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Zeitschrift

Journal of Neuroinflammation

Journal of Neuroinflammation 1/2015

Ausgabe 1/2015

Inhaltsverzeichnis ( 245 Artikel )

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Vitamin D deficiency decreases survival of bacterial meningoencephalitis in mice

Marija Djukic, Nadine Sostmann, Thomas Bertsch, Marianne Mecke, Stefan Nessler, Anja Manig, Uwe-Karsten Hanisch, Jakob Triebel, L Cornelius Bollheimer, Cornel Sieber, Roland Nau

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Retinal pericytes and cytomegalovirus infectivity: implications for HCMV-induced retinopathy and congenital ocular disease

Irene Wilkerson, Joshua Laban, Johnathan M Mitchell, Nader Sheibani, Donald J Alcendor

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Spermine reverses lipopolysaccharide-induced memory deficit in mice

Pâmella Karina Santana Frühauf, Rafael Porto Ineu, Lediane Tomazi, Thiago Duarte, Carlos Fernando Mello, Maribel Antonello Rubin

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Activation of toll like receptor 4 attenuates GABA synthesis and postsynaptic GABA receptor activities in the spinal dorsal horn via releasing interleukin-1 beta

Xisheng Yan, Enshe Jiang, Han-Rong Weng

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism

Nikenza Viceconte, Miguel A Burguillos, Antonio J Herrera, Rocío M De Pablos, Bertrand Joseph, José L Venero

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Differences in the distribution, phenotype and gene expression of subretinal microglia/macrophages in C57BL/6N (Crb1rd8/rd8) versus C57BL6/J (Crb1wt/wt) mice

Bogale Aredo, Kaiyan Zhang, Xiao Chen, Cynthia Xin-Zhao Wang, Tao Li, Rafael L Ufret-Vincenty

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer’s disease through inhibition of inflammation

Tarja Malm, Monica Mariani, Lauren J Donovan, Lee Neilson, Gary E Landreth

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Chemokine-mediated inflammation in the degenerating retina is coordinated by Müller cells, activated microglia, and retinal pigment epithelium

Matt Rutar, Riccardo Natoli, RX Chia, Krisztina Valter, Jan M Provis

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Anti-inflammatory effects of BHBA in both in vivo and in vitro Parkinson’s disease models are mediated by GPR109A-dependent mechanisms

Shou-Peng Fu, Jian-Fa Wang, Wen-Jing Xue, Hong-Mei Liu, Bing-run Liu, Ya-Long Zeng, Su-Nan Li, Bing-Xu Huang, Qing-Kang Lv, Wei Wang, Ju-Xiong Liu

01.12.2015 | Research | Ausgabe 1/2015 Open Access

The spinal anti-inflammatory mechanism of motor cortex stimulation: cause of success and refractoriness in neuropathic pain?

Guilherme D Silva, Patrícia SS Lopes, Erich T Fonoff, Rosana L Pagano

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Scutellarin regulates the Notch pathway and affects the migration and morphological transformation of activated microglia in experimentally induced cerebral ischemia in rats and in activated BV-2 microglia

Yun Yuan, Parakalan Rangarajan, Enci Mary Kan, Yajun Wu, Chunyun Wu, Eng-Ang Ling

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Anti-inflammatory T-cell shift in neuropathic pain

Benjamin Luchting, Banafscheh Rachinger-Adam, Jens Heyn, Ludwig Christian Hinske, Simone Kreth, Shahnaz Christina Azad

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Lipopolysaccharide binding protein, interleukin-10, interleukin-6 and C-reactive protein blood levels in acute ischemic stroke patients with post-stroke infection

Hans Worthmann, Anita B Tryc, Meike Dirks, Ramona Schuppner, Korbinian Brand, Frank Klawonn, Ralf Lichtinghagen, Karin Weissenborn

01.12.2015 | Research | Ausgabe 1/2015 Open Access

CCAAT/enhancer binding protein β directly regulates the expression of the complement component 3 gene in neural cells: implications for the pro-inflammatory effects of this transcription factor

Elena Hernandez-Encinas, Diana Aguilar-Morante, Marta Cortes-Canteli, Jose A Morales-Garcia, Elena Gine, Angel Santos, Ana Perez-Castillo

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Pentraxin 3 mediates neurogenesis and angiogenesis after cerebral ischaemia

Beatriz Rodriguez-Grande, Lidiya Varghese, Francisco Molina-Holgado, Olivera Rajkovic, Cecilia Garlanda, Adam Denes, Emmanuel Pinteaux

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Protective role of fingolimod (FTY720) in rats subjected to subarachnoid hemorrhage

Hao-Liang Xu, Dale A Pelligrino, Chanannait Paisansathan, Fernando D Testai

01.12.2015 | Research | Ausgabe 1/2015 Open Access

In vivo multi-modal imaging of experimental autoimmune uveoretinitis in transgenic reporter mice reveals the dynamic nature of inflammatory changes during disease progression

Xiangting Chen, Jelena M Kezic, John V Forrester, Gabrielle L Goldberg, Ian P Wicks, Claude C Bernard, Paul G McMenamin

01.12.2015 | Research | Ausgabe 1/2015 Open Access

NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model

Chen-Chen Tan, Jian-Guo Zhang, Meng-Shan Tan, Hua Chen, Da-Wei Meng, Teng Jiang, Xiang-Fei Meng, Ying Li, Zhen Sun, Meng-Meng Li, Jin-Tai Yu, Lan Tan

01.12.2015 | Research | Ausgabe 1/2015 Open Access

The cerebrospinal fluid immunoglobulin transcriptome and proteome in neuromyelitis optica reveals central nervous system-specific B cell populations

Markus C Kowarik, Monika Dzieciatkowska, Scott Wemlinger, Alanna M Ritchie, Bernhard Hemmer, Gregory P Owens, Jeffrey L Bennett

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Deferoxamine attenuates lipopolysaccharide-induced neuroinflammation and memory impairment in mice

Xiao-Ying Zhang, Jiang-Bei Cao, Li-Ming Zhang, Yun-Feng Li, Wei-Dong Mi

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons

Giorgio Santoni, Claudio Cardinali, Maria Beatrice Morelli, Matteo Santoni, Massimo Nabissi, Consuelo Amantini

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Beneficial effect of chronic Staphylococcus aureus infection in a model of multiple sclerosis is mediated through the secretion of extracellular adherence protein

Prateek Kumar, Benedikt Kretzschmar, Sabine Herold, Roland Nau, Mario Kreutzfeldt, Sandra Schütze, Mathias Bähr, Katharina Hein

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Anti-inflammatory activity of Wnt signaling in enteric nervous system: in vitro preliminary evidences in rat primary cultures

Rosa Di Liddo, Thomas Bertalot, Anne Schuster, Sandra Schrenk, Alessia Tasso, Ilenia Zanusso, Maria Teresa Conconi, Karl Herbert Schäfer

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Treatment with AMD3100 attenuates the microglial response and improves outcome after experimental stroke

Helene L Walter, Gerlinde van der Maten, Ana Rita Antunes, Tadeusz Wieloch, Karsten Ruscher

01.12.2015 | Research | Ausgabe 1/2015 Open Access

MiR-27a ameliorates inflammatory damage to the blood-spinal cord barrier after spinal cord ischemia: reperfusion injury in rats by downregulating TICAM-2 of the TLR4 signaling pathway

Xiao-Qian Li, Huang-Wei Lv, Zhi-Lin Wang, Wen-Fei Tan, Bo Fang, Hong Ma

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Attenuation of acute stroke injury in rat brain by minocycline promotes blood–brain barrier remodeling and alternative microglia/macrophage activation during recovery

Yirong Yang, Victor M Salayandia, Jeffrey F Thompson, Lisa Y Yang, Eduardo Y Estrada, Yi Yang

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Liver X receptor-dependent inhibition of microglial nitric oxide synthase 2

Julie R Secor McVoy, Hanadi Ajam Oughli, Unsong Oh

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Active immunization with myelin-derived altered peptide ligand reduces mechanical pain hypersensitivity following peripheral nerve injury

Chamini J Perera, Samuel S Duffy, Justin G Lees, Cristina F Kim, Barbara Cameron, Vasso Apostolopoulos, Gila Moalem-Taylor

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Involvement of sigma-1 receptor in astrocyte activation induced by methamphetamine via up-regulation of its own expression

Yuan Zhang, Xuan Lv, Ying Bai, Xinjian Zhu, Xiaodong Wu, Jie Chao, Ming Duan, Shilpa Buch, Ling Chen, Honghong Yao

01.12.2015 | Research | Ausgabe 1/2015 Open Access

miR-146a suppresses cellular immune response during Japanese encephalitis virus JaOArS982 strain infection in human microglial cells

Nikhil Sharma, Ruhi Verma, Kanhaiya Lal Kumawat, Anirban Basu, Sunit K Singh

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Toll-like receptor 4 inhibition within the paraventricular nucleus attenuates blood pressure and inflammatory response in a genetic model of hypertension

Rahul B Dange, Deepmala Agarwal, Ryoichi Teruyama, Joseph Francis

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Sexually dimorphic outcomes and inflammatory responses in hypoxic-ischemic encephalopathy

Mehwish A Mirza, Rodney Ritzel, Yan Xu, Louise D McCullough, Fudong Liu

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Transcription factor myocyte enhancer factor 2D regulates interleukin-10 production in microglia to protect neuronal cells from inflammation-induced death

Shaosong Yang, Li Gao, Fangfang Lu, Bao Wang, Fei Gao, Gang Zhu, Zhibiao Cai, Juan Lai, Qian Yang

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Docosahexaenoic acid (DHA): a modulator of microglia activity and dendritic spine morphology

Philip K-Y Chang, Armen Khatchadourian, Rebecca Anne McKinney, Dusica Maysinger

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Human mesenchymal stem/stromal cells suppress spinal inflammation in mice with contribution of pituitary adenylate cyclase-activating polypeptide (PACAP)

Tomomi Tsumuraya, Hirokazu Ohtaki, Dandan Song, Atsushi Sato, Jun Watanabe, Yutaka Hiraizumi, Tomoya Nakamachi, Zhifang Xu, Kenji Dohi, Hitoshi Hashimoto, Takashi Atsumi, Seiji Shioda

01.12.2015 | Research | Ausgabe 1/2015 Open Access

RNA sequencing reveals distinct mechanisms underlying BET inhibitor JQ1-mediated modulation of the LPS-induced activation of BV-2 microglial cells

Kyoung Hwa Jung, Amitabh Das, Jin Choul Chai, Sun Hwa Kim, Nishi Morya, Kyoung Sun Park, Young Seek Lee, Young Gyu Chai

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Systemic lipopolysaccharide-mediated alteration of cortical neuromodulation involves increases in monoamine oxidase-A and acetylcholinesterase activity

Zhi Ming, Caitlin A Wotton, Robert T Appleton, John C Ching, Matthew E Loewen, Grzegorz Sawicki, Lane K Bekar

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Mesial temporal lobe epilepsy with psychiatric comorbidities: a place for differential neuroinflammatory interplay

Ludmyla Kandratavicius, Jose Eduardo Peixoto-Santos, Mariana Raquel Monteiro, Renata Caldo Scandiuzzi, Carlos Gilberto Carlotti Jr, Joao Alberto Assirati Jr, Jaime Eduardo Hallak, Joao Pereira Leite

01.12.2015 | Research | Ausgabe 1/2015 Open Access

MCP-induced protein 1 mediates the minocycline-induced neuroprotection against cerebral ischemia/reperfusion injury in vitro and in vivo

Zhuqing Jin, Jian Liang, Jing Wang, Pappachan E Kolattukudy

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Effect of thymic stimulation of CD4+ T cell expansion on disease onset and progression in mutant SOD1 mice

Rebecca K Sheean, Richard H Weston, Nirma D Perera, Angela D’Amico, Stephen L Nutt, Bradley J Turner

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-β using BV2 microglial cells and APP/PS1 transgenic mice

Clare H Latta, Tiffany L Sudduth, Erica M Weekman, Holly M Brothers, Erin L Abner, Gabriel J Popa, Michael D Mendenhall, Floracita Gonzalez-Oregon, Kaitlyn Braun, Donna M Wilcock

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Attenuation of microglial activation in a mouse model of Alzheimer’s disease via NFAT inhibition

Lalida Rojanathammanee, Angela M Floden, Gunjan D Manocha, Colin K Combs

01.12.2015 | Short Report | Ausgabe 1/2015 Open Access

The matrix metalloproteinase inhibitor RS-130830 attenuates brain injury in experimental pneumococcal meningitis

Fabian D Liechti, Fabian Bächtold, Denis Grandgirard, David Leppert, Stephen L Leib

01.12.2015 | Research | Ausgabe 1/2015 Open Access

miR-15b/16 protects primary human retinal microvascular endothelial cells against hyperglycemia-induced increases in tumor necrosis factor alpha and suppressor of cytokine signaling 3

Eun-Ah Ye, Jena J Steinle

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Transiently lowering tumor necrosis factor-α synthesis ameliorates neuronal cell loss and cognitive impairments induced by minimal traumatic brain injury in mice

Renana Baratz, David Tweedie, Jia-Yi Wang, Vardit Rubovitch, Weiming Luo, Barry J Hoffer, Nigel H Greig, Chaim G Pick

01.12.2015 | Short report | Ausgabe 1/2015 Open Access

Anti-MOG antibodies are present in a subgroup of patients with a neuromyelitis optica phenotype

Anne-Katrin Pröbstel, Gabrielle Rudolf, Klaus Dornmair, Nicolas Collongues, Jean-Baptiste Chanson, Nicholas SR Sanderson, Raija LP Lindberg, Ludwig Kappos, Jérôme de Seze, Tobias Derfuss

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Brain endogenous angiotensin II receptor type 2 (AT2-R) protects against DOCA/salt-induced hypertension in female rats

Shu-Yan Dai, Wei Peng, Yu-Ping Zhang, Jian-Dong Li, Ying Shen, Xiao-Fei Sun

01.12.2015 | Short report | Ausgabe 1/2015 Open Access

Role of high mobility group box protein 1 (HMGB1) in peripheral blood from patients with multiple sclerosis

Sunny Malhotra, Nicolas Fissolo, Mar Tintoré, Ana Cristina Wing, Joaquin Castilló, Angela Vidal-Jordana, Xavier Montalban, Manuel Comabella

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Endogenous antibodies contribute to macrophage-mediated demyelination in a mouse model for CMT1B

Dennis Klein, Janos Groh, Andreas Weishaupt, Rudolf Martini

01.12.2015 | Short report | Ausgabe 1/2015 Open Access

EP2-PKA signaling is suppressed by triptolide in lipopolysaccharide-induced microglia activation

Ting Zhang, Xiaoli Gong, Guanzheng Hu, Xiaomin Wang

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner

Jie Pan, Jia-li Jin, Hui-ming Ge, Kai-lin Yin, Xiang Chen, Li-juan Han, Yan Chen, Lai Qian, Xiao-xi Li, Yun Xu

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells

Ewa Kozela, Ana Juknat, Nathali Kaushansky, Avraham Ben-Nun, Giovanni Coppola, Zvi Vogel

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Nuclear factor-κB activation in perihematomal brain tissue correlates with outcome in patients with intracerebral hemorrhage

Ze-Li Zhang, Yu-Guang Liu, Qi-Bing Huang, Hong-Wei Wang, Yan Song, Zhen-Kuan Xu, Feng Li

01.12.2015 | Research | Ausgabe 1/2015 Open Access

The induction of neuronal death by up-regulated microglial cathepsin H in LPS-induced neuroinflammation

Kai Fan, Daobo Li, Yanli Zhang, Chao Han, Junjie Liang, Changyi Hou, Hongliang Xiao, Kazuhiro Ikenaka, Jianmei Ma

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Prolactin in combination with interferon-β reduces disease severity in an animal model of multiple sclerosis

Simon Zhornitsky, Trina A Johnson, Luanne M Metz, Samuel Weiss, V Wee Yong

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Calcium dysregulation via L-type voltage-dependent calcium channels and ryanodine receptors underlies memory deficits and synaptic dysfunction during chronic neuroinflammation

Sarah C Hopp, Heather M D’Angelo, Sarah E Royer, Roxanne M Kaercher, Alexis M Crockett, Linda Adzovic, Gary L Wenk

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Inhibition of the spinal astrocytic JNK/MCP-1 pathway activation correlates with the analgesic effects of tanshinone IIA sulfonate in neuropathic pain

Jun Tang, Chao Zhu, Zhi-hong Li, Xiao-yu Liu, Shu-kai Sun, Ting Zhang, Zhuo-jing Luo, Hui Zhang, Wei-yan Li

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Role for cFMS in maintaining alternative macrophage polarization in SIV infection: implications for HIV neuropathogenesis

Lindsey Gerngross, Gabrielle Lehmicke, Aghilas Belkadi, Tracy Fischer

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Involvement of phosphatase and tensin homolog deleted from chromosome 10 in rodent model of neuropathic pain

Shi-Ying Huang, Chun-Sung Sung, Wu-Fu Chen, Chun-Hong Chen, Chien-Wei Feng, San-Nan Yang, Han-Chun Hung, Nan-Fu Chen, Pey-Ru Lin, San-Cher Chen, Hui-Min David Wang, Tian-Huei Chu, Ming-Hong Tai, Zhi-Hong Wen

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Inflammatory mediator release from primary rhesus microglia in response to Borrelia burgdorferi results from the activation of several receptors and pathways

Geetha Parthasarathy, Mario T Philipp

01.12.2015 | Research | Ausgabe 1/2015 Open Access

The inhibitory effect of mesenchymal stem cell on blood–brain barrier disruption following intracerebral hemorrhage in rats: contribution of TSG-6

Min Chen, Xifeng Li, Xin Zhang, Xuying He, Lingfeng Lai, Yanchao Liu, Guohui Zhu, Wei Li, Hui Li, Qinrui Fang, Zequn Wang, Chuanzhi Duan

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Mature oligodendrocytes actively increase in vivo cytoskeletal plasticity following CNS damage

Giuseppe Locatelli, Arianna Baggiolini, Bettina Schreiner, Pushpalatha Palle, Ari Waisman, Burkhard Becher, Thorsten Buch

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains

Linda Adzovic, Ashley E Lynn, Heather M D’Angelo, Alexis M Crockett, Roxanne M Kaercher, Sarah E Royer, Sarah C Hopp, Gary L Wenk

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury

Yonggang Li, Pamela J Lein, Gregory D Ford, Cuimei Liu, Kyndra C Stovall, Todd E White, Donald A Bruun, Teclemichael Tewolde, Alicia S Gates, Timothy J Distel, Monique C Surles-Zeigler, Byron D Ford

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Chronic intestinal inflammation alters hippocampal neurogenesis

Svetlana Zonis, Robert N Pechnick, Vladimir A Ljubimov, Michael Mahgerefteh, Kolja Wawrowsky, Kathrin S Michelsen, Vera Chesnokova

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1)-facilitated HIV restriction in astrocytes is regulated by miRNA-181a

Sudheesh Pilakka-Kanthikeel, Andrea Raymond, Venkata Subba Rao Atluri, Vidya Sagar, Shailendra K Saxena, Patricia Diaz, Semithe Chevelon, Michael Concepcion, Madhavan Nair

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Bone marrow-derived macrophages from aged rats are more responsive to inflammatory stimuli

James P Barrett, Derek A Costello, Joan O’Sullivan, Thelma R Cowley, Marina A Lynch

01.12.2015 | Erratum | Ausgabe 1/2015 Open Access

Erratum: Should development of Alzheimer’s disease-specific intravenous immunoglobulin be considered?

David A Loeffler

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic

Adam D Bachstetter, Scott J Webster, Danielle S Goulding, Jonathan E Morton, D Martin Watterson, Linda J Van Eldik

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3

Chao Li, Jun-nan Li, Joanne Kays, Miguel Guerrero, Grant D Nicol

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Soluble amyloid triggers a myeloid differentiation factor 88 and interferon regulatory factor 7 dependent neuronal type-1 interferon response in vitro

Myles Robert Minter, Bevan Scott Main, Kate Maree Brody, Moses Zhang, Juliet Marie Taylor, Peter John Crack

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Insulin-like growth factors and related proteins in plasma and cerebrospinal fluids of HIV-positive individuals

Hyeon-Sook Suh, Yungtai Lo, Namjong Choi, Scott Letendre, Sunhee C Lee

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Intravenous immunoglobulin (IVIg) dampens neuronal toll-like receptor-mediated responses in ischemia

Ker Zhing Lok, Milan Basta, Silvia Manzanero, Thiruma V Arumugam

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Rodent models of neuroinflammation for Alzheimer’s disease

Amir Nazem, Roman Sankowski, Michael Bacher, Yousef Al-Abed

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Association of brain immune genes with social behavior of inbred mouse strains

Li Ma, Sami Piirainen, Natalia Kulesskaya, Heikki Rauvala, Li Tian

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Early inflammatory mediator gene expression in two models of traumatic brain injury: ex vivo cortical slice in mice and in vivo cortical impact in piglets

David J Graber, Beth A Costine, William F Hickey

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Activated microglia/macrophage whey acidic protein (AMWAP) inhibits NFκB signaling and induces a neuroprotective phenotype in microglia

Alexander Aslanidis, Marcus Karlstetter, Rebecca Scholz, Sascha Fauser, Harald Neumann, Cora Fried, Markus Pietsch, Thomas Langmann

01.12.2015 | Commentary | Ausgabe 1/2015 Open Access

Role of IL-16 in CD4+ T cell-mediated regulation of relapsing multiple sclerosis

Dusanka S Skundric, William W Cruikshank, Jelena Drulovic

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Astrocyte response to IFN-γ limits IL-6-mediated microglia activation and progressive autoimmune encephalomyelitis

Carine Savarin, David R Hinton, Alice Valentin-Torres, Zhihong Chen, Bruce D Trapp, Cornelia C Bergmann, Stephen A Stohlman

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Function and mechanism of toll-like receptors in cerebral ischemic tolerance: from preconditioning to treatment

Peng-Fei Wang, Xiao-Yi Xiong, Jing Chen, Yan-Chun Wang, Wei Duan, Qing-Wu Yang

01.12.2015 | Short report | Ausgabe 1/2015 Open Access

Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells

Rea Pihlaja, Jatta Takkinen, Olli Eskola, Jenni Vasara, Francisco R López-Picón, Merja Haaparanta-Solin, Juha O Rinne

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects

Filipa L Cardoso, Jasmin Herz, Adelaide Fernandes, João Rocha, Bruno Sepodes, Maria A Brito, Dorian B McGavern, Dora Brites

01.12.2015 | Short Report | Ausgabe 1/2015 Open Access

A single dose of a neuron-binding human monoclonal antibody improves brainstem NAA concentrations, a biomarker for density of spinal cord axons, in a model of progressive multiple sclerosis

Bharath Wootla, Aleksandar Denic, Jens O Watzlawik, Arthur E Warrington, Moses Rodriguez

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Amyloid β peptide-induced inhibition of endothelial nitric oxide production involves oxidative stress-mediated constitutive eNOS/HSP90 interaction and disruption of agonist-mediated Akt activation

Folami Lamoke, Valeria Mazzone, Tiziana Persichini, Annamaria Maraschi, Michael Brennan Harris, Richard C Venema, Marco Colasanti, Micaela Gliozzi, Carolina Muscoli, Manuela Bartoli, Vincenzo Mollace

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Brain inflammation and hypertension: the chicken or the egg?

Pawel J Winklewski, Marek Radkowski, Magdalena Wszedybyl-Winklewska, Urszula Demkow

01.12.2015 | Research | Ausgabe 1/2015 Open Access

FTY720 attenuates excitotoxicity and neuroinflammation

Raffaela Cipriani, Juan Carlos Chara, Alfredo Rodríguez-Antigüedad, Carlos Matute

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Aging increases microglial proliferation, delays cell migration, and decreases cortical neurogenesis after focal cerebral ischemia

Ana Moraga, Jesús M Pradillo, Alicia García-Culebras, Sara Palma-Tortosa, Ivan Ballesteros, Macarena Hernández-Jiménez, María A Moro, Ignacio Lizasoain

01.12.2015 | Research | Ausgabe 1/2015 Open Access

CCAAT/enhancer-binding protein δ (C/EBPδ) aggravates inflammation and bacterial dissemination during pneumococcal meningitis

Mercedes Valls Serón, JanWillem Duitman, Madelijn Geldhoff, JooYeon Engelen-Lee, Stefan R Havik, Matthijs C Brouwer, Diederik van de Beek, C Arnold Spek

01.12.2015 | Research | Ausgabe 1/2015 Open Access

4′-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation

Andrea Chicca, Maria Salomé Gachet, Vanessa Petrucci, Wolfgang Schuehly, Roch-Philippe Charles, Jürg Gertsch

01.12.2015 | Short report | Ausgabe 1/2015 Open Access

Absence of toll-like receptor 4 (TLR4) extends survival in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

Jia Y Lee, John D Lee, Simon Phipps, Peter G Noakes, Trent M Woodruff

01.12.2015 | Short report | Ausgabe 1/2015 Open Access

Autoantigen cross-reactive environmental antigen can trigger multiple sclerosis-like disease

Catherine J Reynolds, Malcolm J W Sim, Kathryn J Quigley, Daniel M Altmann, Rosemary J Boyton

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Who let the dogs out?: detrimental role of Galectin-3 in hypoperfusion-induced retinal degeneration

Oscar Manouchehrian, Karin Arnér, Tomas Deierborg, Linnéa Taylor

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson’s disease

Elvira Valera, Michael Mante, Scott Anderson, Edward Rockenstein, Eliezer Masliah

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Oral administration of cytosolic PLA2 inhibitor arachidonyl trifluoromethyl ketone ameliorates cauda equina compression injury in rats

Mushfiquddin Khan, Anandakumar Shunmugavel, Tajinder S Dhammu, Fumiyo Matsuda, Avtar K Singh, Inderjit Singh

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Vaccine-induced Aβ-specific CD8+ T cells do not trigger autoimmune neuroinflammation in a murine model of Alzheimer’s disease

Martine Bruley Rosset, Gabrielle Lui, Cira Dansokho, Thomas Chaigneau, Guillaume Dorothée

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Evidence for a distinct neuro-immune signature in rats that develop behavioural disability after nerve injury

Paul J Austin, Annika M Berglund, Sherman Siu, Nathan T Fiore, Michelle B Gerke-Duncan, Suzanne L Ollerenshaw, Sarah-Jane Leigh, Priya A Kunjan, James WM Kang, Kevin A Keay

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Differential expression and clinical significance of three inflammation-related microRNAs in gangliogliomas

A. S. Prabowo, J. van Scheppingen, A. M. Iyer, J. J. Anink, W. G. M. Spliet, P. C. van Rijen, A. Y. N. Schouten-van Meeteren, E. Aronica

01.12.2015 | Research | Ausgabe 1/2015 Open Access

CXCR2 is essential for cerebral endothelial activation and leukocyte recruitment during neuroinflammation

Fengjiao Wu, Yawei Zhao, Tian Jiao, Dongyan Shi, Xingxing Zhu, Mingshun Zhang, Meiqing Shi, Hong Zhou

01.12.2015 | Research | Ausgabe 1/2015 Open Access

The role of PPAR activation during the systemic response to brain injury

Patrick Losey, Emma Ladds, Maud Laprais, Borna Geuvel, Laura Burns, Regis Bordet, Daniel C Anthony

01.12.2015 | Research | Ausgabe 1/2015 Open Access

TANK-binding kinase 1 (TBK1) modulates inflammatory hyperalgesia by regulating MAP kinases and NF-κB dependent genes

Christine V. Möser, Heike Stephan, Katharina Altenrath, Katharina L. Kynast, Otto Q. Russe, Katrin Olbrich, Gerd Geisslinger, Ellen Niederberger

01.12.2015 | Research | Ausgabe 1/2015 Open Access

The role of the prostaglandin E2 receptors in vulnerability of oligodendrocyte precursor cells to death

Noel G. Carlson, Satya Bellamkonda, Linda Schmidt, Jonathan Redd, Thomas Huecksteadt, Lauren Marissa Weber, Ethan Davis, Blair Wood, Takayuki Maruyama, John W. Rose

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Heat stress-induced memory impairment is associated with neuroinflammation in mice

Wonil Lee, Minho Moon, Hyo Geun Kim, Tae Hee Lee, Myung Sook Oh

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Electroacupuncture remediates glial dysfunction and ameliorates neurodegeneration in the astrocytic α-synuclein mutant mouse model

Jiahui Deng, E Lv, Jian Yang, Xiaoli Gong, Wenzhong Zhang, Xibin Liang, Jiazeng Wang, Jun Jia, Xiaomin Wang

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Inhibition of NADPH oxidase activation reduces EAE-induced white matter damage in mice

Bo Young Choi, Jin Hee Kim, A Ra Kho, In Yeol Kim, Song Hee Lee, Bo Eun Lee, Eunhi Choi, Min Sohn, Mackenzie Stevenson, Tae Nyoung Chung, Tiina M Kauppinen, Sang Won Suh

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Sensitivity of spiral ganglion neurons to damage caused by mobile phone electromagnetic radiation will increase in lipopolysaccharide-induced inflammation in vitro model

Wen-Qi Zuo, Yu-Juan Hu, Yang Yang, Xue-Yan Zhao, Yuan-Yuan Zhang, Wen Kong, Wei-Jia Kong

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Functional differences between microglia and monocytes after ischemic stroke

Rodney M. Ritzel, Anita R. Patel, Jeremy M. Grenier, Joshua Crapser, Rajkumar Verma, Evan R. Jellison, Louise D. McCullough

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Immunoglobulins stimulate cultured Schwann cell maturation and promote their potential to induce axonal outgrowth

Nevena Tzekova, André Heinen, Sebastian Bunk, Corinna Hermann, Hans-Peter Hartung, Birgit Reipert, Patrick Küry

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Mapping neuroinflammation in frontotemporal dementia with molecular PET imaging

Jing Zhang

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Crosstalk between macrophages and astrocytes affects proliferation, reactive phenotype and inflammatory response, suggesting a role during reactive gliosis following spinal cord injury

Niels Haan, Bangfu Zhu, Jian Wang, Xiaoqing Wei, Bing Song

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans

Edwin B. Yan, Tony Frugier, Chai K. Lim, Benjamin Heng, Gayathri Sundaram, May Tan, Jeffrey V. Rosenfeld, David W. Walker, Gilles J. Guillemin, Maria Cristina Morganti-Kossmann

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Neuronal self-injury mediated by IL-1β and MMP-9 in a cerebral palsy model of severe neonatal encephalopathy induced by immune activation plus hypoxia-ischemia

Alexandre Savard, Marie-Elsa Brochu, Mathilde Chevin, Clémence Guiraut, Djordje Grbic, Guillaume Sébire

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Immunosuppressive potential of human amnion epithelial cells in the treatment of experimental autoimmune encephalomyelitis

Courtney A. McDonald, Natalie L. Payne, Guizhi Sun, Leon Moussa, Christopher Siatskas, Rebecca Lim, Euan M. Wallace, Graham Jenkin, Claude C.A. Bernard

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channels expression and impaired tight junction proteins integrity in rat brain

SKS Sarada, M Titto, P Himadri, S Saumya, V Vijayalakshmi

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Systemic inflammation and microglial activation: systematic review of animal experiments

Inge C.M. Hoogland, Carin Houbolt, David J. van Westerloo, Willem A. van Gool, Diederik van de Beek

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure

Maria H. Madeira, Filipe Elvas, Raquel Boia, Francisco Q. Gonçalves, Rodrigo A. Cunha, António Francisco Ambrósio, Ana Raquel Santiago

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Regulation of autophagy by the nuclear factor κB signaling pathway in the hippocampus of rats with sepsis

YunJie Su, Yi Qu, FengYan Zhao, HuaFeng Li, DeZhi Mu, XiHong Li

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Recombinant human PDCD5 (rhPDCD5) protein is protective in a mouse model of multiple sclerosis

Juan Xiao, Wenwei Liu, Yingyu Chen, Wenbin Deng

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Caspase-1 inhibitor ameliorates experimental autoimmune myasthenia gravis by innate dendric cell IL-1-IL-17 pathway

Cong-Cong Wang, Heng Li, Min Zhang, Xiao-Li Li, Long-Tao Yue, Peng Zhang, Yue Zhao, Shan Wang, Ruo-Nan Duan, Yan-Bin Li, Rui-Sheng Duan

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Interleukin-22 is increased in multiple sclerosis patients and targets astrocytes

Guillaume Perriard, Amandine Mathias, Lukas Enz, Mathieu Canales, Myriam Schluep, Melanie Gentner, Nicole Schaeren-Wiemers, Renaud A. Du Pasquier

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Chronic morphine and HIV-1 Tat promote differential central nervous system trafficking of CD3+ and Ly6C+ immune cells in a murine Streptococcus pneumoniae infection model

Raini Dutta, Sabita Roy

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Age-related increases in amyloid beta and membrane attack complex: evidence of inflammasome activation in the rodent eye

Tom Zhao, Jiangyuan Gao, Jenifer Van, Eleanor To, Aikun Wang, Sijia Cao, Jing Z. Cui, Jian-Ping Guo, Moonhee Lee, Patrick L. McGeer, Joanne A. Matsubara

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Cu(II) enhances the effect of Alzheimer’s amyloid-β peptide on microglial activation

Fengxiang Yu, Ping Gong, Zhuqin Hu, Yu Qiu, Yongyao Cui, Xiaoling Gao, Hongzhuan Chen, Juan Li

01.12.2015 | Research | Ausgabe 1/2015 Open Access

HLA-DRα1-mMOG-35-55 treatment of experimental autoimmune encephalomyelitis reduces CNS inflammation, enhances M2 macrophage frequency, and promotes neuroprotection

Gil Benedek, Roberto Meza-Romero, Kelley Jordan, Lucy Keenlyside, Halina Offner, Arthur A. Vandenbark

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Bee venom ameliorates lipopolysaccharide-induced memory loss by preventing NF-kappaB pathway

Sun Mi Gu, Mi Hee Park, Chul Ju Hwang, Ho Sueb Song, Ung Soo Lee, Sang Bae Han, Ki Wan Oh, Young Wan Ham, Min Jong Song, Dong Ju Son, Jin Tae Hong

01.12.2015 | Research | Ausgabe 1/2015 Open Access

TNF-dependent regulation and activation of innate immune cells are essential for host protection against cerebral tuberculosis

Ngiambudulu M. Francisco, Nai-Jen Hsu, Roanne Keeton, Philippa Randall, Boipelo Sebesho, Nasiema Allie, Dhirendra Govender, Valerie Quesniaux, Bernhard Ryffel, Lauriston Kellaway, Muazzam Jacobs

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Tumor necrosis factor-α enhances voltage-gated Na+ currents in primary culture of mouse cortical neurons

Weiqiang Chen, Jiangtao Sheng, Jingfang Guo, Fenfei Gao, Xiangfeng Zhao, Jianping Dai, Gefei Wang, Kangsheng Li

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Humoral factors in ALS patients during disease progression

Jared Ehrhart, Adam J. Smith, Nicole Kuzmin-Nichols, Theresa A. Zesiewicz, Israt Jahan, R. Douglas Shytle, Seol-Hee Kim, Cyndy D. Sanberg, Tuan H. Vu, Clifton L. Gooch, Paul R. Sanberg, Svitlana Garbuzova-Davis

01.12.2015 | Research | Ausgabe 1/2015 Open Access

STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE

Ian L. McWilliams, Rajani Rajbhandari, Susan Nozell, Etty Benveniste, Laurie E. Harrington

01.12.2015 | Short report | Ausgabe 1/2015 Open Access

Increased CCL2, CCL3, CCL5, and IL-1β cytokine concentration in piriform cortex, hippocampus, and neocortex after pilocarpine-induced seizures

Gabriel M. Arisi, Maira L. Foresti, Khurshed Katki, Lee A. Shapiro

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Transcript analysis of laser capture microdissected white matter astrocytes and higher phenol sulfotransferase 1A1 expression during autoimmune neuroinflammation

Flora Guillot, Alexandra Garcia, Marion Salou, Sophie Brouard, David A. Laplaud, Arnaud B. Nicot

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Pro-inflammatory TNFα and IL-1β differentially regulate the inflammatory phenotype of brain microvascular endothelial cells

Simon J. O’Carroll, Dan Ting Kho, Rachael Wiltshire, Vicky Nelson, Odunayo Rotimi, Rebecca Johnson, Catherine E. Angel, E. Scott Graham

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Immune and Epstein-Barr virus gene expression in cerebrospinal fluid and peripheral blood mononuclear cells from patients with relapsing-remitting multiple sclerosis

Caterina Veroni, Fabiana Marnetto, Letizia Granieri, Antonio Bertolotto, Clara Ballerini, Anna Maria Repice, Lucia Schirru, Giancarlo Coghe, Eleonora Cocco, Eleni Anastasiadou, Maria Puopolo, Francesca Aloisi

01.12.2015 | Research | Ausgabe 1/2015 Open Access

β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia

Eun-Jung Lee, Hyun-Myung Ko, Yeon-Hui Jeong, Eun-Mi Park, Hee-Sun Kim

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Evidence for the involvement of gamma delta T cells in the immune response in Rasmussen encephalitis

Geoffrey C. Owens, Kate L. Erickson, Colin C. Malone, Calvin Pan, My N. Huynh, Julia W. Chang, Thabiso Chirwa, Harry V. Vinters, Gary W. Mathern, Carol A. Kruse

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Pathogenesis of intracranial aneurysm is mediated by proinflammatory cytokine TNFA and IFNG and through stochastic regulation of IL10 and TGFB1 by comorbid factors

Sanish Sathyan, Linda V. Koshy, Lekshmi Srinivas, H. V. Easwer, S. Premkumar, Suresh Nair, R. N. Bhattacharya, Jacob P. Alapatt, Moinak Banerjee

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Inhibition of NOX1/4 with GKT137831: a potential novel treatment to attenuate neuroglial cell inflammation in the retina

Devy Deliyanti, Jennifer L. Wilkinson-Berka

01.12.2015 | Research | Ausgabe 1/2015 Open Access

HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-κB pathway in acute glaucoma

Wei Chi, Hongrui Chen, Fei Li, Yingting Zhu, Wei Yin, Yehong Zhuo

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Voluntary exercise attenuates LPS-induced reductions in neurogenesis and increases microglia expression of a proneurogenic phenotype in aged mice

Alyssa M. Littlefield, Sharay E. Setti, Carolina Priester, Rachel A. Kohman

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice

Nabil N. Dagher, Allison R. Najafi, Kara M. Neely Kayala, Monica R. P. Elmore, Terra E. White, Rodrigo Medeiros, Brian L. West, Kim N. Green

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke

Samaneh Maysami, Michael J. Haley, Natalia Gorenkova, Siddharth Krishnan, Barry W McColl, Catherine B Lawrence

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Neuroinflammatory responses in diabetic retinopathy

Ying Yu, Hui Chen, Shao Bo Su

01.12.2015 | Erratum | Ausgabe 1/2015 Open Access

Erratum to: Insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains

Linda Adzovic, Ashley E Lynn, Heather M D’Angelo, Alexis M Crockett, Roxanne M Kaercher, Sarah E Royer, Sarah C Hopp, Gary L Wenk

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes

Elke Ydens, Dieter Demon, Guillaume Lornet, Vicky De Winter, Vincent Timmerman, Mohamed Lamkanfi, Sophie Janssens

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Pharmacological antagonism of interleukin-8 receptor CXCR2 inhibits inflammatory reactivity and is neuroprotective in an animal model of Alzheimer’s disease

Jae K Ryu, T Cho, Hyun B Choi, N Jantaratnotai, James G McLarnon

01.12.2015 | Research | Ausgabe 1/2015 Open Access

CD300f immunoreceptor contributes to peripheral nerve regeneration by the modulation of macrophage inflammatory phenotype

Hugo Peluffo, Patricia Solari-Saquieres, Maria Luciana Negro-Demontel, Isaac Francos-Quijorna, Xavier Navarro, Ruben López-Vales, Joan Sayós, Natalia Lago

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Natalizumab treatment reduces L-selectin (CD62L) in CD4+ T cells

Michela Spadaro, Marzia Caldano, Fabiana Marnetto, Alessandra Lugaresi, Antonio Bertolotto

01.12.2015 | Research | Ausgabe 1/2015 Open Access

1,25-Dihydroxyvitamin D3 attenuates endotoxin-induced production of inflammatory mediators by inhibiting MAPK activation in primary cortical neuron-glia cultures

Ya-Ni Huang, Yi-Jung Ho, Chien-Cheng Lai, Chien-Tsai Chiu, Jia-Yi Wang

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Chronic inflammatory demyelinating polyneuropathy (CIDP): change of serum IgG dimer levels during treatment with intravenous immunoglobulins

Christian Ritter, Ilja Bobylev, Helmar C. Lehmann

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Adjuvant treatment with dexamethasone plus anti-C5 antibodies improves outcome of experimental pneumococcal meningitis: a randomized controlled trial

E. Soemirien Kasanmoentalib, Mercedes Valls Seron, B. Paul Morgan, Matthijs C. Brouwer, Diederik van de Beek

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Active immunization against complement factor C5a: a new therapeutic approach for Alzheimer’s disease

Christine Landlinger, Lisa Oberleitner, Petra Gruber, Birgit Noiges, Kristyna Yatsyk, Radmila Santic, Markus Mandler, Guenther Staffler

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Endogenous BDNF augments NMDA receptor phosphorylation in the spinal cord via PLCγ, PKC, and PI3K/Akt pathways during colitis

Miao Liu, Jarren C Kay, Shanwei Shen, Li-Ya Qiao

01.12.2015 | Research | Ausgabe 1/2015 Open Access

The disruption of mitochondrial axonal transport is an early event in neuroinflammation

Oihana Errea, Beatriz Moreno, Alba Gonzalez-Franquesa, Pablo M. Garcia-Roves, Pablo Villoslada

01.12.2015 | Research | Ausgabe 1/2015 Open Access

An N-terminal antibody promotes the transformation of amyloid fibrils into oligomers and enhances the neurotoxicity of amyloid-beta: the dust-raising effect

Yu-Hui Liu, Xian-Le Bu, Chun-Rong Liang, Ye-Ran Wang, Tao Zhang, Shu-Sheng Jiao, Fan Zeng, Xiu-Qing Yao, Hua-Dong Zhou, Juan Deng, Yan-Jiang Wang

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Time-dependent effects of CX3CR1 in a mouse model of mild traumatic brain injury

Heidi Y. Febinger, Hannah E. Thomasy, Maria N. Pavlova, Kristyn M. Ringgold, Paulien R. Barf, Amrita M. George, Jenna N. Grillo, Adam D. Bachstetter, Jenny A. Garcia, Astrid E. Cardona, Mark R. Opp, Carmelina Gemma

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Osthole confers neuroprotection against cortical stab wound injury and attenuates secondary brain injury

Yang Xia, Liang Kong, Yingjia Yao, Yanan Jiao, Jie Song, Zhenyu Tao, Zhong You, Jingxian Yang

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Role of high-mobility group box 1 in methamphetamine-induced activation and migration of astrocytes

Yuan Zhang, Tiebing Zhu, Xiaotian Zhang, Jie Chao, Gang Hu, Honghong Yao

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Granzyme B-inhibitor serpina3n induces neuroprotection in vitro and in vivo

Yohannes Haile, Katia Carmine-Simmen, Camille Olechowski, Bradley Kerr, R. Chris Bleackley, Fabrizio Giuliani

01.12.2015 | Research | Ausgabe 1/2015 Open Access

The alternatively spliced fibronectin CS1 isoform regulates IL-17A levels and mechanical allodynia after peripheral nerve injury

Huaqing Liu, Jennifer Dolkas, Khan Hoang, Mila Angert, Andrei V. Chernov, Albert G. Remacle, Sergey A. Shiryaev, Alex Y. Strongin, Tasuku Nishihara, Veronica I. Shubayev

01.12.2015 | Letter to the Editor | Ausgabe 1/2015 Open Access

miRNAs and SAMHD1 regulation in vitro and in a model of HIV CNS disease

Kenneth W. Witwer, Erin L. Buchanan, Stephanie L. Myers, Melissa A. McAlexander

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Exposure of neonatal rats to alcohol has differential effects on neuroinflammation and neuronal survival in the cerebellum and hippocampus

Lauren A. Topper, Brian C. Baculis, C. Fernando Valenzuela

01.12.2015 | Research | Ausgabe 1/2015 Open Access

NG2-proteoglycan-dependent contributions of oligodendrocyte progenitors and myeloid cells to myelin damage and repair

Karolina Kucharova, William B. Stallcup

01.12.2015 | Short report | Ausgabe 1/2015 Open Access

Deep brain stimulation induces antiapoptotic and anti-inflammatory effects in epileptic rats

Beatriz O. Amorim, Luciene Covolan, Elenn Ferreira, José Geraldo Brito, Diego P. Nunes, David G. de Morais, José N. Nobrega, Antonio M. Rodrigues, Antonio Carlos G. deAlmeida, Clement Hamani

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Behavioural and neurobiological consequences of macrophage migration inhibitory factor gene deletion in mice

Cecilie Bay-Richter, Shorena Janelidze, Analise Sauro, Richard Bucala, Jack Lipton, Tomas Deierborg, Lena Brundin

01.12.2015 | Erratum | Ausgabe 1/2015 Open Access

Erratum to: Pathogenesis of intracranial aneurysm is mediated by proinflammatory cytokine TNFA and IFNG and through stochastic regulation of IL10 and TGFB1 by comorbid factors

Sanish Sathyan, Linda V. Koshy, Lekshmy Srinivas, H. V. Easwer, S. Premkumar, Suresh Nair, R. N. Bhattacharya, Jacob P. Alapatt, Moinak Banerjee

01.12.2015 | Research | Ausgabe 1/2015 Open Access

IL-17A is implicated in lipopolysaccharide-induced neuroinflammation and cognitive impairment in aged rats via microglial activation

Jie Sun, Susu Zhang, Xiang Zhang, Xiaobao Zhang, Hongquan Dong, Yanning Qian

01.12.2015 | Review | Ausgabe 1/2015 Open Access

‘Medusa head ataxia’: the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII

S. Jarius, B. Wildemann

01.12.2015 | Review | Ausgabe 1/2015 Open Access

‘Medusa head ataxia’: the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 2: Anti-PKC-gamma, anti-GluR-delta2, anti-Ca/ARHGAP26 and anti-VGCC

S. Jarius, B. Wildemann

01.12.2015 | Review | Ausgabe 1/2015 Open Access

‘Medusa head ataxia’: the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 3: Anti-Yo/CDR2, anti-Nb/AP3B2, PCA-2, anti-Tr/DNER, other antibodies, diagnostic pitfalls, summary and outlook

S. Jarius, B. Wildemann

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Immune profile of an atypical EAE model in marmoset monkeys immunized with recombinant human myelin oligodendrocyte glycoprotein in incomplete Freund’s adjuvant

S. Anwar Jagessar, Nicole Heijmans, Erwin L A Blezer, Jan Bauer, Robert Weissert, Bert A. ‘t Hart

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Mast cells in meningiomas and brain inflammation

Stavros Polyzoidis, Triantafyllia Koletsa, Smaro Panagiotidou, Keyoumars Ashkan, Theoharis C. Theoharides

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Lack of neuroinflammation in the HIV-1 transgenic rat: an [18F]-DPA714 PET imaging study

Dianne E. Lee, Xuyi Yue, Wael G. Ibrahim, Margaret R. Lentz, Kristin L. Peterson, Elaine M. Jagoda, Michael Kassiou, Dragan Maric, William C. Reid, Dima A. Hammoud

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Inhibition of NOX2 reduces locomotor impairment, inflammation, and oxidative stress after spinal cord injury

Guzal Khayrullina, Sara Bermudez, Kimberly R. Byrnes

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Interleukin-36γ is expressed by neutrophils and can activate microglia, but has no role in experimental autoimmune encephalomyelitis

Lusine Bozoyan, Aline Dumas, Alexandre Patenaude, Luc Vallières

01.12.2015 | Research | Ausgabe 1/2015 Open Access

NT-020 treatment reduces inflammation and augments Nrf-2 and Wnt signaling in aged rats

Antwoine Flowers, Jea-Young Lee, Sandra Acosta, Charles Hudson, Brent Small, Cyndy D. Sanberg, Paula C. Bickford, Bethany Grimmig

01.12.2015 | Case Report | Ausgabe 1/2015 Open Access

Acute hemorrhagic leukoencephalitis (Weston-Hurst syndrome) in a patient with relapse-remitting multiple sclerosis

Özlem Yildiz, Refik Pul, Peter Raab, Christian Hartmann, Thomas Skripuletz, Martin Stangel

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Early pro-inflammatory cytokine elevations in the DBA/2J mouse model of glaucoma

Gina N. Wilson, Denise M. Inman, Christine M. Dengler-Crish, Matthew A. Smith, Samuel D. Crish

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Deficiency of macrophage migration inhibitory factor attenuates tau hyperphosphorylation in mouse models of Alzheimer’s disease

Shu-Qin Li, Yang Yu, Jin-Zhao Han, Ding Wang, Jin Liu, Feng Qian, Guo-Huang Fan, Richard Bucala, Richard D. Ye

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Induction of virus-specific effector immune cell response limits virus replication and severe disease in mice infected with non-lethal West Nile virus Eg101 strain

Mukesh Kumar, Kelsey Roe, Maile O’Connell, Vivek R. Nerurkar

01.12.2015 | Research | Ausgabe 1/2015 Open Access

HMGB1 release triggered by the interaction of live retinal cells and uveitogenic T cells is Fas/FasL activation-dependent

Guomin Jiang, Yunsong Wang, Juan Yun, Amir Reza Hajrasouliha, Yuan Zhao, Deming Sun, Henry J Kaplan, Hui Shao

01.12.2015 | Review | Ausgabe 1/2015 Open Access

New means to assess neonatal inflammatory brain injury

Chen Jin, Irene Londono, Carina Mallard, Gregory A. Lodygensky

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Adult autologous mesenchymal stem cells for the treatment of suspected non-infectious inflammatory diseases of the canine central nervous system: safety, feasibility and preliminary clinical findings

Offer Zeira, Nimrod Asiag, Marina Aralla, Erica Ghezzi, Letizia Pettinari, Laura Martinelli, Daniele Zahirpour, Maria Pia Dumas, Davide Lupi, Simone Scaccia, Martin Konar, Carlo Cantile

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Sepsis-induced selective parvalbumin interneuron phenotype loss and cognitive impairments may be mediated by NADPH oxidase 2 activation in mice

Mu-Huo Ji, Li-Li Qiu, Hui Tang, Ling-Sha Ju, Xiao-Ru Sun, Hui Zhang, Min Jia, Zhi-Yi Zuo, Jin-Chun Shen, Jian-Jun Yang

01.12.2015 | Research | Ausgabe 1/2015 Open Access

The expression levels of prolyl oligopeptidase responds not only to neuroinflammation but also to systemic inflammation upon liver failure in rat models and cirrhotic patients

Jofre Tenorio-Laranga, Carmina Montoliu, Amparo Urios, Vicente Hernandez-Rabaza, Hanan Ahabrach, J. Arturo García-Horsman, Vicente Felipo

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Fingolimod induces neuroprotective factors in human astrocytes

Franziska S. Hoffmann, Johann Hofereiter, Heike Rübsamen, Johannes Melms, Sigrid Schwarz, Hans Faber, Peter Weber, Benno Pütz, Verena Loleit, Frank Weber, Reinhard Hohlfeld, Edgar Meinl, Markus Krumbholz

01.12.2015 | Research | Ausgabe 1/2015 Open Access

NFκB signaling drives pro-granulocytic astroglial responses to neuromyelitis optica patient IgG

Margaret E. Walker-Caulfield, Yong Guo, Renee K. Johnson, Christina B. McCarthy, Patrick D. Fitz-Gibbon, Claudia F. Lucchinetti, Charles L. Howe

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Microglia processes associate with diffusely injured axons following mild traumatic brain injury in the micro pig

Audrey D. Lafrenaye, Masaki Todani, Susan A. Walker, John T. Povlishock

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Role of glial 14-3-3 gamma protein in autoimmune demyelination

De-Hyung Lee, Petra Steinacker, Silvia Seubert, Tanja Turnescu, Arthur Melms, Arndt Manzel, Markus Otto, Ralf A. Linker

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Expression pattern of Ccr2 and Cx3cr1 in inherited retinal degeneration

Hideo Kohno, Hideto Koso, Kiichiro Okano, Thomas R. Sundermeier, Saburo Saito, Sumiko Watanabe, Hiroshi Tsuneoka, Tsutomu Sakai

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Requirement for endogenous heat shock factor 1 in inducible nitric oxide synthase induction in murine microglia

Chao Huang, Xu Lu, Lijuan Tong, Jili Wang, Wei Zhang, Bo Jiang, Rongrong Yang

01.12.2015 | Research | Ausgabe 1/2015 Open Access

P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite

Liang Feng, Yizhao Chen, Rui Ding, Zhenghao Fu, Shuo Yang, Xinqing Deng, Jun Zeng

01.12.2015 | Erratum | Ausgabe 1/2015 Open Access

Erratum To: Early pro-inflammatory cytokine elevations in the DBA/2J mouse model of glaucoma

Gina N. Wilson, Denise M. Inman, Christine M. Dengler-Crish, Matthew A. Smith, Samuel D. Crish

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Complement receptor 2 is up regulated in the spinal cord following nerve root injury and modulates the spinal cord response

Rickard P. F. Lindblom, Alexander Berg, Mikael Ström, Shahin Aeinehband, Cecilia A. Dominguez, Faiez Al Nimer, Nada Abdelmagid, Matthias Heinig, Johan Zelano, Karin Harnesk, Norbert Hübner, Bo Nilsson, Kristina Nilsson Ekdahl, Margarita Diez, Staffan Cullheim, Fredrik Piehl

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Suppression of MAPK attenuates neuronal cell death induced by activated glia-conditioned medium in alpha-synuclein overexpressing SH-SY5Y cells

Lidia M. Yshii, Alexandre Denadai-Souza, Andrea R. Vasconcelos, Maria Christina W. Avellar, Cristoforo Scavone

01.12.2015 | Research | Ausgabe 1/2015 Open Access

MOG-induced experimental autoimmune encephalomyelitis in the rat species triggers anti-neurofascin antibody response that is genetically regulated

Sevasti Flytzani, Andre Ortlieb Guerreiro-Cacais, Marie N’diaye, Maren Lindner, Christopher Linington, Edgar Meinl, Pernilla Stridh, Maja Jagodic, Tomas Olsson

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Sildenafil reduces neuroinflammation and restores spatial learning in rats with hepatic encephalopathy: underlying mechanisms

Vicente Hernandez-Rabaza, Ana Agusti, Andrea Cabrera-Pastor, Santos Fustero, Oscar Delgado, Lucas Taoro-Gonzalez, Carmina Montoliu, Marta Llansola, Vicente Felipo

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Next-generation sequencing identifies altered whole blood microRNAs in neuromyelitis optica spectrum disorder which may permit discrimination from multiple sclerosis

Andreas Keller, Petra Leidinger, Eckart Meese, Jan Haas, Christina Backes, Ludwig Rasche, Janina R. Behrens, Catherina Pfuhl, Katharina Wakonig, René M. Gieß, Sven Jarius, Benjamin Meder, Judith Bellmann-Strobl, Friedemann Paul, Florence C. Pache, Klemens Ruprecht

01.12.2015 | Research | Ausgabe 1/2015 Open Access

IL-4/10 prevents stress vulnerability following imipramine discontinuation

Arum Han, Hyelim Yeo, Min-Jung Park, Seung Hyun Kim, Hyun Jin Choi, Chang-Won Hong, Min-Soo Kwon

01.12.2015 | Research | Ausgabe 1/2015 Open Access

The nod-like receptor, Nlrp12, plays an anti-inflammatory role in experimental autoimmune encephalomyelitis

Marjan Gharagozloo, Tara M. Mahvelati, Emilie Imbeault, Pavel Gris, Echarki Zerif, Diwakar Bobbala, Subburaj Ilangumaran, Abdelaziz Amrani, Denis Gris

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway

Dennis Y. Chuang, Agnes Simonyi, Paul T. Kotzbauer, Zezong Gu, Grace Y. Sun

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Decreased progranulin levels in patients and rats with subarachnoid hemorrhage: a potential role in inhibiting inflammation by suppressing neutrophil recruitment

Chenhui Zhou, Guangbin Xie, Chunxi Wang, Zihuan Zhang, Qiang Chen, Li Zhang, Lingyun Wu, Yongxiang Wei, Hui Ding, Chunhua Hang, Mengliang Zhou, Jixin Shi

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Targeting translocator protein (18 kDa) (TSPO) dampens pro-inflammatory microglia reactivity in the retina and protects from degeneration

Rebecca Scholz, Albert Caramoy, Mohajeet B. Bhuckory, Khalid Rashid, Mei Chen, Heping Xu, Christian Grimm, Thomas Langmann

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Altered morphological dynamics of activated microglia after induction of status epilepticus

Elena Avignone, Marilyn Lepleux, Julie Angibaud, U. Valentin Nägerl

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Arginase 1+ microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation

Jonathan D. Cherry, John A. Olschowka, M. Kerry O’Banion

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Targeting inflammation to influence mood following spinal cord injury: a randomized clinical trial

David J. Allison, David S. Ditor

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Neuropsychiatric systemic lupus erythematosus persists despite attenuation of systemic disease in MRL/lpr mice

Ariel D. Stock, Jing Wen, Jessica Doerner, Leal C. Herlitz, Maria Gulinello, Chaim Putterman

01.12.2015 | Research | Ausgabe 1/2015 Open Access

MicroRNA367 negatively regulates the inflammatory response of microglia by targeting IRAK4 in intracerebral hemorrhage

Bangqing Yuan, Hanchao Shen, Li Lin, Tonggang Su, Lina Zhong, Zhao Yang

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Self-reactive CD4+ T cells activated during viral-induced demyelination do not prevent clinical recovery

Carine Savarin, Cornelia C. Bergmann, Melanie Gaignage, Stephen A. Stohlman

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degeneration

Rebecca Scholz, Markus Sobotka, Albert Caramoy, Thomas Stempfl, Christoph Moehle, Thomas Langmann

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Silencing of Abcc8 or inhibition of newly upregulated Sur1-Trpm4 reduce inflammation and disease progression in experimental autoimmune encephalomyelitis

Tapas K. Makar, Volodymyr Gerzanich, Vamshi K.C. Nimmagadda, Rupal Jain, Kristal Lam, Fahad Mubariz, David Trisler, Svetlana Ivanova, Seung Kyoon Woo, Min Seong Kwon, Joseph Bryan, Christopher T. Bever, J. Marc Simard

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Endogenous IFN-β signaling exerts anti-inflammatory actions in experimentally induced focal cerebral ischemia

Ana R. Inácio, Yawei Liu, Bettina H. Clausen, Martina Svensson, Krzysztof Kucharz, Yiyi Yang, Totte Stankovich, Reza Khorooshi, Kate L. Lambertsen, Shohreh Issazadeh-Navikas, Tomas Deierborg

01.12.2015 | Research | Ausgabe 1/2015 Open Access

PKR deficiency alters E. coli-induced sickness behaviors but does not exacerbate neuroimmune responses or bacterial load

David Chun-Hei Poon, Yuen-Shan Ho, Ran You, Hei-Long Tse, Kin Chiu, Raymond Chuen-Chung Chang

01.12.2015 | Erratum | Ausgabe 1/2015 Open Access

Erratum to: A role for human brain pericytes in neuroinflammation

Deidre Jansson, Justin Rustenhoven, Sheryl Feng, Daniel Hurley, Robyn L. Oldfield, Peter S. Bergin, Edward W. Mee, Richard L. M. Faull, Mike Dragunow

01.12.2015 | Short report | Ausgabe 1/2015 Open Access

Matrix-derived inflammatory mediator N-acetyl proline-glycine-proline is neurotoxic and upregulated in brain after ischemic stroke

Jeff W. Hill, Edwin M. Nemoto

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Inflammation and neuronal death in the motor cortex of the wobbler mouse, an ALS animal model

Carolin Dahlke, Darius Saberi, Bastian Ott, Beate Brand-Saberi, Thomas Schmitt-John, Carsten Theiss

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Amelioration of Japanese encephalitis by blockage of 4-1BB signaling is coupled to divergent enhancement of type I/II IFN responses and Ly-6Chi monocyte differentiation

Seong Bum Kim, Jin Young Choi, Jin Hyoung Kim, Erdenebelig Uyangaa, Ajit Mahadev Patil, Sang-Youel Park, John Hwa Lee, Koanhoi Kim, Young Woo Han, Seong Kug Eo

01.12.2015 | Research | Ausgabe 1/2015 Open Access

PET imaging studies show enhanced expression of mGluR5 and inflammatory response during progressive degeneration in ALS mouse model expressing SOD1-G93A gene

Anna-Liisa Brownell, Darshini Kuruppu, Kun-Eek Kil, Kimmo Jokivarsi, Pekka Poutiainen, Aijun Zhu, Michelle Maxwell

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Azithromycin drives alternative macrophage activation and improves recovery and tissue sparing in contusion spinal cord injury

Bei Zhang, William M. Bailey, Timothy J. Kopper, Michael B. Orr, David J. Feola, John C. Gensel

01.12.2015 | Research | Ausgabe 1/2015 Open Access

SDF1–CXCR4 signaling contributes to persistent pain and hypersensitivity via regulating excitability of primary nociceptive neurons: involvement of ERK-dependent Nav1.8 up-regulation

Fei Yang, Wei Sun, Yan Yang, Yan Wang, Chun-Li Li, Han Fu, Xiao-Liang Wang, Fan Yang, Ting He, Jun Chen

01.12.2015 | Retraction Note | Ausgabe 1/2015 Open Access

Retraction Note: Chronic neuroinflammation and cognitive impairment following transient global cerebral ischemia: role of fractalkine/CX3CR1 signaling

Teresita L. Briones, Julie Woods, Magdalena Wadowska

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Late prenatal immune activation causes hippocampal deficits in the absence of persistent inflammation across aging

Sandra Giovanoli, Tina Notter, Juliet Richetto, Marie A. Labouesse, Stéphanie Vuillermot, Marco A. Riva, Urs Meyer

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit

William A. Banks, Alicia M. Gray, Michelle A. Erickson, Therese S. Salameh, Mamatha Damodarasamy, Nader Sheibani, James S. Meabon, Emily E. Wing, Yoichi Morofuji, David G. Cook, May J. Reed

01.12.2015 | Short report | Ausgabe 1/2015 Open Access

Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage

Gregory Scott, Peter J. Hellyer, Anil F. Ramlackhansingh, David J. Brooks, Paul M. Matthews, David J. Sharp

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Trazodone regulates neurotrophic/growth factors, mitogen-activated protein kinases and lactate release in human primary astrocytes

Simona Daniele, Elisa Zappelli, Claudia Martini

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Low serum ficolin-3 levels are associated with severity and poor outcome in traumatic brain injury

Jian-Wei Pan, Xiong-Wei Gao, Hao Jiang, Ya-Feng Li, Feng Xiao, Ren-Ya Zhan

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Epistasis analysis links immune cascades and cerebral amyloidosis

Andréa L. Benedet, Aurélie Labbe, Philippe Lemay, Eduardo R. Zimmer, Tharick A. Pascoal, Antoine Leuzy, Sulantha Mathotaarachchi, Sara Mohades, Monica Shin, Alexandre Dionne-Laporte, Thomas Beaudry, Cynthia Picard, Serge Gauthier, Judes Poirier, Guy Rouleau, Pedro Rosa-Neto, for the Alzheimer’s Disease Neuroimaging Initiative

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Ccr2 deletion dissociates cavity size and tau pathology after mild traumatic brain injury

Stefka Gyoneva, Daniel Kim, Atsuko Katsumoto, O. Nicole Kokiko-Cochran, Bruce T. Lamb, Richard M. Ransohoff

01.12.2015 | Research | Ausgabe 1/2015 Open Access

NF-κB transcriptional activation by TNFα requires phospholipase C, extracellular signal-regulated kinase 2 and poly(ADP-ribose) polymerase-1

Billy Vuong, Adam D. J. Hogan-Cann, Conrad C. Alano, Mackenzie Stevenson, Wai Yee Chan, Christopher M. Anderson, Raymond A. Swanson, Tiina M. Kauppinen

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells

Isabella Russo, Giulia Berti, Nicoletta Plotegher, Greta Bernardo, Roberta Filograna, Luigi Bubacco, Elisa Greggio

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Dental follicle mesenchymal stem cell administration ameliorates muscle weakness in MuSK-immunized mice

Canan Ulusoy, Noushin Zibandeh, Selin Yıldırım, Nikolaos Trakas, Paraskevi Zisimopoulou, Melike Küçükerden, Hatice Tașlı, Socrates Tzartos, Kamil Göker, Erdem Tüzün, Tunç Akkoç

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Electroconvulsive seizures (ECS) do not prevent LPS-induced behavioral alterations and microglial activation

E. M. van Buel, F. J. Bosker, J. van Drunen, J. Strijker, W. Douwenga, H. C. Klein, U. L. M. Eisel

01.12.2015 | Research | Ausgabe 1/2015 Open Access

CCR5 limits cortical viral loads during West Nile virus infection of the central nervous system

Douglas M. Durrant, Brian P. Daniels, TracyJo Pasieka, Denise Dorsey, Robyn S. Klein

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Investigation of sex-specific effects of apolipoprotein E on severity of EAE and MS

L. Schrewe, C. M. Lill, T. Liu, A. Salmen, L. A. Gerdes, L. Guillot-Noel, D. A. Akkad, P. Blaschke, C. Graetz, S. Hoffjan, A. Kroner, S. Demir, A. Böhme, P. Rieckmann, A. ElAli, N. Hagemann, D. M. Hermann, I. Cournu-Rebeix, F. Zipp, T. Kümpfel, M. Buttmann, U. K. Zettl, B. Fontaine, L. Bertram, R. Gold, A. Chan

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson’s disease

Changyoun Kim, Emmanuel Ojo-Amaize, Brian Spencer, Edward Rockenstein, Michael Mante, Paula Desplats, Wolf Wrasidlo, Anthony Adame, Emeka Nchekwube, Olusola Oyemade, Joseph Okogun, Michael Chan, Howard Cottam, Eliezer Masliah

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid

Manfred Wuhrer, Maurice H. J. Selman, Liam A. McDonnell, Tania Kümpfel, Tobias Derfuss, Mohsen Khademi, Tomas Olsson, Reinhard Hohlfeld, Edgar Meinl, Markus Krumbholz

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Loss of intraepidermal nerve fiber density during SIV peripheral neuropathy is mediated by monocyte activation and elevated monocyte chemotactic proteins

Jessica R. Lakritz, Jake A. Robinson, Michael J. Polydefkis, Andrew D. Miller, Tricia H. Burdo

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Progesterone treatment reduces neuroinflammation, oxidative stress and brain damage and improves long-term outcomes in a rat model of repeated mild traumatic brain injury

Kyria M. Webster, David K. Wright, Mujun Sun, Bridgette D. Semple, Ezgi Ozturk, Donald G. Stein, Terence J. O’Brien, Sandy R. Shultz

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Monomethyl fumarate promotes Nrf2-dependent neuroprotection in retinal ischemia-reperfusion

Hongkwan Cho, Matthew J. Hartsock, Zhenhua Xu, Meihua He, Elia J. Duh

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Anti-inflammatory effects of dexamethasone and meloxicam on Borrelia burgdorferi-induced inflammation in neuronal cultures of dorsal root ganglia and myelinating cells of the peripheral nervous system

Geeta Ramesh, Olivia C. Meisner, Mario T. Philipp

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Multipotent adult progenitor cells for hypoxic-ischemic injury in the preterm brain

Reint K. Jellema, Daan R. M. G Ophelders, Alex Zwanenburg, Maria Nikiforou, Tammo Delhaas, Peter Andriessen, Robert W. Mays, Robert Deans, Wilfred T. V. Germeraad, Tim G. A. M. Wolfs, Boris W. Kramer

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Interferon-stimulated genes—essential antiviral effectors implicated in resistance to Theiler’s virus-induced demyelinating disease

Lin Li, Reiner Ulrich, Wolfgang Baumgärtner, Ingo Gerhauser

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Antagonist of the neurokinin-1 receptor curbs neuroinflammation in ex vivo and in vitro models of Lyme neuroborreliosis

Alejandra N. Martinez, Geeta Ramesh, Mary B. Jacobs, Mario T. Philipp

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Ligand engagement of Toll-like receptors regulates their expression in cortical microglia and astrocytes

Carla Marinelli, Rosa Di Liddo, Laura Facci, Thomas Bertalot, Maria Teresa Conconi, Morena Zusso, Stephen D. Skaper, Pietro Giusti

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Identification of a novel mechanism of action of fingolimod (FTY720) on human effector T cell function through TCF-1 upregulation

Maria Antonietta Mazzola, Radhika Raheja, Gopal Murugaiyan, Hasan Rajabi, Deepak Kumar, Thomas Pertel, Keren Regev, Russell Griffin, Lilian Aly, Pia Kivisakk, Parham Nejad, Bonny Patel, Nguendab Gwanyalla, Hillary Hei, Bonnie Glanz, Tanuja Chitnis, Howard L. Weiner, Roopali Gandhi

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Acid-sensing ion channel 1a contributes to the effect of extracellular acidosis on NLRP1 inflammasome activation in cortical neurons

Yu-Chan Wang, Wei-Zu Li, Yu Wu, Yan-Yan Yin, Liu-Yi Dong, Zhi-Wu Chen, Wen-Ning Wu

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Modulation of post-stroke degenerative and regenerative processes and subacute protection by site-targeted inhibition of the alternative pathway of complement

Ali Alawieh, Andrew Elvington, Hong Zhu, Jin Yu, Mark S. Kindy, Carl Atkinson, Stephen Tomlinson

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