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BMC Medicine

Ausgabe 1/2019

Inhalt (230 Artikel)

Open Access Research article

Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments—a WWARN individual patient data meta-analysis

Chanaki Amaratunga, Voahangy Hanitriniaina Andrianaranjaka, Elizabeth Ashley, Delia Bethell, Anders Björkman, Craig A. Bonnington, Roland A. Cooper, Mehul Dhorda, Arjen Dondorp, Annette Erhart, Rick M. Fairhurst, Abul Faiz, Caterina Fanello, Mark M. Fukuda, Philippe Guérin, Rob Hooft van Huijsduijnen, Tran Tinh Hien, N. V. Hong, Ye Htut, Fang Huang, Georgina Humphreys, Mallika Imwong, Kalynn Kennon, Pharath Lim, Khin Lin, Chanthap Lon, Andreas Mårtensson, Mayfong Mayxay, Olugbenga Mokuolu, Ulrika Morris, Billy E. Ngasala, Alfred Amambua-Ngwa, Harald Noedl, François Nosten, Marie Onyamboko, Aung Pyae Phyo, Christopher V. Plowe, Sasithon Pukrittayakamee, Milijaona Randrianarivelojosia, Philip J. Rosenthal, David L. Saunders, Carol Hopkins Sibley, Frank Smithuis, Michele D. Spring, Paul Sondo, Sokunthea Sreng, Peter Starzengruber, Kasia Stepniewska, Seila Suon, Shannon Takala-Harrison, Kamala Thriemer, Nguyen Thuy-Nhien, Kyaw Myo Tun, Nicholas J. White, Charles Woodrow

Open Access Research article

Morbidity, mortality and missed appointments in healthcare: a national retrospective data linkage study

Ross McQueenie, David A. Ellis, Alex McConnachie, Philip Wilson, Andrea E. Williamson

Open Access Research article

NMR-based metabolomics identifies patients at high risk of death within two years after acute myocardial infarction in the AMI-Florence II cohort

Alessia Vignoli, Leonardo Tenori, Betti Giusti, Panteleimon G. Takis, Serafina Valente, Nazario Carrabba, Daniela Balzi, Alessandro Barchielli, Niccolò Marchionni, Gian Franco Gensini, Rossella Marcucci, Claudio Luchinat, Anna Maria Gori

Open Access Research article

HIV-1 molecular transmission clusters in nine European countries and Canada: association with demographic and clinical factors

Dimitrios Paraskevis, Apostolos Beloukas, Kostantinos Stasinos, Nikos Pantazis, Carmen de Mendoza, Norbert Bannert, Laurence Meyer, Robert Zangerle, John Gill, Maria Prins, Antonella d’Arminio Montforte, Anne-Marte Bakken Kran, Kholoud Porter, Giota Touloumi

Open Access Research article

Effects of a lifestyle intervention during pregnancy to prevent excessive gestational weight gain in routine care – the cluster-randomised GeliS trial

Julia Kunath, Julia Günther, Kathrin Rauh, Julia Hoffmann, Lynne Stecher, Eva Rosenfeld, Luzia Kick, Kurt Ulm, Hans Hauner

Open Access Research article

Implementation science and stigma reduction interventions in low- and middle-income countries: a systematic review

Christopher G. Kemp, Brooke A. Jarrett, Churl-Su Kwon, Lanxin Song, Nathalie Jetté, Jaime C. Sapag, Judith Bass, Laura Murray, Deepa Rao, Stefan Baral

Open Access Correspondence

Challenges and opportunities in examining and addressing intersectional stigma and health

Janet M. Turan, Melissa A. Elafros, Carmen H. Logie, Swagata Banik, Bulent Turan, Kaylee B. Crockett, Bernice Pescosolido, Sarah M. Murray

Open Access Research article

Safety, activity, and molecular heterogeneity following neoadjuvant non-pegylated liposomal doxorubicin, paclitaxel, trastuzumab, and pertuzumab in HER2-positive breast cancer (Opti-HER HEART): an open-label, single-group, multicenter, phase 2 trial

Joaquín Gavilá, Mafalda Oliveira, Tomás Pascual, Jose Perez-Garcia, Xavier Gonzàlez, Jordi Canes, Laia Paré, Isabel Calvo, Eva Ciruelos, Montserrat Muñoz, Juan A. Virizuela, Isabel Ruiz, Raquel Andrés, Antonia Perelló, Jerónimo Martínez, Serafín Morales, Mercedes Marín-Aguilera, Débora Martínez, Juan C. Quero, Antonio Llombart-Cussac, Aleix Prat

Open Access Research article

The impact of repeated vaccination on influenza vaccine effectiveness: a systematic review and meta-analysis

Lauren C. Ramsay, Sarah A. Buchan, Robert G. Stirling, Benjamin J. Cowling, Shuo Feng, Jeffrey C. Kwong, Bryna F. Warshawsky

Open Access Research article

Serious adverse events reported in placebo randomised controlled trials of oral naltrexone: a systematic review and meta-analysis

Monica Bolton, Alex Hodkinson, Shivani Boda, Alan Mould, Maria Panagioti, Sarah Rhodes, Lisa Riste, Harm van Marwijk

Open Access Opinion

Real-world data and the patient perspective: the PROmise of social media?

Laura McDonald, Bill Malcolm, Sreeram Ramagopalan, Hayley Syrad

Open Access Mini Review

The democratization of scientific publishing

Clare Fiala, Eleftherios P. Diamandis

Open Access Opinion

Out of the silos: identifying cross-cutting features of health-related stigma to advance measurement and intervention

Wim H. van Brakel, Janine Cataldo, Sandeep Grover, Brandon A. Kohrt, Laura Nyblade, Melissa Stockton, Edwin Wouters, Lawrence H. Yang

Open Access Research article

From high to low malaria transmission in Zanzibar—challenges and opportunities to achieve elimination

A. Björkman, D. Shakely, A. S. Ali, U. Morris, H. Mkali, A. K. Abbas, A-W Al-Mafazy, K. A. Haji, J. Mcha, R. Omar, J. Cook, K. Elfving, M. Petzold, M. C. Sachs, B. Aydin-Schmidt, C. Drakeley, M. Msellem, A. Mårtensson

Open Access Research article

The effect of a lifestyle intervention in obese pregnant women on gestational metabolic profiles: findings from the UK Pregnancies Better Eating and Activity Trial (UPBEAT) randomised controlled trial

Harriet L. Mills, Nashita Patel, Sara L. White, Dharmintra Pasupathy, Annette L. Briley, Diana L. Santos Ferreira, Paul T. Seed, Scott M. Nelson, Naveed Sattar, Kate Tilling, Lucilla Poston, Deborah A. Lawlor

Open Access Research article

Clinical and economic outcomes of remotely delivered cognitive behaviour therapy versus treatment as usual for repeat unscheduled care users with severe health anxiety: a multicentre randomised controlled trial

Richard Morriss, Shireen Patel, Sam Malins, Boliang Guo, Fred Higton, Marilyn James, Mengjun Wu, Paula Brown, Naomi Boycott, Catherine Kaylor-Hughes, Martin Morris, Emma Rowley, Jayne Simpson, David Smart, Michelle Stubley, Joe Kai, Helen Tyrer

Open Access Research article

A scoping review of health-related stigma outcomes for high-burden diseases in low- and middle-income countries

Jeremy C. Kane, Melissa A. Elafros, Sarah M. Murray, Ellen M. H. Mitchell, Jura L. Augustinavicius, Sara Causevic, Stefan D. Baral

Open Access Research article

A randomised controlled trial of a mitochondrial therapeutic target for bipolar depression: mitochondrial agents, N-acetylcysteine, and placebo

Michael Berk, Alyna Turner, Gin S. Malhi, Chee H. Ng, Susan M. Cotton, Seetal Dodd, Yuval Samuni, Michelle Tanious, Claire McAulay, Nathan Dowling, Jerome Sarris, Lauren Owen, Astrid Waterdrinker, Deidre Smith, Olivia M. Dean

Open Access Research article

The association between adherence to the Mediterranean diet and hepatic steatosis: cross-sectional analysis of two independent studies, the UK Fenland Study and the Swiss CoLaus Study

Saman Khalatbari-Soltani, Fumiaki Imamura, Soren Brage, Emanuella De Lucia Rolfe, Simon J Griffin, Nicholas J Wareham, Pedro Marques-Vidal, Nita G Forouhi

Open Access Research article

Mortality after inpatient treatment for diarrhea in children: a cohort study

Alison Talbert, Moses Ngari, Evasius Bauni, Martha Mwangome, Neema Mturi, Mark Otiende, Kathryn Maitland, Judd Walson, James A. Berkley

Open Access Research article

Disparities in access to diagnosis and care in Blantyre, Malawi, identified through enhanced tuberculosis surveillance and spatial analysis

Peter MacPherson, McEwen Khundi, Marriott Nliwasa, Augustine T. Choko, Vincent K. Phiri, Emily L. Webb, Peter J. Dodd, Ted Cohen, Rebecca Harris, Elizabeth L. Corbett

Open Access Research article

Antibody responses to merozoite antigens after natural Plasmodium falciparum infection: kinetics and longevity in absence of re-exposure

Victor Yman, Michael T. White, Muhammad Asghar, Christopher Sundling, Klara Sondén, Simon J. Draper, Faith H. A. Osier, Anna Färnert

Open Access Research article

Are China’s oldest-old living longer with less disability? A longitudinal modeling analysis of birth cohorts born 10 years apart

Zuyun Liu, Ling Han, Qiushi Feng, Matthew E. Dupre, Danan Gu, Heather G. Allore, Thomas M. Gill, Collin F. Payne

Open Access Research article

Discontinuation of adjuvant hormone therapy among breast cancer patients not previously attending mammography screening

Wei He, Louise Eriksson, Sven Törnberg, Fredrik Strand, Per Hall, Kamila Czene

Open Access Correspondence

Stigma in health facilities: why it matters and how we can change it

Laura Nyblade, Melissa A. Stockton, Kayla Giger, Virginia Bond, Maria L. Ekstrand, Roger Mc Lean, Ellen M. H. Mitchell, La Ron E. Nelson, Jaime C. Sapag, Taweesap Siraprapasiri, Janet Turan, Edwin Wouters

Open Access Research article

The potential impact and cost-effectiveness of tobacco reduction strategies for tuberculosis prevention in Canadian Inuit communities

Dieynaba S. N’Diaye, Ntwali Placide Nsengiyumva, Aashna Uppal, Olivia Oxlade, Gonzalo G. Alvarez, Kevin Schwartzman

Open Access Research article

Prenatal cadmium exposure is associated with shorter leukocyte telomere length in Chinese newborns

Lina Zhang, Lulu Song, Bingqing Liu, Mingyang Wu, Lulin Wang, Bin Zhang, Chao Xiong, Wei Xia, Yuanyuan Li, Zhongqiang Cao, Youjie Wang, Shunqing Xu

Open Access Research article

Deferred and referred deliveries contribute to stillbirths in the Indian state of Bihar: results from a population-based survey of all births

Rakhi Dandona, G. Anil Kumar, Md. Akbar, Debarshi Bhattacharya, Priya Nanda, Lalit Dandona

Open Access Research article

On the estimation of population cause-specific mortality fractions from in-hospital deaths

Gail M. Williams, Ian Douglas Riley, Riley H. Hazard, Hafizur R. Chowhury, Nurul Alam, Peter Kim Streafield, Veronica Tallo, Diozele Sanvictores, Marilla Lucero, Tim Adair, Alan D. Lopez

Open Access Commentary

Adverse events and nocebo phenomena: treatment or disease specific?

Panagiotis Zis, Panagiota Sykioti

Open Access Correspondence

The Health Stigma and Discrimination Framework: a global, crosscutting framework to inform research, intervention development, and policy on health-related stigmas

Anne L. Stangl, Valerie A. Earnshaw, Carmen H. Logie, Wim van Brakel, Leickness C. Simbayi, Iman Barré, John F. Dovidio

Open Access Opinion

Participatory praxis as an imperative for health-related stigma research

Laurel Sprague, Rima Afifi, George Ayala, Musah Lumumba El-nasoor

Open Access Correction

Correction to: A randomised controlled trial of a mitochondrial therapeutic target for bipolar depression: mitochondrial agents, N-acetylcysteine, and placebo

Michael Berk, Alyna Turner, Gin S. Malhi, Chee H. Ng, Susan M. Cotton, Seetal Dodd, Yuval Samuni, Michelle Tanious, Claire McAulay, Nathan Dowling, Jerome Sarris, Lauren Owen, Astrid Waterdrinker, Deidre Smith, Olivia M. Dean

Open Access Research article

Disaggregating catastrophic health expenditure by disease area: cross-country estimates based on the World Health Surveys

Annie Haakenstad, Matthew Coates, Andrew Marx, Gene Bukhman, Stéphane Verguet

Open Access Research article

High-throughput, non-invasive prenatal testing for fetal rhesus D status in RhD-negative women: a systematic review and meta-analysis

Huiqin Yang, Alexis Llewellyn, Ruth Walker, Melissa Harden, Pedro Saramago, Susan Griffin, Mark Simmonds

Open Access Research article

Thymic size is increased by infancy, but not pregnancy, nutritional supplementation in rural Gambian children: a randomized clinical trial

Sophie E. Moore, Anthony J. C. Fulford, Fatou Sosseh, Patrick Nshe, Momodou K. Darboe, Andrew M. Prentice

Open Access Editorial

Advancing health equity through cross-cutting approaches to health-related stigma

Gretchen L. Birbeck, Virginia Bond, Valerie Earnshaw, Musah Lumumba El-Nasoor

Open Access Research article

A systematic review of multi-level stigma interventions: state of the science and future directions

Deepa Rao, Ahmed Elshafei, Minh Nguyen, Mark L. Hatzenbuehler, Sarah Frey, Vivian F. Go

Open Access Research article

Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury

Yihua Bei, Li-Long Pan, Qiulian Zhou, Cuimei Zhao, Yuan Xie, Chengfei Wu, Xiangmin Meng, Huanyu Gu, Jiahong Xu, Lei Zhou, Joost P. G. Sluijter, Saumya Das, Birgitta Agerberth, Jia Sun, Junjie Xiao

Open Access Research article

HBV vaccination and PMTCT as elimination tools in the presence of HIV: insights from a clinical cohort and dynamic model

Anna L. McNaughton, José Lourenço, Louise Hattingh, Emily Adland, Samantha Daniels, Anriette Van Zyl, Connie S. Akiror, Susan Wareing, Katie Jeffery, M. Azim Ansari, Paul Klenerman, Philip J. R. Goulder, Sunetra Gupta, Pieter Jooste, Philippa C. Matthews

Open Access Research article

Building a learning community of Australian clinical genomics: a social network study of the Australian Genomic Health Alliance

Janet C. Long, Chiara Pomare, Stephanie Best, Tiffany Boughtwood, Kathryn North, Louise A. Ellis, Kate Churruca, Jeffrey Braithwaite

Open Access Research article

Induction and decay of functional complement-fixing antibodies by the RTS,S malaria vaccine in children, and a negative impact of malaria exposure

Liriye Kurtovic, Paul A. Agius, Gaoqian Feng, Damien R. Drew, Itziar Ubillos, Jahit Sacarlal, John J. Aponte, Freya J. I. Fowkes, Carlota Dobaño, James G. Beeson

Open Access Research article

The cost of diagnostic uncertainty: a prospective economic analysis of febrile children attending an NHS emergency department

Simon Leigh, Alison Grant, Nicola Murray, Brian Faragher, Henal Desai, Samantha Dolan, Naeema Cabdi, James B. Murray, Yasmin Rejaei, Stephanie Stewart, Karl Edwardson, Jason Dean, Bimal Mehta, Shunmay Yeung, Frans Coenen, Louis W. Niessen, Enitan D. Carrol

Open Access Research article

The effectiveness and cost-effectiveness of strength and balance Exergames to reduce falls risk for people aged 55 years and older in UK assisted living facilities: a multi-centre, cluster randomised controlled trial

Emma K. Stanmore, Alexandra Mavroeidi, Lex D. de Jong, Dawn A. Skelton, Chris J. Sutton, Valerio Benedetto, Luke A. Munford, Wytske Meekes, Vicky Bell, Chris Todd

Open Access Research article

The equity impact of brief opportunistic interventions to promote weight loss in primary care: secondary analysis of the BWeL randomised trial

J. Graham, K. Tudor, S. A. Jebb, A. Lewis, S. Tearne, P. Adab, R. Begh, K. Jolly, A. Daley, A. Farley, D. Lycett, A. Nickless, P. Aveyard

Open Access Correspondence

What causes severe malaria and its complications in children? Lessons learned over the past 15 years

Andrea L. Conroy, Dibyadyuti Datta, Chandy C. John

Open Access Research article

Giving permission to care for people with dementia in residential homes: learning from a realist synthesis of hearing-related communication

Brian Crosbie, Melanie Ferguson, Geoff Wong, Dawn-Marie Walker, Stevie Vanhegan, Tom Dening

Open Access Research article

Girl child marriage, socioeconomic status, and undernutrition: evidence from 35 countries in Sub-Saharan Africa

Yvette Efevbera, Jacqueline Bhabha, Paul Farmer, Günther Fink

Open Access Research article

Characterizing the transitioning epidemiology of herpes simplex virus type 1 in the USA: model-based predictions

Houssein H. Ayoub, Hiam Chemaitelly, Laith J. Abu-Raddad

Open Access Research article

Real-time analysis of the diphtheria outbreak in forcibly displaced Myanmar nationals in Bangladesh

Flavio Finger, Sebastian Funk, Kate White, M. Ruby Siddiqui, W. John Edmunds, Adam J. Kucharski

Open Access Research article

Quantifying harms to others due to alcohol consumption in Germany: a register-based study

Ludwig Kraus, Nicki-Nils Seitz, Kevin D. Shield, Gerrit Gmel, Jürgen Rehm

Open Access Research article

Repeated clinical malaria episodes are associated with modification of the immune system in children

Yaw Bediako, Rhys Adams, Adam J. Reid, John Joseph Valletta, Francis M. Ndungu, Jan Sodenkamp, Jedidah Mwacharo, Joyce Mwongeli Ngoi, Domtila Kimani, Oscar Kai, Juliana Wambua, George Nyangweso, Etienne P. de Villiers, Mandy Sanders, Magda Ewa Lotkowska, Jing-Wen Lin, Sarah Manni, John W. G. Addy, Mario Recker, Chris Newbold, Matthew Berriman, Philip Bejon, Kevin Marsh, Jean Langhorne

Open Access Correspondence

Digital health at fifteen: more human (more needed)

Kit Huckvale, C. Jason Wang, Azeem Majeed, Josip Car

Open Access Research article

Cognitive decline and mortality among community-dwelling Chinese older people

Xiaozhen Lv, Wenyuan Li, Yuan Ma, Huashuai Chen, Yi Zeng, Xin Yu, Albert Hofman, Huali Wang

Open Access Review

ApoE4: an emerging therapeutic target for Alzheimer’s disease

Mirna Safieh, Amos D. Korczyn, Daniel M. Michaelson

Open Access Research article

Comparison of depression prevalence estimates in meta-analyses based on screening tools and rating scales versus diagnostic interviews: a meta-research review

Brooke Levis, Xin Wei Yan, Chen He, Ying Sun, Andrea Benedetti, Brett D. Thombs

Open Access Research article

Development and validation of a prognostic model to predict the prognosis of patients who underwent chemotherapy and resection of pancreatic adenocarcinoma: a large international population-based cohort study

Lei Huang, Yesilda Balavarca, Lydia van der Geest, Valery Lemmens, Liesbet Van Eycken, Harlinde De Schutter, Tom B. Johannesen, Vesna Zadnik, Maja Primic-Žakelj, Margit Mägi, Robert Grützmann, Marc G. Besselink, Petra Schrotz-King, Hermann Brenner, Lina Jansen

Open Access Research article

Comparison of statins for secondary prevention in patients with ischemic stroke or transient ischemic attack: a systematic review and network meta-analysis

Irene Tramacere, Giorgio B. Boncoraglio, Rita Banzi, Cinzia Del Giovane, Koren H. Kwag, Alessandro Squizzato, Lorenzo Moja

Open Access Forum

‘Fit-for-purpose?’ – challenges and opportunities for applications of blockchain technology in the future of healthcare

Tim K. Mackey, Tsung-Ting Kuo, Basker Gummadi, Kevin A. Clauson, George Church, Dennis Grishin, Kamal Obbad, Robert Barkovich, Maria Palombini

Open Access Guideline

Microbiology Investigation Criteria for Reporting Objectively (MICRO): a framework for the reporting and interpretation of clinical microbiology data

Paul Turner, Andrew Fox-Lewis, Poojan Shrestha, David A. B. Dance, Tri Wangrangsimakul, Tomas-Paul Cusack, Clare L. Ling, Jill Hopkins, Tamalee Roberts, Direk Limmathurotsakul, Ben S. Cooper, Susanna Dunachie, Catrin E. Moore, Christiane Dolecek, H. Rogier van Doorn, Philippe J. Guerin, Nicholas P. J. Day, Elizabeth A. Ashley

Open Access Research article

Improving engagement with healthcare in hepatitis C: a randomised controlled trial of a peer support intervention

Helen R. Stagg, Julian Surey, Marie Francis, Jennifer MacLellan, Graham R. Foster, André Charlett, Ibrahim Abubakar

Open Access Research article

B-type natriuretic peptide trumps other prognostic markers in patients assessed for coronary disease

Dipak Kotecha, Marcus D. Flather, Dan Atar, Peter Collins, John Pepper, Elizabeth Jenkins, Christopher M. Reid, David Eccleston

Open Access Research article

Predicting COPD 1-year mortality using prognostic predictors routinely measured in primary care

C. I. Bloom, F. Ricciardi, L. Smeeth, P. Stone, J. K. Quint

Open Access Research article

Relationship between multimorbidity, demographic factors and mortality: findings from the UK Biobank cohort

Bhautesh Dinesh Jani, Peter Hanlon, Barbara I. Nicholl, Ross McQueenie, Katie I. Gallacher, Duncan Lee, Frances S. Mair

Open Access Research article

A step beyond the hygiene hypothesis—immune-mediated classes determined in a population-based study

Vladeta Ajdacic-Gross, Margot Mutsch, Stephanie Rodgers, Anja Tesic, Mario Müller, Erich Seifritz, En-Young N. Wagner, Roland von Känel, Markus A. Landolt, Nina Steinemann, Viktor von Wyl, Enrique Castelao, Marie-Pierre F. Strippoli, Jennifer Glaus, Caroline Vandeleur, Pedro M. Marques-Vidal, Peter Vollenweider, Martin Preisig

Open Access Research article

Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study

Andrea L. Jorgensen, Clare Prince, Gail Fitzgerald, Anita Hanson, Jennifer Downing, Julia Reynolds, J. Eunice Zhang, Ana Alfirevic, Munir Pirmohamed

Open Access Research article

Exploring telomere length in mother–newborn pairs in relation to exposure to multiple toxic metals and potential modifying effects by nutritional factors

Maria Herlin, Karin Broberg, Annachiara Malin Igra, Huiqi Li, Florencia Harari, Marie Vahter

Open Access Research article

Prospective association between ultra-processed food consumption and incident depressive symptoms in the French NutriNet-Santé cohort

Moufidath Adjibade, Chantal Julia, Benjamin Allès, Mathilde Touvier, Cédric Lemogne, Bernard Srour, Serge Hercberg, Pilar Galan, Karen E. Assmann, Emmanuelle Kesse-Guyot

Open Access Research article

What to do with diabetes therapies when HbA1c lowering is inadequate: add, switch, or continue? A MASTERMIND study

Andrew P. McGovern, John M. Dennis, Beverley M. Shields, Andrew T. Hattersley, Ewan R. Pearson, Angus G. Jones, William E Henley, Mike Lonergan, Lauren R Rodgers, Willie T Hamilton, Naveed A Sattar, Rury R Holman, Catherine Angwin, Kennedy J Cruickshank, Andrew J Farmer, Stephen CL Gough, Alastair M Gray, Christopher Hyde, Christopher Jennison, Mark Walker

Open Access Opinion

Data management and sharing policy: the first step towards promoting data sharing

Naomi Waithira, Brian Mutinda, Phaik Yeong Cheah

Open Access Research article

Population-level mathematical modeling of antimicrobial resistance: a systematic review

Anna Maria Niewiadomska, Bamini Jayabalasingham, Jessica C. Seidman, Lander Willem, Bryan Grenfell, David Spiro, Cecile Viboud

Open Access Research article

Mortality associated with alternative primary healthcare policies: a nationwide microsimulation modelling study in Brazil

Davide Rasella, Thomas Hone, Luis Eugenio de Souza, Renato Tasca, Sanjay Basu, Christopher Millett

Open Access Research article

Is resistant hypertension an independent predictor of all-cause mortality in individuals with type 2 diabetes? A prospective cohort study

Anna Solini, Giuseppe Penno, Emanuela Orsi, Enzo Bonora, Cecilia Fondelli, Roberto Trevisan, Monica Vedovato, Franco Cavalot, Olga Lamacchia, Marco G. Baroni, Antonio Nicolucci, Giuseppe Pugliese, Antonio Nicolucci, Giuseppe Pugliese, Lucilla Bollanti, Elena Alessi, Martina Vitale, Tiziana Cirrito, Paolo Cavallo-Perin, Gabriella Gruden, Bartolomeo Lorenzati, Franco Cavalot, Mariella Trovati, Leonardo Di Martino, Fabio Mazzaglia, Giampaolo Zerbini, Valentina Martina, Silvia Maestroni, Valentina Capuano, Emanuela Orsi, Eva Palmieri, Elena Lunati, Valeria Grancini, Veronica Resi, Antonio Pontiroli, Annamaria Veronelli, Barbara Zecchini, Maura Arosio, Laura Montefusco, Antonio Rossi, Guido Adda, Roberto Trevisan, Anna Corsi, Mascia Albizzi, Enzo Bonora, Giacomo Zoppini, Angelo Avogaro, Monica Vedovato, Giuseppe Penno, Laura Pucci, Daniela Lucchesi, Eleonora Russo, Monia Garofolo, Anna Solini, Francesco Dotta, Cecilia Fondelli, Laura Nigi, Susanna Morano, Tiziana Filardi, Irene Turinese, Marco Rossetti, Raffaella Buzzetti, Chiara Foffi, Mauro Cignarelli, Olga Lamacchia, Sabina Pinnelli, Lucia Monaco, Francesco Giorgino, Luigi Laviola, Annalisa Natalicchio, Giorgio Sesti, Francesco Andreozzi, Marco Giorgio Baroni, Giuseppina Frau, Alessandra Boi

Open Access Correspondence

Ethical challenges in global health-related stigma research

Joseph Millum, Megan Campbell, Florencia Luna, Arianne Malekzadeh, Quarraisha Abdool Karim

Open Access Research article

Elevated plasma copeptin levels identify the presence and severity of non-alcoholic fatty liver disease in obesity

Ilaria Barchetta, Sofia Enhörning, Flavia Agata Cimini, Danila Capoccia, Caterina Chiappetta, Claudio Di Cristofano, Gianfranco Silecchia, Frida Leonetti, Olle Melander, Maria Gisella Cavallo

Open Access Research article

The introduction of ‘No jab, No school’ policy and the refinement of measles immunisation strategies in high-income countries

Filippo Trentini, Piero Poletti, Alessia Melegaro, Stefano Merler

Open Access Research article

DECIDE: a cluster-randomized controlled trial to reduce unnecessary caesarean deliveries in Burkina Faso

Charles Kaboré, Valéry Ridde, Nils Chaillet, Fadima Yaya Bocoum, Ana Pilar Betrán, Alexandre Dumont

Open Access Minireview

Vedolizumab trough level monitoring in inflammatory bowel disease: a state-of-the-art overview

Lieven Pouillon, Séverine Vermeire, Peter Bossuyt

Open Access Minireview

Recent advances in triple negative breast cancer: the immunotherapy era

Antonio Marra, Giulia Viale, Giuseppe Curigliano

Open Access Research article

Claims of causality in health news: a randomised trial

Rachel C. Adams, Aimée Challenger, Luke Bratton, Jacky Boivin, Lewis Bott, Georgina Powell, Andy Williams, Christopher D. Chambers, Petroc Sumner

Open Access Research article

Variation in health system performance for managing diabetes among states in India: a cross-sectional study of individuals aged 15 to 49 years

Jonas Prenissl, Lindsay M. Jaacks, Viswanathan Mohan, Jennifer Manne-Goehler, Justine I. Davies, Ashish Awasthi, Anne Christine Bischops, Rifat Atun, Till Bärnighausen, Sebastian Vollmer, Pascal Geldsetzer

Open Access Research article

The classification of feeding and eating disorders in the ICD-11: results of a field study comparing proposed ICD-11 guidelines with existing ICD-10 guidelines

Angélica M. Claudino, Kathleen M. Pike, Phillipa Hay, Jared W. Keeley, Spencer C. Evans, Tahilia J. Rebello, Rachel Bryant-Waugh, Yunfei Dai, Min Zhao, Chihiro Matsumoto, Cecile Rausch Herscovici, Blanca Mellor-Marsá, Anne-Claire Stona, Cary S. Kogan, Howard F. Andrews, Palmiero Monteleone, David Joseph Pilon, Cornelia Thiels, Pratap Sharan, Samir Al-Adawi, Geoffrey M. Reed

Open Access Research article

The frailty index is a predictor of cause-specific mortality independent of familial effects from midlife onwards: a large cohort study

Xia Li, Alexander Ploner, Ida K. Karlsson, Xingrong Liu, Patrik K. E. Magnusson, Nancy L. Pedersen, Sara Hägg, Juulia Jylhävä

Open Access Research article

Risks and clinical predictors of cirrhosis and hepatocellular carcinoma diagnoses in adults with diagnosed NAFLD: real-world study of 18 million patients in four European cohorts

Myriam Alexander, A. Katrina Loomis, Johan van der Lei, Talita Duarte-Salles, Daniel Prieto-Alhambra, David Ansell, Alessandro Pasqua, Francesco Lapi, Peter Rijnbeek, Mees Mosseveld, Dawn M. Waterworth, Stuart Kendrick, Naveed Sattar, William Alazawi

Open Access Correspondence

Response to Daly-Smith et al.’s commentary on ‘The Daily Mile makes primary school children more active, less sedentary and improves their fitness and body composition: a quasi-experimental pilot study’

Ross A. Chesham, Josephine N. Booth, Emma L. Sweeney, Gemma C. Ryde, Trish Gorely, Naomi E. Brooks, Colin N. Moran

Open Access Research article

Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria

Andrea L. Conroy, Robert O. Opoka, Paul Bangirana, Richard Idro, John M. Ssenkusu, Dibyadyuti Datta, James S. Hodges, Catherine Morgan, Chandy C. John

Open Access Research article

Ethnic differences in prediabetes incidence among immigrants to Canada: a population-based cohort study

Ghazal S. Fazli, Rahim Moineddin, Arlene S. Bierman, Gillian L. Booth

Open Access Research article

Childhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespan: results from the World Mental Health Surveys

Ymkje Anna de Vries, Ali Al-Hamzawi, Jordi Alonso, Guilherme Borges, Ronny Bruffaerts, Brendan Bunting, José Miguel Caldas-de-Almeida, Alfredo H. Cia, Giovanni De Girolamo, Rumyana V. Dinolova, Oluyomi Esan, Silvia Florescu, Oye Gureje, Josep Maria Haro, Chiyi Hu, Elie G. Karam, Aimee Karam, Norito Kawakami, Andrzej Kiejna, Viviane Kovess-Masfety, Sing Lee, Zeina Mneimneh, Fernando Navarro-Mateu, Marina Piazza, Kate Scott, Margreet ten Have, Yolanda Torres, Maria Carmen Viana, Ronald C. Kessler, Peter de Jonge, Sergio Aguilar-Gaxiola, Ali Al-Hamzawi, Mohammed Salih Al-Kaisy, Jordi Alonso, Laura Helena Andrade, Corina Benjet, Guilherme Borges, Evelyn J. Bromet, Ronny Bruffaerts, Brendan Bunting, Jose Miguel Caldas de Almeida, Graça Cardoso, Somnath Chatterji, Alfredo H. Cia, Louisa Degenhardt, Koen Demyttenaere, Silvia Florescu, Giovanni de Girolamo, Oye Gureje, Josep Maria Haro, Hristo Hinkov, Chi-yi Hu, Peter de Jonge, Aimee Nasser Karam, Elie G. Karam, Norito Kawakami, Ronald C. Kessler, Andrzej Kiejna, Viviane Kovess-Masfety, Sing Lee, Jean-Pierre Lepine, Daphna Levinson, John McGrath, Maria Elena Medina-Mora, Zeina Mneimneh, Jacek Moskalewicz, Fernando Navarro-Mateu, Beth-Ellen Pennell, Marina Piazza, Jose Posada-Villa, Kate M. Scott, Tim Slade, Juan Carlos Stagnaro, Dan J. Stein, Margreet ten Have, Yolanda Torres, Maria Carmen Viana, Harvey Whiteford, David R. Williams, Bogdan Wojtyniak

Open Access Software

An integrated approach to processing WHO-2016 verbal autopsy data: the InterVA-5 model

Peter Byass, Laith Hussain-Alkhateeb, Lucia D’Ambruoso, Samuel Clark, Justine Davies, Edward Fottrell, Jon Bird, Chodziwadziwa Kabudula, Stephen Tollman, Kathleen Kahn, Linus Schiöler, Max Petzold

Open Access Research article

The XN-30 hematology analyzer for rapid sensitive detection of malaria: a diagnostic accuracy study

Annelies Post, Berenger Kaboré, Isaie J. Reuling, Joel Bognini, Wouter van der Heijden, Salou Diallo, Palpouguini Lompo, Basile Kam, Natacha Herssens, Kjerstin Lanke, Teun Bousema, Robert W. Sauerwein, Halidou Tinto, Jan Jacobs, Quirijn de Mast, Andre J. van der Ven

Open Access Research article

Three randomized controlled trials evaluating the impact of “spin” in health news stories reporting studies of pharmacologic treatments on patients’/caregivers’ interpretation of treatment benefit

Isabelle Boutron, Romana Haneef, Amélie Yavchitz, Gabriel Baron, John Novack, Ivan Oransky, Gary Schwitzer, Philippe Ravaud

Open Access Research article

Tissue-infiltrating lymphocytes signature predicts survival in patients with early/intermediate stage hepatocellular carcinoma

Meng-Xin Tian, Wei-Ren Liu, Han Wang, Yu-Fu Zhou, Lei Jin, Xi-Fei Jiang, Chen-Yang Tao, Zheng Tang, Pei-Yun Zhou, Yuan Fang, Wei-Feng Qu, Zhen-Bin Ding, Yuan-Fei Peng, Zhi Dai, Shuang-Jian Qiu, Jian Zhou, Wan Yee Lau, Jia Fan, Ying-Hong Shi

Open Access Research article

A rapid research needs appraisal methodology to identify evidence gaps to inform clinical research priorities in response to outbreaks—results from the Lassa fever pilot

Louise Sigfrid, Catrin Moore, Alex P. Salam, Nicola Maayan, Candyce Hamel, Chantelle Garritty, Vittoria Lutje, Brian Buckley, Karla Soares-Weiser, Rachel Marshall, Mike Clarke, Peter Horby

Open Access Research article

Physical activity, multimorbidity, and life expectancy: a UK Biobank longitudinal study

Yogini V. Chudasama, Kamlesh K. Khunti, Francesco Zaccardi, Alex V. Rowlands, Thomas Yates, Clare L. Gillies, Melanie J. Davies, Nafeesa N. Dhalwani

Open Access Research article

Performance of the Framingham risk models and pooled cohort equations for predicting 10-year risk of cardiovascular disease: a systematic review and meta-analysis

Johanna A. Damen, Romin Pajouheshnia, Pauline Heus, Karel G. M. Moons, Johannes B. Reitsma, Rob J. P. M. Scholten, Lotty Hooft, Thomas P. A. Debray

Open Access Research article

A multi-centre, UK-based, non-inferiority randomised controlled trial of 4 follow-up assessment methods in stroke survivors

Jonathan Hewitt, Anna Pennington, Alexander Smith, Stephanie Gething, Michelle Price, James White, Richard Dewar, Ben Carter

Open Access Review

The effects of antipsychotic medications on microbiome and weight gain in children and adolescents

Tali Bretler, Hagar Weisberg, Omry Koren, Hadar Neuman

Open Access Research article

Defining responders to therapies by a statistical modeling approach applied to randomized clinical trial data

Francesca Bovis, Luca Carmisciano, Alessio Signori, Matteo Pardini, Joshua R. Steinerman, Thomas Li, Aaron P. Tansy, Maria Pia Sormani

Open Access Research article

Effect of body mass index on pregnancy outcomes in a freeze-all policy: an analysis of 22,043 first autologous frozen-thawed embryo transfer cycles in China

Jie Zhang, Hongfang Liu, Xiaoyan Mao, Qiuju Chen, Yong Fan, Yitao Xiao, Yun Wang, Yanping Kuang

Open Access Opinion

Optimising trial designs to identify appropriate antibiotic treatment durations

Koen B. Pouwels, Mo Yin, Christopher C. Butler, Ben S. Cooper, Sarah Wordsworth, A. Sarah Walker, Julie V. Robotham

Open Access Research article

Automated versus physician assignment of cause of death for verbal autopsies: randomized trial of 9374 deaths in 117 villages in India

Prabhat Jha, Dinesh Kumar, Rajesh Dikshit, Atul Budukh, Rehana Begum, Prabha Sati, Patrycja Kolpak, Richard Wen, Shyamsundar J. Raithatha, Utkarsh Shah, Zehang Richard Li, Lukasz Aleksandrowicz, Prakash Shah, Kapila Piyasena, Tyler H. McCormick, Hellen Gelband, Samuel J. Clark

Open Access Research article

Postmarketing commitments for novel drugs and biologics approved by the US Food and Drug Administration: a cross-sectional analysis

Joshua D. Wallach, Anita T. Luxkaranayagam, Sanket S. Dhruva, Jennifer E. Miller, Joseph S. Ross

Open Access Research article

A scoping review on the roles and tasks of peer reviewers in the manuscript review process in biomedical journals

Ketevan Glonti, Daniel Cauchi, Erik Cobo, Isabelle Boutron, David Moher, Darko Hren

Open Access Research article

HIV epidemiology among female sex workers and their clients in the Middle East and North Africa: systematic review, meta-analyses, and meta-regressions

Hiam Chemaitelly, Helen A. Weiss, Clara Calvert, Manale Harfouche, Laith J. Abu-Raddad

Open Access Research article

Suicide attempts in US adults with lifetime DSM-5 eating disorders

Tomoko Udo, Sarah Bitley, Carlos M. Grilo

Open Access Correspondence

DIABRISK-SL trial: further consideration of age and impact of imputations

Efstathia Gkioni, Ketevan Glonti, Susanna Dodd, Carrol Gamble

Open Access Research article

Gastroenteritis aggressive versus slow treatment for rehydration (GASTRO): a phase II rehydration trial for severe dehydration: WHO plan C versus slow rehydration

Kirsty A. Houston, Jack Gibb, Peter Olupot-Olupot, Nchafatso Obonyo, Ayub Mpoya, Margaret Nakuya, Rita Muhindo, Sophie Uyoga, Jennifer A. Evans, Roisin Connon, Diana M. Gibb, Elizabeth C. George, Kathryn Maitland

Open Access Research article

Observational study: 27 years of severe malaria surveillance in Kilifi, Kenya

Patricia Njuguna, Kathryn Maitland, Amek Nyaguara, Daniel Mwanga, Polycarp Mogeni, Neema Mturi, Shebe Mohammed, Gabriel Mwambingu, Caroline Ngetsa, Kenedy Awuondo, Brett Lowe, Ifedayo Adetifa, J. Anthony G. Scott, Thomas N. Williams, Sarah Atkinson, Faith Osier, Robert W. Snow, Kevin Marsh, Benjamin Tsofa, Norbert Peshu, Mainga Hamaluba, James A. Berkley, Charles R. J. Newton, John Fondo, Anisa Omar, Philip Bejon

Open Access Research article

Landmark models to define the age-adjusted risk of developing stage 1 type 1 diabetes across childhood and adolescence

Verena Sophia Hoffmann, Andreas Weiß, Christiane Winkler, Annette Knopff, Manja Jolink, Ezio Bonifacio, Anette-G. Ziegler

Open Access Commentary

The TABLET trial: limitations and implications

Chrysoula Dosiou, Alex Stagnaro-Green

Open Access Research article

Medication management support in diabetes: a systematic assessment of diabetes self-management apps

Zhilian Huang, Elaine Lum, Geronimo Jimenez, Monika Semwal, Peter Sloot, Josip Car

Open Access Research article

Tobacco smoking and risk of 36 cardiovascular disease subtypes: fatal and non-fatal outcomes in a large prospective Australian study

Emily Banks, Grace Joshy, Rosemary J. Korda, Bill Stavreski, Kay Soga, Sam Egger, Cathy Day, Naomi E. Clarke, Sarah Lewington, Alan D. Lopez

Open Access Research article

The global impact and cost-effectiveness of a melioidosis vaccine

Nantasit Luangasanatip, Stefan Flasche, David A. B. Dance, Direk Limmathurotsakul, Bart J. Currie, Chiranjay Mukhopadhyay, Tim Atkins, Richard Titball, Mark Jit

Open Access Research article

Hospitalisation rates and predictors in people with dementia: a systematic review and meta-analysis

Hilary Shepherd, Gill Livingston, Justin Chan, Andrew Sommerlad

Open Access Research article

Next-generation sequencing identifies monogenic diabetes in 16% of patients with late adolescence/adult-onset diabetes selected on a clinical basis: a cross-sectional analysis

Xavier Donath, Cécile Saint-Martin, Danièle Dubois-Laforgue, Ramanan Rajasingham, François Mifsud, Cécile Ciangura, José Timsit, Christine Bellanné-Chantelot

Open Access Debate

Why we need a small data paradigm

Eric B. Hekler, Predrag Klasnja, Guillaume Chevance, Natalie M. Golaszewski, Dana Lewis, Ida Sim

Open Access Research article

GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network

Bahram Namjou, Todd Lingren, Yongbo Huang, Sreeja Parameswaran, Beth L. Cobb, Ian B. Stanaway, John J. Connolly, Frank D. Mentch, Barbara Benoit, Xinnan Niu, Wei-Qi Wei, Robert J. Carroll, Jennifer A. Pacheco, Isaac T. W. Harley, Senad Divanovic, David S. Carrell, Eric B. Larson, David J. Carey, Shefali Verma, Marylyn D. Ritchie, Ali G. Gharavi, Shawn Murphy, Marc S. Williams, David R. Crosslin, Gail P. Jarvik, Iftikhar J. Kullo, Hakon Hakonarson, Rongling Li, Stavra A. Xanthakos, John B. Harley

Open Access Research article

Sex differences in the association between diabetes and risk of cardiovascular disease, cancer, and all-cause and cause-specific mortality: a systematic review and meta-analysis of 5,162,654 participants

Yafeng Wang, Adrienne O’Neil, Yurui Jiao, Lijun Wang, Jingxin Huang, Yutao Lan, Yikun Zhu, Chuanhua Yu

Open Access Opinion

Building the case for actionable ethics in digital health research supported by artificial intelligence

Camille Nebeker, John Torous, Rebecca J. Bartlett Ellis

Open Access Research article

Delirium detection in older acute medical inpatients: a multicentre prospective comparative diagnostic test accuracy study of the 4AT and the confusion assessment method

Susan D. Shenkin, Christopher Fox, Mary Godfrey, Najma Siddiqi, Steve Goodacre, John Young, Atul Anand, Alasdair Gray, Janet Hanley, Allan MacRaild, Jill Steven, Polly L. Black, Zoë Tieges, Julia Boyd, Jacqueline Stephen, Christopher J. Weir, Alasdair M. J. MacLullich

Open Access Research article

Health professions digital education on clinical practice guidelines: a systematic review by Digital Health Education collaboration

Lorainne Tudor Car, Aijia Soong, Bhone Myint Kyaw, Kee Leng Chua, Naomi Low-Beer, Azeem Majeed

Open Access Research article

Distinct mortality patterns at 0–2 days versus the remaining neonatal period: results from population-based assessment in the Indian state of Bihar

Rakhi Dandona, G. Anil Kumar, Debarshi Bhattacharya, Md. Akbar, Yamini Atmavilas, Priya Nanda, Lalit Dandona

Open Access Research article

Low serum IGF1 is associated with hypertension and predicts early cardiovascular events in women with rheumatoid arthritis

Malin C. Erlandsson, Lovisa Lyngfelt, N. David Åberg, Caroline Wasén, Rachelle A. Espino, Sofia Töyrä Silfverswärd, Mitra Nadali, Katharina Jood, Karin M.E. Andersson, Rille Pullerits, Maria I. Bokarewa

Open Access Review

Celiac disease: a comprehensive current review

Giacomo Caio, Umberto Volta, Anna Sapone, Daniel A. Leffler, Roberto De Giorgio, Carlo Catassi, Alessio Fasano

Open Access Editorial

Beyond the hype of big data and artificial intelligence: building foundations for knowledge and wisdom

Josip Car, Aziz Sheikh, Paul Wicks, Marc S. Williams

Open Access Research article

The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort

Magdalena Nowakowska, Salwa S. Zghebi, Darren M. Ashcroft, Iain Buchan, Carolyn Chew-Graham, Tim Holt, Christian Mallen, Harm Van Marwijk, Niels Peek, Rafael Perera-Salazar, David Reeves, Martin K. Rutter, Stephen F. Weng, Nadeem Qureshi, Mamas A. Mamas, Evangelos Kontopantelis

Open Access Correspondence

Antenatal iron supplementation and birth weight in conditions of high exposure to infectious diseases

Hans Verhoef, Martin N. Mwangi, Carla Cerami, Andrew M. Prentice

Open Access Correction

Correction to: Three randomized controlled trials evaluating the impact of “spin” in health news stories reporting studies of pharmacologic treatments on patients’/caregivers’ interpretation of treatment benefit

Isabelle Boutron, Romana Haneef, Amélie Yavchitz, Gabriel Baron, John Novack, Ivan Oransky, Gary Schwitzer, Philippe Ravaud

Open Access Research article

Mortality following myocardial infarction among HIV-infected persons: the Center for AIDS Research Network Of Integrated Clinical Systems (CNICS)

Matthew J. Feinstein, Robin M. Nance, J. A. Chris Delaney, Susan R. Heckbert, Matthew J. Budoff, Daniel R. Drozd, Greer A. Burkholder, James H. Willig, Michael J. Mugavero, William C. Mathews, Richard D. Moore, Joseph J. Eron, Sonia Napravnik, Peter W. Hunt, Elvin Geng, Priscilla Hsue, Inga Peter, William B. Lober, Kristina Crothers, Carl Grunfeld, Michael S. Saag, Mari M. Kitahata, Donald M. Lloyd-Jones, Heidi M. Crane

Open Access Research article

The long-term survival characteristics of a cohort of colorectal cancer patients and baseline variables associated with survival outcomes with or without time-varying effects

Yajun Yu, Megan Carey, William Pollett, Jane Green, Elizabeth Dicks, Patrick Parfrey, Yildiz E. Yilmaz, Sevtap Savas

Open Access Research article

The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis

Robert J. Commons, Julie A. Simpson, Kamala Thriemer, Cindy S. Chu, Nicholas M. Douglas, Tesfay Abreha, Sisay G. Alemu, Arletta Añez, Nicholas M. Anstey, Abraham Aseffa, Ashenafi Assefa, Ghulam R. Awab, J. Kevin Baird, Bridget E. Barber, Isabelle Borghini-Fuhrer, Umberto D’Alessandro, Prabin Dahal, André Daher, Peter J. de Vries, Annette Erhart, Margarete S. M. Gomes, Matthew J. Grigg, Jimee Hwang, Piet A. Kager, Tsige Ketema, Wasif A. Khan, Marcus V. G. Lacerda, Toby Leslie, Benedikt Ley, Kartini Lidia, Wuelton M. Monteiro, Dhelio B. Pereira, Giao T. Phan, Aung P. Phyo, Mark Rowland, Kavitha Saravu, Carol H. Sibley, André M. Siqueira, Kasia Stepniewska, Walter R. J. Taylor, Guy Thwaites, Binh Q. Tran, Tran T. Hien, José Luiz F. Vieira, Sonam Wangchuk, James Watson, Timothy William, Charles J. Woodrow, Francois Nosten, Philippe J. Guerin, Nicholas J. White, Ric N. Price

Open Access Opinion

When to keep it simple – adaptive designs are not always useful

James M. S. Wason, Peter Brocklehurst, Christina Yap

Open Access Research article

Antibiotic use and the risk of rheumatoid arthritis: a population-based case-control study

Alyshah Abdul Sultan, Christian Mallen, Sara Muller, Samantha Hider, Ian Scott, Toby Helliwell, Lindsay J. Hall

Open Access Research article

Informing decision-making for universal access to quality tuberculosis diagnosis in India: an economic-epidemiological model

Hojoon Sohn, Parastu Kasaie, Emily Kendall, Gabriela B. Gomez, Anna Vassall, Madhukar Pai, David Dowdy

Open Access Research article

Two dose levels of rabbit antithymocyte globulin as graft-versus-host disease prophylaxis in haploidentical stem cell transplantation: a multicenter randomized study

Ren Lin, Yu Wang, Fen Huang, Zhiping Fan, Shen Zhang, Ting Yang, Yajing Xu, Na Xu, Li Xuan, Jieyu Ye, Jing Sun, Xiaojun Huang, Qifa Liu

Open Access Research article

RTS,S/AS01E immunization increases antibody responses to vaccine-unrelated Plasmodium falciparum antigens associated with protection against clinical malaria in African children: a case-control study

Carlota Dobaño, Itziar Ubillos, Chenjerai Jairoce, Ben Gyan, Marta Vidal, Alfons Jiménez, Rebeca Santano, David Dosoo, Augusto J. Nhabomba, Aintzane Ayestaran, Ruth Aguilar, Nana Aba Williams, Núria Díez-Padrisa, David Lanar, Virander Chauhan, Chetan Chitnis, Sheetij Dutta, Deepak Gaur, Evelina Angov, Kwaku Poku Asante, Seth Owusu-Agyei, Clarissa Valim, Benoit Gamain, Ross L. Coppel, David Cavanagh, James G. Beeson, Joseph J. Campo, Gemma Moncunill

Open Access Commentary

New approaches for detecting cancer with circulating cell-free DNA

Clare Fiala, Eleftherios P. Diamandis

Open Access Research article

Vitamin D and cause-specific vascular disease and mortality: a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults

Tao Huang, Shoaib Afzal, Canqing Yu, Yu Guo, Zheng Bian, Ling Yang, Iona Y. Millwood, Robin G. Walters, Yiping Chen, Ningyu Chen, Ruqin Gao, Junshi Chen, Robert Clarke, Zhengming Chen, Christina Ellervik, Børge G. Nordestgaard, Jun Lv, Liming Li, Junshi Chen, Zhengming Chen, Robert Clarke, Rory Collins, Yu Guo, Liming Li, Jun Lv, Richard Peto, Robin Walters, Daniel Avery, Ruth Boxall, Derrick Bennett, Yumei Chang, Yiping Chen, Zhengming Chen, Robert Clarke, Huaidong Du, Simon Gilbert, Alex Hacker, Mike Hill, Michael Holmes, Andri Iona, Christiana Kartsonaki, Rene Kerosi, Ling Kong, Om Kurmi, Garry Lancaster, Sarah Lewington, Kuang Lin, John McDonnell, Iona Millwood, Qunhua Nie, Jayakrishnan Radhakrishnan, Paul Ryder, Sam Sansome, Dan Schmidt, Paul Sherliker, Rajani Sohoni, Becky Stevens, Iain Turnbull, Robin Walters, Jenny Wang, Lin Wang, Neil Wright, Ling Yang, Xiaoming Yang, Zheng Bian, Yu Guo, Xiao Han, Can Hou, Jun Lv, Pei Pei, Chao Liu, Yunlong Tan, Canqing Yu, Zengchang Pang, Ruqin Gao, Shanpeng Li, Shaojie Wang, Yongmei Liu, Ranran Du, Yajing Zang, Liang Cheng, Xiaocao Tian, Hua Zhang, Yaoming Zhai, Feng Ning, Xiaohui Sun, Feifei Li, Silu Lv, Junzheng Wang, Wei Hou, Mingyuan Zeng, Ge Jiang, Xue Zhou, Liqiu Yang, Hui He, Bo Yu, Yanjie Li, Qinai Xu, Quan Kang, Ziyan Guo, Dan Wang, Ximin Hu, Jinyan Chen, Yan Fu, Zhenwang Fu, Xiaohuan Wang, Min Weng, Zhendong Guo, Shukuan Wu, Yilei Li, Huimei Li, Zhifang Fu, Ming Wu, Yonglin Zhou, Jinyi Zhou, Ran Tao, Jie Yang, Jian Su, Fang Liu, Jun Zhang, Yihe Hu, Yan Lu, Liangcai Ma, Aiyu Tang, Shuo Zhang, Jianrong Jin, Jingchao Liu, Zhenzhu Tang, Naying Chen, Ying Huang, Mingqiang Li, Jinhuai Meng, Rong Pan, Qilian Jiang, Jian Lan, Yun Liu, Liuping Wei, Liyuan Zhou, Ningyu Chen, Ping Wang, Fanwen Meng, Yulu Qin, Sisi Wang, Xianping Wu, Ningmei Zhang, Xiaofang Chen, Weiwei Zhou, Guojin Luo, Jianguo Li, Xiaofang Chen, Xunfu Zhong, Jiaqiu Liu, Qiang Sun, Pengfei Ge, Xiaolan Ren, Caixia Dong, Hui Zhang, Enke Mao, Xiaoping Wang, Tao Wang, Xi Zhang, Ding Zhang, Gang Zhou, Shixian Feng, Liang Chang, Lei Fan, Yulian Gao, Tianyou He, Huarong Sun, Pan He, Chen Hu, Xukui Zhang, Huifang Wu, Pan He, Min Yu, Ruying Hu, Hao Wang, Yijian Qian, Chunmei Wang, Kaixu Xie, Lingli Chen, Yidan Zhang, Dongxia Pan, Qijun Gu, Yuelong Huang, Biyun Chen, Li Yin, Huilin Liu, Zhongxi Fu, Qiaohua Xu, Xin Xu, Hao Zhang, Huajun Long, Xianzhi Li, Libo Zhang, Zhe Qiu

Open Access Research article

Clinical and cost-effectiveness of contingency management for cannabis use in early psychosis: the CIRCLE randomised clinical trial

Luke Sheridan Rains, Louise Marston, Mark Hinton, Steven Marwaha, Thomas Craig, David Fowler, Michael King, Rumana Z. Omar, Paul McCrone, Jonathan Spencer, Joanne Taylor, Sophie Colman, Catherine Harder, Eleanor Gilbert, Amie Randhawa, Kirsty Labuschagne, Charlotte Jones, Theodora Stefanidou, Marina Christoforou, Meghan Craig, John Strang, Tim Weaver, Sonia Johnson

Open Access Guideline

Guidelines for multi-model comparisons of the impact of infectious disease interventions

Saskia den Boon, Mark Jit, Marc Brisson, Graham Medley, Philippe Beutels, Richard White, Stefan Flasche, T. Déirdre Hollingsworth, Tini Garske, Virginia E. Pitzer, Martine Hoogendoorn, Oliver Geffen, Andrew Clark, Jane Kim, Raymond Hutubessy

Open Access Research article

A novel sub-epidemic modeling framework for short-term forecasting epidemic waves

Gerardo Chowell, Amna Tariq, James M. Hyman

Open Access Research article

Persistent C-peptide secretion in Type 1 diabetes and its relationship to the genetic architecture of diabetes

Paul M. McKeigue, Athina Spiliopoulou, Stuart McGurnaghan, Marco Colombo, Luke Blackbourn, Timothy J. McDonald, Suna Onengut-Gomuscu, Stephen S. Rich, Colin N. A. Palmer, John A. McKnight, Mark W. J. Strachan, Alan W. Patrick, John Chalmers, Robert S. Lindsay, John R. Petrie, Sandeep Thekkepat, Andrew Collier, Sandra MacRury, Helen M. Colhoun

Open Access Commentary

Gene–environment interactions and vitamin D effects on cardiovascular risk

Guido Iaccarino, Bruno Trimarco

Open Access Research article

Trends of blood pressure and heart rate in normal pregnancies: a systematic review and meta-analysis

Lise Loerup, Rebecca M. Pullon, Jacqueline Birks, Susannah Fleming, Lucy H. Mackillop, Stephen Gerry, Peter J. Watkinson

Open Access Research article

Dissecting genetic factors affecting phenylephrine infusion rates during anesthesia: a genome-wide association study employing EHR data

Yanfei Zhang, S. Mark Poler, Jiang Li, Vida Abedi, Sarah A. Pendergrass, Marc S. Williams, Ming Ta Michael Lee

Open Access Research article

‘Caveat emptor’: the cautionary tale of endocarditis and the potential pitfalls of clinical coding data—an electronic health records study

Nicola Fawcett, Bernadette Young, Leon Peto, T. Phuong Quan, Richard Gillott, Jianhua Wu, Chris Middlemass, Sheila Weston, Derrick W. Crook, Tim E. A. Peto, Berit Muller-Pebody, Alan P. Johnson, A. Sarah Walker, Jonathan A. T. Sandoe

Open Access Research article

A systematic review of clinical guidelines on the management of acute, community-acquired CNS infections

Louise Sigfrid, Chelsea Perfect, Amanda Rojek, Kajsa-Stina Longuere, Sam Lipworth, Eli Harriss, James Lee, Alex Salam, Gail Carson, Herman Goossens, Peter Horby

Open Access Research article

A dynamic neural network model for predicting risk of Zika in real time

Mahmood Akhtar, Moritz U. G. Kraemer, Lauren M. Gardner

Open Access Research article

Estimating the burden of dengue and the impact of release of wMel Wolbachia-infected mosquitoes in Indonesia: a modelling study

Kathleen M. O’Reilly, Emilie Hendrickx, Dinar D. Kharisma, Nandyan N. Wilastonegoro, Lauren B. Carrington, Iqbal R. F. Elyazar, Adam J. Kucharski, Rachel Lowe, Stefan Flasche, David M. Pigott, Robert C. Reiner Jr, W. John Edmunds, Simon I. Hay, Laith Yakob, Donald S. Shepard, Oliver J. Brady

Open Access Opinion

The implications of three major new trials for the effect of water, sanitation and hygiene on childhood diarrhea and stunting: a consensus statement

Oliver Cumming, Benjamin F. Arnold, Radu Ban, Thomas Clasen, Joanna Esteves Mills, Matthew C. Freeman, Bruce Gordon, Raymond Guiteras, Guy Howard, Paul R. Hunter, Richard B. Johnston, Amy J. Pickering, Andrew J. Prendergast, Annette Prüss-Ustün, Jan Willem Rosenboom, Dean Spears, Shelly Sundberg, Jennyfer Wolf, Clair Null, Stephen P. Luby, Jean H. Humphrey, John M. Colford Jr.

Open Access Research article

Vibration of effects from diverse inclusion/exclusion criteria and analytical choices: 9216 different ways to perform an indirect comparison meta-analysis

Clément Palpacuer, Karima Hammas, Renan Duprez, Bruno Laviolle, John P. A. Ioannidis, Florian Naudet

Open Access Research article

The case for a universal hepatitis C vaccine to achieve hepatitis C elimination

Nick Scott, David P. Wilson, Alexander J. Thompson, Eleanor Barnes, Manal El-Sayed, Adele Schwartz Benzaken, Heidi E. Drummer, Margaret E. Hellard

Open Access Commentary

Surveillance and monitoring of antimicrobial resistance: limitations and lessons from the GRAM project

Jesse Schnall, Arjun Rajkhowa, Kevin Ikuta, Puja Rao, Catrin E. Moore

Open Access Correspondence

Fifteen years of epidemiology in BMC Medicine

Deborah A. Lawlor

Open Access Research article

Prospective analysis of circulating metabolites and breast cancer in EPIC

Mathilde His, Vivian Viallon, Laure Dossus, Audrey Gicquiau, David Achaintre, Augustin Scalbert, Pietro Ferrari, Isabelle Romieu, N. Charlotte Onland-Moret, Elisabete Weiderpass, Christina C. Dahm, Kim Overvad, Anja Olsen, Anne Tjønneland, Agnès Fournier, Joseph A. Rothwell, Gianluca Severi, Tilman Kühn, Renée T. Fortner, Heiner Boeing, Antonia Trichopoulou, Anna Karakatsani, Georgia Martimianaki, Giovanna Masala, Sabina Sieri, Rosario Tumino, Paolo Vineis, Salvatore Panico, Carla H. van Gils, Therese H. Nøst, Torkjel M. Sandanger, Guri Skeie, J. Ramón Quirós, Antonio Agudo, Maria-Jose Sánchez, Pilar Amiano, José María Huerta, Eva Ardanaz, Julie A. Schmidt, Ruth C. Travis, Elio Riboli, Konstantinos K. Tsilidis, Sofia Christakoudi, Marc J. Gunter, Sabina Rinaldi

Open Access Commentary

C-peptide persistence in type 1 diabetes: ‘not drowning, but waving’?

R. David Leslie, Tanwi Vartak

Open Access Research Article

Combining serological and contact data to derive target immunity levels for achieving and maintaining measles elimination

Sebastian Funk, Jennifer K. Knapp, Emmaculate Lebo, Susan E. Reef, Alya J. Dabbagh, Katrina Kretsinger, Mark Jit, W. John Edmunds, Peter M. Strebel

Open Access Review

Environmental enteric dysfunction: a review of potential mechanisms, consequences and management strategies

Kirkby D. Tickell, Hannah E. Atlas, Judd L. Walson

Open Access Research article

The VENUSS prognostic model to predict disease recurrence following surgery for non-metastatic papillary renal cell carcinoma: development and evaluation using the ASSURE prospective clinical trial cohort

Tobias Klatte, Kevin M. Gallagher, Luca Afferi, Alessandro Volpe, Nils Kroeger, Silvia Ribback, Alan McNeill, Antony C. P. Riddick, James N. Armitage, Tevita F. ‘Aho, Tim Eisen, Kate Fife, Axel Bex, Allan J. Pantuck, Grant D. Stewart

Open Access Commentary

Response to ‘The implications of three major new trials for the effect of water, sanitation and hygiene on childhood diarrhea and stunting: a consensus statement’ by Cumming et al.

Megan Wilson-Jones, Kyla Smith, Dan Jones, Helen Hamilton, Leah Richardson, Alison Macintyre, Om Prasad Gautam, Erik Harvey, Henry Northover

Open Access Research article

Tracking pregnant women displacements in Sao Paulo, Brazil: a complex systems approach to regionalization through the emergence of patterns

Felix Rigoli, Sergio Mascarenhas, Domingos Alves, Tiago Canelas, Geraldo Duarte

Open Access Research article

Comparing the prognostic value of geriatric health indicators: a population-based study

Alberto Zucchelli, Davide L. Vetrano, Giulia Grande, Amaia Calderón-Larrañaga, Laura Fratiglioni, Alessandra Marengoni, Debora Rizzuto

Open Access Research article

Customized versus population birth weight charts for identification of newborns at risk of long-term adverse cardio-metabolic and respiratory outcomes: a population-based prospective cohort study

Jan S. Erkamp, Vincent W. V. Jaddoe, Annemarie G. M. G. J. Mulders, Eric A. P. Steegers, Irwin K. M. Reiss, Liesbeth Duijts, Romy Gaillard

Open Access Research article

Age-treatment subgroup analyses in Cochrane intervention reviews: a meta-epidemiological study

Patrick Liu, John P. A. Ioannidis, Joseph S. Ross, Sanket S. Dhruva, Anita T. Luxkaranayagam, Vasilis Vasiliou, Joshua D. Wallach

Open Access Commentary

Adaptive trials, efficiency, and ethics

Spencer Phillips Hey

Open Access Research article

Development and validation of a novel MR imaging predictor of response to induction chemotherapy in locoregionally advanced nasopharyngeal cancer: a randomized controlled trial substudy (NCT01245959)

Di Dong, Fan Zhang, Lian-Zhen Zhong, Meng-Jie Fang, Cheng-Long Huang, Ji-Jin Yao, Ying Sun, Jie Tian, Jun Ma, Ling-Long Tang

Open Access Research article

Socioeconomic status and stroke incidence, prevalence, mortality, and worldwide burden: an ecological analysis from the Global Burden of Disease Study 2017

Abolfazl Avan, Hadi Digaleh, Mario Di Napoli, Saverio Stranges, Reza Behrouz, Golnaz Shojaeianbabaei, Amin Amiri, Reza Tabrizi, Naghmeh Mokhber, J. David Spence, Mahmoud Reza Azarpazhooh

Open Access Opinion

Three myths about risk thresholds for prediction models

Laure Wynants, Maarten van Smeden, David J. McLernon, Dirk Timmerman, Ewout W. Steyerberg, Ben Van Calster

Open Access Correspondence

Interventions to prevent, delay or reverse frailty in older people: a journey towards clinical guidelines

Maura Marcucci, Sarah Damanti, Federico Germini, Joao Apostolo, Elzbieta Bobrowicz-Campos, Holly Gwyther, Carol Holland, Donata Kurpas, Maria Bujnowska-Fedak, Katarzyna Szwamel, Silvina Santana, Alessandro Nobili, Barbara D’Avanzo, Antonio Cano

Open Access Commentary

Cannabis use in first episode psychosis: what we have tried and why it hasn’t worked

Michael G. McDonell, Oladunni Oluwoye

Open Access Opinion

Key challenges for delivering clinical impact with artificial intelligence

Christopher J. Kelly, Alan Karthikesalingam, Mustafa Suleyman, Greg Corrado, Dominic King

Open Access Research article

Effect of continued folic acid supplementation beyond the first trimester of pregnancy on cognitive performance in the child: a follow-up study from a randomized controlled trial (FASSTT Offspring Trial)

Helene McNulty, Mark Rollins, Tony Cassidy, Aoife Caffrey, Barry Marshall, James Dornan, Marian McLaughlin, Breige A. McNulty, Mary Ward, J. J. Strain, Anne M. Molloy, Diane J. Lees-Murdock, Colum P. Walsh, Kristina Pentieva

Open Access Research article

Aspirin for primary prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups

Georg Gelbenegger, Marek Postula, Ladislav Pecen, Sigrun Halvorsen, Maciej Lesiak, Christian Schoergenhofer, Bernd Jilma, Christian Hengstenberg, Jolanta M. Siller-Matula

Open Access Research article

Growth faltering is associated with altered brain functional connectivity and cognitive outcomes in urban Bangladeshi children exposed to early adversity

Wanze Xie, Sarah K. G. Jensen, Mark Wade, Swapna Kumar, Alissa Westerlund, Shahria H. Kakon, Rashidul Haque, William A. Petri, Charles A. Nelson

Open Access Research article

Synthetic high-density lipoprotein nanoparticles for the treatment of Niemann–Pick diseases

Mark L. Schultz, Maria V. Fawaz, Ruth D. Azaria, Todd C. Hollon, Elaine A. Liu, Thaddeus J. Kunkel, Troy A. Halseth, Kelsey L. Krus, Ran Ming, Emily E. Morin, Hayley S. McLoughlin, David D. Bushart, Henry L. Paulson, Vikram G. Shakkottai, Daniel A. Orringer, Anna S. Schwendeman, Andrew P. Lieberman

Open Access Research article

Representation of people with comorbidity and multimorbidity in clinical trials of novel drug therapies: an individual-level participant data analysis

Peter Hanlon, Laurie Hannigan, Jesus Rodriguez-Perez, Colin Fischbacher, Nicky J. Welton, Sofia Dias, Frances S. Mair, Bruce Guthrie, Sarah Wild, David A. McAllister

Open Access Research article

Unravelling the complex nature of resilience factors and their changes between early and later adolescence

J. Fritz, J. Stochl, E. I. Fried, I. M. Goodyer, C. D. van Borkulo, P. O. Wilkinson, A.-L. van Harmelen

Open Access Research article

NG2 glia regulate brain innate immunity via TGF-β2/TGFBR2 axis

Shu-zhen Zhang, Qin-qin Wang, Qiao-qiao Yang, Huan-yu Gu, Yan-qing Yin, Yan-dong Li, Jin-can Hou, Rong Chen, Qing-qing Sun, Ying-feng Sun, Gang Hu, Jia-wei Zhou

Open Access Research article

Accuracy in detecting inadequate research reporting by early career peer reviewers using an online CONSORT-based peer-review tool (COBPeer) versus the usual peer-review process: a cross-sectional diagnostic study

Anthony Chauvin, Philippe Ravaud, David Moher, David Schriger, Sally Hopewell, Daniel Shanahan, Sabina Alam, Gabriel Baron, Jean-Philippe Regnaux, Perrine Crequit, Valeria Martinez, Carolina Riveros, Laurence Le Cleach, Alessandro Recchioni, Douglas G. Altman, Isabelle Boutron

Open Access Research article

Bleeding in cardiac patients prescribed antithrombotic drugs: electronic health record phenotyping algorithms, incidence, trends and prognosis

Laura Pasea, Sheng-Chia Chung, Mar Pujades-Rodriguez, Anoop D. Shah, Samantha Alvarez-Madrazo, Victoria Allan, James T. Teo, Daniel Bean, Reecha Sofat, Richard Dobson, Amitava Banerjee, Riyaz S. Patel, Adam Timmis, Spiros Denaxas, Harry Hemingway

Open Access Research article

Validation of the AJCC prognostic stage for HER2-positive breast cancer in the ShortHER trial

Maria Vittoria Dieci, Giancarlo Bisagni, Alba A. Brandes, Antonio Frassoldati, Luigi Cavanna, Francesco Giotta, Michele Aieta, Vittorio Gebbia, Antonino Musolino, Ornella Garrone, Michela Donadio, Anita Rimanti, Alessandra Beano, Claudio Zamagni, Hector Soto Parra, Federico Piacentini, Saverio Danese, Antonella Ferro, Katia Cagossi, Samanta Sarti, Anna Rita Gambaro, Sante Romito, Viviana Bazan, Laura Amaducci, Gabriella Moretti, Maria Pia Foschini, Sara Balduzzi, Roberto Vicini, Roberto D’Amico, Gaia Griguolo, Valentina Guarneri, Pier Franco Conte

Open Access Research article

Profiling Mycobacterium tuberculosis transmission and the resulting disease burden in the five highest tuberculosis burden countries

Romain Ragonnet, James M. Trauer, Nicholas Geard, Nick Scott, Emma S. McBryde

Open Access Editorial

Tackling the triple threats of childhood malnutrition

Martha Mwangome, Andrew M. Prentice

Open Access Review

The epidemiological burden of obesity in childhood: a worldwide epidemic requiring urgent action

Mariachiara Di Cesare, Maroje Sorić, Pascal Bovet, J Jaime Miranda, Zulfiqar Bhutta, Gretchen A Stevens, Avula Laxmaiah, Andre-Pascal Kengne, James Bentham

Open Access Research article

Can public health policies on alcohol and tobacco reduce a cancer epidemic? Australia's experience

Heng Jiang, Michael Livingston, Robin Room, Yong Gan, Dallas English, Richard Chenhall

Open Access Research article

Determinants of linear growth faltering among children with moderate-to-severe diarrhea in the Global Enteric Multicenter Study

Rebecca L. Brander, Patricia B. Pavlinac, Judd L. Walson, Grace C. John-Stewart, Marcia R. Weaver, Abu S. G. Faruque, Anita K. M. Zaidi, Dipika Sur, Samba O. Sow, M. Jahangir Hossain, Pedro L. Alonso, Robert F. Breiman, Dilruba Nasrin, James P. Nataro, Myron M. Levine, Karen L. Kotloff

Open Access Research article

In utero exposure to mercury and childhood overweight or obesity: counteracting effect of maternal folate status

Guoying Wang, Jessica DiBari, Eric Bind, Andrew M. Steffens, Jhindan Mukherjee, Tami R. Bartell, David C. Bellinger, Xiumei Hong, Yuelong Ji, Mei-Cheng Wang, Marsha Wills-Karp, Tina L. Cheng, Xiaobin Wang

Open Access Research article

Insulin resistance and systemic metabolic changes in oral glucose tolerance test in 5340 individuals: an interventional study

Qin Wang, Jari Jokelainen, Juha Auvinen, Katri Puukka, Sirkka Keinänen-Kiukaanniemi, Marjo-Riitta Järvelin, Johannes Kettunen, Ville-Petteri Mäkinen, Mika Ala-Korpela

Open Access Research article

The quality of preventive care for pre-school aged children in Australian general practice

Louise K. Wiles, Carl de Wet, Chris Dalton, Elisabeth Murphy, Mark F. Harris, Peter D. Hibbert, Charlotte J. Molloy, Gaston Arnolda, Hsuen P. Ting, Jeffrey Braithwaite

Open Access Research article

Determinants of high residual post-PCV13 pneumococcal vaccine-type carriage in Blantyre, Malawi: a modelling study

J. Lourenço, U. Obolski, T. D. Swarthout, A. Gori, N. Bar-Zeev, D. Everett, A. W. Kamng’ona, T. S. Mwalukomo, A. A. Mataya, C. Mwansambo, M. Banda, S. Gupta, N. French, R. S. Heyderman

Open Access Research article

Differential impact of malaria control interventions on P. falciparum and P. vivax infections in young Papua New Guinean children

Maria Ome-Kaius, Johanna Helena Kattenberg, Sophie Zaloumis, Matthew Siba, Benson Kiniboro, Shadrach Jally, Zahra Razook, Daisy Mantila, Desmond Sui, Jason Ginny, Anna Rosanas-Urgell, Stephan Karl, Thomas Obadia, Alyssa Barry, Stephen J. Rogerson, Moses Laman, Daniel Tisch, Ingrid Felger, James W. Kazura, Ivo Mueller, Leanne J. Robinson

Open Access Research article

Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and risk of in situ breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Nena Karavasiloglou, Anika Hüsing, Giovanna Masala, Carla H. van Gils, Renée Turzanski Fortner, Jenny Chang-Claude, Inge Huybrechts, Elisabete Weiderpass, Marc Gunter, Patrick Arveux, Agnès Fournier, Marina Kvaskoff, Anne Tjønneland, Cecilie Kyrø, Christina C. Dahm, Helene Tilma Vistisen, Marije F. Bakker, Maria-Jose Sánchez, María Dolores Chirlaque López, Carmen Santiuste, Eva Ardanaz, Virginia Menéndez, Antonio Agudo, Antonia Trichopoulou, Anna Karakatsani, Carlo La Vecchia, Eleni Peppa, Domenico Palli, Claudia Agnoli, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Salma Tunå Butt, Signe Borgquist, Guri Skeie, Matthias Schulze, Timothy Key, Kay-Tee Khaw, Kostantinos K. Tsilidis, Merete Ellingjord-Dale, Elio Riboli, Rudolf Kaaks, Laure Dossus, Sabine Rohrmann, Tilman Kühn

Open Access Research article

Determinants and extent of weight recording in UK primary care: an analysis of 5 million adults’ electronic health records from 2000 to 2017

B. D. Nicholson, P. Aveyard, C. R. Bankhead, W. Hamilton, F. D. R. Hobbs, S. Lay-Flurrie

Open Access Research article

RETRACTED ARTICLE: Therapeutic effect of nanoliposomal PCSK9 vaccine in a mouse model of atherosclerosis

Amir Abbas Momtazi-Borojeni, Mahmoud Reza Jaafari, Ali Badiee, Maciej Banach, Amirhossein Sahebkar

Open Access Research article

Patterns of symptoms before a diagnosis of first episode psychosis: a latent class analysis of UK primary care electronic health records

Ying Chen, Saeed Farooq, John Edwards, Carolyn A. Chew-Graham, David Shiers, Martin Frisher, Richard Hayward, Athula Sumathipala, Kelvin P. Jordan

Open Access Research article

Suicide prevention and depression apps’ suicide risk assessment and management: a systematic assessment of adherence to clinical guidelines

Laura Martinengo, Louise Van Galen, Elaine Lum, Martin Kowalski, Mythily Subramaniam, Josip Car

Open Access Research article

Travel time to health facilities in areas of outbreak potential: maps for guiding local preparedness and response

E. N. Hulland, K. E. Wiens, S. Shirude, J. D. Morgan, A. Bertozzi-Villa, T. H. Farag, N. Fullman, M. U. G. Kraemer, M. K. Miller-Petrie, V. Gupta, R. C. Reiner Jr., P. Rabinowitz, J. N. Wasserheit, B. P. Bell, S. I. Hay, D. J. Weiss, D. M. Pigott

Open Access Research article

The NASSS framework for ex post theorisation of technology-supported change in healthcare: worked example of the TORPEDO programme

Seye Abimbola, Bindu Patel, David Peiris, Anushka Patel, Mark Harris, Tim Usherwood, Trisha Greenhalgh

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Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

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Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

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