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Die Ophthalmologie

Erschienen in:

01.03.2021 | Peeling | Leitthema

Biomarker bei durchgreifenden und lamellären Defekten der Makula

verfasst von: Prof. M. Maier, FEBO, R. Schumann, J. Friedrich, J. Klaas, C. Haritoglou

Erschienen in: Die Ophthalmologie | Ausgabe 4/2021

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Zusammenfassung

Hintergrund

Unter „Biomarker“ versteht man „biologische Marker“, die objektiv auf den Gesundheitszustand hinweisen können. Neben funktionellen und zeitlichen Faktoren haben insbesondere bildgebende Biomarker in den letzten Jahren an Bedeutung gewonnen. Bei durchgreifenden und lamellären Defekten der Makula wurden zahlreiche bildgebende Parameter beschrieben. Diese Erkenntnisse führten für beide Krankheitsbilder zu neuen Einteilungen, die sich auf wichtige „Biomarker“ dieser Krankheitsbilder und charakteristische Merkmale beschriebener Unterformen stützen.

Methode

Bildgebende Biomarker für durchgreifende und lamelläre Defekte der Makula werden im Hinblick auf die Klassifikation und ihre funktionelle prognostische Bedeutung beschrieben. Die Bedeutung dieser Biomarker wird dargestellt.

Ergebnisse

Biomarker sind die Grundlage für die aktuelle Klassifikation von durchgreifenden und lamellären Makuladefekten. Biomarker dienen weiterhin zur prognostischen und therapeutischen Einschätzung und beeinflussen die operative Strategie. Zur Behandlung eines durchgreifenden Makulaforamens gibt es abhängig von der Foramengröße und anderen Biomarkern verschiedene operative Strategien. So erhöht die invertierte ILM(„internal limiting membrane“)-Flap-Technik die Verschlussrate bei großen Makulaforamina. Zeigt ein Makulaschichtforamen eine deutliche Progredienz des Befundes, so ermöglicht eine frühzeitige operative Intervention eine gute anatomische und funktionelle Prognose.

Schlussfolgerung

Die multimodale Diagnostik liefert bei Makulaforamen und Makulaschichtforamen wichtige prä-, intra- und postoperative Merkmale, die als Biomarker für die genaue Klassifikation, die Therapiestrategie sowie die Beurteilung der Prognose von herausragender Bedeutung sind.

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Titel: Biomarker bei durchgreifenden und lamellären Defekten der Makula
verfasst von: Prof. M. Maier, FEBO
R. Schumann
J. Friedrich
J. Klaas
C. Haritoglou
Publikationsdatum: 01.03.2021
Verlag: Springer Medizin
Schlagwörter: Peeling
Biomarker
Erschienen in: Die Ophthalmologie / Ausgabe 4/2021
Print ISSN: 2731-720X
Elektronische ISSN: 2731-7218
DOI: https://doi.org/10.1007/s00347-021-01340-5

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Biomarker bei durchgreifenden und lamellären Defekten der Makula

Zusammenfassung

Hintergrund

Methode

Ergebnisse

Schlussfolgerung

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

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Update Augenheilkunde

Springer Medizin

Zusammenfassung

Hintergrund

Methode

Ergebnisse

Schlussfolgerung

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