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Erschienen in: Die Dermatologie 5/2021

06.04.2021 | Ästhetische Dermatologie | Leitthema

Neue Botulinumtoxine in der ästhetischen Dermatologie

Ein umfassender Überblick

verfasst von: A. Patil, M. Kassir, U. Wollina, M. Goldust

Erschienen in: Die Dermatologie | Ausgabe 5/2021

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Zusammenfassung

Die Gesichtsrejuvenation genießt sehr große Popularität unter Patienten wie Ärzten. Botulinumtoxine (BoNTs) aus Bakterien stellen gut tolerierte Optionen der minimal-invasiven Intervention in der Gesichtsverjüngung und bei anderen ästhetischen Prozeduren dar. Diese Produkte haben die ästhetischen Behandlungen revolutioniert. Es existieren mehrere Subtypen des Toxins. Zurzeit werden die Subtypen A und B für medizinische Zwecke genutzt. Allerdings ist nur der Subtyp A für kosmetische Anwendungen in Deutschland und den USA zugelassen. Jedes der BoNT-A-Produkte hat eine einzigartige Zusammensetzung. Das Verständnis der verschiedenen BoNT-A-Produkte ist unabdingbar für die individuelle Auswahl zur Behandlung der Patienten. In dieser Übersicht besprechen wir die BoNT-Produkte für die ästhetische Anwendung.
Literatur
1.
Zurück zum Zitat De Boulle K, Fagien S, Sommer B, Glogau R (2010) Treating glabellar lines with botulinum toxin type A‑hemagglutinin complex: a review of the science, the clinical data, and patient satisfaction. Clin Interv Aging 5:101–118PubMedPubMedCentral De Boulle K, Fagien S, Sommer B, Glogau R (2010) Treating glabellar lines with botulinum toxin type A‑hemagglutinin complex: a review of the science, the clinical data, and patient satisfaction. Clin Interv Aging 5:101–118PubMedPubMedCentral
2.
Zurück zum Zitat Wiest LG (2009) An overview of the cosmetic treatment of facial muscles with a new botulinum toxin. Acta Dermatovenerol Croat 17:48–53PubMed Wiest LG (2009) An overview of the cosmetic treatment of facial muscles with a new botulinum toxin. Acta Dermatovenerol Croat 17:48–53PubMed
3.
Zurück zum Zitat Ting PT, Freiman A (2004) The story of Clostridium botulinum: from food poisoning to Botox. Clin Med 4:258–261CrossRef Ting PT, Freiman A (2004) The story of Clostridium botulinum: from food poisoning to Botox. Clin Med 4:258–261CrossRef
4.
Zurück zum Zitat Carruthers A, Kane MAC, Flynn TC et al (2013) The convergence of medicine and neurotoxins: a focus on botulinum toxin type a and its application in aesthetic medicine – a global, evidence-based botulinum toxin consensus education initiative part I: Botulinum toxin in clinical and cosmetic practice. Dermatol Surg 39:493–509PubMedCrossRef Carruthers A, Kane MAC, Flynn TC et al (2013) The convergence of medicine and neurotoxins: a focus on botulinum toxin type a and its application in aesthetic medicine – a global, evidence-based botulinum toxin consensus education initiative part I: Botulinum toxin in clinical and cosmetic practice. Dermatol Surg 39:493–509PubMedCrossRef
5.
Zurück zum Zitat Feily A, Fallahi H, Zandian D, Kalantar H (2011) A succinct review of botulinum toxin in dermatology; update of cosmetic and noncosmetic use. J Cosmetic Dermatol 10:58–67CrossRef Feily A, Fallahi H, Zandian D, Kalantar H (2011) A succinct review of botulinum toxin in dermatology; update of cosmetic and noncosmetic use. J Cosmetic Dermatol 10:58–67CrossRef
6.
Zurück zum Zitat Hexsel D, Spencer JM, Woolery-Lloyd H, Gilbert E ( (2010) Practical applications of a new botulinum toxin. J Drugs Dermatol 9(3 Suppl):S31–S37 Hexsel D, Spencer JM, Woolery-Lloyd H, Gilbert E ( (2010) Practical applications of a new botulinum toxin. J Drugs Dermatol 9(3 Suppl):S31–S37
7.
Zurück zum Zitat Lowe NJ, Shah A, Lowe PL, Patnaik R (2010) Dosing, efficacy and safety plus the use of computerized photography for botulinum toxins type A for upper facial lines. J Cosmet Laser Ther 12:106–111PubMedCrossRef Lowe NJ, Shah A, Lowe PL, Patnaik R (2010) Dosing, efficacy and safety plus the use of computerized photography for botulinum toxins type A for upper facial lines. J Cosmet Laser Ther 12:106–111PubMedCrossRef
8.
Zurück zum Zitat Wright G, Lax A, Mehta SB (2018) A review of the longevity of effect of botulinum toxin in wrinkle treatments. Br Dent J 224:255–260PubMedCrossRef Wright G, Lax A, Mehta SB (2018) A review of the longevity of effect of botulinum toxin in wrinkle treatments. Br Dent J 224:255–260PubMedCrossRef
11.
Zurück zum Zitat Freeman SR, Cohen JL (2008) New neurotoxins on the horizon. Aesthet Surg J 28:325–330PubMedCrossRef Freeman SR, Cohen JL (2008) New neurotoxins on the horizon. Aesthet Surg J 28:325–330PubMedCrossRef
12.
Zurück zum Zitat Kumar R, Dhaliwal HP, Kukreja RV, Singh BR (2016) The botulinum toxin as a therapeutic agent: molecular structure and mechanism of action in motor and sensory systems. Semin Neurol 36:10–19PubMedCrossRef Kumar R, Dhaliwal HP, Kukreja RV, Singh BR (2016) The botulinum toxin as a therapeutic agent: molecular structure and mechanism of action in motor and sensory systems. Semin Neurol 36:10–19PubMedCrossRef
13.
Zurück zum Zitat Kaltreider SA, Kennedy RH, Woog JJ et al (2005) Cosmetic oculofacial applications of botulinum toxin a report by the American Academy of Ophthalmology. Ophthalmology 112:1159–1167PubMedCrossRef Kaltreider SA, Kennedy RH, Woog JJ et al (2005) Cosmetic oculofacial applications of botulinum toxin a report by the American Academy of Ophthalmology. Ophthalmology 112:1159–1167PubMedCrossRef
14.
Zurück zum Zitat Lowe N, Lowe P (2012) Botulinum toxins for facial lines: a concise review. Dermatol Ther 2:14CrossRef Lowe N, Lowe P (2012) Botulinum toxins for facial lines: a concise review. Dermatol Ther 2:14CrossRef
15.
Zurück zum Zitat Sattler G (2010) Current and future botulinum neurotoxin type a preparations in aesthetics: a literature review. J Drugs Dermatol 9:1065–1071PubMed Sattler G (2010) Current and future botulinum neurotoxin type a preparations in aesthetics: a literature review. J Drugs Dermatol 9:1065–1071PubMed
17.
Zurück zum Zitat Walker JJ, Dayan SH (2014) Comparison and overview of currently available neurotoxins. J Clin Aesthet Dermatol 7:31–39PubMedPubMedCentral Walker JJ, Dayan SH (2014) Comparison and overview of currently available neurotoxins. J Clin Aesthet Dermatol 7:31–39PubMedPubMedCentral
18.
Zurück zum Zitat Park J‑Y, Sunga O, Wanitphakdeedecha R, Frevert J (2020) Neurotoxin impurities: a review of threats to efficacy. Plast Reconstr Surg Glob Open 8:e2627PubMedPubMedCentralCrossRef Park J‑Y, Sunga O, Wanitphakdeedecha R, Frevert J (2020) Neurotoxin impurities: a review of threats to efficacy. Plast Reconstr Surg Glob Open 8:e2627PubMedPubMedCentralCrossRef
19.
Zurück zum Zitat Carruthers JA, Lowe NJ, Menter MA et al (2002) A multicenter, double-blind, randomized, placebo-controlled study of the efficacy and safety of botulinum toxin type A in the treatment of glabellar lines. J Am Acad Dermatol 46:840–849PubMedCrossRef Carruthers JA, Lowe NJ, Menter MA et al (2002) A multicenter, double-blind, randomized, placebo-controlled study of the efficacy and safety of botulinum toxin type A in the treatment of glabellar lines. J Am Acad Dermatol 46:840–849PubMedCrossRef
20.
Zurück zum Zitat Carruthers A, Carruthers J, Lowe NJ et al (2004) One-year, randomized, multicenter, two-period study of the safety and efficacy of repeated treatments with botulinum toxin type A in patients with glabellar lines. J Clin Res 7:1–20 Carruthers A, Carruthers J, Lowe NJ et al (2004) One-year, randomized, multicenter, two-period study of the safety and efficacy of repeated treatments with botulinum toxin type A in patients with glabellar lines. J Clin Res 7:1–20
21.
Zurück zum Zitat Carruthers A, Carruthers J, Fagien S et al (2016) Repeated onabotulinumtoxin a treatment of glabellar lines at rest over three treatment cycles. Dermatol Surg 42:1094–1101PubMedPubMedCentralCrossRef Carruthers A, Carruthers J, Fagien S et al (2016) Repeated onabotulinumtoxin a treatment of glabellar lines at rest over three treatment cycles. Dermatol Surg 42:1094–1101PubMedPubMedCentralCrossRef
22.
Zurück zum Zitat Frampton JE, Easthope SE (2003) Botulinum toxin A (Botox Cosmetic): a review of its use in the treatment of glabellar frown lines. Am J Clin Dermatol 4:709–725PubMedCrossRef Frampton JE, Easthope SE (2003) Botulinum toxin A (Botox Cosmetic): a review of its use in the treatment of glabellar frown lines. Am J Clin Dermatol 4:709–725PubMedCrossRef
24.
Zurück zum Zitat Carruthers A, Carruthers J (2008) Botulinum toxin products overview. Skin Therapy Lett 13:1–4PubMed Carruthers A, Carruthers J (2008) Botulinum toxin products overview. Skin Therapy Lett 13:1–4PubMed
25.
Zurück zum Zitat Nestor M, Ablon G, Pickett A (2017) Key parameters for the use of abobotulinumtoxin A in aesthetics: onset and duration. Aesthet Surg J 37:S20–S31PubMedPubMedCentralCrossRef Nestor M, Ablon G, Pickett A (2017) Key parameters for the use of abobotulinumtoxin A in aesthetics: onset and duration. Aesthet Surg J 37:S20–S31PubMedPubMedCentralCrossRef
26.
Zurück zum Zitat Kane MAC, Brandt F, Rohrich RJ et al (2009) Evaluation of variable-dose treatment with a new U.S. Botulinum Toxin Type A (Dysport) for correction of moderate to severe glabellar lines: results from a phase III, randomized, double-blind, placebo-controlled study. Plast Reconstr Surg 124:1619–1629PubMedCrossRef Kane MAC, Brandt F, Rohrich RJ et al (2009) Evaluation of variable-dose treatment with a new U.S. Botulinum Toxin Type A (Dysport) for correction of moderate to severe glabellar lines: results from a phase III, randomized, double-blind, placebo-controlled study. Plast Reconstr Surg 124:1619–1629PubMedCrossRef
27.
Zurück zum Zitat Brandt F, Swanson N, Baumann L, Huber B (2009) Randomized, placebo-controlled study of a new botulinum toxin type a for treatment of glabellar lines: efficacy and safety. Dermatol Surg 35:1893–1901PubMedCrossRef Brandt F, Swanson N, Baumann L, Huber B (2009) Randomized, placebo-controlled study of a new botulinum toxin type a for treatment of glabellar lines: efficacy and safety. Dermatol Surg 35:1893–1901PubMedCrossRef
28.
Zurück zum Zitat Baumann L, Brandt FS, Kane MAC, Donofrio LM (2009) An analysis of efficacy data from four phase III studies of botulinum neurotoxin type A‑ABO for the treatment of glabellar lines. Aesthet Surg J 29(Suppl 6):S57–S65PubMedCrossRef Baumann L, Brandt FS, Kane MAC, Donofrio LM (2009) An analysis of efficacy data from four phase III studies of botulinum neurotoxin type A‑ABO for the treatment of glabellar lines. Aesthet Surg J 29(Suppl 6):S57–S65PubMedCrossRef
29.
Zurück zum Zitat Cohen JL, Schlessinger J, Cox SE, Lin X, Reloxin Investigational Group (2009) An analysis of the long-term safety data of repeat administrations of botulinum neurotoxin type A‑ABO for the treatment of glabellar lines. Aesthet Surg J 29(Suppl 6):S43–S49PubMedCrossRef Cohen JL, Schlessinger J, Cox SE, Lin X, Reloxin Investigational Group (2009) An analysis of the long-term safety data of repeat administrations of botulinum neurotoxin type A‑ABO for the treatment of glabellar lines. Aesthet Surg J 29(Suppl 6):S43–S49PubMedCrossRef
30.
Zurück zum Zitat Rubin M, Dover J, Mass C, Nestor M (2009) An analysis of safety data from five phase III clinical trials on the use of botulinum neurotoxin type A‑ABO for the treatment of glabellar lines. Aesthet Surg J 29(Suppl 6):S50–S56PubMedCrossRef Rubin M, Dover J, Mass C, Nestor M (2009) An analysis of safety data from five phase III clinical trials on the use of botulinum neurotoxin type A‑ABO for the treatment of glabellar lines. Aesthet Surg J 29(Suppl 6):S50–S56PubMedCrossRef
31.
Zurück zum Zitat Lawrence I, Moy R (2009) An evaluation of neutralizing antibody induction during treatment of glabellar lines with a new US formulation of botulinum neurotoxin type A. Aesthet Surg J 29(Suppl 6):S66–S71PubMedCrossRef Lawrence I, Moy R (2009) An evaluation of neutralizing antibody induction during treatment of glabellar lines with a new US formulation of botulinum neurotoxin type A. Aesthet Surg J 29(Suppl 6):S66–S71PubMedCrossRef
32.
Zurück zum Zitat Gubanova E, Tabet MH, Bergerova Y et al (2018) Assessment of subject and physician satisfaction after long-term treatment of glabellar lines with abobotulinumtoxinA (Dysport ®/Azzalure ®): Primary results of the APPEAL noninterventional study. Aesthetic Plast Surg 42:1672–1680PubMedPubMedCentralCrossRef Gubanova E, Tabet MH, Bergerova Y et al (2018) Assessment of subject and physician satisfaction after long-term treatment of glabellar lines with abobotulinumtoxinA (Dysport ®/Azzalure ®): Primary results of the APPEAL noninterventional study. Aesthetic Plast Surg 42:1672–1680PubMedPubMedCentralCrossRef
34.
Zurück zum Zitat Cohen JL, Scuderi N (2017) Safety and patient satisfaction of abobotulinumtoxina for aesthetic use: a systematic review. Aesthet Surg J 37:S32–S44PubMedPubMedCentralCrossRef Cohen JL, Scuderi N (2017) Safety and patient satisfaction of abobotulinumtoxina for aesthetic use: a systematic review. Aesthet Surg J 37:S32–S44PubMedPubMedCentralCrossRef
35.
Zurück zum Zitat Redaelli A, Saromytskaya A, Roland Payne C et al (2017) International experts recommendations on the use of AboBotulinum Toxin A (AboTA) for facial rejuvenation and primary hyperhidrosis. Cosmet Med Int 3:70–80 Redaelli A, Saromytskaya A, Roland Payne C et al (2017) International experts recommendations on the use of AboBotulinum Toxin A (AboTA) for facial rejuvenation and primary hyperhidrosis. Cosmet Med Int 3:70–80
36.
Zurück zum Zitat Kim JE, Song EJ, Choi GS et al (2015) The efficacy and safety of liquid-type botulinum toxin type A for the management of moderate to severe glabellar frown lines. Plast Reconstr Surg 135:732–741PubMedCrossRef Kim JE, Song EJ, Choi GS et al (2015) The efficacy and safety of liquid-type botulinum toxin type A for the management of moderate to severe glabellar frown lines. Plast Reconstr Surg 135:732–741PubMedCrossRef
37.
Zurück zum Zitat Ascher B, Rzany B, Kestemont P et al (2020) Liquid formulation of abobotulinumtoxin A: A 6‑month, phase 3, double-blind, randomized, placebo-controlled study of a single treatment, ready-to-use toxin for moderate-to-severe glabellar lines. Aesthet Surg J 40:93–104PubMedCrossRef Ascher B, Rzany B, Kestemont P et al (2020) Liquid formulation of abobotulinumtoxin A: A 6‑month, phase 3, double-blind, randomized, placebo-controlled study of a single treatment, ready-to-use toxin for moderate-to-severe glabellar lines. Aesthet Surg J 40:93–104PubMedCrossRef
38.
Zurück zum Zitat Ascher B, Rzany B, Kestemont P et al (2020) significantly increased patient satisfaction following liquid formulation abobotulinumtoxin A treatment in glabellar lines: face‑q outcomes from a phase 3 clinical trial. Aesthet Surg J 40:1000–1008PubMedCrossRef Ascher B, Rzany B, Kestemont P et al (2020) significantly increased patient satisfaction following liquid formulation abobotulinumtoxin A treatment in glabellar lines: face‑q outcomes from a phase 3 clinical trial. Aesthet Surg J 40:1000–1008PubMedCrossRef
39.
Zurück zum Zitat Frevert J (2009) Xeomin: an innovative new botulinum toxin type A. Eur J Neurol 16(Suppl 2):11–13PubMedCrossRef Frevert J (2009) Xeomin: an innovative new botulinum toxin type A. Eur J Neurol 16(Suppl 2):11–13PubMedCrossRef
40.
Zurück zum Zitat Oh H‑M, Park JH, Song DH, Chung ME (2015) Efficacy and safety of a new botulinum toxin type a free of complexing proteins. Toxins 8:4PubMedCentralCrossRef Oh H‑M, Park JH, Song DH, Chung ME (2015) Efficacy and safety of a new botulinum toxin type a free of complexing proteins. Toxins 8:4PubMedCentralCrossRef
42.
Zurück zum Zitat Kerscher M, Rzany B, Prager W et al (2015) efficacy and safety of incobotulinumtoxin A in the treatment of upper facial lines: results from a randomized, double-blind, placebo-controlled, phase III study. Dermatol Surg 41:1149–1157PubMedCrossRef Kerscher M, Rzany B, Prager W et al (2015) efficacy and safety of incobotulinumtoxin A in the treatment of upper facial lines: results from a randomized, double-blind, placebo-controlled, phase III study. Dermatol Surg 41:1149–1157PubMedCrossRef
43.
Zurück zum Zitat Prager W, Nogueira Teixeira D, Leventhal PS (2017) Incobotulinumtoxin A for aesthetic indications: a systematic review of prospective comparative trials. Dermatol Surg 43:959–966PubMedCrossRef Prager W, Nogueira Teixeira D, Leventhal PS (2017) Incobotulinumtoxin A for aesthetic indications: a systematic review of prospective comparative trials. Dermatol Surg 43:959–966PubMedCrossRef
44.
Zurück zum Zitat Jones DH, Kerscher M, Geister T, Hast MA, Weissenberger P (2017) Efficacy of incobotulinumtoxin A for the treatment of glabellar frown lines in male subjects: post-hoc analyses from randomized, double-blind pivotal studies. Dermatol Surg 43:S235–S241PubMedCrossRef Jones DH, Kerscher M, Geister T, Hast MA, Weissenberger P (2017) Efficacy of incobotulinumtoxin A for the treatment of glabellar frown lines in male subjects: post-hoc analyses from randomized, double-blind pivotal studies. Dermatol Surg 43:S235–S241PubMedCrossRef
45.
Zurück zum Zitat Chao YY, Tseng FW, Yang YL et al (2019) Incobotulinumtoxin A for the treatment of glabellar frown lines: a prospective, multicenter, single-arm study in Taiwan. J Clin Aesthet Dermatol 12:E53–E57PubMedPubMedCentral Chao YY, Tseng FW, Yang YL et al (2019) Incobotulinumtoxin A for the treatment of glabellar frown lines: a prospective, multicenter, single-arm study in Taiwan. J Clin Aesthet Dermatol 12:E53–E57PubMedPubMedCentral
46.
Zurück zum Zitat Fischer T, Sattler G, Prager W et al (2020) Safety, tolerability, and efficacy of repeat-dose injections of incobotulinumtoxin A in the treatment of upper facial lines: results from a prospective, open-label, phase III study. J Drugs Dermatol 19:461–469PubMedCrossRef Fischer T, Sattler G, Prager W et al (2020) Safety, tolerability, and efficacy of repeat-dose injections of incobotulinumtoxin A in the treatment of upper facial lines: results from a prospective, open-label, phase III study. J Drugs Dermatol 19:461–469PubMedCrossRef
47.
Zurück zum Zitat Kerscher M, Fabi S, Fischer T et al (2020) Incobotulinumtoxin A demonstrates safety and prolonged duration of effect in a dose-ranging study for glabellar lines. J Drugs Dermatol 19:985–991PubMedCrossRef Kerscher M, Fabi S, Fischer T et al (2020) Incobotulinumtoxin A demonstrates safety and prolonged duration of effect in a dose-ranging study for glabellar lines. J Drugs Dermatol 19:985–991PubMedCrossRef
48.
Zurück zum Zitat de Sanctis Pecora C, Pinheiro MVB, Ventura Ferreira K, Jacobino de Barros Nunes G, Miot HA (2021) The One21 technique: an individualized treatment for glabellar lines based on clinical and anatomical landmarks. Clin Cosmet Investig Dermatol 14:97–105PubMedPubMedCentralCrossRef de Sanctis Pecora C, Pinheiro MVB, Ventura Ferreira K, Jacobino de Barros Nunes G, Miot HA (2021) The One21 technique: an individualized treatment for glabellar lines based on clinical and anatomical landmarks. Clin Cosmet Investig Dermatol 14:97–105PubMedPubMedCentralCrossRef
49.
Zurück zum Zitat Vachiramon V, Subpayasarn U, Triyangkulsri K, Jurairattanaporn N, Rattananukrom T (2021) Different injection patterns of incobotulinumtoxinA for crow’s feet: a split-face comparative study. J Eur Acad Dermatol Venereol 35:256–262PubMedCrossRef Vachiramon V, Subpayasarn U, Triyangkulsri K, Jurairattanaporn N, Rattananukrom T (2021) Different injection patterns of incobotulinumtoxinA for crow’s feet: a split-face comparative study. J Eur Acad Dermatol Venereol 35:256–262PubMedCrossRef
50.
Zurück zum Zitat Park JY, Cho SI, Hur K, Lee DH (2021) Intradermal microdroplet injection of diluted incobotulinumtoxin‑A for sebum control, face lifting, and pore size improvement. J Drugs Dermatol 20:49–54PubMedCrossRef Park JY, Cho SI, Hur K, Lee DH (2021) Intradermal microdroplet injection of diluted incobotulinumtoxin‑A for sebum control, face lifting, and pore size improvement. J Drugs Dermatol 20:49–54PubMedCrossRef
51.
Zurück zum Zitat Ferreira LM, Filho ST, Costa RO et al (2009) Efficacy and tolerability of a new botulinum toxin type a for cosmetic treatment of dynamic facial wrinkles: a prospective, phase III multicenter study. Surg Cosmet Dermatol 1:58–63 Ferreira LM, Filho ST, Costa RO et al (2009) Efficacy and tolerability of a new botulinum toxin type a for cosmetic treatment of dynamic facial wrinkles: a prospective, phase III multicenter study. Surg Cosmet Dermatol 1:58–63
52.
Zurück zum Zitat da Costa A, Pereira ESP, de Oliveira Pereira M et al (2019) Six-month comparative analysis monitoring the progression of the largest diameter of the sweating Inhibition halo of different botulinum toxins type‑A. Aesthet Surg J 39:993–1004PubMedCrossRef da Costa A, Pereira ESP, de Oliveira Pereira M et al (2019) Six-month comparative analysis monitoring the progression of the largest diameter of the sweating Inhibition halo of different botulinum toxins type‑A. Aesthet Surg J 39:993–1004PubMedCrossRef
54.
Zurück zum Zitat Cheon HI, Jung N, Won CH et al (2019) Efficacy and safety of prabotulinumtoxin A and onabotulinumtoxin A for crow’s feet: a phase 3, multicenter, randomized, double-blind, split-face study. Dermatol Surg 45:1610–1619PubMedCrossRef Cheon HI, Jung N, Won CH et al (2019) Efficacy and safety of prabotulinumtoxin A and onabotulinumtoxin A for crow’s feet: a phase 3, multicenter, randomized, double-blind, split-face study. Dermatol Surg 45:1610–1619PubMedCrossRef
55.
Zurück zum Zitat Carruthers J, Solish N, Humphrey S et al (2017) injectable daxibotulinumtoxin A for the treatment of glabellar lines: a phase 2, randomized, dose-ranging, double-blind, multicenter comparison with onabotulinumtoxina and placebo. Dermatol Surg 43:1321–1331PubMedCrossRef Carruthers J, Solish N, Humphrey S et al (2017) injectable daxibotulinumtoxin A for the treatment of glabellar lines: a phase 2, randomized, dose-ranging, double-blind, multicenter comparison with onabotulinumtoxina and placebo. Dermatol Surg 43:1321–1331PubMedCrossRef
56.
Zurück zum Zitat Carruthers JD, Fagien S, Joseph JH et al (2020) Daxibotulinumtoxin A for injection for the treatment of glabellar lines: results from each of two multicenter, randomized, double-blind, placebo-controlled, phase 3 studies (SAKURA 1 and SAKURA 2). Plast Reconstr Surg 145:45–58PubMedCrossRef Carruthers JD, Fagien S, Joseph JH et al (2020) Daxibotulinumtoxin A for injection for the treatment of glabellar lines: results from each of two multicenter, randomized, double-blind, placebo-controlled, phase 3 studies (SAKURA 1 and SAKURA 2). Plast Reconstr Surg 145:45–58PubMedCrossRef
57.
Zurück zum Zitat Fabi SG, Cohen JL, Green LJ et al (2021) Daxibotulinumtoxin A for injection for the treatment of glabellar lines: efficacy results from sakura 3, a large, open-label, phase 3 safety study. Dermatol Surg 47:48–54PubMedCrossRef Fabi SG, Cohen JL, Green LJ et al (2021) Daxibotulinumtoxin A for injection for the treatment of glabellar lines: efficacy results from sakura 3, a large, open-label, phase 3 safety study. Dermatol Surg 47:48–54PubMedCrossRef
58.
Zurück zum Zitat Green JB, Mariwalla K, Coleman K et al (2021) A large, open-label, phase 3 safety study of daxibotulinumtoxin A for injection in glabellar lines: a focus on safety from the SAKURA 3 study. Dermatol Surg 47:42–46PubMedCrossRef Green JB, Mariwalla K, Coleman K et al (2021) A large, open-label, phase 3 safety study of daxibotulinumtoxin A for injection in glabellar lines: a focus on safety from the SAKURA 3 study. Dermatol Surg 47:42–46PubMedCrossRef
59.
Zurück zum Zitat Clinical Trial.gov: NCT00752050; NCT00752258; NCT00752297. Clinical Trial.gov: NCT00752050; NCT00752258; NCT00752297.
61.
Zurück zum Zitat Yoon JS, Kim JC, Lee SY (2009) Double-blind, randomized, comparative study of Meditoxin versus Botox in the treatment of essential blepharospasm. Korean J Ophthalmol 23:137–141PubMedPubMedCentralCrossRef Yoon JS, Kim JC, Lee SY (2009) Double-blind, randomized, comparative study of Meditoxin versus Botox in the treatment of essential blepharospasm. Korean J Ophthalmol 23:137–141PubMedPubMedCentralCrossRef
62.
63.
Zurück zum Zitat Jeong-yeo L (2020) Drug Ministry revokes Meditoxin license. The Korean Herald vom 18. Juni 2020 Jeong-yeo L (2020) Drug Ministry revokes Meditoxin license. The Korean Herald vom 18. Juni 2020
64.
Zurück zum Zitat Frevert J, Ahn KY, Park MY, Sunga O (2018) Comparison of botulinum neurotoxin type A formulations in Asia. Clin Cosmet Investig Dermatol 11:327–331PubMedPubMedCentralCrossRef Frevert J, Ahn KY, Park MY, Sunga O (2018) Comparison of botulinum neurotoxin type A formulations in Asia. Clin Cosmet Investig Dermatol 11:327–331PubMedPubMedCentralCrossRef
66.
Zurück zum Zitat Wollina U, Konrad H (2005) Managing adverse events associated with botulinum toxin type A: a focus on cosmetic procedures. Am J Clin Dermatol 6:141–150PubMedCrossRef Wollina U, Konrad H (2005) Managing adverse events associated with botulinum toxin type A: a focus on cosmetic procedures. Am J Clin Dermatol 6:141–150PubMedCrossRef
67.
Zurück zum Zitat Philipp-Dormston WG, Bergfeld D, Sommer B, die Onabotulinumtoxin-Konsensusgruppe (2013) Konsensusempfehlungen zur Behandlung mit Onabotulinumtoxin A in der ästhetischen Medizin. J Dtsch Dermatol Ges 11(S1):1–42 Philipp-Dormston WG, Bergfeld D, Sommer B, die Onabotulinumtoxin-Konsensusgruppe (2013) Konsensusempfehlungen zur Behandlung mit Onabotulinumtoxin A in der ästhetischen Medizin. J Dtsch Dermatol Ges 11(S1):1–42
68.
Zurück zum Zitat Anido J, Arenas D, Arruabarrena C et al (2017) Tailored botulinum toxin type A injections in aesthetic medicine: consensus panel recommendations for treating the forehead based on individual facial anatomy and muscle tone. Clin Cosmet Investig Dermatol 10:413–421PubMedPubMedCentralCrossRef Anido J, Arenas D, Arruabarrena C et al (2017) Tailored botulinum toxin type A injections in aesthetic medicine: consensus panel recommendations for treating the forehead based on individual facial anatomy and muscle tone. Clin Cosmet Investig Dermatol 10:413–421PubMedPubMedCentralCrossRef
Metadaten
Titel
Neue Botulinumtoxine in der ästhetischen Dermatologie
Ein umfassender Überblick
verfasst von
A. Patil
M. Kassir
U. Wollina
M. Goldust
Publikationsdatum
06.04.2021
Verlag
Springer Medizin
Erschienen in
Die Dermatologie / Ausgabe 5/2021
Print ISSN: 2731-7005
Elektronische ISSN: 2731-7013
DOI
https://doi.org/10.1007/s00105-021-04801-9

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