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Journal of Translational Medicine

Ausgabe 1/2016

Inhalt (345 Artikel)

Open Access Research

A therapeutic cancer vaccine against GL261 murine glioma

Mark S. Kindy, Jin Yu, Hong Zhu, Michael T. Smith, Sebastiano Gattoni-Celli

Open Access Methodology

Kinetics of human myeloid-derived suppressor cells after blood draw

Eva Grützner, Renate Stirner, Lukas Arenz, Anastasia P. Athanasoulia, Kathrin Schrödl, Carola Berking, Johannes R. Bogner, Rika Draenert

Open Access Review

Insulin-like growth factor-1 deficiency and metabolic syndrome

G. A. Aguirre, J. Rodríguez De Ita, R. G. de la Garza, I. Castilla-Cortazar

Open Access Research

Nanoproteomic analysis of ischemia-dependent changes in signaling protein phosphorylation in colorectal normal and cancer tissue

Florian T. Unger, Nicole Lange, Jana Krüger, Carolyn Compton, Helen Moore, Lokesh Agrawal, Hartmut Juhl, Kerstin A. David

Open Access Research

Both HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells

Jiaqi Liu, Jianying Gu, Zihao Feng, Yanhong Yang, Ningwen Zhu, Weiyue Lu, Fazhi Qi

Open Access Research

NGF eye-drops topical administration in patients with retinitis pigmentosa, a pilot study

Benedetto Falsini, Giancarlo Iarossi, Antonio Chiaretti, Antonio Ruggiero, Luigi Manni, Lucia Galli-Resta, Giovanni Corbo, Edoardo Abed

Open Access Research

Discrimination of cirrhotic nodules, dysplastic lesions and hepatocellular carcinoma by their vibrational signature

Chengyuan Peng, Slávka Kaščáková, Franck Chiappini, Natalia Olaya, Christophe Sandt, Ibraheem Yousef, Didier Samuel, Paul Dumas, Catherine Guettier, François Le Naour

Open Access Research

Chemotherapy outcome predictive effectiveness by the Oncogramme: pilot trial on stage-IV colorectal cancer

Christophe Bounaix Morand du Puch, Michelle Nouaille, Stéphanie Giraud, Anaïs Labrunie, Sandrine Luce, Pierre-Marie Preux, François Labrousse, Alain Gainant, Nicole Tubiana-Mathieu, Valérie Le Brun-Ly, Denis Valleix, Angélique Guillaudeau, Laura Mesturoux, Béma Coulibaly, Christophe Lautrette, Muriel Mathonnet

Open Access Research

The association of liver fat content and serum alanine aminotransferase with bone mineral density in middle-aged and elderly Chinese men and postmenopausal women

Ming-Feng Xia, Huan-Dong Lin, Hong-Mei Yan, Hua Bian, Xin-Xia Chang, Lin-Shan Zhang, Wan-Yuan He, Xin Gao

Open Access Research

Changes in plasma biomarkers following treatment with cabozantinib in metastatic castration-resistant prostate cancer: a post hoc analysis of an extension cohort of a phase II trial

Raya Leibowitz-Amit, Melania Pintilie, Leila Khoja, Arun A. Azad, Raanan Berger, A. Douglas Laird, Dana T. Aftab, Kim N. Chi, Anthony M. Joshua

Open Access Research

Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation

Tri Vuong, Jean-François Mallet, Maria Ouzounova, Sam Rahbar, Hector Hernandez-Vargas, Zdenko Herceg, Chantal Matar

Open Access Review

p90 ribosomal S6 kinase: a potential therapeutic target in lung cancer

Noufira Poomakkoth, Aya Issa, Nabeel Abdulrahman, Somaia Gamal Abdelaziz, Fatima Mraiche

Open Access Review

Translational research—the need of a new bioethics approach

Sorin Hostiuc, Alin Moldoveanu, Maria-Iuliana Dascălu, Runar Unnthorsson, Ómar I. Jóhannesson, Ioan Marcus

Open Access Research

Autoantibody signatures defined by serological proteome analysis in sera from patients with cholangiocarcinoma

Mohammad Zahid Mustafa, Viet Hung Nguyen, François Le Naour, Eleonora De Martin, Elvire Beleoken, Catherine Guettier, Catherine Johanet, Didier Samuel, Jean-Charles Duclos-Vallee, Eric Ballot

Open Access Research

Combining patient proteomics and in vitro cardiomyocyte phenotype testing to identify potential mediators of heart failure with preserved ejection fraction

Roseanne Raphael, Diana Purushotham, Courtney Gastonguay, Marla A. Chesnik, Wai-Meng Kwok, Hsiang-En Wu, Sanjiv J. Shah, Shama P. Mirza, Jennifer L. Strande

Open Access Research

Mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome

Paul Billing-Ross, Arnaud Germain, Kaixiong Ye, Alon Keinan, Zhenglong Gu, Maureen R. Hanson

Open Access Review

Improving the outcome of kidney transplantation by ameliorating renal ischemia reperfusion injury: lost in translation?

T. C. Saat, E. K. van den Akker, J. N. M. IJzermans, F. J. M. F. Dor, R. W. F. de Bruin

Open Access Review

Obesity and colorectal cancer: molecular features of adipose tissue

Javier Martinez-Useros, Jesus Garcia-Foncillas

Open Access Research

Pharmacogenetics driving personalized medicine: analysis of genetic polymorphisms related to breast cancer medications in Italian isolated populations

Massimiliano Cocca, Davide Bedognetti, Martina La Bianca, Paolo Gasparini, Giorgia Girotto

Open Access Research

Upregulation of miR-483-3p contributes to endothelial progenitor cells dysfunction in deep vein thrombosis patients via SRF

Lingshang Kong, Nan Hu, Xiaolong Du, Wenbin Wang, Hong Chen, Wendong Li, Sen Wei, Hao Zhuang, Xiaoqiang Li, Chenglong Li

Open Access Erratum

Erratum to: Analysis of in vitro ADCC and clinical response to trastuzumab: possible relevance of FcγRIIIA/FcγRIIA gene polymorphisms and HER-2 expression levels on breast cancer cell lines

Silvia Boero, Anna Morabito, Barbara Banelli, Barbara Cardinali, Beatrice Dozin, Gianluigi Lunardi, Patrizia Piccioli, Sonia Lastraioli, Roberta Carosio, Sandra Salvi, Alessia Levaggi, Francesca Poggio, Alessia D’Alonzo, Massimo Romani, Lucia Del Mastro, Alessandro Poggi, Maria Pia Pistillo

Open Access Research

CpG-oligodeoxynucleotides exert remarkable antitumor activity against diffuse malignant peritoneal mesothelioma orthotopic xenografts

Michelandrea De Cesare, Lucia Sfondrini, Marzia Pennati, Cinzia De Marco, Valentina Motta, Elda Tagliabue, Marcello Deraco, Andrea Balsari, Nadia Zaffaroni

Open Access Research

Overexpression of HMGA2 promotes tongue cancer metastasis through EMT pathway

Xiao-Peng Zhao, Hong Zhang, Jiu-Yang Jiao, Dong-Xiao Tang, Yu-ling Wu, Chao-Bin Pan

Open Access Research

Obesity inhibits the osteogenic differentiation of human adipose-derived stem cells

Amy L. Strong, Ryan S. Hunter, Robert B. Jones, Annie C. Bowles, Maria F. Dutreil, Dina Gaupp, Daniel J. Hayes, Jeffrey M. Gimble, Benjamin Levi, Margaret A. McNulty, Bruce A. Bunnell

Open Access Research

Human endometrial regenerative cells attenuate renal ischemia reperfusion injury in mice

Peng Sun, Jian Liu, Wenwen Li, Xiaoxi Xu, Xiangying Gu, HongYue Li, Hongqiu Han, Caigan Du, Hao Wang

Open Access Research

Exome sequencing identifies a mutation in TMC1 as a novel cause of autosomal recessive nonsyndromic hearing loss

Jiongjiong Hu, Fei Liu, Wenjun Xia, Lili Hao, Jun Lan, Zhenghua Zhu, Jing Ye, Duan Ma, Zhaoxin Ma

Open Access Review

The role of cancer-associated fibroblasts in esophageal cancer

Jiangfeng Wang, Guangyu Zhang, Jianbo Wang, Lu Wang, Xiaochen Huang, Yufeng Cheng

Open Access Research

A multiplex immunoassay for the non-invasive detection of bladder cancer

Yoshiko Shimizu, Hideki Furuya, Peter Bryant Greenwood, Owen Chan, Yunfeng Dai, Mark D. Thornquist, Steve Goodison, Charles J. Rosser

Open Access Research

CD24 associates with EGFR and supports EGF/EGFR signaling via RhoA in gastric cancer cells

Wenjie Deng, Luo Gu, Xiaojie Li, Jianchao Zheng, Yujie Zhang, Biao Duan, Jie Cui, Jing Dong, Jun Du

Open Access Research

Betel quid dependence is associated with functional connectivity changes of the anterior cingulate cortex: a resting-state fMRI study

Tao Liu, Jianjun Li, Zhongyan Zhao, Yuan Zhong, Zhiqiang Zhang, Qiang Xu, Guoshuai Yang, Guangming Lu, Suyue Pan, Feng Chen

Open Access Commentary

Paracrine effects of TLR4-polarised mesenchymal stromal cells are mediated by extracellular vesicles

Marie-Theres Zeuner, Ketan Patel, Bernd Denecke, Bernd Giebel, Darius Widera

Open Access Research

Induction of heme oxygenase-1 by hemin protects lung against orthotopic autologous liver transplantation-induced acute lung injury in rats

Xinjin Chi, Na Guo, Weifeng Yao, Yi Jin, Wanling Gao, Jun Cai, Ziqing Hei

Open Access Research

Colorectal cancer-derived microvesicles modulate differentiation of human monocytes to macrophages

Monika Baj-Krzyworzeka, Bożenna Mytar, Rafał Szatanek, Marcin Surmiak, Kazimierz Węglarczyk, Jarek Baran, Maciej Siedlar

Open Access Research

c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition

Camilla Palumbo, Anastasia De Luca, Nicola Rosato, Mariantonietta Forgione, Dante Rotili, Anna Maria Caccuri

Open Access Research

From competency to dormancy: a 3D model to study cancer cells and drug responsiveness

Josephine Y. Fang, Shih-Jye Tan, Yi-Chen Wu, Zhi Yang, Ba X. Hoang, Bo Han

Open Access Research

Transforming growth factor-beta 1 produced by vascular smooth muscle cells predicts fibrosis in the gastrocnemius of patients with peripheral artery disease

Duy M. Ha, Lauren C. Carpenter, Panagiotis Koutakis, Stanley A. Swanson, Zhen Zhu, Mina Hanna, Holly K. DeSpiegelaere, Iraklis I. Pipinos, George P. Casale

Open Access Research

Effectiveness of pure argon for renal transplant preservation in a preclinical pig model of heterotopic autotransplantation

Alice Faure, Laurie Bruzzese, Jean-Guillaume Steinberg, Yves Jammes, Julia Torrents, Stephane V. Berdah, Emmanuelle Garnier, Tristan Legris, Anderson Loundou, Matthieu Chalopin, Guy Magalon, Regis Guieu, Emmanuel Fenouillet, Eric Lechevallier

Open Access Research

Fusion cytokine IL-2-GMCSF enhances anticancer immune responses through promoting cell–cell interactions

Qian Wen, Wenjing Xiong, Jianchun He, Shimeng Zhang, Xialin Du, Sudong Liu, Juanjuan Wang, Mingqian Zhou, Li Ma

Open Access Research

The long non-coding RNA TUG1 indicates a poor prognosis for colorectal cancer and promotes metastasis by affecting epithelial-mesenchymal transition

Junfeng Sun, Chaohui Ding, Zhen Yang, Tao Liu, Xiefu Zhang, Chunlin Zhao, Jiaxiang Wang

Open Access Erratum

Erratum to: NGF eye-drops topical administration in patients with retinitis pigmentosa, a pilot study

Benedetto Falsini, Giancarlo Iarossi, Antonio Chiaretti, Antonio Ruggiero, Luigi Manni, Lucia Galli-Resta, Giovanni Corbo, Edoardo Abed

Open Access Research

Mesenchymal stem cells and their secreted molecules predominantly ameliorate fulminant hepatic failure and chronic liver fibrosis in mice respectively

Biao Huang, Xixi Cheng, Huafeng Wang, Wenjing Huang, Zha la Ga hu, Dan Wang, Kai Zhang, Huan Zhang, Zhenyi Xue, Yurong Da, Ning Zhang, Yongcheng Hu, Zhi Yao, Liang Qiao, Fei Gao, Rongxin Zhang

Open Access Research

Suppression of RAF/MEK or PI3K synergizes cytotoxicity of receptor tyrosine kinase inhibitors in glioma tumor-initiating cells

Takashi Shingu, Lindsay Holmes, Verlene Henry, Qianghu Wang, Khatri Latha, Anupama E. Gururaj, Laura A. Gibson, Tiffany Doucette, Frederick F. Lang, Ganesh Rao, Liang Yuan, Erik P. Sulman, Nicholas P. Farrell, Waldemar Priebe, Kenneth R. Hess, Yaoqi A. Wang, Jian Hu, Oliver Bögler

Open Access Review

Stem/progenitor cells in endogenous repairing responses: new toolbox for the treatment of acute lung injury

Ce Yang, Jianxin Jiang, Xuetao Yang, Haiyan Wang, Juan Du

Open Access Research

Inhibition of cancer cell growth by ruthenium complexes

Joji Iida, Elisabeth T. Bell-Loncella, Marc L. Purazo, Yifeng Lu, Jesse Dorchak, Rebecca Clancy, Julianna Slavik, Mary Lou Cutler, Craig D. Shriver

Open Access Research

Detection of ALDH1 activity in rabbit hepatic VX2 tumors and isolation of ALDH1 positive cancer stem cells

Prashasnika Gehlot, Vivek Shukla, Sanjay Gupta, Paul E. Makidon

Open Access Meeting report

First translational ‘Think Tank’ on cerebrovascular disease, cognitive impairment and dementia

Frank C. Barone, Deborah Gustafson, Howard A. Crystal, Herman Moreno, Mateusz G. Adamski, Ken Arai, Alison E. Baird, Clotilde Balucani, Adam M. Brickman, David Cechetto, Philip Gorelick, Geert Jan Biessels, Amanda Kiliaan, Lenore Launer, Julie Schneider, Farzaneh A. Sorond, Rachel Whitmer, Clinton Wright, Zheng Gang Zhang

Open Access Research

Gene expression identifies heterogeneity of metastatic behavior among gastrointestinal stromal tumors

Keith M. Skubitz, Kate Geschwind, Wayne W. Xu, Joseph S. Koopmeiners, Amy P. N. Skubitz

Open Access Research

Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation

Irma Mahmutovic Persson, Hamid Akbarshahi, Mandy Menzel, Angelica Brandelius, Lena Uller

Open Access Research

Elevated urinary urea by high-protein diet could be one of the inducements of bladder disorders

Ming Liu, Min Li, Jiangfeng Liu, Hongkai Wang, Dandan Zhong, Hong Zhou, Baoxue Yang

Open Access Research

C14orf166 overexpression correlates with tumor progression and poor prognosis of breast cancer

Tuck-yun Cheang, Hong-yan Zhou, Wei Chen, Bing Zhang, Liangshuai Liu, Jianyong Yang, Shenming Wang, Heping Li

Open Access Research

C14orf166 is a high-risk biomarker for bladder cancer and promotes bladder cancer cell proliferation

Mingkun Chen, Yunlin Ye, Baojia Zou, Suping Guo, Fangjian Zhou, Keshi Lu, Jianye Liu, Zhenzhou Xu, Hui Han, Zhuowei Liu, Yonghong Li, Kai Yao, Cundong Liu, Zike Qin

Open Access Research

Exosome-mediated transfer of miR-222 is sufficient to increase tumor malignancy in melanoma

Federica Felicetti, Alessandra De Feo, Carolina Coscia, Rossella Puglisi, Francesca Pedini, Luca Pasquini, Maria Bellenghi, Maria Cristina Errico, Elena Pagani, Alessandra Carè

Open Access Research

Combination of double negative T cells and anti-thymocyte serum reverses type 1 diabetes in NOD mice

Tianhui Liu, Min Cong, Guangyong Sun, Ping Wang, Yue Tian, Wen Shi, Xinmin Li, Hong You, Dong Zhang

Open Access Research

A novel multi-drug metronomic chemotherapy significantly delays tumor growth in mice

Maria Tagliamonte, Annacarmen Petrizzo, Maria Napolitano, Antonio Luciano, Domenica Rea, Antonio Barbieri, Claudio Arra, Piera Maiolino, Marialina Tornesello, Gennaro Ciliberto, Franco M. Buonaguro, Luigi Buonaguro

Open Access Erratum

Erratum to: Radiation treatment monitoring using multimodal functional imaging: PET/CT (18F-Fluoromisonidazole & 18F-Fluorocholine) and DCE-US

Natalia Arteaga-Marrero, Cecilie Brekke Rygh, Jose F. Mainou-Gomez, Tom C. H. Adamsen, Nataliya Lutay, Rolf K. Reed, Dag R. Olsen

Open Access Research

Adverse effects of hydroxyethyl starch (HES 130/0.4) on intestinal barrier integrity and metabolic function are abrogated by supplementation with Albumin

Yuk Lung Wong, Ingmar Lautenschläger, Karina Zitta, Christin Schildhauer, Kerstin Parczany, Christoph Röcken, Markus Steinfath, Norbert Weiler, Martin Albrecht

Open Access Research

Human lung adenocarcinoma cell cultures derived from malignant pleural effusions as model system to predict patients chemosensitivity

Giuseppe Roscilli, Claudia De Vitis, Fabiana Fosca Ferrara, Alessia Noto, Emanuela Cherubini, Alberto Ricci, Salvatore Mariotta, Enrico Giarnieri, Maria Rosaria Giovagnoli, Maria Rosaria Torrisi, Francesca Bergantino, Susan Costantini, Francesca Fenizia, Matilde Lambiase, Luigi Aurisicchio, Nicola Normanno, Gennaro Ciliberto, Rita Mancini

Open Access Research

Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans

Stephanie Fresnay, Monica A. McArthur, Laurence Magder, Thomas C. Darton, Claire Jones, Claire S. Waddington, Christoph J. Blohmke, Brian Angus, Myron M. Levine, Andrew J. Pollard, Marcelo B. Sztein

Open Access Review

Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state

Dandan Guan, Lidan Zhao, Daiwen Chen, Bing Yu, Jie Yu

Open Access Research

High expression of the human equilibrative nucleoside transporter 1 gene predicts a good response to decitabine in patients with myelodysplastic syndrome

Lingyun Wu, Wenhui Shi, Xiao Li, Chunkang Chang, Feng Xu, Qi He, Dong Wu, Jiying Su, Liyu Zhou, Luxi Song, Chao Xiao, Zheng Zhang

Open Access Research

PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma

Yael Babichev, Leah Kabaroff, Alessandro Datti, David Uehling, Methvin Isaac, Rima Al-awar, Michael Prakesch, Ren X. Sun, Paul C. Boutros, Rosemarie Venier, Brendan C. Dickson, Rebecca A. Gladdy

Open Access Research

Analysis of cellular and humoral immune responses against cytomegalovirus in patients with autoimmune Addison’s disease

Kine Edvardsen, Alexander Hellesen, Eystein S. Husebye, Eirik Bratland

Open Access Research

Bortezomib-mediated downregulation of S-phase kinase protein-2 (SKP2) causes apoptotic cell death in chronic myelogenous leukemia cells

Ahmad Iskandarani, Ajaz A. Bhat, Kodappully S. Siveen, Kirti S. Prabhu, Shilpa Kuttikrishnan, Muzammil A. Khan, Roopesh Krishnankutty, Michal Kulinski, Rihab R. Nasr, Ramzi M. Mohammad, Shahab Uddin

Open Access Reviewer acknowledgement

Journal of Translational Medicine reviewer acknowledgement 2015

Francesco Marincola

Open Access Research

Phosphatase of regenerating liver 3 (PRL-3) is overexpressed in human prostate cancer tissue and promotes growth and migration

Esten N. Vandsemb, Helena Bertilsson, Pegah Abdollahi, Øystein Størkersen, Thea Kristin Våtsveen, Morten Beck Rye, Torstein Baade Rø, Magne Børset, Tobias S. Slørdahl

Open Access Research

Gene expression analysis of bone metastasis and circulating tumor cells from metastatic castrate-resistant prostate cancer patients

Won Jin Cho, Daniel S. M. Oliveira, Abdo J. Najy, Leandro E. Mainetti, Hussein D. Aoun, Michael L. Cher, Elisabeth Heath, Hyeong-Reh C. Kim, R. Daniel Bonfil

Open Access Research

Advantages of pure platelet-rich plasma compared with leukocyte- and platelet-rich plasma in promoting repair of bone defects

Wenjing Yin, Xin Qi, Yuelei Zhang, Jiagen Sheng, Zhengliang Xu, Shicong Tao, Xuetao Xie, Xiaolin Li, Changqing Zhang

Open Access Research

The lack of aspirin resistance in patients with coronary artery disease

Nóra Homoródi, Emese G. Kovács, Sarolta Leé, Éva Katona, Amir H. Shemirani, Gizella Haramura, László Balogh, Zsuzsanna Bereczky, Gabriella Szőke, Hajna Péterfy, Róbert G. Kiss, István Édes, László Muszbek

Open Access Research

Human epithelial-type ovarian tumour marker beta-2-microglobulin is regulated by the TGF-β signaling pathway

Wenwen Sun, Lu Gui, Xulei Zuo, Lingyun Zhang, Daibing Zhou, Xiaoling Duan, Weimin Ren, Guoxiong Xu

Open Access Research

Automation of cellular therapy product manufacturing: results of a split validation comparing CD34 selection of peripheral blood stem cell apheresis product with a semi-manual vs. an automatic procedure

Christiane Hümmer, Carolin Poppe, Milica Bunos, Belinda Stock, Eva Wingenfeld, Volker Huppert, Juliane Stuth, Kristina Reck, Mike Essl, Erhard Seifried, Halvard Bonig

Open Access Research

IL-17 mediates inflammatory reactions via p38/c-Fos and JNK/c-Jun activation in an AP-1-dependent manner in human nucleus pulposus cells

Jing-kun Li, Lin Nie, Yun-peng Zhao, Yuan-qiang Zhang, Xiaoqing Wang, Shuai-shuai Wang, Yi Liu, Hua Zhao, Lei Cheng

Open Access Research

RETRACTED ARTICLE: Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade

Hsing-Chun Kuo, Chien-Chang Lu, Chien-Heng Shen, Shui-Yi Tung, Meng Chiao Hsieh, Ko-Chao Lee, Li-Ya Lee, Chin-Chu Chen, Chih-Chuan Teng, Wen-Shih Huang, Te-Chuan Chen, Kam-Fai Lee

Open Access Research

Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease

Si-Wei Li, Jin Wang, Ying Yang, Zhi-Jie Liu, Lin Cheng, Huan-Yu Liu, Pei Ma, Wan Luo, Song-Mei Liu

Open Access Research

The association between S100A13 and HMGA1 in the modulation of thyroid cancer proliferation and invasion

Jing Zhong, Chang Liu, Ya-jun Chen, Qing-hai Zhang, Jing Yang, Xuan Kang, Si-Rui Chen, Ge-bo Wen, Xu-yu Zu, Ren-xian Cao

Open Access Research

Resolvin D1 mitigates energy metabolism disorder after ischemia–reperfusion of the rat lung

Qifeng Zhao, Ji Wu, Qingwang Hua, Zhiyong Lin, Leping Ye, Weixi Zhang, Guowei Wu, Jie Du, Jie Xia, Maoping Chu, Xingti Hu

Open Access Research

Single nucleotide polymorphisms in apoptosis pathway are associated with response to imatinib therapy in chronic myeloid leukemia

Qiaoli Zheng, Jiang Cao, Nada Hamad, Hyeoung-Joon Kim, Joon Ho Moon, Sang Kyun Sohn, Chul Won Jung, Jeffrey H. Lipton, Dennis Dong Hwan Kim

Open Access Research

A phase I study of high-dose rosuvastatin with standard dose erlotinib in patients with advanced solid malignancies

Glenwood D. Goss, Derek J. Jonker, Scott A. Laurie, Johanne I. Weberpals, Amit M. Oza, Johanna N. Spaans, Charles la Porte, Jim Dimitroulakos

Open Access Research

miR-29b and miR-198 overexpression in CD8+ T cells of renal cell carcinoma patients down-modulates JAK3 and MCL-1 leading to immune dysfunction

Margherita Gigante, Paola Pontrelli, Wolfgang Herr, Maddalena Gigante, Morena D’Avenia, Gianluigi Zaza, Elisabetta Cavalcanti, Matteo Accetturo, Giuseppe Lucarelli, Giuseppe Carrieri, Michele Battaglia, Walter J. Storkus, Loreto Gesualdo, Elena Ranieri

Open Access Review

Clinical relevance of the tumor microenvironment and immune escape of oral squamous cell carcinoma

Alexander W. Eckert, Claudia Wickenhauser, Paul C. Salins, Matthias Kappler, Juergen Bukur, Barbara Seliger

Open Access Research

Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress

Radhakrishnan Rajesh Kumar, Madhusudhanan Narasimhan, Gobinath Shanmugam, Jennifer Hong, Asokan Devarajan, Sethu Palaniappan, Jianhua Zhang, Ganesh V. Halade, Victor M. Darley-Usmar, John R. Hoidal, Namakkal S. Rajasekaran

Open Access Research

Preclinical exploration of combining plasmacytoid and myeloid dendritic cell vaccination with BRAF inhibition

Jurjen Tel, Rutger Koornstra, Nienke de Haas, Vincent van Deutekom, Harm Westdorp, Steve Boudewijns, Nielka van Erp, Stefania Di Blasio, Winald Gerritsen, Carl G. Figdor, I. Jolanda M. de Vries, Stanleyson V. Hato

Open Access Review

Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis

Mehdi Mirsaeidi, Sanaz Gidfar, Ann Vu, Dean Schraufnagel

Open Access Review

Safety of targeting tumor endothelial cell antigens

Samuel C. Wagner, Neil H. Riordan, Thomas E. Ichim, Julia Szymanski, Hong Ma, Jesus A. Perez, Javier Lopez, Juan J. Plata-Munoz, Francisco Silva, Amit N. Patel, Santosh Kesari

Open Access Research

Predictive role of the Mediterranean diet on mortality in individuals at low cardiovascular risk: a 12-year follow-up population-based cohort study

Simona Bo, Valentina Ponzo, Ilaria Goitre, Maurizio Fadda, Andrea Pezzana, Guglielmo Beccuti, Roberto Gambino, Maurizio Cassader, Laura Soldati, Fabio Broglio

Open Access Research

Characterization of viscosupplementation formulations using chemical exchange saturation transfer (ViscoCEST)

Mohammad Haris, Anup Singh, Sanjana Reddy, Puneet Bagga, J. Bruce Kneeland, Fotios P. Tjoumakaris, Hari Hariharan, Francesco M. Marincola, Ravinder Reddy

Open Access Research

Unexpected impairment of TNF-α-induced maturation of human dendritic cells in vitro by IL-4

Valérie Chabot, Laurence Martin, Daniel Meley, Luc Sensebé, Christophe Baron, Yvon Lebranchu, Frédéric Dehaut, Florence Velge-Roussel

Open Access Research

The MHC-II transactivator CIITA inhibits Tat function and HIV-1 replication in human myeloid cells

Greta Forlani, Filippo Turrini, Silvia Ghezzi, Alessandra Tedeschi, Guido Poli, Roberto S. Accolla, Giovanna Tosi

Open Access Research

Quantitative assessment of BRAF V600 mutant circulating cell-free tumor DNA as a tool for therapeutic monitoring in metastatic melanoma patients treated with BRAF/MEK inhibitors

Max Schreuer, Geert Meersseman, Sari Van Den Herrewegen, Yanina Jansen, Ines Chevolet, Ambre Bott, Sofie Wilgenhof, Teofila Seremet, Bart Jacobs, Ronald Buyl, Geert Maertens, Bart Neyns

Open Access Meeting report

Genetics of multifactorial disorders: proceedings of the 6th Pan Arab Human Genetics Conference

Pratibha Nair, Sami Bizzari, Nirmal Rajah, Nada Assaf, Mahmoud Taleb Al-Ali, Abdul Rezzak Hamzeh

Open Access Research

Fn14-Fc suppresses germinal center formation and pathogenic B cells in a lupus mouse model via inhibition of the TWEAK/Fn14 Pathway

Hong-Ki Min, Sung-Min Kim, Jin-Sil Park, Jae-Kyeong Byun, Jennifer Lee, Seung-Ki Kwok, Young-Woo Park, Mi-La Cho, Sung-Hwan Park

Open Access Research

Autoantigen-specific immunosuppression with tolerogenic peripheral blood cells prevents relapses in a mouse model of relapsing-remitting multiple sclerosis

Christian Kleist, Elisabeth Mohr, Sadanand Gaikwad, Laura Dittmar, Stefanie Kuerten, Michael Platten, Walter Mier, Michael Schmitt, Gerhard Opelz, Peter Terness

Open Access Research

CTLA-4 polymorphisms and haplotype correlate with survival in ALL after allogeneic stem cell transplantation from related HLA-haplotype-mismatched donor

X.-Y. Qin, Y. Wang, G.-X. Li, Y.-Z. Qin, F.-R. Wang, L.-P. Xu, H. Chen, W. Han, J.-Z. Wang, X.-H. Zhang, Y.-J. Chang, K.-Y. Liu, Z.-F. Jiang, X.-J. Huang

Open Access Research

Effects of vagus nerve stimulation on cognitive functioning in rats with cerebral ischemia reperfusion

Ai-fen Liu, Feng-bo Zhao, Jing Wang, Yi-Fan Lu, Jian Tian, Yin Zhao, Yan Gao, Xia-jun Hu, Xiao-yan Liu, Jie Tan, Yun-li Tian, Jing Shi

Open Access Protocol

Rationale and design of the DP-TRANSFERS project: diabetes prevention-transferring findings from European research to society in Catalonia

Bernardo Costa, Conxa Castell, Xavier Cos, Claustre Solé, Santiago Mestre, Marta Canela, Antoni Boquet, Joan-Josep Cabré, Francisco Barrio, Gemma Flores-Mateo, Daniel Ferrer-Vidal, Jaana Lindström

Open Access Research

Atractylenolide I modulates ovarian cancer cell-mediated immunosuppression by blocking MD-2/TLR4 complex-mediated MyD88/NF-κB signaling in vitro

Hong Liu, Guonan Zhang, Jianming Huang, Shiqi Ma, Kun Mi, Jia Cheng, Yi Zhu, Xiao Zha, Wei Huang

Open Access Review

Changing R&D models in research-based pharmaceutical companies

Alexander Schuhmacher, Oliver Gassmann, Markus Hinder

Open Access Research

GIFT4 fusokine converts leukemic B cells into immune helper cells

Jiusheng Deng, Andrea Pennati, Jonathon B. Cohen, Yuanqiang Wu, Spencer Ng, Jian Hui Wu, Christopher R. Flowers, Jacques Galipeau

Open Access Research

Calprotectin could be a potential biomarker for acute appendicitis

Peter C. Ambe, Daniel Gödde, Lars Bönicke, Marios Papadakis, Stephan Störkel, Hubert Zirngibl

Open Access Research

Development of a deregulating microRNA panel for the detection of early relapse in postoperative colorectal cancer patients

I-Ping Yang, Hsiang-Lin Tsai, Zhi-Feng Miao, Ching-Wen Huang, Chao-Hung Kuo, Jeng-Yih Wu, Wen-Ming Wang, Suh-Hang Hank Juo, Jaw-Yuan Wang

Open Access Research

Early administration of trimetazidine attenuates diabetic cardiomyopathy in rats by alleviating fibrosis, reducing apoptosis and enhancing autophagy

Lei Zhang, Wen-yuan Ding, Zhi-hao Wang, Meng-xiong Tang, Feng Wang, Ya Li, Ming Zhong, Yun Zhang, Wei Zhang

Open Access Research

Associations between serum uric acid and the incidence of hypertension: a Chinese senior dynamic cohort study

Fengjiang Wei, Ning Sun, Chunyou Cai, Shuzhi Feng, Jianli Tian, Wentao Shi, Weili Xu, Yaogang Wang, Xilin Yang, Wei-Dong Li

Open Access Research

Patient-derived xenografts faithfully replicated clinical outcome in a phase II co-clinical trial of arsenic trioxide in relapsed small cell lung cancer

Taofeek K. Owonikoko, Guojing Zhang, Hyun S. Kim, Renea M. Stinson, Rabih Bechara, Chao Zhang, Zhengjia Chen, Nabil F. Saba, Suchita Pakkala, Rathi Pillai, Xingming Deng, Shi-Yong Sun, Michael R. Rossi, Gabriel L. Sica, Suresh S. Ramalingam, Fadlo R. Khuri

Open Access Research

Testing chemotherapy efficacy in HER2 negative breast cancer using patient-derived spheroids

Kathrin Halfter, Oliver Hoffmann, Nina Ditsch, Mareike Ahne, Frank Arnold, Stefan Paepke, Dieter Grab, Ingo Bauerfeind, Barbara Mayer

Open Access Review

Metronomic temozolomide as second line treatment for metastatic poorly differentiated pancreatic neuroendocrine carcinoma

C. De Divitiis, C. von Arx, A. M. Grimaldi, D. Cicala, F. Tatangelo, A. Arcella, G. M. Romano, E. Simeone, R. V. Iaffaioli, P. A. Ascierto, S. Tafuto

Open Access Research

Peroxiredoxin 1 induces inflammatory cytokine response and predicts outcome of cardiogenic shock patients necessitating extracorporeal membrane oxygenation: an observational cohort study and translational approach

Chia-Hsiung Liu, Shuenn-Wen Kuo, Li-Ming Hsu, Shu-Chien Huang, Chih-Hsien Wang, Pi-Ru Tsai, Yih-Sharng Chen, Tzuu-Shuh Jou, Wen-Je Ko

Open Access Research

Next-generation sequencing for diagnosis of thoracic aortic aneurysms and dissections: diagnostic yield, novel mutations and genotype phenotype correlations

J. K. Poninska, Z. T. Bilinska, M. Franaszczyk, E. Michalak, M. Rydzanicz, E. Szpakowski, A. Pollak, B. Milanowska, G. Truszkowska, P. Chmielewski, A. Sioma, H. Janaszek-Sitkowska, A. Klisiewicz, I. Michalowska, M. Makowiecka-Ciesla, P. Kolsut, P. Stawinski, B. Foss-Nieradko, M. Szperl, J. Grzybowski, P. Hoffman, A. Januszewicz, M. Kusmierczyk, R. Ploski

Open Access Research

Dual effects of VEGF-B on activating cardiomyocytes and cardiac stem cells to protect the heart against short- and long-term ischemia–reperfusion injury

Guo-hua Li, Bin Luo, Yan-xia Lv, Fei Zheng, Lu Wang, Meng-xi Wei, Xian-yu Li, Lei Zhang, Jia-ning Wang, Shi-you Chen, Jun-Ming Tang, Xiaohua He

Open Access Research

Clinical significance of frequent somatic mutations detected by high-throughput targeted sequencing in archived colorectal cancer samples

Ashraf Dallol, Abdelbaset Buhmeida, Mahmoud Shaheen Al-Ahwal, Jaudah Al-Maghrabi, Osama Bajouh, Shadi Al-Khayyat, Rania Alam, Atlal Abusanad, Rola Turki, Aisha Elaimi, Hani A. Alhadrami, Mohammed Abuzenadah, Huda Banni, Mohammed H. Al-Qahtani, Adel M. Abuzenadah

Open Access Research

Lenalidomide normalizes tumor vessels in colorectal cancer improving chemotherapy activity

V. Leuci, F. Maione, R. Rotolo, E. Giraudo, F. Sassi, G. Migliardi, M. Todorovic, L. Gammaitoni, G. Mesiano, L. Giraudo, P. Luraghi, F. Leone, F. Bussolino, G. Grignani, M. Aglietta, L. Trusolino, A. Bertotti, D. Sangiolo

Open Access Research

Serum microRNA-1233 is a specific biomarker for diagnosing acute pulmonary embolism

Thorsten Kessler, Jeanette Erdmann, Baiba Vilne, Petra Bruse, Volkhard Kurowski, Patrick Diemert, Heribert Schunkert, Hendrik B. Sager

Open Access Research

Altered neuroendocrine control and association to clinical symptoms in adolescent chronic fatigue syndrome: a cross-sectional study

Vegard Bruun Wyller, Valieria Vitelli, Dag Sulheim, Even Fagermoen, Anette Winger, Kristin Godang, Jens Bollerslev

Open Access Research

MiR-19a, miR-122 and miR-223 are differentially regulated by hepatitis B virus X protein and involve in cell proliferation in hepatoma cells

Guifang Yu, Xuezhu Chen, Shudi Chen, Weipeng Ye, Kailian Hou, Min Liang

Open Access Review

Early life programming of pain: focus on neuroimmune to endocrine communication

I. Zouikr, M. D. Bartholomeusz, D. M. Hodgson

Open Access Research

Expression of fibroblast growth factor receptor family members is associated with prognosis in early stage cervical cancer patients

Chel Hun Choi, Joon-Yong Chung, Jae-Hoon Kim, Byoung-Gie Kim, Stephen M. Hewitt

Open Access Research

GNAS mutations as prognostic biomarker in patients with relapsed peritoneal pseudomyxoma receiving metronomic capecitabine and bevacizumab: a clinical and translational study

Filippo Pietrantonio, Rosa Berenato, Claudia Maggi, Marta Caporale, Massimo Milione, Federica Perrone, Elena Tamborini, Dario Baratti, Shigeki Kusamura, Luigi Mariani, Monica Niger, Alessia Mennitto, Annunziata Gloghini, Ilaria Bossi, Giulio Settanni, Adele Busico, Pietro Francesco Bagnoli, Maria Di Bartolomeo, Marcello Deraco, Filippo de Braud

Open Access Research

Suction assisted liposuction does not impair the regenerative potential of adipose derived stem cells

Dominik Duscher, Anna Luan, Robert C. Rennert, David Atashroo, Zeshaan N. Maan, Elizabeth A. Brett, Alexander J. Whittam, Natalie Ho, Michelle Lin, Michael S. Hu, Graham G. Walmsley, Raphael Wenny, Manfred Schmidt, Arndt F. Schilling, Hans-Günther Machens, Georg M. Huemer, Derrick C. Wan, Michael T. Longaker, Geoffrey C. Gurtner

Open Access Research

Finding a new therapeutic approach for no-option Parkinsonisms: mesenchymal stromal cells for progressive supranuclear palsy

Margherita Canesi, Rosaria Giordano, Lorenza Lazzari, Maurizio Isalberti, Ioannis Ugo Isaias, Riccardo Benti, Paolo Rampini, Giorgio Marotta, Aurora Colombo, Emanuele Cereda, Mariangela Dipaola, Tiziana Montemurro, Mariele Viganò, Silvia Budelli, Elisa Montelatici, Cristiana Lavazza, Agostino Cortelezzi, Gianni Pezzoli

Open Access Research

Significant association and synergistic adverse prognostic effect of podocalyxin-like protein and epidermal growth factor receptor expression in colorectal cancer

Anna H. Larsson, Sophie Lehn, Sakarias Wangefjord, Emelie Karnevi, Eugenia Kuteeva, Magnus Sundström, Björn Nodin, Mathias Uhlén, Jakob Eberhard, Helgi Birgisson, Karin Jirström

Open Access Research

Novel patient-derived xenograft mouse model for pancreatic acinar cell carcinoma demonstrates single agent activity of oxaliplatin

Jason C. Hall, Laura A. Marlow, Adam C. Mathias, Louis K. Dawson, William F. Durham, Kenneth A. Meshaw, Robert J. Mullin, Aidan J. Synnott, Daniel L. Small, Murli Krishna, Daniel von Hoff, Julia Schüler, Steven N. Hart, Fergus J. Couch, Gerardo Colon-Otero, John A. Copland

Open Access Research

Bioelectrical phase angle and psoriasis: a novel association with psoriasis severity, quality of life and metabolic syndrome

Luigi Barrea, Paolo Emidio Macchia, Carolina Di Somma, Maddalena Napolitano, Anna Balato, Andrea Falco, Maria Cristina Savanelli, Nicola Balato, Annamaria Colao, Silvia Savastano

Open Access Research

The important role of the receptor for activated C kinase 1 (RACK1) in nasopharyngeal carcinoma progression

Hong Peng, Ping-Gui Gong, Jin-Bang Li, Long-Mei Cai, Le Yang, Yun-yi Liu, Kai-tai Yao, Xin Li

Open Access Research

Ex-vivo characterization of circulating colon cancer cells distinguished in stem and differentiated subset provides useful biomarker for personalized metastatic risk assessment

Natalia Malara, Valentina Trunzo, Umberto Foresta, Nicola Amodio, Stefania De Vitis, Laura Roveda, Mariagiovanna Fava, MariaLaura Coluccio, Roberta Macrì, Anna Di Vito, Nicola Costa, Chiara Mignogna, Domenico Britti, Ernesto Palma, Vincenzo Mollace

Open Access Research

Single dose GLP toxicity and biodistribution study of a conditionally replicative adenovirus vector, CRAd-S-pk7, administered by intracerebral injection to Syrian hamsters

Julius Woongki Kim, Brenda Auffinger, Drew A. Spencer, Jason Miska, Alan L. Chang, Joshua Robert Kane, Jacob S. Young, Deepak Kanojia, Jian Qiao, Jill F. Mann, Lingjiao Zhang, Meijing Wu, Atique U. Ahmed, Karen S. Aboody, Theresa V. Strong, Charles D. Hébert, Maciej S. Lesniak

Open Access Research

Norovirus (NoV) specific protective immune responses induced by recombinant P dimer vaccine are enhanced by the mucosal adjuvant FlaB

Vivek Verma, Wenzhi Tan, Sao Puth, Kyoung-Oh Cho, Shee Eun Lee, Joon Haeng Rhee

Open Access Research

MYC copy gain, chromosomal instability and PI3K activation as potential markers of unfavourable outcome in trastuzumab-treated patients with metastatic breast cancer

Helen Gogas, Vassiliki Kotoula, Zoi Alexopoulou, Christos Christodoulou, Ioannis Kostopoulos, Mattheos Bobos, Georgia Raptou, Elpida Charalambous, Eleftheria Tsolaki, Ioannis Xanthakis, George Pentheroudakis, Angelos Koutras, Dimitrios Bafaloukos, Pavlos Papakostas, Gerasimos Aravantinos, Amanda Psyrri, Kalliopi Petraki, Konstantine T. Kalogeras, Dimitrios Pectasides, George Fountzilas

Open Access Research

PFN2, a novel marker of unfavorable prognosis, is a potential therapeutic target involved in esophageal squamous cell carcinoma

Xiao-bin Cui, Shu-mao Zhang, Yue-xun Xu, Hong-wei Dang, Chun-xia Liu, Liang-hai Wang, Lan Yang, Jian-ming Hu, Wei-hua Liang, Jin-fang Jiang, Na Li, Yong Li, Yun-zhao Chen, Feng Li

Open Access Research

Impaired CD8+ T cell responses upon Toll-like receptor activation in common variable immunodeficiency

Camila de Lollo, Dewton de Moraes Vasconcelos, Luanda Mara da Silva Oliveira, Tiago de Oliveira Titz, Magda Carneiro-Sampaio, Cristina Miuki Abe Jacob, Alberto José da Silva Duarte, Maria Notomi Sato

Open Access Research

Longitudinal brain structural alterations and systemic inflammation in obstructive sleep apnea before and after surgical treatment

Wei-Che Lin, Chih-Cheng Huang, Hsiu-Ling Chen, Kun-Hsien Chou, Pei-Chin Chen, Nai-Wen Tsai, Meng-Hsiang Chen, Michael Friedman, Hsin-Ching Lin, Cheng-Hsien Lu

Open Access Research

Measurement of 1,5-anhydroglucitol in blood and saliva: from non-targeted metabolomics to biochemical assay

Anna Halama, Michal Kulinski, Sara Abdul Kader, Noothan J. Satheesh, Abdul Badi Abou-Samra, Karsten Suhre, Ramzi M. Mohammad

Open Access Research

Slow induction of brain death leads to decreased renal function and increased hepatic apoptosis in rats

Rolando A. Rebolledo, Dane Hoeksma, Christina M. V. Hottenrott, Yves J. L. Bodar, Petra J. Ottens, Janneka Wiersema-Buist, Henri G. D. Leuvenink

Open Access Research

An 18 gene expression-based score classifier predicts the clinical outcome in stage 4 neuroblastoma

Daniela Formicola, Giuseppe Petrosino, Vito Alessandro Lasorsa, Piero Pignataro, Flora Cimmino, Simona Vetrella, Luca Longo, Gian Paolo Tonini, André Oberthuer, Achille Iolascon, Matthias Fischer, Mario Capasso

Open Access Review

Regulatory mechanisms of microRNA expression

Lyudmila F. Gulyaeva, Nicolay E. Kushlinskiy

Open Access Research

Clinical significance of T-bet, GATA-3, and Bcl-6 transcription factor expression in bladder carcinoma

Islem Ben Bahria-Sediki, Nadhir Yousfi, Catherine Paul, Mohamed Chebil, Mohamed Cherif, Rachida Zermani, Amel Ben Ammar El Gaaied, Ali Bettaieb

Open Access Research

Clinical-scale expansion of mesenchymal stromal cells: a large banking experience

Chantal Lechanteur, Alexandra Briquet, Olivier Giet, Olivier Delloye, Etienne Baudoux, Yves Beguin

Open Access Review

The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction

Giuseppe Lo Sasso, Walter K. Schlage, Stéphanie Boué, Emilija Veljkovic, Manuel C. Peitsch, Julia Hoeng

Open Access Methodology

Integrated whole-heart computational workflow for inverse potential mapping and personalized simulations

P. Bhagirath, A. W. M. van der Graaf, J. de Hooge, N. M. S. de Groot, M. J. W. Götte

Open Access Research

Pharmacologic rationale for the NK1R antagonist, aprepitant as adjunctive therapy in HIV

Jeffrey S. Barrett, Sergei Spitsin, Ganesh Moorthy, Kyle Barrett, Kate Baker, Andrew Lackner, Florin Tulic, Angela Winters, Dwight L. Evans, Steven D. Douglas

Open Access Research

Proteomic analysis of short-term preload-induced eccentric cardiac hypertrophy

Belal A. Mohamed, Abdul R. Asif, Moritz Schnelle, Mohamed Qasim, Sara Khadjeh, Dawid Lbik, Peter Schott, Gerd Hasenfuss, Karl Toischer

Open Access Research

Centrosome associated genes pattern for risk sub-stratification in multiple myeloma

Fedor Kryukov, Pavel Nemec, Lenka Radova, Elena Kryukova, Samuel Okubote, Jiri Minarik, Zdena Stefanikova, Ludek Pour, Roman Hajek

Open Access Research

Prognostic impact of high levels of circulating plasmacytoid dendritic cells in breast cancer

Jithendra Kini Bailur, Brigitte Gueckel, Graham Pawelec

Open Access Review

mTOR inhibitors effects on regulatory T cells and on dendritic cells

Giovanni Stallone, Barbara Infante, Adelaide Di Lorenzo, Federica Rascio, Gianluigi Zaza, Giuseppe Grandaliano

Open Access Research

Cathepsin A inhibition attenuates myocardial infarction-induced heart failure on the functional and proteomic levels

Agnese Petrera, Johann Gassenhuber, Sven Ruf, Deepika Gunasekaran, Jennifer Esser, Jasmin Hasmik Shahinian, Thomas Hübschle, Hartmut Rütten, Thorsten Sadowski, Oliver Schilling

Open Access Research

Genetic variants of DNA repair genes predict the survival of patients with esophageal squamous cell cancer receiving platinum-based adjuvant chemotherapy

Fei Zhou, Meiling Zhu, Mengyun Wang, Lixin Qiu, Lei Cheng, Ming Jia, Jiaqing Xiang, Qingyi Wei

Open Access Research

Melittin-MIL-2 fusion protein as a candidate for cancer immunotherapy

Mingjun Liu, Haitao Wang, Linjie Liu, Bin Wang, Guirong Sun

Open Access Research

Anti-dsDNA antibodies bind to TLR4 and activate NLRP3 inflammasome in lupus monocytes/macrophages

Hui Zhang, Rong Fu, Chaohuan Guo, Yuefang Huang, Hongyue Wang, Shuang Wang, Jijun Zhao, Niansheng Yang

Open Access Research

Deciphering the gene expression profile of peroxisome proliferator-activated receptor signaling pathway in the left atria of patients with mitral regurgitation

Mien-Cheng Chen, Jen-Ping Chang, Yu-Sheng Lin, Kuo-Li Pan, Wan-Chun Ho, Wen-Hao Liu, Tzu-Hao Chang, Yao-Kuang Huang, Chih-Yuan Fang, Chien-Jen Chen

Open Access Research

Effects of the intramyocardial implantation of stromal vascular fraction in patients with chronic ischemic cardiomyopathy

K. Comella, J. Parcero, H. Bansal, J. Perez, J. Lopez, A. Agrawal, T. Ichim

Open Access Research

Development and validation of a classification and scoring system for the diagnosis of oral squamous cell carcinomas through confocal laser endomicroscopy

Nicolai Oetter, Christian Knipfer, Maximilian Rohde, Cornelius von Wilmowsky, Andreas Maier, Kathrin Brunner, Werner Adler, Friedrich-Wilhelm Neukam, Helmut Neumann, Florian Stelzle

Open Access Research

Longitudinal study of DNA methylation during the first 5 years of life

Rocio G. Urdinguio, María Isabel Torró, Gustavo F. Bayón, Julio Álvarez-Pitti, Agustín F. Fernández, Pau Redon, Mario F. Fraga, Empar Lurbe

Open Access Research

Diffusion-weighted and dynamic contrast-enhanced MRI of pancreatic adenocarcinoma xenografts: associations with tumor differentiation and collagen content

Catherine S. Wegner, Jon-Vidar Gaustad, Lise Mari K. Andersen, Trude G. Simonsen, Einar K. Rofstad

Open Access Research

Vaccination with endosomal unknown epitopes produces therapeutic response in rheumatoid arthritis patients and modulates adjuvant arthritis of rats

Innocenzo Caruso, Salvatore Santandrea, Mariarita Gismondo, Alessandra Lombardi, Franco Montrone, Enzo Massimo Caruso, Piercarlo Sarzi Puttini

Open Access Research

Microcirculatory blood flow during cardiac arrest and cardiopulmonary resuscitation does not correlate with global hemodynamics: an experimental study

Petra Krupičková, Mikuláš Mlček, Michal Huptych, Zuzana Mormanová, Tomáš Bouček, Tomáš Belza, Stanislav Lacko, Miloš Černý, Petr Neužil, Otomar Kittnar, Aleš Linhart, Jan Bělohlávek

Open Access Research

Ultrastructural regenerating features of nasal mucosa following microdebrider-assisted turbinoplasty are related to clinical recovery

Giampiero Neri, Fiorella Cazzato, Valentina Mastronardi, Mara Pugliese, Maria Antonietta Centurione, Roberta Di Pietro, Lucia Centurione

Open Access Research

Guizhi-Shaoyao-Zhimu decoction attenuates rheumatoid arthritis partially by reversing inflammation-immune system imbalance

Qiuyan Guo, Xia Mao, Yanqiong Zhang, Shuqin Meng, Yue Xi, Yi Ding, Xiaocun Zhang, Yuntao Dai, Xia Liu, Chao Wang, Yuting Li, Na Lin

Open Access Research

MicroRNA-142-5p contributes to Hashimoto’s thyroiditis by targeting CLDN1

Jin Zhu, Yuehua Zhang, Weichen Zhang, Wei Zhang, Linni Fan, Lu Wang, Yixiong Liu, Shasha Liu, Ying Guo, Yingmei Wang, Jun Yi, Qingguo Yan, Zhe Wang, Gaosheng Huang

Open Access Research

Modulation of the sympathetic nervous system by renal denervation prevents reduction of aortic distensibility in atherosclerosis prone ApoE-deficient rats

Mathias Hohl, Dominik Linz, Peter Fries, Andreas Müller, Jonas Stroeder, Daniel Urban, Thimoteus Speer, Jürgen Geisel, Björn Hummel, Ulrich Laufs, Stephan H. Schirmer, Michael Böhm, Felix Mahfoud

Open Access Research

Expression of serine/glycine metabolism-related proteins is different according to the thyroid cancer subtype

Woo Young Sun, Hye Min Kim, Woo-Hee Jung, Ja Seung Koo

Open Access Research

Organizing pneumonia in mice and men

Nicole Izykowski, Mark Kuehnel, Kais Hussein, Kristin Mitschke, Michael Gunn, Sabina Janciauskiene, Axel Haverich, Gregor Warnecke, Florian Laenger, Ulrich Maus, Danny Jonigk

Open Access Research

ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model

Amy M. Archer, Rana Saber, Shawn Rose, Alexander Shaffer, Alexander V. Misharin, FuNien Tsai, G. Kenneth Haines III, Salina Dominguez, Mesut Eren, Douglas E. Vaughan, Carla M. Cuda, Harris Perlman

Open Access Research

Activation of myeloid dendritic cells, effector cells and regulatory T cells in lichen planus

Rosana Domingues, Gabriel Costa de Carvalho, Valéria Aoki, Alberto José da Silva Duarte, Maria Notomi Sato

Open Access Research

Definition by FSH, AMH and embryo numbers of good-, intermediate- and poor-prognosis patients suggests previously unknown IVF outcome-determining factor associated with AMH

Norbert Gleicher, Vitaly A. Kushnir, Aritro Sen, Sarah K. Darmon, Andrea Weghofer, Yan-Guang Wu, Qi Wang, Lin Zhang, David F. Albertini, David H. Barad

Open Access Research

New perspective in diagnostics of mitochondrial disorders: two years’ experience with whole-exome sequencing at a national paediatric centre

Ewa Pronicka, Dorota Piekutowska-Abramczuk, Elżbieta Ciara, Joanna Trubicka, Dariusz Rokicki, Agnieszka Karkucińska-Więckowska, Magdalena Pajdowska, Elżbieta Jurkiewicz, Paulina Halat, Joanna Kosińska, Agnieszka Pollak, Małgorzata Rydzanicz, Piotr Stawinski, Maciej Pronicki, Małgorzata Krajewska-Walasek, Rafał Płoski

Open Access Methodology

Validation of an IFNγ/IL2 FluoroSpot assay for clinical trial monitoring

Nina Körber, Uta Behrends, Alexander Hapfelmeier, Ulrike Protzer, Tanja Bauer

Open Access Research

Resveratrol increases AdipoR1 and AdipoR2 expression in type 2 diabetic nephropathy

Hoon Suk Park, Ji Hee Lim, Min Young Kim, Yaeni Kim, You Ah Hong, Sun Ryoung Choi, Sungjin Chung, Hyung Wook Kim, Bum Soon Choi, Yong Soo Kim, Yoon Sik Chang, Cheol Whee Park

Open Access Research

Major components of metabolic syndrome and nutritional intakes in different genotype of UCP2 −866G/A gene polymorphisms in patients with NAFLD

Mahdieh Abbasalizad Farhangi, Fatemeh Mohseni, Safar Farajnia, Mohammad-Asghari Jafarabadi

Open Access Research

ProInflam: a webserver for the prediction of proinflammatory antigenicity of peptides and proteins

Sudheer Gupta, Midhun K. Madhu, Ashok K. Sharma, Vineet K. Sharma

Open Access Research

Decreased IL-17 during treatment of sputum smear-positive pulmonary tuberculosis due to increased regulatory T cells and IL-10

Lichen Xu, Guangying Cui, Hongyu Jia, Yunan Zhu, Yulong Ding, Jianing Chen, Chong Lu, Ping Ye, Hainv Gao, Lanjuan Li, Weihang Ma, Jianxin Lyu, Hongyan Diao

Open Access Research

Exosome-like vesicles in uterine aspirates: a comparison of ultracentrifugation-based isolation protocols

Irene Campoy, Lucia Lanau, Tatiana Altadill, Tamara Sequeiros, Silvia Cabrera, Montserrat Cubo-Abert, Assumpción Pérez-Benavente, Angel Garcia, Salvador Borrós, Anna Santamaria, Jordi Ponce, Xavier Matias-Guiu, Jaume Reventós, Antonio Gil-Moreno, Marina Rigau, Eva Colas

Open Access Research

Exosomes in the nose induce immune cell trafficking and harbour an altered protein cargo in chronic airway inflammation

Cecilia Lässer, Serena E. O’Neil, Ganesh V. Shelke, Carina Sihlbom, Sara F. Hansson, Yong Song Gho, Bo Lundbäck, Jan Lötvall

Open Access Research

Long noncoding RNA dysregulation in ischemic heart failure

Simona Greco, Germana Zaccagnini, Alessandra Perfetti, Paola Fuschi, Rea Valaperta, Christine Voellenkle, Serenella Castelvecchio, Carlo Gaetano, Nicoletta Finato, Antonio Paolo Beltrami, Lorenzo Menicanti, Fabio Martelli

Open Access Research

TWEAK-binding autoantibodies are generated during psoriatic arthritis and are not influenced by anti-TNF therapy

Sandrine Guis, Philippe Berbis, Delphine Stephan, Daniel Bertin, Florent Amatore, Nathalie Balandraud, Nathalie Lesavre, Sophie Desplat-Jégo

Open Access Research

Interaction between polyphenols intake and PON1 gene variants on markers of cardiovascular disease: a nutrigenetic observational study

Federica Rizzi, Costanza Conti, Elena Dogliotti, Annalisa Terranegra, Erika Salvi, Daniele Braga, Flavia Ricca, Sara Lupoli, Alessandra Mingione, Francesca Pivari, Caterina Brasacchio, Matteo Barcella, Martina Chittani, Francesca D’Avila, Maurizio Turiel, Monica Lazzaroni, Laura Soldati, Daniele Cusi, Cristina Barlassina

Open Access Research

Vascular-targeted TNFα and IFNγ inhibits orthotopic colorectal tumor growth

Jing Shen, Zhi Jie Li, Long Fei Li, Lan Lu, Zhan Gang Xiao, William Ka Kei Wu, Lin Zhang, Ming Xing Li, Wei Hu, Kam Ming Chan, Chi Hin Cho

Open Access Research

HBx-induced MiR-1269b in NF-κB dependent manner upregulates cell division cycle 40 homolog (CDC40) to promote proliferation and migration in hepatoma cells

Xiao-xiao Kong, Yan-ru Lv, Li-ping Shao, Xiang-yang Nong, Guang-ling Zhang, Yi Zhang, Hong-xia Fan, Min Liu, Xin Li, Hua Tang

Open Access Research

Rebamipide prevents peripheral arthritis and intestinal inflammation by reciprocally regulating Th17/Treg cell imbalance in mice with curdlan-induced spondyloarthritis

Hong-Ki Min, Jae-Kyung Kim, Seon-Yeong Lee, Eun-Kyung Kim, Seung Hoon Lee, Jennifer Lee, Seung-Ki Kwok, Mi-La Cho, Sung-Hwan Park

Open Access Research

Amelioration of autoimmune arthritis by adoptive transfer of Foxp3-expressing regulatory B cells is associated with the Treg/Th17 cell balance

Mi Kyung Park, Young Ok Jung, Seon-Yeong Lee, Seung Hoon Lee, Yu Jung Heo, Eun Kyung Kim, Hye Jwa Oh, Young Mee Moon, Hye-Jin Son, Min Jung Park, Sung Hwan Park, Ho Youn Kim, Mi La Cho, Jun Ki Min

Open Access Research

Transcriptome-wide based identification of miRs in congenital anomalies of the kidney and urinary tract (CAKUT) in children: the significant upregulation of tissue miR-144 expression

Ivan Jovanovic, Maja Zivkovic, Mirjana Kostic, Zoran Krstic, Tamara Djuric, Ivana Kolic, Dragan Alavantic, Aleksandra Stankovic

Open Access Research

Propofol attenuated liver transplantation-induced acute lung injury via connexin43 gap junction inhibition

Dongdong Yuan, Guangjie Su, Yue Liu, Xinjin Chi, Jiayu Feng, Qianqian Zhu, Jun Cai, Gangjian Luo, Ziqing Hei

Open Access Research

Is targeted fortification of human breast milk an optimal nutrition strategy for preterm infants? An interventional study

Laura Morlacchi, Domenica Mallardi, Maria Lorella Giannì, Paola Roggero, Orsola Amato, Pasqua Piemontese, Dario Consonni, Fabio Mosca

Open Access Research

Calnexin, an ER-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer

Deborah Ryan, Steven Carberry, Áine C. Murphy, Andreas U. Lindner, Joanna Fay, Suzanne Hector, Niamh McCawley, Orna Bacon, Caoimhin G. Concannon, Elaine W. Kay, Deborah A. McNamara, Jochen H. M. Prehn

Open Access Research

Matrix- and plasma-derived peptides promote tissue-specific injury responses and wound healing in diabetic swine

Anthony R. Sheets, Conner J. Massey, Stephen M. Cronk, Mark D. Iafrati, Ira M. Herman

Open Access Methodology

Detection of tumor-associated cells in cryopreserved peripheral blood mononuclear cell samples for retrospective analysis

Peixuan Zhu, Melissa L. Stanton, Erik P. Castle, Richard W. Joseph, Daniel L. Adams, Shuhong Li, Platte Amstutz, Cha-Mei Tang, Thai H. Ho

Open Access Research

Flow diverter effect of LVIS stent on cerebral aneurysm hemodynamics: a comparison with Enterprise stents and the Pipeline device

Chao Wang, Zhongbin Tian, Jian Liu, Linkai Jing, Nikhil Paliwal, Shengzhang Wang, Ying Zhang, Jianping Xiang, Adnan H. Siddiqui, Hui Meng, Xinjian Yang

Open Access Research

miR-122-mediated translational repression of PEG10 and its suppression in human hepatocellular carcinoma

Yu-Chiau Shyu, Tung-Liang Lee, Mu-Jie Lu, Jim-Ray Chen, Rong-Nan Chien, Huang-Yang Chen, Ji-Fan Lin, Ann-Ping Tsou, Yu-Hsien Chen, Chia-Wen Hsieh, Ting-Shuo Huang

Open Access Research

Evaluation of the biomarker candidate MFAP4 for non-invasive assessment of hepatic fibrosis in hepatitis C patients

Thilo Bracht, Christian Mölleken, Maike Ahrens, Gereon Poschmann, Anders Schlosser, Martin Eisenacher, Kai Stühler, Helmut E. Meyer, Wolff H. Schmiegel, Uffe Holmskov, Grith L. Sorensen, Barbara Sitek

Open Access Research

LRG1 downregulation in allergic airway disorders and its expression in peripheral blood and tissue cells

Lijing Hao, Hua Xie, Bin Zhang, Dong Chen, Shufen Wang, Huiyun Zhang, Shaoheng He

Open Access Research

Serum metabolites predict response to angiotensin II receptor blockers in patients with diabetes mellitus

Michelle J. Pena, Andreas Heinzel, Peter Rossing, Hans-Henrik Parving, Guido Dallmann, Kasper Rossing, Steen Andersen, Bernd Mayer, Hiddo J. L. Heerspink

Open Access Research

Classical V600E and other non-hotspot BRAF mutations in adult differentiated thyroid cancer

Avaniyapuram Kannan Murugan, Ebtesam Qasem, Hindi Al-Hindi, Yufei Shi, Ali S. Alzahrani

Open Access Research

Immune response and innervation signatures in aseptic hip implant loosening

Daniel M. Vasconcelos, Manuel Ribeiro-da-Silva, António Mateus, Cecília Juliana Alves, Gil Costa Machado, Joana Machado-Santos, Diogo Paramos-de-Carvalho, Inês S. Alencastre, Rui Henrique, Gilberto Costa, Mário A. Barbosa, Meriem Lamghari

Open Access Research

GRIM19 ameliorates acute graft-versus-host disease (GVHD) by modulating Th17 and Treg cell balance through down-regulation of STAT3 and NF-AT activation

Min-Jung Park, Seung Hoon Lee, Sung-Hee Lee, Eun-Kyung Kim, Eun Jung Lee, Young-Mee Moon, Mi- La Cho

Open Access Research

Age-associated hydroxymethylation in human bone-marrow mesenchymal stem cells

Estela G. Toraño, Gustavo F. Bayón, Álvaro del Real, Marta I. Sierra, María G. García, Antonella Carella, Thalia Belmonte, Rocío G. Urdinguio, Isabel Cubillo, Javier García-Castro, Jesús Delgado-Calle, Flor M. Pérez-Campo, José A. Riancho, Mario F. Fraga, Agustín F. Fernández

Open Access Research

Characterisation and comparison of adipose tissue macrophages from human subcutaneous, visceral and perivascular adipose tissue

Ivana Kralova Lesna, Anna Kralova, Sona Cejkova, Jiri Fronek, Marek Petras, Alena Sekerkova, Filip Thieme, Libor Janousek, Rudolf Poledne

Open Access Research

Invariant asymmetry renews the lymphatic vasculature during homeostasis

Alicia L. Connor, Philip M. Kelley, Richard M. Tempero

Open Access Erratum

Erratum to: Resveratrol increases AdipoR1 and AdipoR2 expression in type 2 diabetic nephropathy

Hoon Suk Park, Ji Hee Lim, Min Young Kim, Yaeni Kim, You Ah Hong, Sun Ryoung Choi, Sungjin Chung, Hyung Wook Kim, Bum Soon Choi, Yong Soo Kim, Yoon Sik Chang, Cheol Whee Park

Open Access Research

miR-145 mediated the role of aspirin in resisting VSMCs proliferation and anti-inflammation through CD40

Xin Guo, Lijin Yu, Min Chen, Tian Wu, Xiangdong Peng, Ren Guo, Bikui Zhang

Open Access Research

Effects of acute hypoxia on human adipose tissue lipoprotein lipase activity and lipolysis

Bimit Mahat, Étienne Chassé, Jean-François Mauger, Pascal Imbeault

Open Access Research

Aerobic exercise training protects against endothelial dysfunction by increasing nitric oxide and hydrogen peroxide production in LDL receptor-deficient mice

Daniele M. Guizoni, Gabriel G. Dorighello, Helena C. F. Oliveira, Maria A. Delbin, Marta H. Krieger, Ana P. Davel

Open Access Research

A short CD3/CD28 costimulation combined with IL-21 enhance the generation of human memory stem T cells for adoptive immunotherapy

C. Alvarez-Fernández, L. Escribà-Garcia, S. Vidal, J. Sierra, J. Briones

Open Access Research

Increased MACC1 levels in tissues and blood identify colon adenoma patients at high risk

Hassan Ashktorab, Pia Hermann, Mehdi Nouraie, Babak Shokrani, Edward Lee, Tahmineh Haidary, Hassan Brim, Ulrike Stein

Open Access Research

Serum IgG against Simian Virus 40 antigens are hampered by high levels of sHLA-G in patients affected by inflammatory neurological diseases, as multiple sclerosis

Roberta Rizzo, Silvia Pietrobon, Elisa Mazzoni, Daria Bortolotti, Fernanda Martini, Massimiliano Castellazzi, Ilaria Casetta, Enrico Fainardi, Dario Di Luca, Enrico Granieri, Mauro Tognon, E Granieri, M Castellazzi, I Casetta, MR Tola, E S Fainardi, F Dallocchio, T Bellini, R Rizzo, A Rotola, D Di Luca, S Seraceni, C Contini, S Sabbioni, M Negrini, M Tognon, T Antonelli, E Groppo, M Gentile, E Baldi, ML Caniatti, S Ceruti, MR Manfrinato, A Trentini, D Bortolotti, E Miotto, M Ferracin, E Mazzoni, S Pietrobon, I Masini, JC Rotondo, F Martini, A Baruzzi, R D’Alessandro, R Michelucci, F Salvi, S Stecchi, C Scandellari, G Terzano, F Granella, P Nichelli, P Sola, D Ferraro, F Vitetta, AM Simone, R Bedin, N Marcello, L Motti, S Montepietra, D Guidetti, P Immovilli, E Montanari, I Pesci, A Guareschi, G Greco, M Santangelo, AM Mauro, S Malagù, F Rasi, M Spadoni, M Galeotti, L Fiorani, W Neri, A Ravasio, M Pasquinelli, S Gutman, C Monaldini

Open Access Research

Visualization of atherosclerosis as detected by coronary artery calcium and carotid intima-media thickness reveals significant atherosclerosis in a cross-sectional study of psoriasis patients in a tertiary care center

S. Santilli, D. R. Kast, I. Grozdev, L. Cao, R. L. Feig, J. B. Golden, S. M. Debanne, R. C. Gilkeson, C. E. Orringer, T. S. McCormick, N. L. Ward, K. D. Cooper, N. J. Korman

Open Access Erratum

Erratum to: Comparison of hemostatic dressings for superficial wounds using a new spectrophotometric coagulation assay

Julian-Dario Rembe, Julia K. Böhm, Carolin Fromm-Dornieden, Nadine Schäfer, Marc Maegele, Matthias Fröhlich, Ewa K. Stuermer

Open Access Research

miRNAs and sports: tracking training status and potentially confounding diagnoses

Anne Hecksteden, Petra Leidinger, Christina Backes, Stefanie Rheinheimer, Mark Pfeiffer, Alexander Ferrauti, Michael Kellmann, Farbod Sedaghat, Benjamin Meder, Eckart Meese, Tim Meyer, Andreas Keller

Open Access Methodology

Fully automated macromolecule suppressed single voxel glutamate spectroscopy (FAMOUS SVGS)

Ravi Prakash Reddy Nanga, Hari Hariharan, Ravinder Reddy

Open Access Erratum

Erratum to: Amelioration of autoimmune arthritis by adoptive transfer of Foxp3-expressing regulatory B cells is associated with the Treg/Th17 cell balance

Mi-Kyung Park, Young Ok Jung, Seon-Yeong Lee, Seung Hoon Lee, Yu-Jung Heo, Eun-Kyung Kim, Hye-Jwa Oh, Young-Mee Moon, Hye-Jin Son, Min-Jung Park, Sung-Hwan Park, Ho-Youn Kim, Mi-La Cho, Jun-Ki Min

Open Access Erratum

Erratum to: Calnexin, an ER stress-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer

Deborah Ryan, Steven Carberry, Áine C. Murphy, Andreas U. Lindner, Joanna Fay, Suzanne Hector, Niamh McCawley, Orna Bacon, Caoimhin G. Concannon, Elaine W. Kay, Deborah A. McNamara, Jochen H. M. Prehn

Open Access Research

Production of functional, stable, unmutated recombinant human papillomavirus E6 oncoprotein: implications for HPV-tumor diagnosis and therapy

Elena Illiano, Olivia Costantina Demurtas, Silvia Massa, Paola Di Bonito, Valerio Consalvi, Roberta Chiaraluce, Carlo Zanotto, Carlo De Giuli Morghen, Antonia Radaelli, Aldo Venuti, Rosella Franconi

Open Access Research

Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells

Huafang Su, Fuqiang Lin, Xia Deng, Lanxiao Shen, Ya Fang, Zhenghua Fei, Lihao Zhao, Xuebang Zhang, Huanle Pan, Deyao Xie, Xiance Jin, Congying Xie

Open Access Research

In vivo monitoring of lung inflammation in CFTR-deficient mice

Fabio Stellari, Gabriella Bergamini, Francesca Ruscitti, Angela Sandri, Francesca Ravanetti, Gaetano Donofrio, Federico Boschi, Gino Villetti, Claudio Sorio, Barouk M. Assael, Paola Melotti, Maria M. Lleo

Open Access Research

Differential tumor infiltration by T-cells characterizes intrinsic molecular subtypes in breast cancer

M. Miyan, J. Schmidt-Mende, R. Kiessling, I. Poschke, J. de Boniface

Open Access Research

The GLP-1 receptor agonists exenatide and liraglutide activate Glucose transport by an AMPK-dependent mechanism

Francesco Andreozzi, Gregory Alexander Raciti, Cecilia Nigro, Gaia Chiara Mannino, Teresa Procopio, Alberto M. Davalli, Francesco Beguinot, Giorgio Sesti, Claudia Miele, Franco Folli

Open Access Research

Rapid reconstitution of CD4 T cells and NK cells protects against CMV-reactivation after allogeneic stem cell transplantation

Julia Drylewicz, Ingrid M. M. Schellens, Rogier Gaiser, Nening M. Nanlohy, Esther D. Quakkelaar, Henny Otten, Suzanne van Dorp, Ronald Jacobi, Leonie Ran, Sanne Spijkers, Dan Koning, Rob Schuurman, Ellen Meijer, Floortje L. Pietersma, Jurgen Kuball, Debbie van Baarle

Open Access Research

Molecular and epigenetic features of melanomas and tumor immune microenvironment linked to durable remission to ipilimumab-based immunotherapy in metastatic patients

Teofila Seremet, Alexander Koch, Yanina Jansen, Max Schreuer, Sofie Wilgenhof, Véronique Del Marmol, Danielle Liènard, Kris Thielemans, Kelly Schats, Mark Kockx, Wim Van Criekinge, Pierre G. Coulie, Tim De Meyer, Nicolas van Baren, Bart Neyns

Open Access Review

Microbiota and chronic inflammatory arthritis: an interwoven link

Andrea Picchianti Diamanti, M. Manuela Rosado, Bruno Laganà, Raffaele D’Amelio

Open Access Research

Classifying publications from the clinical and translational science award program along the translational research spectrum: a machine learning approach

Alisa Surkis, Janice A. Hogle, Deborah DiazGranados, Joe D. Hunt, Paul E. Mazmanian, Emily Connors, Kate Westaby, Elizabeth C. Whipple, Trisha Adamus, Meridith Mueller, Yindalon Aphinyanaphongs

Open Access Research

Strong predictive value of mannose-binding lectin levels for cardiovascular risk of hemodialysis patients

Felix Poppelaars, Mariana Gaya da Costa, Stefan P. Berger, Solmaz Assa, Anita H. Meter-Arkema, Mohamed R. Daha, Willem J. van Son, Casper F. M. Franssen, Marc A. J. Seelen

Open Access Research

Integrative analysis of metabolome and gut microbiota in diet-induced hyperlipidemic rats treated with berberine compounds

Meng Li, Xiangbing Shu, Hanchen Xu, Chunlei Zhang, Lili Yang, Li Zhang, Guang Ji

Open Access Research

Role of KIR and CD16A genotypes in colorectal carcinoma genetic risk and clinical stage

Angelica Canossi, Anna Aureli, Tiziana Del Beato, Piero Rossi, Luana Franceschilli, Flavio De Sanctis, Pierpaolo Sileri, Nicola di Lorenzo, Oreste Buonomo, Davide Lauro, Adriano Venditti, Giuseppe Sconocchia

Open Access Research

Salivary peptidome profiling for diagnosis of severe early childhood caries

Xiangyu Sun, Xin Huang, Xu Tan, Yan Si, Xiaozhe Wang, Feng Chen, Shuguo Zheng

Open Access Research

Oncolytic virus efficiency inhibited growth of tumour cells with multiple drug resistant phenotype in vivo and in vitro

Elena P. Goncharova, Julia S. Ruzhenkova, Ivan S. Petrov, Sergey N. Shchelkunov, Marina A. Zenkova

Open Access Research

Could patents interfere with the development of a cardiovascular polypill?

Reed F. Beall, Jon-David R. Schwalm, Mark D. Huffman, Tara McCready, Salim Yusuf, Amir Attaran

Open Access Research

Type 2 diabetes is associated with decreased PGC1α expression in epicardial adipose tissue of patients with coronary artery disease

Inmaculada Moreno-Santos, Luis Miguel Pérez-Belmonte, Manuel Macías-González, María José Mataró, Daniel Castellano, Miguel López-Garrido, Carlos Porras-Martín, Pedro L. Sánchez-Fernández, Juan José Gómez-Doblas, Fernando Cardona, Eduardo de Teresa-Galván, Manuel Jiménez-Navarro

Open Access Research

Phenotypic and metabolic features of mouse diaphragm and gastrocnemius muscles in chronic lung carcinogenesis: influence of underlying emphysema

Anna Salazar-Degracia, David Blanco, Mònica Vilà-Ubach, Gabriel de Biurrun, Carlos Ortiz de Solórzano, Luis M. Montuenga, Esther Barreiro

Open Access Erratum

Erratum to: Strong predictive value of mannose-binding lectin levels for cardiovascular risk of hemodialysis patients

Felix Poppelaars, Mariana Gaya da Costa, Stefan P. Berger, Solmaz Assa, Anita H. Meter-Arkema, Mohamed R. Daha, Willem J. van Son, Casper F. M. Franssen, Marc A. J. Seelen

Open Access Research

Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: multicenter randomized controlled clinical trial (phase I/II)

José M. Lamo-Espinosa, Gonzalo Mora, Juan F. Blanco, Froilán Granero-Moltó, Jorge M. Nuñez-Córdoba, Carmen Sánchez-Echenique, José M. Bondía, Jesús Dámaso Aquerreta, Enrique J. Andreu, Enrique Ornilla, Eva M. Villarón, Andrés Valentí-Azcárate, Fermín Sánchez-Guijo, María Consuelo del Cañizo, Juan Ramón Valentí-Nin, Felipe Prósper

Open Access Research

Proton-pump inhibitor omeprazole attenuates hyperoxia induced lung injury

Jute Richter, Julio Jimenez, Taro Nagatomo, Jaan Toelen, Paul Brady, Thomas Salaets, Flore Lesage, Jeroen Vanoirbeek, Jan Deprest

Open Access Research

Micro-RNA-21 (biomarker) and global longitudinal strain (functional marker) in detection of myocardial fibrotic burden in severe aortic valve stenosis: a pilot study

Iacopo Fabiani, Cristian Scatena, Chiara Maria Mazzanti, Lorenzo Conte, Nicola Riccardo Pugliese, Sara Franceschi, Francesca Lessi, Michele Menicagli, Andrea De Martino, Stefano Pratali, Uberto Bortolotti, Antonio Giuseppe Naccarato, Salvatore La Carrubba, Vitantonio Di Bello

Open Access Research

Methylation pattern analysis in prostate cancer tissue: identification of biomarkers using an MS-MLPA approach

Giorgia Gurioli, Samanta Salvi, Filippo Martignano, Flavia Foca, Roberta Gunelli, Matteo Costantini, Giacomo Cicchetti, Ugo De Giorgi, Persio Dello Sbarba, Daniele Calistri, Valentina Casadio

Open Access Research

Fibrinogen consumption is related to intracranial clot burden in acute ischemic stroke: a retrospective hyperdense artery study

Slaven Pikija, Vladimir Trkulja, Johannes Sebastian Mutzenbach, Mark R. McCoy, Patricia Ganger, Johann Sellner

Open Access Research

Association of biomarkers with health-related quality of life and history of stressors in myalgic encephalomyelitis/chronic fatigue syndrome patients

Emmanuel Fenouillet, Aude Vigouroux, Jean Guillaume Steinberg, Alexandre Chagvardieff, Frédérique Retornaz, Regis Guieu, Yves Jammes

Open Access Review

Integrative systems medicine approaches to identify molecular targets in lymphoid malignancies

Raffaele Frazzi, Charles Auffray, Angela Ferrari, Perla Filippini, Sergio Rutella, Alfredo Cesario

Open Access Research

Intra-discal injection of autologous, hypoxic cultured bone marrow-derived mesenchymal stem cells in five patients with chronic lower back pain: a long-term safety and feasibility study

Christian Elabd, Christopher J. Centeno, John R. Schultz, Gregory Lutz, Thomas Ichim, Francisco J. Silva

Open Access Research

Mechanisms underlying the antihypertensive properties of Urtica dioica

Rahila Qayyum, Hafiz Misbah-ud-Din Qamar, Shamim Khan, Umme Salma, Taous Khan, Abdul Jabbar Shah

Open Access Research

A validated cellular biobank for β-thalassemia

Lucia Carmela Cosenza, Laura Breda, Giulia Breveglieri, Cristina Zuccato, Alessia Finotti, Ilaria Lampronti, Monica Borgatti, Francesco Chiavilli, Maria Rita Gamberini, Stefania Satta, Laura Manunza, Franca Rosa De Martis, Paolo Moi, Stefano Rivella, Roberto Gambari, Nicoletta Bianchi

Open Access Review

Ockham’s razor for the MET-driven invasive growth linking idiopathic pulmonary fibrosis and cancer

Giulia M. Stella, Alessandra Gentile, Alice Balderacchi, Federica Meloni, Melissa Milan, Silvia Benvenuti

Open Access Research

Relationship of TRIM5 and TRIM22 polymorphisms with liver disease and HCV clearance after antiviral therapy in HIV/HCV coinfected patients

Luz M. Medrano, Norma Rallón, Juan Berenguer, María A. Jiménez-Sousa, Vicente Soriano, Teresa Aldámiz-Echevarria, Amanda Fernández-Rodríguez, Marcial García, Francisco Tejerina, Isidoro Martínez, José M. Benito, Salvador Resino

Open Access Research

Biomarkers of inflammation and innate immunity in atrophic nonunion fracture

Dominique de Seny, Gaël Cobraiville, Pierre Leprince, Marianne Fillet, Charlotte Collin, Myrielle Mathieu, Jean-Philippe Hauzeur, Valérie Gangji, Michel G. Malaise

Open Access Research

Spontaneous onset and transplant models of the Vk*MYC mouse show immunological sequelae comparable to human multiple myeloma

Rachel E. Cooke, Nicholas A. Gherardin, Simon J. Harrison, Hang Quach, Dale I. Godfrey, Miles Prince, Rachel Koldej, David S. Ritchie

Open Access Research

Triglyceride glucose-waist circumference, a novel and effective predictor of diabetes in first-degree relatives of type 2 diabetes patients: cross-sectional and prospective cohort study

Shuang Zheng, Sheng Shi, Xingxing Ren, Tingting Han, Yangxue Li, Yawen Chen, Wei Liu, Peter C. Hou, Yaomin Hu

Open Access Research

Repositioning of bromocriptine for treatment of acute myeloid leukemia

María Carmen Lara-Castillo, Josep Maria Cornet-Masana, Amaia Etxabe, Antònia Banús-Mulet, Miguel Ángel Torrente, Meritxell Nomdedeu, Marina Díaz-Beyá, Jordi Esteve, Ruth M. Risueño

Open Access Research

Salivary psoriasin (S100A7) correlates with diffusion capacity of carbon monoxide in a large cohort of systemic sclerosis patients

Laura Giusti, Francesca Sernissi, Elena Donadio, Federica Ciregia, Camillo Giacomelli, Gino Giannaccini, Maria Rosa Mazzoni, Antonio Lucacchini, Laura Bazzichi

Open Access Research

Moniliformediquinone as a potential therapeutic agent, inactivation of hepatic stellate cell and inhibition of liver fibrosis in vivo

Tsui-Hwa Tseng, Wea-Lung Lin, Zi-Hui Chen, Yean-Jang Lee, Ming-Shiun Shie, Kam-Fai Lee, Chien-Heng Shen, Hsing-Chun Kuo

Open Access Research

In-vitro influence of mycophenolate mofetil (MMF) and Ciclosporin A (CsA) on cytokine induced killer (CIK) cell immunotherapy

Melanie Bremm, Sabine Huenecke, Olga Zimmermann, Verena Pfirrmann, Andrea Quaiser, Halvard Bonig, Jan Soerensen, Thomas Klingebiel, Eva Rettinger, Peter Bader, Claudia Cappel

Open Access Review

Decoding the usefulness of non-coding RNAs as breast cancer markers

Maria Amorim, Sofia Salta, Rui Henrique, Carmen Jerónimo

Open Access Research

Lipid profiling of the therapeutic effects of berberine in patients with nonalcoholic fatty liver disease

Xinxia Chang, Zhe Wang, Jinlan Zhang, Hongmei Yan, Hua Bian, Mingfeng Xia, Huandong Lin, Jiandong Jiang, Xin Gao

Open Access Review

Update on Poly-ADP-ribose polymerase inhibition for ovarian cancer treatment

Anselmo Papa, Davide Caruso, Martina Strudel, Silverio Tomao, Federica Tomao

Open Access Research

Liposome encapsulated perfluorohexane enhances radiotherapy in mice without additional oxygen supply

Linfeng Xu, Xuefeng Qiu, Yanting Zhang, Kai Cao, Xiaozhi Zhao, Jinhui Wu, Yiqiao Hu, Hongqian Guo

Open Access Review

Repurposing of approved cardiovascular drugs

Junichi Ishida, Masaaki Konishi, Nicole Ebner, Jochen Springer

Open Access Research

Celecoxib suppresses autophagy and enhances cytotoxicity of imatinib in imatinib-resistant chronic myeloid leukemia cells

Ying Lu, Ling-Ling Liu, Shou-Sheng Liu, Zhi-Gang Fang, Yong Zou, Xu-Bin Deng, Zi-Jie Long, Quentin Liu, Dong-Jun Lin

Open Access Review

Recent advances in bioprinting techniques: approaches, applications and future prospects

Jipeng Li, Mingjiao Chen, Xianqun Fan, Huifang Zhou

Open Access Commentary

Continued importance in translation from research to health policy in China

Jun Zhang, Fan Jiang, Xiaoming Shen

Open Access Meeting report

Immunoscore and Immunoprofiling in cancer: an update from the melanoma and immunotherapy bridge 2015

J. Galon, B. A. Fox, C. B. Bifulco, G. Masucci, T. Rau, G. Botti, F. M. Marincola, G. Ciliberto, F. Pages, P. A. Ascierto, M. Capone

Open Access Research

Non-invasive detection of 2-hydroxyglutarate in IDH-mutated gliomas using two-dimensional localized correlation spectroscopy (2D L-COSY) at 7 Tesla

Gaurav Verma, Suyash Mohan, MacLean P. Nasrallah, Steven Brem, John Y. K. Lee, Sanjeev Chawla, Sumei Wang, Rajakumar Nagarajan, M. Albert Thomas, Harish Poptani

Open Access Research

Immunogenic FEAT protein circulates in the bloodstream of cancer patients

Yan Li, Kyosuke Kobayashi, Marwa M. Mona, Chikako Satomi, Shinji Okano, Hiroyuki Inoue, Kenzaburo Tani, Atsushi Takahashi

Open Access Research

Leptin decreases the expression of low-density lipoprotein receptor via PCSK9 pathway: linking dyslipidemia with obesity

Ying Du, Sha Li, Chuan-Jue Cui, Yan Zhang, Sheng-Hua Yang, Jian-Jun Li

Open Access Research

Inhibition of complement improves graft outcome in a pig model of kidney autotransplantation

Pierre-Olivier Delpech, Raphael Thuillier, Thibault SaintYves, Jerome Danion, Sylvain Le Pape, Edwin S. van Amersfoort, Beatrijs Oortwijn, Gilles Blancho, Thierry Hauet

Open Access Research

Small cell lung cancer growth is inhibited by miR-342 through its effect of the target gene IA-2

Huanyu Xu, Tao Cai, Gilberto N. Carmona, Liron Abuhatzira, Abner L. Notkins

Open Access Erratum

Erratum to: Oncolytic virus efficiency inhibited growth of tumour cells with multiple drug resistant phenotype in vivo and in vitro

Elena P. Goncharova, Julia S. Ruzhenkova, Ivan S. Petrov, Sergey N. Shchelkunov, Marina A. Zenkova

Open Access Research

The fibrolytic potentials of vitamin D and thymoquinone remedial therapies: insights from liver fibrosis established by CCl4 in rats

Abdelghany Hassan Abdelghany, Mohammad A. BaSalamah, Shakir Idris, Jawwad Ahmad, Bassem Refaat

Open Access Research

Gemcitabine reduces MDSCs, tregs and TGFβ-1 while restoring the teff/treg ratio in patients with pancreatic cancer

Emma Eriksson, Jessica Wenthe, Sandra Irenaeus, Angelica Loskog, Gustav Ullenhag

Open Access Research

IL-27 attenuates airway inflammation in a mouse asthma model via the STAT1 and GADD45γ/p38 MAPK pathways

Xiaoqiong Su, Jue Pan, Fengxi Bai, Honglei Yuan, Nian Dong, Dandan Li, Xiangdong Wang, Zhihong Chen

Open Access Research

Walking performance is positively correlated to calf muscle fiber size in peripheral artery disease subjects, but fibers show aberrant mitophagy: an observational study

Sarah H. White, Mary M. McDermott, Robert L. Sufit, Kate Kosmac, Alex W. Bugg, Marta Gonzalez-Freire, Luigi Ferrucci, Lu Tian, Lihui Zhao, Ying Gao, Melina R. Kibbe, Michael H. Criqui, Christiaan Leeuwenburgh, Charlotte A. Peterson

Open Access Research

Ion channels expression and function are strongly modified in solid tumors and vascular malformations

Antonella Biasiotta, Daniela D’Arcangelo, Francesca Passarelli, Ezio Maria Nicodemi, Antonio Facchiano

Open Access Research

Discovery of immunodominant T-cell epitopes reveals penton protein as a second immunodominant target in human adenovirus infection

Sabine Tischer, René Geyeregger, Julian Kwoczek, Albert Heim, Constanca Figueiredo, Rainer Blasczyk, Britta Maecker-Kolhoff, Britta Eiz-Vesper

Open Access Research

A multiplex urinary immunoassay for bladder cancer detection: analysis of a Japanese cohort

Steve Goodison, Osamu Ogawa, Yoshiyuki Matsui, Takashi Kobayashi, Makito Miyake, Sayuri Ohnishi, Kiyohide Fujimoto, Yunfeng Dai, Yoshiko Shimizu, Kazue Tsukikawa, Hideki Furuya, Charles J. Rosser

Open Access Review

Retroviral vectors and transposons for stable gene therapy: advances, current challenges and perspectives

José Eduardo Vargas, Leonardo Chicaybam, Renato Tetelbom Stein, Amilcar Tanuri, Andrés Delgado-Cañedo, Martin H. Bonamino

Open Access Research

Increased urinary CD80 excretion and podocyturia in Fabry disease

H. Trimarchi, R. Canzonieri, A. Schiel, C. Costales-Collaguazo, J. Politei, A. Stern, M. Paulero, T. Rengel, J. Andrews, M. Forrester, M. Lombi, V. Pomeranz, R. Iriarte, A. Muryan, E. Zotta, M. D. Sanchez-Niño, A. Ortiz

Open Access Research

Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males

Tatiana Moro, Grant Tinsley, Antonino Bianco, Giuseppe Marcolin, Quirico Francesco Pacelli, Giuseppe Battaglia, Antonio Palma, Paulo Gentil, Marco Neri, Antonio Paoli

Open Access Research

China suboptimal health cohort study: rationale, design and baseline characteristics

Youxin Wang, Siqi Ge, Yuxiang Yan, Anxin Wang, Zhongyao Zhao, Xinwei Yu, Jing Qiu, Mohamed Ali Alzain, Hao Wang, Honghong Fang, Qing Gao, Manshu Song, Jie Zhang, Yong Zhou, Wei Wang

Open Access Research

Prognostic impact of KRAS, NRAS, BRAF, and PIK3CA mutations in primary colorectal carcinomas: a population-based study

Grazia Palomba, Valentina Doneddu, Antonio Cossu, Panagiotis Paliogiannis, Antonella Manca, Milena Casula, Maria Colombino, Annamaria Lanzillo, Efisio Defraia, Antonio Pazzola, Giovanni Sanna, Carlo Putzu, Salvatore Ortu, Mario Scartozzi, Maria Teresa Ionta, Giovanni Baldino, Giuseppina Sarobba, Francesca Capelli, Tito Sedda, Luciano Virdis, Michela Barca, Giulia Gramignano, Mario Budroni, Francesco Tanda, Giuseppe Palmieri

Open Access Erratum

Erratum to: miRNAs and sports: tracking training status and potentially confounding diagnoses

Anne Hecksteden, Petra Leidinger, Christina Backes, Stefanie Rheinheimer, Mark Pfeiffer, Alexander Ferrauti, Michael Kellmann, Farbod Sedaghat-Hamedani, Benjamin Meder, Eckart Meese, Tim Meyer, Andreas Keller

Open Access Research

Effect of helium pre- or postconditioning on signal transduction kinases in patients undergoing coronary artery bypass graft surgery

Kirsten F. Smit, Daniel Brevoord, Stefan De Hert, Bas A. de Mol, Raphaela P. Kerindongo, Susan van Dieren, Wolfgang S. Schlack, Markus W. Hollmann, Nina C. Weber, Benedikt Preckel

Open Access Meeting report

Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway

Ana I. Robles, Karina Standahl Olsen, Dana W.T. Tsui, Vassilis Georgoulias, Jenette Creaney, Katalin Dobra, Mogens Vyberg, Nagahiro Minato, Robert A. Anders, Anne-Lise Børresen-Dale, Jianwei Zhou, Pål Sætrom, Boye Schnack Nielsen, Michaela B. Kirschner, Hans E. Krokan, Vassiliki Papadimitrakopoulou, Ioannis Tsamardinos, Oluf D. Røe

Open Access Research

Clinical outcomes in ALK-rearranged lung adenocarcinomas according to ALK fusion variants

Yoon Jin Cha, Hye Ryun Kim, Hyo Sup Shim

Open Access Review

Exosomes in tumor microenvironment: novel transporters and biomarkers

Zhen Wang, Jun-Qiang Chen, Jin-lu Liu, Lei Tian

Open Access Review

Microbiota and neurologic diseases: potential effects of probiotics

Giulia Umbrello, Susanna Esposito

Open Access Research

Impact of aging on host immune response and survival in melanoma: an analysis of 3 patient cohorts

Sarah A. Weiss, Joseph Han, Farbod Darvishian, Jeremy Tchack, Sung Won Han, Karolina Malecek, Michelle Krogsgaard, Iman Osman, Judy Zhong

Open Access Research

Human endometrial regenerative cells alleviate carbon tetrachloride-induced acute liver injury in mice

Shanzheng Lu, Ganggang Shi, Xiaoxi Xu, Grace Wang, Xu Lan, Peng Sun, Xiang Li, Baoren Zhang, Xiangying Gu, Thomas E. Ichim, Hao Wang

Open Access Research

Pulsed high-dose dexamethasone modulates Th1-/Th2-chemokine imbalance in immune thrombocytopenia

Zongtang Liu, Meiying Wang, Shufen Zhou, Ji Ma, Yan Shi, Jun Peng, Ming Hou, Chengshan Guo

Open Access Research

Mesenchymal stromal cells derived from cervical cancer produce high amounts of adenosine to suppress cytotoxic T lymphocyte functions

María de Lourdes Mora-García, Rosario García-Rocha, Omar Morales-Ramírez, Juan José Montesinos, Benny Weiss-Steider, Jorge Hernández-Montes, Luis Roberto Ávila-Ibarra, Christian Azucena Don-López, Marco Antonio Velasco-Velázquez, Vianey Gutiérrez-Serrano, Alberto Monroy-García

Open Access Research

Integrins β1 and β3 are biomarkers of uterine condition for embryo transfer

Guowu Chen, Aijie Xin, Yulin Liu, Changgen Shi, Junling Chen, Xiaofeng Tang, Ying Chen, Min Yu, Xiandong Peng, Lu Li, Xiaoxi Sun

Open Access Commentary

Does upregulated host cell receptor expression provide a link between bacterial adhesion and chronic respiratory disease?

Ronan F. O’Toole, Shakti D. Shukla, Eugene H. Walters

Open Access Research

Intraoperative hemidiaphragm electrical stimulation reduces oxidative stress and upregulates autophagy in surgery patients undergoing mechanical ventilation: exploratory study

Robert T. Mankowski, Shakeel Ahmed, Thomas Beaver, Marvin Dirain, Chul Han, Phillip Hess, Tomas Martin, Barbara K. Smith, Shinichi Someya, Christiaan Leeuwenburgh, A. Daniel Martin

Open Access Research

Angiopoietin-2 impairs collateral artery growth associated with the suppression of the infiltration of macrophages in mouse hindlimb ischaemia

Xiaoyong Tan, Kai Yan, Meiping Ren, Ni Chen, Yongjie Li, Xin Deng, Liqun Wang, Rong Li, Mao Luo, Yong Liu, Yan Liu, Jianbo Wu

Open Access Research

Putrescine treatment reverses α-tocopherol-induced desynchronization of polyamine and retinoid metabolism during rat liver regeneration

Lourdes Sánchez-Sevilla, Edgar Mendieta-Condado, Rolando Hernández-Muñoz

Open Access Research

A proof-of-concept study with the tyrosine kinase inhibitor nilotinib in spondyloarthritis

Jacqueline E. Paramarta, Maureen C. Turina, Troy Noordenbos, Tanja F. Heijda, Iris C. Blijdorp, Nataliya Yeremenko, Dominique Baeten

Open Access Erratum

Erratum to: Early administration of trimetazidine attenuates diabetic cardiomyopathy in rats by alleviating fibrosis, reducing apoptosis and enhancing autophagy

Lei Zhang, Wen-yuan Ding, Zhi-hao Wang, Meng-xiong Tang, Feng Wang, Ya Li, Ming Zhong, Yun Zhang, Wei Zhang

Open Access Research

Immunological profiling of patients with ulcerative colitis leads to identification of two inflammatory conditions and CD1a as a disease marker

M. Föhlinger, P. Palamides, U. Mansmann, F. Beigel, M. Siebeck, R. Gropp

Open Access Research

Effects by periodontitis on pristane-induced arthritis in rats

Kaja Eriksson, Erik Lönnblom, Gregory Tour, Anna Kats, Piotr Mydel, Pierre Georgsson, Catharina Hultgren, Nastya Kharlamova, Ulrika Norin, Jörgen Jönsson, Anna Lundmark, Annelie Hellvard, Karin Lundberg, Leif Jansson, Rikard Holmdahl, Tülay Yucel-Lindberg

Open Access Research

Soluble programmed cell death receptor-1 (sPD-1): a potential biomarker with anti-inflammatory properties in human and experimental acute respiratory distress syndrome (ARDS)

Sean F. Monaghan, Chun-Shiang Chung, Yaping Chen, Joanne Lomas-Neira, William G. Fairbrother, Daithi S. Heffernan, William G. Cioffi, Alfred Ayala

Open Access Meeting report

Future perspectives in melanoma research

Paolo A. Ascierto, Sanjiv Agarwala, Gerardo Botti, Alessandra Cesano, Gennaro Ciliberto, Michael A. Davies, Sandra Demaria, Reinhard Dummer, Alexander M. Eggermont, Soldano Ferrone, Yang Xin Fu, Thomas F. Gajewski, Claus Garbe, Veronica Huber, Samir Khleif, Michael Krauthammer, Roger S. Lo, Giuseppe Masucci, Giuseppe Palmieri, Michael Postow, Igor Puzanov, Ann Silk, Stefani Spranger, David F. Stroncek, Ahmad Tarhini, Janis M. Taube, Alessandro Testori, Ena Wang, Jennifer A. Wargo, Cassian Yee, Hassane Zarour, Laurence Zitvogel, Bernard A. Fox, Nicola Mozzillo, Francesco M. Marincola, Magdalena Thurin

Open Access Research

Safety and feasibility of cell-based therapy of autologous bone marrow-derived mononuclear cells in plate-stabilized proximal humeral fractures in humans

Caroline Seebach, Dirk Henrich, Simon Meier, Christoph Nau, Halvard Bonig, Ingo Marzi

Open Access Review

Action mechanism and cardiovascular effect of anthocyanins: a systematic review of animal and human studies

Jordano Ferreira Reis, Valter Vinicius Silva Monteiro, Rafaelli de Souza Gomes, Matheus Moraes do Carmo, Glauber Vilhena da Costa, Paula Cardoso Ribera, Marta Chagas Monteiro

Open Access Research

Changes in ceftriaxone pharmacokinetics/pharmacodynamics during the early phase of sepsis: a prospective, experimental study in the rat

Valentina Selmi, Beatrice Loriga, Luca Vitali, Martina Carlucci, Alessandro Di Filippo, Giulio Carta, Eleonora Sgambati, Lorenzo Tofani, Angelo Raffaele De Gaudio, Andrea Novelli, Chiara Adembri

Open Access Research

An ex vivo human cartilage repair model to evaluate the potency of a cartilage cell transplant

Christoph Bartz, Miriam Meixner, Petra Giesemann, Giulietta Roël, Grit-Carsta Bulwin, Jeske J. Smink

Open Access Erratum

Erratum to: The expression of CXCL13 and its relation to unfavorable clinical characteristics in young breast cancer

Lujia Chen, Zhongxi Huang, Guangyu Yao, Xiaoming Lyu, Jinbang Li, Xiaolei Hu, Yahong Cai, Wenji Li, Changsheng Ye, Xin Li

Open Access Research

Culture expansion of adipose derived stromal cells. A closed automated Quantum Cell Expansion System compared with manual flask-based culture

Mandana Haack-Sørensen, Bjarke Follin, Morten Juhl, Sonja K. Brorsen, Rebekka H. Søndergaard, Jens Kastrup, Annette Ekblond

Open Access Research

E-cadherin genetic variants predict survival outcome in breast cancer patients

Hager Memni, Yosra Macherki, Zahra Klayech, Ahlem Ben-Haj-Ayed, Karim Farhat, Yassmine Remadi, Sallouha Gabbouj, Wijden Mahfoudh, Nadia Bouzid, Noureddine Bouaouina, Lotfi Chouchane, Abdelfattah Zakhama, Elham Hassen

Open Access Research

AQP5-1364A/C polymorphism and the AQP5 expression influence sepsis survival and immune cell migration: a prospective laboratory and patient study

Katharina Rump, Matthias Unterberg, Lars Bergmann, Agnes Bankfalvi, Anil Menon, Simon Schäfer, André Scherag, Zainab Bazzi, Winfried Siffert, Jürgen Peters, Michael Adamzik

Open Access Review

Next-generation sequencing in thyroid cancer

Yoon Jin Cha, Ja Seung Koo

Open Access Research

A novel non-Hodgkin lymphoma murine model closer to the standard clinical scenario

Thais Bascuas, María Moreno, Amy Mónaco, Laura Reyes, Andrea Paolino, Patricia Oliver, María G. Kramer, Henry Engler, José P. Pacheco, Sofía Grille, José A. Chabalgoity

Open Access Review

Bridging the gap between clinicians and systems biologists: from network biology to translational biomedical research

Natini Jinawath, Sacarin Bunbanjerdsuk, Maneerat Chayanupatkul, Nuttapong Ngamphaiboon, Nithi Asavapanumas, Jisnuson Svasti, Varodom Charoensawan

Open Access Research

BoHV-4-based vector delivering Ebola virus surface glycoprotein

Alfonso Rosamilia, Sarah Jacca, Giulia Tebaldi, Silvia Tiberti, Valentina Franceschi, Francesca Macchi, Sandro Cavirani, Gary Kobinger, Donald P. Knowles, Gaetano Donofrio

Open Access Research

Performance evaluation of the touchscreen-based Muse™ Auto CD4/CD4% single-platform system for CD4 T cell numeration in absolute number and in percentage using blood samples from children and adult patients living in the Central African Republic

Christian Diamant Mossoro-Kpinde, André Kouabosso, Ralph-Sydney Mboumba Bouassa, Jean De Dieu Longo, Edouard Kokanzo, Rosine Féissona, Gérard Grésenguet, Laurent Bélec

Open Access Research

Targeted myocardial gene expression in failing hearts by RNA sequencing

Kajari Dhar, Alexandra M. Moulton, Eric Rome, Fang Qiu, Jeff Kittrell, Eugenia Raichlin, Ronald Zolty, John Y. Um, Michael J. Moulton, Hesham Basma, Daniel R. Anderson, James D. Eudy, Brian D. Lowes

Open Access Research

Analysis of long noncoding RNA expression in hepatocellular carcinoma of different viral etiology

Quan Zhang, Kentaro Matsuura, David E. Kleiner, Fausto Zamboni, Harvey J. Alter, Patrizia Farci

Open Access Commentary

Developing translational medicine professionals: the Marie Skłodowska-Curie action model

Alessandra Petrelli, Berent J. Prakken, Norman D. Rosenblum

Open Access Meeting report

Bridging the gap to therapeutic strategies based on connexin/pannexin biology

Christian C. Naus, Christian Giaume

Open Access Research

The magnitude of nephron number reduction mediates intrauterine growth-restriction-induced long term chronic renal disease in the rat. A comparative study in two experimental models

Farid Boubred, Laurent Daniel, Christophe Buffat, Michel Tsimaratos, Charles Oliver, Martine Lelièvre-Pégorier, Umberto Simeoni

Open Access Research

Factors affecting long-term efficacy of T regulatory cell-based therapy in type 1 diabetes

Natalia Marek-Trzonkowska, Małgorzata Myśliwiec, Dorota Iwaszkiewicz-Grześ, Mateusz Gliwiński, Ilona Derkowska, Magdalena Żalińska, Maciej Zieliński, Marcelina Grabowska, Hanna Zielińska, Karolina Piekarska, Anna Jaźwińska-Curyłło, Radosław Owczuk, Agnieszka Szadkowska, Krystyna Wyka, Piotr Witkowski, Wojciech Młynarski, Przemysława Jarosz-Chobot, Artur Bossowski, Janusz Siebert, Piotr Trzonkowski

Open Access Research

CDKN2B methylation is associated with carotid artery calcification in ischemic stroke patients

Shuyu Zhou, Yumeng Zhang, Li Wang, Zhizhong Zhang, Biyang Cai, Keting Liu, Hao Zhang, Minhui Dai, Lingli Sun, Xiaomeng Xu, Huan Cai, Xinfeng Liu, Guangming Lu, Gelin Xu

Open Access Commentary

Sickle cell vaso-occlusive crisis: it’s a gut feeling

Seah H. Lim, Loren Fast, Alison Morris

Open Access Review

Intestinal dysbiosis and allogeneic hematopoietic progenitor cell transplantation

Vikram M. Raghunathan, Iris Sheng, Seah H. Lim

Open Access Research

Thyroid hormones associate with risk of incident chronic kidney disease and rapid decline in renal function: a prospective investigation

Xiaolin Huang, Lin Ding, Kui Peng, Lin Lin, Tiange Wang, Zhiyun Zhao, Yu Xu, Jieli Lu, Yuhong Chen, Weiqing Wang, Yufang Bi, Guang Ning, Min Xu

Open Access Research

PDGF-AA mediates mesenchymal stromal cell chemotaxis to the head and neck squamous cell carcinoma tumor microenvironment

Tammara L. Watts, Ruwen Cui, Peter Szaniszlo, Vicente A. Resto, Don W. Powell, Irina V. Pinchuk

Open Access Research

Hyperbranched polyglycerol is superior to glucose for long-term preservation of peritoneal membrane in a rat model of chronic peritoneal dialysis

Caigan Du, Asher A. Mendelson, Qiunong Guan, Ghida Dairi, Irina Chafeeva, Gerald da Roza, Jayachandran N. Kizhakkedathu

Open Access Research

FGFR1 and NTRK3 actionable alterations in “Wild-Type” gastrointestinal stromal tumors

Eileen Shi, Juliann Chmielecki, Chih-Min Tang, Kai Wang, Michael C. Heinrich, Guhyun Kang, Christopher L. Corless, David Hong, Katherine E. Fero, James D. Murphy, Paul T. Fanta, Siraj M. Ali, Martina De Siena, Adam M. Burgoyne, Sujana Movva, Lisa Madlensky, Gregory M. Heestand, Jonathan C. Trent, Razelle Kurzrock, Deborah Morosini, Jeffrey S. Ross, Olivier Harismendy, Jason K. Sicklick

Open Access Research

Colonization of xenograft tumors by oncolytic vaccinia virus (VACV) results in enhanced tumor killing due to the involvement of myeloid cells

Mehmet Okyay Kilinc, Klaas Ehrig, Maysam Pessian, Boris R. Minev, Aladar A. Szalay

Open Access Research

Directed differentiation of human iPSC into insulin producing cells is improved by induced expression of PDX1 and NKX6.1 factors in IPC progenitors

Maciej P. Walczak, Anna M. Drozd, Ewelina Stoczynska-Fidelus, Piotr Rieske, Dawid P. Grzela

Open Access Commentary

Association of mitochondrial DNA variants with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) symptoms

Maureen R. Hanson, Zhenglong Gu, Alon Keinan, Kaixiong Ye, Arnaud Germain, Paul Billing-Ross

Open Access Research

Repressed SIRT1/PGC-1α pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration

Nady Golestaneh, Yi Chu, Shuk Kei Cheng, Hong Cao, Eugenia Poliakov, Daniel M. Berinstein

Open Access Research

Does therapeutic hypothermia during extracorporeal cardiopulmonary resuscitation preserve cardiac function?

Harald A. Bergan, Per S. Halvorsen, Helge Skulstad, Erik Fosse, Jan F. Bugge

Open Access Research

LncRNA MALAT1 promotes development of mantle cell lymphoma by associating with EZH2

Xin Wang, Lalit Sehgal, Neeraj Jain, Tamer Khashab, Rohit Mathur, Felipe Samaniego

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Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

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