jeffrey Cummings, Arturo Montes, Sana Kamboj, Jorge Fonseca Cacho
Association between Life’s Simple 7 and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact adults: the CABLE study
Yong-Li Zhao, Ya-Nan Ou, Ya-Hui Ma, Yu-Yuan Huang, Yan-Lin Bi, Lan Tan, Jin-Tai Yu
Long-term low-dose acetylsalicylic use shows protective potential for the development of both vascular dementia and Alzheimer’s disease in patients with coronary heart disease but not in other individuals from the general population: results from two large cohort studies
Thi Ngoc Mai Nguyen, Li-Ju Chen, Kira Trares, Hannah Stocker, Bernd Holleczek, Konrad Beyreuther, Hermann Brenner, Ben Schöttker
Retraction Note: Increased Aβ42-α7-like nicotinic acetylcholine receptor complex level in lymphocytes is associated with apolipoprotein E4-driven Alzheimer’s disease pathogenesis
Hoau-Yan Wang, Caryn Trocmé-Thibierge, Andres Stucky, Sanket M. Shah, Jessica Kvasic, Amber Khan, Philippe Morain, Isabelle Guignot, Eva Bouguen, Karine Deschet, Maria Pueyo, Elisabeth Mocaer, Pierre-Jean Ousset, Bruno Vellas, Vera Kiyasova
Mapping the genetic landscape of early-onset Alzheimer’s disease in a cohort of 36 families
Merel O. Mol, Sven J. van der Lee, Marc Hulsman, Yolande A. L. Pijnenburg, Phillip Scheltens, Harro Seelaar, John C. van Swieten, Laura Donker Kaat, Henne Holstege, Jeroen G. J. van Rooij
Quantification of SNAP-25 with mass spectrometry and Simoa: a method comparison in Alzheimer’s disease
Johanna Nilsson, Nicholas J. Ashton, Andrea L. Benedet, Laia Montoliu-Gaya, Johan Gobom, Tharick A. Pascoal, Mira Chamoun, Erik Portelius, Andreas Jeromin, Muriel Mendes, Henrik Zetterberg, Pedro Rosa-Neto, Ann Brinkmalm, Kaj Blennow
The relationship between retinal layers and brain areas in asymptomatic first-degree relatives of sporadic forms of Alzheimer’s disease: an exploratory analysis
Inés López-Cuenca, Alberto Marcos-Dolado, Miguel Yus-Fuertes, Elena Salobrar-García, Lorena Elvira-Hurtado, José A. Fernández-Albarral, Juan J. Salazar, Ana I. Ramírez, Lidia Sánchez-Puebla, Manuel Enrique Fuentes-Ferrer, Ana Barabash, Federico Ramírez-Toraño, Lidia Gil-Martínez, Juan Arrazola-García, Pedro Gil, Rosa de Hoz, José M. Ramírez
Longitudinal evaluation of neuroinflammation and oxidative stress in a mouse model of Alzheimer disease using positron emission tomography
Luka Rejc, Vanessa Gómez-Vallejo, Ana Joya, Gemma Arsequell, Ander Egimendia, Pilar Castellnou, Xabier Ríos-Anglada, Unai Cossío, Zuriñe Baz, Leyre Iglesias, Estibaliz Capetillo-Zarate, Pedro Ramos-Cabrer, Abraham Martin, Jordi Llop
Correction: Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)—study protocol for a randomized controlled trial
Miranka Wirth, Claudia Schwarz, Gloria Benson, Nora Horn, Ralph Buchert, Catharina Lange, Theresa Köbe, Stefan Hetzer, Marta Maglione, Eva Michael, Stefanie Märschenz, Knut Mai, Ute Kopp, Dietmar Schmitz, Ulrike Grittner, Stephan J. Sigrist, Slaven Stekovic, Frank Madeo, Agnes Flöel
Correction: Diagnostic and prognostic performance to detect Alzheimer’s disease and clinical progression of a novel assay for plasma p-tau217
Colin Groot, Claudia Cicognola, Divya Bali, Gallen Triana-Baltzer, Jeffrey L. Dage, Michael J. Pontecorvo, Hartmuth C. Kolb, Rik Ossenkoppele, Shorena Janelidze, Oskar Hansson
Hormone therapy and the decreased risk of dementia in women with depression: a population-based cohort study
Hyewon Kim, Juhwan Yoo, Kyungdo Han, Dong-Yun Lee, Maurizio Fava, David Mischoulon, Hong Jin Jeon
Near-infrared light reduces β-amyloid-stimulated microglial toxicity and enhances survival of neurons: mechanisms of light therapy for Alzheimer’s disease
Yurii V. Stepanov, Iuliia Golovynska, Renlong Zhang, Sergii Golovynskyi, Liudmyla I. Stepanova, Oleksandr Gorbach, Taisa Dovbynchuk, Liudmyla V. Garmanchuk, Tymish Y. Ohulchanskyy, Junle Qu
Anticipated reactions to learning Alzheimer’s disease biomarker results
Lindsay R. Clark, Claire M. Erickson, Erin M. Jonaitis, Yue Ma, Nathaniel A. Chin, Kristin Basche, Frederick B. Ketchum, Carey E. Gleason
Fully automated and highly specific plasma β-amyloid immunoassays predict β-amyloid status defined by amyloid positron emission tomography with high accuracy
Kazuto Yamashita, Masahiro Miura, Shunsuke Watanabe, Kengo Ishiki, Yuji Arimatsu, Junko Kawahira, Toshiko Kubo, Katsutaka Sasaki, Takayuki Arai, Kei Hagino, Yasuhiro Irino, Kota Nagai, David Verbel, Akihiko Koyama, Shobha Dhadda, Hayato Niiro, Shigeki Iwanaga, Toshiyuki Sato, Tomokazu Yoshida, Atsushi Iwata
Effect of the ABCA1 agonist CS-6253 on amyloid-β and lipoprotein metabolism in cynomolgus monkeys
Sasan D. Noveir, Bilal E. Kerman, Haotian Xian, Cristiana Meuret, Sabrina Smadi, Ashley E. Martinez, Johannes Johansson, Henrik Zetterberg, Bryan A. Parks, Zsuzsanna Kuklenyik, Wendy J. Mack, Jan O. Johansson, Hussein N. Yassine
Imipramine and olanzapine block apoE4-catalyzed polymerization of Aβ and show evidence of improving Alzheimer’s disease cognition
Noah R. Johnson, Athena C.-J. Wang, Christina Coughlan, Stefan Sillau, Esteban Lucero, Lisa Viltz, Neil Markham, Cody Allen, A. Ranjitha Dhanasekaran, Heidi J. Chial, Huntington Potter
White matter hyperintensities are a prominent feature of autosomal dominant Alzheimer’s disease that emerge prior to dementia
Dorothee Schoemaker, Maria Clara Zanon Zotin, Kewei Chen, Kay C. Igwe, Clara Vila-Castelar, Jairo Martinez, Ana Baena, Joshua T. Fox-Fuller, Francisco Lopera, Eric M. Reiman, Adam M. Brickman, Yakeel T. Quiroz
Genetic prion diseases presenting as frontotemporal dementia: clinical features and diagnostic challenge
Zhongyun Chen, Min Chu, Li Liu, Jing Zhang, Yu Kong, Kexin Xie, Yue Cui, Hong Ye, Junjie Li, Lin Wang, Liyong Wu
Associations between proton pump inhibitors and Alzheimer’s disease: a nested case–control study using a Korean nationwide health screening cohort
Hyo Geun Choi, Joo-Hee Kim, Ji Hee Kim, Eun Soo Kim, Ha Young Park, Kyueng-Whan Min, Mi Jung Kwon
Phosphodiesterase 5 inhibitor mirodenafil ameliorates Alzheimer-like pathology and symptoms by multimodal actions
Byung Woo Kang, Fred Kim, Joon-Yong Cho, SangYun Kim, Jinseol Rhee, Jai Jun Choung
The impact of subthreshold levels of amyloid deposition on conversion to dementia in patients with amyloid-negative amnestic mild cognitive impairment
Hyung-Ji Kim, Jungsu S. Oh, Jae-Sung Lim, Sunju Lee, Sungyang Jo, E-Nae Chung, Woo-Hyun Shim, Minyoung Oh, Jae Seung Kim, Jee Hoon Roh, Jae-Hong Lee
Multidomain trials to prevent dementia: addressing methodological challenges
Manuel Montero-Odasso, G Y Zou, Nellie Kamkar, Howard H. Feldman, Sylvie Belleville, Howard Chertkow, Haakon B Nygaard, Surim Son, Mark Speechley
P-tau subgroups in AD relate to distinct amyloid production and synaptic integrity profiles
Kirsten E. J. Wesenhagen, Betty M. Tijms, Lynn Boonkamp, Patty L. Hoede, Julie Goossens, Nele Dewit, Philip Scheltens, Eugeen Vanmechelen, Pieter Jelle Visser, Charlotte E. Teunissen
Prodromal characteristics of dementia with Lewy bodies: baseline results of the MEMENTO memory clinics nationwide cohort
Frederic Blanc, Vincent Bouteloup, Claire Paquet, Marie Chupin, Florence Pasquier, Audrey Gabelle, Mathieu Ceccaldi, Paulo Loureiro de Sousa, Pierre Krolak-Salmon, Renaud David, Clara Fischer, Jean-François Dartigues, David Wallon, Olivier Moreaud, Mathilde Sauvée, Catherine Belin, Sandrine Harston, Anne Botzung, Timothée Albasser, Catherine Demuynck, Izzie Namer, Marie-Odile Habert, Stéphane Kremer, Olivier Bousiges, Marc Verny, Candice Muller, Nathalie Philippi, Geneviève Chene, Benjamin Cretin, Jean-François Mangin, Carole Dufouil
The effects of exercise programs on cognition, activities of daily living, and neuropsychiatric symptoms in community-dwelling people with dementia—a systematic review
Kathrin Steichele, Anne Keefer, Nikolas Dietzel, Elmar Graessel, Hans-Ulrich Prokosch, Peter L. Kolominsky-Rabas
Grey matter changes on brain MRI in subjective cognitive decline: a systematic review
Pablo Arrondo, Óscar Elía-Zudaire, Gloria Martí-Andrés, María A. Fernández-Seara, Mario Riverol
Decreased visual acuity is related to thinner cortex in cognitively normal adults: cross-sectional, single-center cohort study
Gyule Han, Ji Sun Kim, Yu Hyun Park, Sung Hoon Kang, Hang-Rai Kim, Song Hwangbo, Tae-Young Chung, Hee Young Shin, Duk L. Na, Sang Won Seo, Dong Hui Lim, Hee Jin Kim
YKL-40 changes are not detected in post-mortem brain of patients with Alzheimer’s disease and frontotemporal lobar degeneration
Yanaika S. Hok-A-Hin, Jeroen J. M. Hoozemans, William T. Hu, Dorine Wouters, Jennifer C. Howell, Alberto Rábano, Wiesje M. van der Flier, Yolande A. L. Pijnenburg, Charlotte E. Teunissen, Marta del Campo
A multiscale brain network model links Alzheimer’s disease-mediated neuronal hyperactivity to large-scale oscillatory slowing
Anne M. van Nifterick, Alida A. Gouw, Ronald E. van Kesteren, Philip Scheltens, Cornelis J. Stam, Willem de Haan
Issues and recommendations for the residual approach to quantifying cognitive resilience and reserve
Jeremy A. Elman, Jacob W. Vogel, Diana I. Bocancea, Rik Ossenkoppele, Anna C. van Loenhoud, Xin M. Tu, William S. Kremen
Krüppel-like factor 5 accelerates the pathogenesis of Alzheimer’s disease via BACE1-mediated APP processing
Yaqi Wang, Yuting Cui, Jing Liu, Qiao Song, Min Cao, Yuli Hou, Xiaomin Zhang, Peichang Wang
Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways
Kristen R. Ibanez, Karen N. McFarland, Jennifer Phillips, Mariet Allen, Christian B. Lessard, Lillian Zobel, Elsa Gonzalez De La Cruz, Shivani Shah, Quan Vo, Xue Wang, Zachary Quicksall, Daniel Ryu, Cory Funk, Nilüfer Ertekin-Taner, Stefan Prokop, Todd E. Golde, Paramita Chakrabarty
Evaluation of tau deposition using 18F-PI-2620 PET in MCI and early AD subjects—a MissionAD tau sub-study
Santiago Bullich, Andre Mueller, Susan De Santi, Norman Koglin, Stephen Krause, June Kaplow, Michio Kanekiyo, Núria Roé-Vellvé, Audrey Perrotin, Aleksandar Jovalekic, David Scott, Michelle Gee, Andrew Stephens, Michael Irizarry
Inflammatory plasma biomarkers in subjects with preclinical Alzheimer’s disease
Samantha Prins, Marieke L. de Kam, Charlotte E. Teunissen, Geert Jan Groeneveld
Early diagnosis of Alzheimer’s disease using machine learning: a multi-diagnostic, generalizable approach
Vasco Sá Diogo, Hugo Alexandre Ferreira, Diana Prata
Discovery and validation of dominantly inherited Alzheimer’s disease mutations in populations from Latin America
Leonel Tadao Takada, Carmen Aláez-Verson, Bhagyashri D. Burgute, Ricardo Nitrini, Ana Luisa Sosa, Raphael Machado Castilhos, Marcia Fagundes Chaves, Erika-Mariana Longoria, Karol Carrillo-Sánchez, Sonia Maria Dozzi Brucki, Luis Leonardo Flores-Lagunes, Carolina Molina, Marcos Jimenez Olivares, Ellen Ziegemeier, Jennifer Petranek, Alison M. Goate, Carlos Cruchaga, Alan E. Renton, Maria Victoria Fernández, Gregory S. Day, Eric McDade, Randall J. Bateman, Celeste M. Karch, Jorge J. Llibre-Guerra
Investigating the power of eyes open resting state EEG for assisting in dementia diagnosis
Jack L. Jennings, Luis R. Peraza, Mark Baker, Kai Alter, John-Paul Taylor, Roman Bauer
Development of multivariable prediction models for institutionalization and mortality in the full spectrum of Alzheimer’s disease
Arenda Mank, Ingrid S. van Maurik, Judith J. M. Rijnhart, Els D. bakker, Vincent Bouteloup, Lisa Le Scouarnec, Charlotte E. Teunissen, Frederik Barkhof, Philip Scheltens, Johannes Berkhof, Wiesje M. van der Flier
An explainable self-attention deep neural network for detecting mild cognitive impairment using multi-input digital drawing tasks
Natthanan Ruengchaijatuporn, Itthi Chatnuntawech, Surat Teerapittayanon, Sira Sriswasdi, Sirawaj Itthipuripat, Solaphat Hemrungrojn, Prodpran Bunyabukkana, Aisawan Petchlorlian, Sedthapong Chunamchai, Thiparat Chotibut, Chaipat Chunharas
Perspectives and challenges in patient stratification in Alzheimer’s disease
Carla Abdelnour, Federica Agosta, Marco Bozzali, Bertrand Fougère, Atsushi Iwata, Ramin Nilforooshan, Leonel T. Takada, Félix Viñuela, Martin Traber
Italian adaptation of the Uniform Data Set Neuropsychological Test Battery (I-UDSNB 1.0): development and normative data
Francesca Conca, Valentina Esposito, Francesco Rundo, Davide Quaranta, Cristina Muscio, Rosa Manenti, Giulia Caruso, Ugo Lucca, Alessia Antonella Galbussera, Sonia Di Tella, Francesca Baglio, Federica L’Abbate, Elisa Canu, Valentina Catania, Massimo Filippi, Giulia Mattavelli, Barbara Poletti, Vincenzo Silani, Raffaele Lodi, Maddalena De Matteis, Michelangelo Stanzani Maserati, Andrea Arighi, Emanuela Rotondo, Antonio Tanzilli, Andrea Pace, Federica Garramone, Carlo Cavaliere, Matteo Pardini, Cristiano Rizzetto, Sandro Sorbi, Roberta Perri, Pietro Tiraboschi, Nicola Canessa, Maria Cotelli, Raffaele Ferri, Sandra Weintraub, Camillo Marra, Fabrizio Tagliavini, Eleonora Catricalà, Stefano Francesco Cappa
Tau levels are higher in objective subtle cognitive decline but not subjective memory complaint
Kelsey R. Thomas, Alexandra J. Weigand, Lauren C. Edwards, Emily C. Edmonds, Katherine J. Bangen, Gema Ortiz, Kayla S. Walker, Mark W. Bondi
Plasma apolipoprotein E levels in longitudinally followed patients with mild cognitive impairment and Alzheimer’s disease
Andreas Giannisis, Asma Al-Grety, Henrik Carlsson, Kalicharan Patra, Daniel Twohig, Sigrid Botne Sando, Camilla Lauridsen, Guro Berge, Gøril Rolfseng Grøntvedt, Geir Bråthen, Linda R. White, Kim Kultima, Henrietta M. Nielsen
Choroid and choriocapillaris changes in early-stage Parkinson’s disease: a swept-source optical coherence tomography angiography-based cross-sectional study
Yifan Zhang, Li Yang, Yuzhu Gao, Dan Zhang, Yunhan Tao, Hanyue Xu, Yi Chen, Yanming Xu, Ming Zhang
Increased plasma and brain immunoglobulin A in Alzheimer’s disease is lost in apolipoprotein E ε4 carriers
Dovilė Pocevičiūtė, Cristina Nuñez-Diaz, Bodil Roth, Shorena Janelidze, Andreas Giannisis, Oskar Hansson, Malin Wennström
Differential impairment of cerebrospinal fluid synaptic biomarkers in the genetic forms of frontotemporal dementia
Aitana Sogorb-Esteve, Johanna Nilsson, Imogen J. Swift, Carolin Heller, Martina Bocchetta, Lucy L. Russell, Georgia Peakman, Rhian S. Convery, John C. van Swieten, Harro Seelaar, Barbara Borroni, Daniela Galimberti, Raquel Sanchez-Valle, Robert Laforce Jr., Fermin Moreno, Matthis Synofzik, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Rik Vandenberghe, Elizabeth Finger, Fabrizio Tagliavini, Isabel Santana, Chris R. Butler, Simon Ducharme, Alexander Gerhard, Adrian Danek, Johannes Levin, Markus Otto, Sandro Sorbi, Isabelle Le Ber, Florence Pasquier, Johan Gobom, Ann Brinkmalm, Kaj Blennow, Henrik Zetterberg, Jonathan D. Rohrer, Annabel Nelson, Arabella Bouzigues, Caroline V Greaves, David Cash, David L Thomas, Emily Todd, Hanya Benotmane, Jennifer Nicholas, Kiran Samra, Rachelle Shafei, Carolyn Timberlake, Thomas Cope, Timothy Rittman, Alberto Benussi, Enrico Premi, Roberto Gasparotti, Silvana Archetti, Stefano Gazzina, Valentina Cantoni, Andrea Arighi, Chiara Fenoglio, Elio Scarpini, Giorgio Fumagalli, Vittoria Borracci, Giacomina Rossi, Giorgio Giaccone, Giuseppe Di Fede, Paola Caroppo, Pietro Tiraboschi, Sara Prioni, Veronica Redaelli, David Tang-Wai, Ekaterina Rogaeva, Miguel Castelo-Branco, Morris Freedman, Ron Keren, Sandra Black, Sara Mitchell, Christen Shoesmith, Robart Bartha, Rosa Rademakers, Jackie Poos, Janne M. Papma, Lucia Giannini, Rick van Minkelen, Yolande Pijnenburg, Benedetta Nacmias, Camilla Ferrari, Cristina Polito, Gemma Lombardi, Valentina Bessi, Michele Veldsman, Christin Andersson, Hakan Thonberg, Linn Öijerstedt, Vesna Jelic, Paul Thompson, Tobias Langheinrich, Albert Lladó, Anna Antonell, Jaume Olives, Mircea Balasa, Nuria Bargalló, Sergi Borrego-Ecija, Alexandre de Mendonça, Ana Verdelho, Carolina Maruta, Catarina B. Ferreira, Gabriel Miltenberger, Frederico Simões do Couto, Alazne Gabilondo, Ana Gorostidi, Jorge Villanua, Marta Cañada, Mikel Tainta, Miren Zulaica, Myriam Barandiaran, Patricia Alves, Benjamin Bender, Carlo Wilke, Lisa Graf, Annick Vogels, Mathieu Vandenbulcke, Philip Van Damme, Rose Bruffaerts, Koen Poesen, Pedro Rosa-Neto, Serge Gauthier, Agnès Camuzat, Alexis Brice, Anne Bertrand, Aurélie Funkiewiez, Daisy Rinaldi, Dario Saracino, Olivier Colliot, Sabrina Sayah, Catharina Prix, Elisabeth Wlasich, Olivia Wagemann, Sandra Loosli, Sonja Schönecker, Tobias Hoegen, Jolina Lombardi, Sarah Anderl-Straub, Adeline Rollin, Gregory Kuchcinski, Maxime Bertoux, Thibaud Lebouvier, Vincent Deramecourt, Beatriz Santiago, Diana Duro, Maria João Leitão, Maria Rosario Almeida, Miguel Tábuas-Pereira, Sónia Afonso
Rationale and design of the “NEurodegeneration: Traumatic brain injury as Origin of the Neuropathology (NEwTON)” study: a prospective cohort study of individuals at risk for chronic traumatic encephalopathy
Suzan van Amerongen, Dewi K. Caton, Rik Ossenkoppele, Frederik Barkhof, Petra J. W. Pouwels, Charlotte E. Teunissen, Annemieke J. M. Rozemuller, Jeroen J. M. Hoozemans, Yolande A. L. Pijnenburg, Philip Scheltens, Everard G. B. Vijverberg
Hypnosis for pain and anxiety management in cognitively impaired older adults undergoing scheduled lumbar punctures: a randomized controlled pilot study
Pauline Courtois-Amiot, Anaïs Cloppet-Fontaine, Aurore Poissonnet, Elodie Benit, Muriel Dauzet, Agathe Raynaud-Simon, Claire Paquet, Matthieu Lilamand
Dynamic network model reveals distinct tau spreading patterns in early- and late-onset Alzheimer disease
Wha Jin Lee, Hanna Cho, Min Seok Baek, Han-Kyeol Kim, Jae Hoon Lee, Young Hoon Ryu, Chul Hyoung Lyoo, Joon-Kyung Seong
Static and dynamic functional connectivity variability of the anterior-posterior hippocampus with subjective cognitive decline
Qiang Wang, Ben Chen, Xiaomei Zhong, Le Hou, Min Zhang, Mingfeng Yang, Zhangying Wu, Xinru Chen, Naikeng Mai, Huarong Zhou, Gaohong Lin, Si Zhang, Yuping Ning
Neural correlates of episodic memory in adults with Down syndrome and Alzheimer’s disease
Bessy Benejam, Mateus Rozalem Aranha, Laura Videla, Concepción Padilla, Silvia Valldeneu, Susana Fernández, Miren Altuna, Maria Carmona-Iragui, Isabel Barroeta, Maria Florencia Iulita, Víctor Montal, Jordi Pegueroles, Alexandre Bejanin, Sandra Giménez, Sofía González-Ortiz, Sebastián Videla, David Bartrés-Faz, Daniel Alcolea, Rafael Blesa, Alberto Lleó, Juan Fortea
Longitudinal change in ATN biomarkers in cognitively normal individuals
Jarith L. Ebenau, Denise Visser, Lior A. Kroeze, Mardou S. S. A. van Leeuwenstijn, Argonde C. van Harten, Albert D. Windhorst, Sandeep V. S. Golla, Ronald Boellaard, Philip Scheltens, Frederik Barkhof, Bart N. M. van Berckel, Wiesje M. van der Flier
Effects of a mindfulness-based versus a health self-management intervention on objective cognitive performance in older adults with subjective cognitive decline (SCD): a secondary analysis of the SCD-Well randomized controlled trial
Tim Whitfield, Harriet Demnitz-King, Marco Schlosser, Thorsten Barnhofer, Eric Frison, Nina Coll-Padros, Sophie Dautricourt, Florence Requier, Marion Delarue, Julie Gonneaud, Olga M. Klimecki, Antoine Lutz, Léo Paly, Eric Salmon, Ann-Katrin Schild, Zuzana Walker, Frank Jessen, Gaël Chételat, Fabienne Collette, Miranka Wirth, Natalie L. Marchant, Amélie Michon, Raquel Sanchez-Valle, Claudia Schwars, Cindy Lai, Roxane Coueron, Eider M. Arenaza-Urquijo, Géraldine Poisnel, Floriane Delphin-Combe, Julien Asselineau, Pierre Krolak-Salmon, José Luis Molinuevo, Florence Allais, Romain Bachelet, Viviane Belleoud, Clara Benson, Beatriz Bosch, Maria Pilar Casanova, Hélène Espérou, Karine Goldet, Idir Hamdidouche, Maria Leon, Dix Meiberth, Hendrik Mueller, Theresa Mueller, Valentin Ourry, Leslie Reyrolle, Ana Salinero, Lena Sannemann, Yamna Satgunasingam, Hilde Steinhauser, Patrik Vuilleumier, Cédrick Wallet, Janet Wingrove
Subjective cognitive decline and anxious/depressive symptoms during the COVID-19 pandemic: what is the role of stress perception, stress resilience, and β-amyloid?
Muge Akinci, Gonzalo Sánchez-Benavides, Anna Brugulat-Serrat, Cleofé Peña-Gómez, Eleni Palpatzis, Mahnaz Shekari, Carme Deulofeu, Sherezade Fuentes-Julian, Gemma Salvadó, José Maria González-de-Echávarri, Marc Suárez-Calvet, Carolina Minguillón, Karine Fauria, José Luis Molinuevo, Juan Domingo Gispert, Oriol Grau-Rivera, Eider M. Arenaza-Urquijo, Annabella Beteta, Raffaele Cacciaglia, Alba Cañas, Irene Cumplido, Ruth Dominguez, Maria Emilio, Carles Falcon, Laura Hernandez, Gema Huesa, Jordi Huguet, Paula Marne, Tania Menchón, Grégory Operto, Albina Polo, Blanca Rodríguez-Fernández, Sandra Pradas, Iman Sadeghi, Anna Soteras, Laura Stankeviciute, Marc Vilanova, Natalia Vilor-Tejedor
Diagnostic performance of automated plasma amyloid-β assays combined with pre-analytical immunoprecipitation
Hans-W. Klafki, Jonathan Vogelgsang, Ekaterina Manuilova, Chris Bauer, Alexander Jethwa, Hermann Esselmann, Anke Jahn-Brodmann, Dirk Osterloh, Ingolf Lachmann, Benedict Breitling, Carolin Rauter, Niels Hansen, Caroline Bouter, Stefan Palme, Johannes Schuchhardt, Jens Wiltfang
Association of the inflammation-related proteome with dementia development at older age: results from a large, prospective, population-based cohort study
Kira Trares, Megha Bhardwaj, Laura Perna, Hannah Stocker, Agnese Petrera, Stefanie M. Hauck, Konrad Beyreuther, Hermann Brenner, Ben Schöttker
Predicting conversion of brain β-amyloid positivity in amyloid-negative individuals
Chae Jung Park, Younghoon Seo, Yeong Sim Choe, Hyemin Jang, Hyejoo Lee, Jun Pyo Kim
Immune-mediated diseases are associated with a higher incidence of dementia: a prospective cohort study of 375,894 individuals
Ya-Ru Zhang, Liu Yang, Hui-Fu Wang, Bang-Sheng Wu, Shu-Yi Huang, Wei Cheng, Jian-Feng Feng, Jin-Tai Yu
Correction: Applicability of in vivo staging of regional amyloid burden in a cognitively normal cohort with subjective memory complaints: the INSIGHT-preAD study
Fatemah A. Sakr, Michel J. Grothe, Enrica Cavedo, Irina Jelistratova, Marie-Odile Habert, Martin Dyrba, Gabriel Gonzalez-Escamilla, Hugo Bertin, Maxime Locatelli, Stephane Lehericy, Stefan Teipel, Bruno Dubois, Harald Hampel, Hovagim Bakardjian, Habib Benali, Hugo Bertin, Joel Bonheur, Laurie Boukadida, Nadia Boukerrou, Enrica Cavedo, Patrizia Chiesa, Olivier Colliot, Bruno Dubois, Marion Dubois, Stéphane Epelbaum, Geoffroy Gagliardi, Remy Genthon, Marie-Odile Habert, Harald Hampel, Marion Houot, Aurélie Kas, Foudil Lamari, Marcel Levy, Simone Lista, Christiane Metzinger, Fanny Mochel, Francis Nyasse, Catherine Poisson, Marie-Claude Potier, Marie Revillon, Antonio Santos, Katia Santos Andrade, Marine Sole, Mohmed Surtee, Michel Thiebaud de Schotten, Andrea Vergallo, Nadjia Younsi, Lisi Flores Aguilar, Claudio Babiloni, Filippo Baldacci, Norbert Benda, Keith L. Black, Arun L. W. Bokde, Ubaldo Bonuccelli, Karl Broich, René S. Bun, Francesco Cacciola, Juan Castrillo, Enrica Cavedo, Roberto Ceravolo, Patrizia A. Chiesa, Olivier Colliot, Cristina-Maria Coman, Jean-Christophe Corvol, Augusto Claudio Cuello, Jeffrey L. Cummings, Herman Depypere, Bruno Dubois, Andrea Duggento, Stanley Durrleman, Valentina Escott-Price, Howard Federoff, Maria Teresa Ferretti, Massimo Fiandaca, Richard A. Frank, Francesco Garaci, Remy Genthon, Nathalie George, Filippo S. Giorgi, Manuela Graziani, Marion Haberkamp, Marie-Odile Habert, Harald Hampel, Karl Herholz, Eric Karran, Seung H. Kim, Yosef Koronyo, Maya Koronyo-Hamaoui, Foudil Lamari, Todd Langevin, Stéphane Lehéricy, Simone Lista, Jean Lorenceau, Mark Mapstone, Christian Neri, Robert Nisticò, Francis Nyasse-Messene, Sid E. O’bryant, George Perry, Craig Ritchie, Katrine Rojkova, Simone Rossi, Amira Saidi, Emiliano Santarnecchi, Lon S. Schneider, Olaf Sporns, Nicola Toschi, Steven R. Verdooner, Andrea Vergallo, Nicolas Villain, Lindsay A. Welikovitch, Janet Woodcock, Erfan Younesi
A longitudinal study on quality of life along the spectrum of Alzheimer’s disease
Arenda Mank, Judith J. M. Rijnhart, Ingrid S. van Maurik, Linus Jönsson, Ron Handels, Els D. Bakker, Charlotte E. Teunissen, Bart N. M. van Berckel, Argonde C. van Harten, Johannes Berkhof, Wiesje M. van der Flier
Distinct sex-specific DNA methylation differences in Alzheimer’s disease
Tiago C. Silva, Wei Zhang, Juan I. Young, Lissette Gomez, Michael A. Schmidt, Achintya Varma, X. Steven Chen, Eden R. Martin, Lily Wang
Cumulative effect of simvastatin, l-arginine, and tetrahydrobiopterin on cerebral blood flow and cognitive function in Alzheimer’s disease
Elizabeth Degrush, Mohammed Salman Shazeeb, David Drachman, Zeynep Vardar, Clifford Lindsay, Matthew J. Gounis, Nils Henninger
Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation
Andrea Arighi, Marina Arcaro, Giorgio Giulio Fumagalli, Tiziana Carandini, Anna Margherita Pietroboni, Luca Sacchi, Chiara Fenoglio, Maria Serpente, Federica Sorrentino, Giovanni Isgrò, Federico Turkheimer, Elio Scarpini, Daniela Galimberti
Nanoscale alterations in GABAB receptors and GIRK channel organization on the hippocampus of APP/PS1 mice
Alejandro Martín-Belmonte, Carolina Aguado, Rocío Alfaro-Ruiz, Ana Esther Moreno-Martínez, Luis de la Ossa, Ester Aso, Laura Gómez-Acero, Ryuichi Shigemoto, Yugo Fukazawa, Francisco Ciruela, Rafael Luján
Characteristics of very late-onset schizophrenia-like psychosis as prodromal dementia with Lewy bodies: a cross-sectional study
Hideki Kanemoto, Yuto Satake, Takashi Suehiro, Daiki Taomoto, Fuyuki Koizumi, Shunsuke Sato, Tamiki Wada, Keiko Matsunaga, Eku Shimosegawa, Mamoru Hashimoto, Kenji Yoshiyama, Manabu Ikeda
Association of Alzheimer’s disease polygenic risk scores with amyloid accumulation in cognitively intact older adults
Emma S. Luckett, Yasmina Abakkouy, Mariska Reinartz, Katarzyna Adamczuk, Jolien Schaeverbeke, Sare Verstockt, Steffi De Meyer, Koen Van Laere, Patrick Dupont, Isabelle Cleynen, Rik Vandenberghe
Higher levels of myelin are associated with higher resistance against tau pathology in Alzheimer’s disease
Anna Rubinski, Nicolai Franzmeier, Anna Dewenter, Ying Luan, Ruben Smith, Olof Strandberg, Rik Ossenkoppele, Martin Dichgans, Oskar Hansson, Michael Ewers
Immuno-digital invasive cleavage assay for analyzing Alzheimer’s amyloid ß-bound extracellular vesicles
Kohei Yuyama, Hui Sun, Yasuyuki Igarashi, Kenji Monde, Takumi Hirase, Masato Nakayama, Yoichi Makino
Imaging markers of cerebral amyloid angiopathy and hypertensive arteriopathy differentiate Alzheimer disease subtypes synergistically
Ting-Bin Chen, Wei-Ju Lee, Jun-Peng Chen, Shiang-Yu Chang, Chun-Fu Lin, Hung-Chieh Chen
Memory markers in the continuum of the Alzheimer’s clinical syndrome
Mario A. Parra, Clara Calia, Vivek Pattan, Sergio Della Sala
Dramatic impacts on brain pathology, anxiety, and cognitive function in the knock-in APPNL-G-F mouse model of Alzheimer disease following long-term voluntary exercise
Jogender Mehla, Scott H. Deibel, Hadil Karem, Shakhawat Hossain, Sean G. Lacoursiere, Robert J. Sutherland, Majid H. Mohajerani, Robert J. McDonald
Axonal degeneration and amyloid pathology predict cognitive decline beyond cortical atrophy
Anna Linnéa Svenningsson, Erik Stomrud, Sebastian Palmqvist, Oskar Hansson, Rik Ossenkoppele
Gender-specific relationship between thigh muscle and fat mass and brain amyloid-β positivity
Sung Hoon Kang, Kyung Hyun Lee, Yoosoo Chang, Yeong Sim Choe, Jun Pyo Kim, Hyemin Jang, Hee Young Shin, Hee Jin Kim, Seong-Beom Koh, Duk L. Na, Sang Won Seo, Mira Kang
Investigating the association between cancer and dementia risk: a longitudinal cohort study
Dan-Dan Zhang, Ya-Nan Ou, Liu Yang, Ya-Hui Ma, Lan Tan, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Associations of resting heart rate with incident dementia, cognition, and brain structure: a prospective cohort study of UK biobank
Yue-Ting Deng, Kevin Kuo, Bang-Sheng Wu, Ya-Nan Ou, Liu Yang, Ya-Ru Zhang, Shu-Yi Huang, Shi-Dong Chen, Yu Guo, Rui-Qi Zhang, Lan Tan, Qiang Dong, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Altered basal forebrain function during whole-brain network activity at pre- and early-plaque stages of Alzheimer’s disease in TgF344-AD rats
Monica van den Berg, Mohit H. Adhikari, Marlies Verschuuren, Isabel Pintelon, Tamara Vasilkovska, Johan Van Audekerke, Stephan Missault, Loran Heymans, Peter Ponsaerts, Winnok H. De Vos, Annemie Van der Linden, Georgios A. Keliris, Marleen Verhoye
Serum phosphorylated tau protein 181 and neurofilament light chain in cognitively impaired heart failure patients
Jan Traub, Markus Otto, Roxane Sell, Dennis Göpfert, György Homola, Petra Steinacker, Patrick Oeckl, Caroline Morbach, Stefan Frantz, Mirko Pham, Stefan Störk, Guido Stoll, Anna Frey
Increasing brain glucose metabolism by ligustrazine piperazine ameliorates cognitive deficits through PPARγ-dependent enhancement of mitophagy in APP/PS1 mice
Zongyang Li, Xiangbao Meng, Guoxu Ma, Wenlan Liu, Weiping Li, Qian Cai, Sicen Wang, Guodong Huang, Yuan Zhang
Serum total TDP-43 levels are decreased in frontotemporal dementia patients with C9orf72 repeat expansion or concomitant motoneuron disease phenotype
Kasper Katisko, Nadine Huber, Tarja Kokkola, Päivi Hartikainen, Johanna Krüger, Anna-Leena Heikkinen, Veera Paananen, Ville Leinonen, Ville E. Korhonen, Seppo Helisalmi, Sanna-Kaisa Herukka, Valentina Cantoni, Yasmine Gadola, Silvana Archetti, Anne M. Remes, Annakaisa Haapasalo, Barbara Borroni, Eino Solje
Eicosanoid lipidome activation in post-mortem brain tissues of individuals with APOE4 and Alzheimer’s dementia
Brandon Ebright, Isaac Assante, Roy A. Poblete, Shaowei Wang, Marlon V. Duro, David A. Bennett, Zoe Arvanitakis, Stan G. Louie, Hussein N. Yassine
Diagnostic value of plasma p-tau181, NfL, and GFAP in a clinical setting cohort of prevalent neurodegenerative dementias
Simone Baiardi, Corinne Quadalti, Angela Mammana, Sofia Dellavalle, Corrado Zenesini, Luisa Sambati, Roberta Pantieri, Barbara Polischi, Luciano Romano, Matteo Suffritti, Giuseppe Mario Bentivenga, Vanda Randi, Michelangelo Stanzani-Maserati, Sabina Capellari, Piero Parchi
Modifiable and non-modifiable risk factors of dementia on midlife cerebral small vessel disease in cognitively healthy middle-aged adults: the PREVENT-Dementia study
Audrey Low, Maria A. Prats-Sedano, Elizabeth McKiernan, Stephen F. Carter, James D. Stefaniak, Stefania Nannoni, Li Su, Maria-Eleni Dounavi, Graciela Muniz-Terrera, Karen Ritchie, Brian Lawlor, Lorina Naci, Paresh Malhotra, Clare Mackay, Ivan Koychev, Craig W. Ritchie, Hugh S. Markus, John T. O’Brien
Classification accuracy of blood-based and neurophysiological markers in the differential diagnosis of Alzheimer’s disease and frontotemporal lobar degeneration
Alberto Benussi, Valentina Cantoni, Jasmine Rivolta, Silvana Archetti, Anna Micheli, Nicholas Ashton, Henrik Zetterberg, Kaj Blennow, Barbara Borroni
Reading activities compensate for low education-related cognitive deficits
Yue Wang, Shinan Wang, Wanlin Zhu, Na Liang, Chen Zhang, Yuankun Pei, Qing Wang, Shiping Li, Jiong Shi
Development and clinical validation of CT-based regional modified Centiloid method for amyloid PET
Soo-Jong Kim, Hongki Ham, Yu Hyun Park, Yeong Sim Choe, Young Ju Kim, Hyemin Jang, Duk L. Na, Hee Jin Kim, Seung Hwan Moon, Sang Won Seo
Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ
Kyung Won Jo, Dohyun Lee, Dong Gon Cha, Eunji Oh, Yoon Ha Choi, Somi Kim, Eun Seo Park, Jong Kyoung Kim, Kyong-Tai Kim
Methodological quality of systematic reviews on treatments for Alzheimer’s disease: a cross-sectional study
Claire C. W. Zhong, Jinglun Zhao, Charlene H. L. Wong, Irene X. Y. Wu, Chen Mao, Jerry W. F. Yeung, Vincent C. H. Chung
Sex differences in Alzheimer’s disease: plasma MMP-9 and markers of disease severity
Amaryllis A. Tsiknia, Erin E. Sundermann, Emilie T. Reas, Steven D. Edland, James B. Brewer, Douglas Galasko, Sarah J. Banks
Apolipoprotein E imbalance in the cerebrospinal fluid of Alzheimer’s disease patients
Matthew Paul Lennol, Irene Sánchez-Domínguez, Inmaculada Cuchillo-Ibañez, Elena Camporesi, Gunnar Brinkmalm, Daniel Alcolea, Juan Fortea, Alberto Lleó, Guadalupe Soria, Fernando Aguado, Henrik Zetterberg, Kaj Blennow, Javier Sáez-Valero
Plasma amyloid-beta oligomer is related to subjective cognitive decline and brain amyloid status
Keun You Kim, Jaesub Park, Yong Hyu Jeong, Hyun Jeong Kim, Eun Lee, Jin Young Park, Eosu Kim, Woo Jung Kim
Blood-based lipidomic signature of severe obstructive sleep apnoea in Alzheimer’s disease
Farida Dakterzada, Iván D. Benítez, Adriano Targa, Anna Carnes, Montse Pujol, Mariona Jové, Olga Mínguez, Rafi Vaca, Manuel Sánchez-de-la-Torre, Ferran Barbé, Reinald Pamplona, Gerard Piñol-Ripoll
Genistein effect on cognition in prodromal Alzheimer’s disease patients. The GENIAL clinical trial
José Viña, Joaquín Escudero, Miquel Baquero, Mónica Cebrián, Juan Antonio Carbonell-Asíns, José Enrique Muñoz, Encarnación Satorres, Juan Carlos Meléndez, José Ferrer-Rebolleda, Mª del Puig Cózar-Santiago, Jose Manuel Santabárbara-Gómez, Mariona Jové, Reinald Pamplona, Francisco José Tarazona-Santabalbina, Consuelo Borrás
Plasma adiponectin levels predict cognitive decline and cortical thinning in mild cognitive impairment with beta-amyloid pathology
Keun You Kim, Junghee Ha, Minae Kim, So Yeon Cho, Hyunjeong Kim, Eosu Kim
Combining tau-PET and fMRI meta-analyses for patient-centered prediction of cognitive decline in Alzheimer’s disease
Davina Biel, Ying Luan, Matthias Brendel, Paul Hager, Anna Dewenter, Alexis Moscoso, Diana Otero Svaldi, Ixavier A. Higgins, Michael Pontecorvo, Sebastian Römer, Anna Steward, Anna Rubinski, Lukai Zheng, Michael Schöll, Sergey Shcherbinin, Michael Ewers, Nicolai Franzmeier
Genetically predicted telomere length and Alzheimer’s disease endophenotypes: a Mendelian randomization study
Blanca Rodríguez-Fernández, Natalia Vilor-Tejedor, Eider M. Arenaza-Urquijo, Gonzalo Sánchez-Benavides, Marc Suárez-Calvet, Grégory Operto, Carolina Minguillón, Karine Fauria, Gwendlyn Kollmorgen, Ivonne Suridjan, Manuel Castro de Moura, David Piñeyro, Manel Esteller, Kaj Blennow, Henrik Zetterberg, Immaculata De Vivo, José Luis Molinuevo, Arcadi Navarro, Juan Domingo Gispert, Aleix Sala-Vila, Marta Crous-Bou, Müge Akinci, Annabella Beteta, Anna Brugulat-Serrat, Raffaele Cacciaglia, Alba Cañas, Irene Cumplido, Carme Deulofeu, Ruth Dominguez, Maria Emilio, Carles Falcon, Sherezade Fuentes, Oriol Grau-Rivera, José M. González-de-Echávarri, Laura Hernandez, Patricia Genius, Gema Huesa, Jordi Huguet, Eva M. Palacios, Paula Marne, Tania Menchón, Marta Milà-Alomà, Cleofé Peña-Gomez, Albina Polo, Sandra Pradas, Gemma Salvadó, Mahnaz Shekari, Anna Soteras, Laura Stankeviciute, Marc Vilanova
Driving assessment in preclinical Alzheimer’s disease: progress to date and the path forward
Sayeh Bayat, Catherine M. Roe
RENEWAL: REpurposing study to find NEW compounds with Activity for Lewy body dementia—an international Delphi consensus
John T. O’Brien, Leonidas Chouliaras, Janet Sultana, John-Paul Taylor, Clive Ballard, Dag Aarsland, Frederic Blanc, Bradley Boeve, David J. Brooks, K. Ray Chaudhuri, Jeffrey Cummings, Howard H. Feldman, Leon Flicker, James E. Galvin, Donald G. Grosset, Manabu Ikeda, Susan Kohlhaas, Brian Lawlor, Afina W. Lemstra, Iracema Leroi, Elisabet Londos, James B. Leverenz, Simon Lewis, Ian McKeith, Roger Mills, Richard Oakley, Jill Richardson, Marwan Sabbagh, John Skidmore, Per Svennigsson, Pietro Tiraboschi, Daniel Weintraub, Zuzana Walker, Rosie Watson, Rimona S. Weil, Caroline H. Williams-Gray, Alison Yarnall
Selection of the optimal channel configuration for implementing wearable EEG devices for the diagnosis of mild cognitive impairment
Kyeonggu Lee, Kang-Min Choi, Seonghun Park, Seung-Hwan Lee, Chang-Hwan Im
Budget impact analysis of the use of Souvenaid in patients with prodromal Alzheimer’s Disease in Spain
Javier Mar, Oliver Ibarrondo, Igor Larrañaga, Lorea Mar-Barrutia, Myriam Soto-Gordoa
Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer’s disease
Edward N. Wilson, Christina B. Young, Javier Ramos Benitez, Michelle S. Swarovski, Igor Feinstein, Manu Vandijck, Yann Le Guen, Nandita M. Kasireddy, Marian Shahid, Nicole K. Corso, Qian Wang, Gabriel Kennedy, Alexandra N. Trelle, Betty Lind, Divya Channappa, Malia Belnap, Veronica Ramirez, Irina Skylar-Scott, Kyan Younes, Maya V. Yutsis, Nathalie Le Bastard, Joseph F. Quinn, Christopher H. van Dyck, Angus Nairn, Carolyn A. Fredericks, Lu Tian, Geoffrey A. Kerchner, Thomas J. Montine, Sharon J. Sha, Guido Davidzon, Victor W. Henderson, Frank M. Longo, Michael D. Greicius, Anthony D. Wagner, Tony Wyss-Coray, Kathleen L. Poston, Elizabeth C. Mormino, Katrin I. Andreasson
Attitudes about involvement in hypothetical clinical trial protocols in Mexican and Mexican-American at risk for autosomal dominant Alzheimer’s disease
Angélica Zuno-Reyes, Esmeralda Matute, Karin Ernstrom, Mellissa Withers, Yaneth Rodriguez-Agudelo, Rema Raman, John M. Ringman
Multi-platform proteomic analysis of Alzheimer’s disease cerebrospinal fluid and plasma reveals network biomarkers associated with proteostasis and the matrisome
Eric B. Dammer, Lingyan Ping, Duc M. Duong, Erica S. Modeste, Nicholas T. Seyfried, James J. Lah, Allan I. Levey, Erik C. B. Johnson
Visinin-like protein 1 levels in blood and CSF as emerging markers for Alzheimer’s and other neurodegenerative diseases
Steffen Halbgebauer, Petra Steinacker, Daniel Riedel, Patrick Oeckl, Sarah Anderl-Straub, Jolina Lombardi, Christine A. F. von Arnim, Magdalena Nagl, Armin Giese, Albert C. Ludolph, Markus Otto
Research attitudes in families of individuals with Down syndrome: importance for clinical trials
Ira T. Lott, Katharine A. Kirby, Eric Doran, Joshua D. Grill
Aryloxypropanolamine targets amyloid aggregates and reverses Alzheimer-like phenotypes in Alzheimer mouse models
Hee Yang Lee, Soljee Yoon, Jeong Hwa Lee, Keunwan Park, Youngeun Jung, Illhwan Cho, Donghee Lee, Jisu Shin, Kyeonghwan Kim, Sunmi Kim, Jimin Kim, Koeun Kim, Seung Hoon Han, Seong Muk Kim, Hye Ju Kim, Hye Yun Kim, Ikyon Kim, Young Soo Kim
Gantenerumab: an anti-amyloid monoclonal antibody with potential disease-modifying effects in early Alzheimer’s disease
Randall J. Bateman, Jeffrey Cummings, Scott Schobel, Stephen Salloway, Bruno Vellas, Mercè Boada, Sandra E. Black, Kaj Blennow, Paulo Fontoura, Gregory Klein, Sheila Seleri Assunção, Janice Smith, Rachelle S. Doody
β-Synuclein as a candidate blood biomarker for synaptic degeneration in Alzheimer’s disease
Pablo Mohaupt, Marie-Laure Pons, Jérôme Vialaret, Constance Delaby, Christophe Hirtz, Sylvain Lehmann
Blood–brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease
Fadi Rofo, Nicole G. Metzendorf, Cristina Saubi, Laura Suominen, Ana Godec, Dag Sehlin, Stina Syvänen, Greta Hultqvist
Proteomic profiling of circulating plasma exosomes reveals novel biomarkers of Alzheimer’s disease
Huimin Cai, Yana Pang, Qi Wang, Wei Qin, Cuibai Wei, Ying Li, Tingting Li, Fangyu Li, Qigeng Wang, Yan Li, Yiping Wei, Longfei Jia
Consistency of efficacy results across various clinical measures and statistical methods in the lecanemab phase 2 trial of early Alzheimer’s disease
Shobha Dhadda, Michio Kanekiyo, David Li, Chad J. Swanson, Michael Irizarry, Scott Berry, Lynn D. Kramer, Donald A. Berry
The hibernation-derived compound SUL-138 shifts the mitochondrial proteome towards fatty acid metabolism and prevents cognitive decline and amyloid plaque formation in an Alzheimer’s disease mouse model
Christina F. de Veij Mestdagh, Frank Koopmans, Jonathan C. Breiter, Jaap A. Timmerman, Pieter C. Vogelaar, Guido Krenning, Huibert D. Mansvelder, August B. Smit, Robert H. Henning, Ronald E. van Kesteren
The role of type 2 diabetes in the association between habitual glucosamine use and dementia: a prospective cohort study
Chenjie Xu, Yabing Hou, Xuexian Fang, Hongxi Yang, Zhi Cao
Associations of MRI-visible perivascular spaces with longitudinal cognitive decline across the Alzheimer’s disease spectrum
Ming-Liang Wang, Qiao-Qiao Zou, Zheng Sun, Xiao-Er Wei, Peng-Yang Li, Xue Wu, Yue-Hua Li
Deep learning-based speech analysis for Alzheimer’s disease detection: a literature review
Qin Yang, Xin Li, Xinyun Ding, Feiyang Xu, Zhenhua Ling
Granulovacuolar degeneration bodies are independently induced by tau and α-synuclein pathology
Marta Jorge-Oliva, Jasper F. M. Smits, Vera I. Wiersma, Jeroen J. M. Hoozemans, Wiep Scheper
Treatment needs of dementia with Lewy bodies according to patients, caregivers, and physicians: a cross-sectional, observational, questionnaire-based study in Japan
Mamoru Hashimoto, Yuta Manabe, Takuhiro Yamaguchi, Shunji Toya, Manabu Ikeda
Association of neurofilament light chain with renal function: mechanisms and clinical implications
Rongxiang Tang, Matthew S. Panizzon, Jeremy A. Elman, Nathan A. Gillespie, Richard L. Hauger, Robert A. Rissman, Michael J. Lyons, Michael C. Neale, Chandra A. Reynolds, Carol E. Franz, William S. Kremen
Persisting neuropsychiatric symptoms, Alzheimer’s disease, and cerebrospinal fluid cortisol and dehydroepiandrosterone sulfate
Sami Ouanes, Miriam Rabl, Christopher Clark, Clemens Kirschbaum, Julius Popp
Lecanemab in patients with early Alzheimer’s disease: detailed results on biomarker, cognitive, and clinical effects from the randomized and open-label extension of the phase 2 proof-of-concept study
Eric McDade, Jeffrey L. Cummings, Shobha Dhadda, Chad J. Swanson, Larisa Reyderman, Michio Kanekiyo, Akihiko Koyama, Michael Irizarry, Lynn D. Kramer, Randall J. Bateman
CSF tau368/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-tau181 and p-tau217 in cognitively impaired individuals
Joel Simrén, Wagner S. Brum, Nicholas J. Ashton, Andrea L. Benedet, Thomas K. Karikari, Hlin Kvartsberg, Emma Sjons, Firoza Z. Lussier, Mira Chamoun, Jenna Stevenson, Robert Hopewell, Vanessa Pallen, Keqiang Ye, Tharick A. Pascoal, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow
Synergistic interaction of high blood pressure and cerebral beta-amyloid on tau pathology
Taewon Kim, Dahyun Yi, Min Soo Byun, Hyejin Ahn, Joon Hyung Jung, Nayeong Kong, Min Jung Kim, Gijung Jung, Jun-Young Lee, Yun-Sang Lee, Yu Kyeong Kim, Dong Young Lee
ApoJ/Clusterin concentrations are determinants of cerebrospinal fluid cholesterol efflux capacity and reduced levels are associated with Alzheimer’s disease
Yi-An Ko, Jeffrey T. Billheimer, Nicholas N. Lyssenko, Alexandra Kueider-Paisley, David A. Wolk, Steven E. Arnold, Yuk Yee Leung, Leslie M. Shaw, John Q. Trojanowski, Rima F. Kaddurah-Daouk, Mitchel A. Kling, Daniel J. Rader
The performance of plasma amyloid beta measurements in identifying amyloid plaques in Alzheimer’s disease: a literature review
Abby L. Brand, Paige E. Lawler, James G. Bollinger, Yan Li, Suzanne E. Schindler, Melody Li, Samir Lopez, Vitaliy Ovod, Akinori Nakamura, Leslie M. Shaw, Henrik Zetterberg, Oskar Hansson, Randall J. Bateman
Aβ42 oligomer-specific antibody ALZ-201 reduces the neurotoxicity of Alzheimer’s disease brain extracts
Anders Sandberg, Ernesto Berenjeno-Correa, Rosa Crespo Rodriguez, Michael Axenhus, Sophia Schedin Weiss, Kevin Batenburg, Jeroen J. M. Hoozemans, Lars O. Tjernberg, Wiep Scheper
Subjective cognitive decline is a better marker for future cognitive decline in females than in males
Michael D. Oliver, Cassandra Morrison, Farooq Kamal, Jillian Graham, Mahsa Dadar
CYP46A1 activation by low-dose efavirenz enhances brain cholesterol metabolism in subjects with early Alzheimer’s disease
Alan J. Lerner, Steven E. Arnold, Erin Maxfield, Aaron Koenig, Maria E. Toth, Brooke Fortin, Natalia Mast, Bianca A. Trombetta, John Denker, Andrew A. Pieper, Curtis Tatsuoka, Sangeetha Raghupathy, Irina A. Pikuleva
A low-dimensional cognitive-network space in Alzheimer’s disease and frontotemporal dementia
Lorenzo Pini, Siemon C de Lange, Francesca Benedetta Pizzini, Ilaria Boscolo Galazzo, Rosa Manenti, Maria Cotelli, Samantha Galluzzi, Maria Sofia Cotelli, Maurizio Corbetta, Martijn P van den Heuvel, Michela Pievani
Paroxysmal slow wave events are associated with cognitive impairment in patients with obstructive sleep apnea
Mengfan Li, Zhuoran Sun, Hairong Sun, Guochen Zhao, Bing Leng, Tengqun Shen, Song Xue, Huimin Hou, Zhenguang Li, Jinbiao Zhang
Alpha-synuclein: a pathological factor with Aβ and tau and biomarker in Alzheimer’s disease
Kyu Hwan Shim, Min Ju Kang, Young Chul Youn, Seong Soo A. An, SangYun Kim
Effects of non-modifiable risk factors of Alzheimer’s disease on intracortical myelin content
Marina Fernandez-Alvarez, Mercedes Atienza, Jose L. Cantero