Ausgabe 1/2011
Inhalt (88 Artikel)
Localization of sequence variations in PGC-1α influence their modifying effect in Huntington disease
Hong Van B Che, Silke Metzger, Esteban Portal, Carolin Deyle, Olaf Riess, Huu Phuc Nguyen
6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death
Alison I Bernstein, Sean P Garrison, Gerard P Zambetti, Karen L O'Malley
Flipping the switches: CD40 and CD45 modulation of microglial activation states in HIV associated dementia (HAD)
Jon Salemi, Demian F Obregon, Anthony Cobb, Spenser Reed, Edin Sadic, Jingji Jin, Francisco Fernandez, Jun Tan, Brian Giunta
Brimonidine prevents axonal and somatic degeneration of retinal ganglion cell neurons
Wendi S Lambert, Lupe Ruiz, Samuel D Crish, Larry A Wheeler, David J Calkins
MyD88-adaptor protein acts as a preventive mechanism for memory deficits in a mouse model of Alzheimer's disease
Jean-Philippe Michaud, Karine L Richard, Serge Rivest
Leucine-rich repeat kinase 2 and alpha-synuclein: intersecting pathways in the pathogenesis of Parkinson's disease?
Elisa Greggio, Marco Bisaglia, Laura Civiero, Luigi Bubacco
Preclinical study of dimebon on β-amyloid-mediated neuropathology in Alzheimer's disease
Jun Wang, Mario G Ferruzzi, Merina Varghese, Xianjuan Qian, Alice Cheng, Mathew Xie, Wei Zhao, Lap Ho, Giulio M Pasinetti
Glutathione Peroxidase 4 is associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson's brain
Frederick P Bellinger, Miyoko T Bellinger, Lucia A Seale, Andrea S Takemoto, Arjun V Raman, Takanori Miki, Amy B Manning-Boğ, Marla J Berry, Lon R White, G Webster Ross
A novel neuron-enriched protein SDIM1 is down regulated in Alzheimer's brains and attenuates cell death induced by DNAJB4 over-expression in neuro-progenitor cells
Joy X Lei, Cristina G Cassone, Christian Luebbert, Qing Yan Liu
Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation
Richard C Davis, Ian T Marsden, Michael T Maloney, Laurie S Minamide, Marcia Podlisny, Dennis J Selkoe, James R Bamburg
Pathophysiology, treatment, and animal and cellular models of human ischemic stroke
Trent M Woodruff, John Thundyil, Sung-Chun Tang, Christopher G Sobey, Stephen M Taylor, Thiruma V Arumugam
Tyrosine Phosphorylation of Tau by the Src Family Kinases Lck and Fyn
Timothy ME Scales, Pascal Derkinderen, Kit-Yi Leung, Helen L Byers, Malcolm A Ward, Caroline Price, Ian N Bird, Timothy Perera, Stuart Kellie, Ritchie Williamson, Brian H Anderton, C Hugh Reynolds
Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway
Huang Guo, Theresa M Barrett, Zhihui Zhong, José A Fernández, John H Griffin, Robert S Freeman, Berislav V Zlokovic
Inhibition of RhoA GTPase and the subsequent activation of PTP1B protects cultured hippocampal neurons against amyloid β toxicity
Pedro J Chacon, Rosa Garcia-Mejias, Alfredo Rodriguez-Tebar
Reciprocal relationship between APP positioning relative to the membrane and PS1 conformation
Kengo Uemura, Katherine C Farner, Navine Nasser-Ghodsi, Phill Jones, Oksana Berezovska
TRPM8 and Nav1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons
Robert J Gasperini, Xu Hou, Helena Parkington, Harry Coleman, David W Klaver, Adele J Vincent, Lisa C Foa, David H Small
Differential regulation of BACE1 expression by oxidative and nitrosative signals
Young-Don Kwak, Ruishan Wang, Jing Jing Li, Yun-Wu Zhang, Huaxi Xu, Francesca-Fang Liao
A new role for interferon gamma in neural stem/precursor cell dysregulation
Janine Walter, Silke D Honsek, Sebastian Illes, Jennifer M Wellen, Hans-Peter Hartung, Christine R Rose, Marcel Dihné
Extracellular and intraneuronal HMW-AbetaOs represent a molecular basis of memory loss in Alzheimer's disease model mouse
Ayumi Takamura, Yasuhide Okamoto, Takeshi Kawarabayashi, Tatsuki Yokoseki, Masao Shibata, Akihiro Mouri, Toshitaka Nabeshima, Hui Sun, Koji Abe, Tsuneo Urisu, Naoki Yamamoto, Mikio Shoji, Katsuhiko Yanagisawa, Makoto Michikawa, Etsuro Matsubara
Transcriptional Regulation of TMP21 by NFAT
Shengchun Liu, Si Zhang, Kelley Bromley-Brits, Fang Cai, Weihui Zhou, Kun Xia, Jill Mittelholtz, Weihong Song
T cell mediated cerebral hemorrhages and microhemorrhages during passive Aβ immunization in APPPS1 transgenic mice
Melanie Meyer-Luehmann, J Rodrigo Mora, Matthew Mielke, Tara L Spires-Jones, Alix de Calignon, Ulrich H von Andrian, Bradley T Hyman
Impairment of brain endothelial glucose transporter by methamphetamine causes blood-brain barrier dysfunction
P M Abdul Muneer, Saleena Alikunju, Adam M Szlachetka, L Charles Murrin, James Haorah
Generation and Characterization of a genetic zebrafish model of SMA carrying the human SMN2gene
Le T Hao, Arthur HM Burghes, Christine E Beattie
Sensory-motor deficits and neurofilament disorganization in gigaxonin-null mice
Thibault Ganay, Alexia Boizot, Renaud Burrer, Jean Paul Chauvin, Pascale Bomont
Biology and pathophysiology of the amyloid precursor protein
Hui Zheng, Edward H Koo
A mutation in the dynein heavy chain gene compensates for energy deficit of mutant SOD1 mice and increases potentially neuroprotective IGF-1
Anissa Fergani, Judith Eschbach, Hugues Oudart, Yves Larmet, Birgit Schwalenstocker, Albert C Ludolph, Jean-Philippe Loeffler, Luc Dupuis
Lack of neuroprotection in the absence of P2X7 receptors in toxin-induced animal models of Parkinson's disease
Zsuzsanna Hracskó, Mária Baranyi, Cecilia Csölle, Flóra Gölöncsér, Emilia Madarász, Ágnes Kittel, Beáta Sperlágh
Cu, Zn-superoxide dismutase 1 (SOD1) is a novel target of Puromycin-sensitive aminopeptidase (PSA/NPEPPS): PSA/NPEPPS is a possible modifier of amyotrophic lateral sclerosis
Guijie Ren, Zhongcai Ma, Maria Hui, Lili C Kudo, Koon-Sea Hui, Stanislav L Karsten
Similarities and differences in structure, expression, and functions of VLDLR and ApoER2
Sunil S Reddy, Teal E Connor, Edwin J Weeber, William Rebeck
Gene expression endophenotypes: a novel approach for gene discovery in Alzheimer's disease
Nilüfer Ertekin-Taner
PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease
Elahe Taherzadeh-Fard, Carsten Saft, Denis A Akkad, Stefan Wieczorek, Aiden Haghikia, Andrew Chan, Jörg T Epplen, Larissa Arning
Rheumatoid arthritis-associated polymorphisms are not protective against Alzheimer's disease
Christopher R Simmons, Fanggeng Zou, Steven G Younkin, Steven Estus
Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation
Fanjun Meng, Dongdong Yao, Yang Shi, Jonathan Kabakoff, Wei Wu, Joshua Reicher, Yuliang Ma, Bernd Moosmann, Eliezer Masliah, Stuart A Lipton, Zezong Gu
Anchored FRET sensors detect local caspase activation prior to neuronal degeneration
Ricardo A Figueroa, Veronica Ramberg, Tom Gatsinzi, Malin Samuelsson, Mu Zhang, Kerstin Iverfeldt, Einar Hallberg
DJ-1 can inhibit microtubule associated protein 1 B formed aggregates
Zhiquan Wang, Yu Zhang, Shi Zhang, Qianqian Guo, Yuyan Tan, Xinyi Wang, Ran Xiong, Jianqing Ding, Shengdi Chen
Molecular interplay between leptin, insulin-like growth factor-1, and β-amyloid in organotypic slices from rabbit hippocampus
Gurdeep Marwarha, Jaya RP Prasanthi, Jared Schommer, Bhanu Dasari, Othman Ghribi
Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo
Hermann C Altmeppen, Johannes Prox, Berta Puig, Mark A Kluth, Christian Bernreuther, Dana Thurm, Ellen Jorissen, Bettina Petrowitz, Udo Bartsch, Bart De Strooper, Paul Saftig, Markus Glatzel
Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons
Qiuli Liang, Xiaosen Ouyang, Lonnie Schneider, Jianhua Zhang
Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice
Cristian A Lasagna-Reeves, Diana L Castillo-Carranza, Urmi Sengupta, Audra L Clos, George R Jackson, Rakez Kayed
Pleiotrophin over-expression provides trophic support to dopaminergic neurons in parkinsonian rats
Irene RE Taravini, Mariela Chertoff, Eduardo G Cafferata, José Courty, Mario G Murer, Fernando J Pitossi, Oscar S Gershanik
Disruption of the NF-κB/IκBα Autoinhibitory Loop Improves Cognitive Performance and Promotes Hyperexcitability of Hippocampal Neurons
David J Shim, Li Yang, J Graham Reed, Jeffrey L Noebels, Paul J Chiao, Hui Zheng
Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats
Yoshihisa Kitamura, Shotaro Watanabe, Masanobu Taguchi, Kentaro Takagi, Takuya Kawata, Kazuko Takahashi-Niki, Hiroyuki Yasui, Hiroshi Maita, Sanae MM Iguchi-Ariga, Hiroyoshi Ariga
Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration
Arunkumar Asaithambi, Arthi Kanthasamy, Hariharan Saminathan, Vellareddy Anantharam, Anumantha G Kanthasamy
Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neurons
Cha-Gyun Jung, Kyung-Ok Uhm, Yutaka Miura, Takashi Hosono, Hirofumi Horike, Kum Kum Khanna, Mi-Jeong Kim, Makoto Michikawa
Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease
Xiao-dong Pan, Yuan-gui Zhu, Nan Lin, Jing Zhang, Qin-yong Ye, Hua-pin Huang, Xiao-chun Chen
BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina
Jeffrey M Harder, Richard T Libby
Bovine spongiform encephalopathy infection alters endogenous retrovirus expression in distinct brain regions of cynomolgus macaques (Macaca fascicularis)
Alex D Greenwood, Michelle Vincendeau, Ann-Christin Schmädicke, Judith Montag, Wolfgang Seifarth, Dirk Motzkus
Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis
Wei Zhao, Merina Varghese, Shrishailam Yemul, Yong Pan, Alice Cheng, Paul Marano, Sadiq Hassan, Prashant Vempati, Fei Chen, Xianjuan Qian, Giulio M Pasinetti
Replication of EPHA1 and CD33 associations with late-onset Alzheimer's disease: a multi-centre case-control study
Minerva M Carrasquillo, Olivia Belbin, Talisha A Hunter, Li Ma, Gina D Bisceglio, Fanggeng Zou, Julia E Crook, V Shane Pankratz, Sigrid B Sando, Jan O Aasly, Maria Barcikowska, Zbigniew K Wszolek, Dennis W Dickson, Neill R Graff-Radford, Ronald C Petersen, Peter Passmore, Kevin Morgan, Steven G Younkin
Mutant Prpf31 causes pre-mRNA splicing defects and rod photoreceptor cell degeneration in a zebrafish model for Retinitis pigmentosa
Jun Yin, Jan Brocher, Utz Fischer, Christoph Winkler
A Wnt1 regulated Frizzled-1/β-Cateninsignaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection
Francesca L'Episcopo, Maria F Serapide, Cataldo Tirolo, Nunzio Testa, Salvatore Caniglia, Maria C Morale, Stefano Pluchino, Bianca Marchetti
Upregulation of cathepsin D in the caudate nucleus of primates with experimental parkinsonism
Sowmya V Yelamanchili, Amrita Datta Chaudhuri, Claudia T Flynn, Howard S Fox
C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress
Jodi Meyerowitz, Sarah J Parker, Laura J Vella, Dominic CH Ng, Katherine A Price, Jeffrey R Liddell, Aphrodite Caragounis, Qiao-Xin Li, Colin L Masters, Takashi Nonaka, Masato Hasegawa, Marie A Bogoyevitch, Katja M Kanninen, Peter J Crouch, Anthony R White
An organotypic slice culture model of chronic white matter injury with maturation arrest of oligodendrocyte progenitors
Justin M Dean, Art Riddle, Jennifer Maire, Kelly D Hansen, Marnie Preston, Anthony P Barnes, Larry S Sherman, Stephen A Back
Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: mechanism for deficient glutamatergic transmission?
Markel Olabarria, Harun N Noristani, Alexei Verkhratsky, José J Rodríguez
High-level inhibition of mitochondrial complexes III and IV is required to increase glutamate release from the nerve terminal
Seán M Kilbride, Sonia A Gluchowska, Jayne E Telford, Catherine O'Sullivan, Gavin P Davey
Renin angiotensin system and gender differences in dopaminergic degeneration
Ana I Rodriguez-Perez, Rita Valenzuela, Belen Joglar, Pablo Garrido-Gil, Maria J Guerra, Jose L Labandeira-Garcia
TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6
Fabienne C Fiesel, Christine Schurr, Stephanie S Weber, Philipp J Kahle
Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons
Subbiah Pugazhenthi, Maorong Wang, Serena Pham, Chun-I Sze, Christopher B Eckman
A glycine zipper motif mediates the formation of toxic β-amyloid oligomers in vitro and in vivo
Virginia Fonte, Vishantie Dostal, Christine M Roberts, Patrick Gonzales, Pascale Lacor, Jordi Magrane, Natalie Dingwell, Emily Y Fan, Michael A Silverman, Gretchen H Stein, Christopher D Link
Alzheimer's disease: synapses gone cold
Robert M Koffie, Bradley T Hyman, Tara L Spires-Jones
Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease
Jeffrey B Carroll, Amber L Southwell, Rona K Graham, Jason P Lerch, Dagmar E Ehrnhoefer, Li-Ping Cao, Wei-Ning Zhang, Yu Deng, Nagat Bissada, R Mark Henkelman, Michael R Hayden
Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk
Christopher R Simmons, Fanggeng Zou, Steven G Younkin, Steven Estus
Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold
Andreas M Grabrucker, Michael J Schmeisser, Patrick T Udvardi, Magali Arons, Michael Schoen, Nathaniel S Woodling, Katrin I Andreasson, Patrick R Hof, Joseph D Buxbaum, Craig C Garner, Tobias M Boeckers
Decreased expression of B cell related genes in leukocytes of women with Parkinson's disease
Merav Kedmi, Anat Bar-Shira, Tanya Gurevich, Nir Giladi, Avi Orr-Urtreger
Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function
Charlotte Delay, Frédéric Calon, Paul Mathews, Sébastien S Hébert
Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders
Leslie Crews, Rebecca Ruf, Christina Patrick, Wilmar Dumaop, Margarita Trejo-Morales, Cristian L Achim, Edward Rockenstein, Eliezer Masliah
Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo
Amandine Jullienne, Axel Montagne, Cyrille Orset, Flavie Lesept, David E Jane, Daniel T Monaghan, Eric Maubert, Denis Vivien, Carine Ali
Conditional BDNF release under pathological conditions improves Huntington's disease pathology by delaying neuronal dysfunction
Albert Giralt, Olga Carretón, Cristina Lao-Peregrin, Eduardo D Martín, Jordi Alberch
Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease
Hong Jiang, Harald Hampel, David Prvulovic, Anders Wallin, Kaj Blennow, Rena Li, Yong Shen
Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice
Ya-Fei Xu, Yong-Jie Zhang, Wen-Lang Lin, Xiangkun Cao, Caroline Stetler, Dennis W Dickson, Jada Lewis, Leonard Petrucelli
Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity
Xavier Xifró, Marta Anglada-Huguet, Laura Rué, Ana Saavedra, Esther Pérez-Navarro, Jordi Alberch
Dopamine and α-synuclein dysfunction in Smad3 null mice
Silvia Tapia-González, Rosa M Giráldez-Pérez, M Isabel Cuartero, M José Casarejos, M Ángeles Mena, Xiao-Fan Wang, Amelia Sánchez-Capelo
Generation and characterization of transgenic mice expressing mitochondrial targeted red fluorescent protein selectively in neurons: modeling mitochondriopathy in excitotoxicity and amyotrophic lateral sclerosis
Yi Wang, Yan Pan, Ann Price, Lee J Martin
Dantrolene is neuroprotective in Huntington's disease transgenic mouse model
Xi Chen, Jun Wu, Svetlana Lvovskaya, Emily Herndon, Charlene Supnet, Ilya Bezprozvanny
Coordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alcα with a new ELISA system
Tomoko Konno, Saori Hata, Yukiko Hamada, Yuko Horikoshi-Sakuraba, Tadashi Nakaya, Yuhki Saito, Tohru Yamamoto, Takayuki Yamamoto, Masahiro Maeda, Takeshi Ikeuchi, Sam Gandy, Hiroyasu Akatsu, Toshiharu Suzuki
Superoxide dismutase 1 encoding mutations linked to ALS adopts a spectrum of misfolded states
Mercedes Prudencio, David R Borchelt
Aberrant septin 11 is associated with sporadic frontotemporal lobar degeneration
Yair M Gozal, Nicholas T Seyfried, Marla Gearing, Jonathan D Glass, Craig J Heilman, Joanne Wuu, Duc M Duong, Dongmei Cheng, Qiangwei Xia, Howard D Rees, Jason J Fritz, Deborah S Cooper, Junmin Peng, Allan I Levey, James J Lah
Resorufin analogs preferentially bind cerebrovascular amyloid: potential use as imaging ligands for cerebral amyloid angiopathy
Byung Hee Han, Meng-liang Zhou, Ananth K Vellimana, Eric Milner, David H Kim, Jacob K Greenberg, Wenhua Chu, Robert H Mach, Gregory J Zipfel
Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice
Ping Gong, Jelita Roseman, Celia G Fernandez, Kulandaivelu S Vetrivel, Vytautas P Bindokas, Lois A Zitzow, Satyabrata Kar, Angèle T Parent, Gopal Thinakaran
Adult hippocampal neurogenesis and its role in Alzheimer's disease
Yangling Mu, Fred H Gage
The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb
Tharinda W Rajapaksha, William A Eimer, Thomas C Bozza, Robert Vassar
Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons
Yofre Cabeza-Arvelaiz, Sheila M Fleming, Franziska Richter, Eliezer Masliah, Marie-Francoise Chesselet, Robert H Schiestl
Mitosis-specific phosphorylation of amyloid precursor protein at Threonine 668 leads to its altered processing and association with centrosomes
Monique Judge, Lisa Hornbeck, Huntington Potter, Jaya Padmanabhan
Fractalkine/CX3CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death
Masami Suzuki, Nazira El-Hage, Shiping Zou, Yun-Kyung Hahn, Mary E Sorrell, Jamie L Sturgill, Daniel H Conrad, Pamela E Knapp, Kurt F Hauser
Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα
Bin Xing, Adam D Bachstetter, Linda J Van Eldik
Transthyretin and the brain re-visited: Is neuronal synthesis of transthyretin protective in Alzheimer's disease?
Xinyi Li, Joel N Buxbaum
Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo
Paramita Chakrabarty, Amanda Herring, Carolina Ceballos-Diaz, Pritam Das, Todd E Golde