Critical Care

Diminished adrenal sensitivity to endogenous and exogenous adrenocorticotropic hormone in critical illness: a prospective cohort study

Margriet FC de Jong, Nienke Molenaar, Albertus Beishuizen, AB Johan Groeneveld

Furosemide versus ethacrynic acid in pediatric patients undergoing cardiac surgery: a randomized controlled trial

Zaccaria Ricci, Roberta Haiberger, Chiara Pezzella, Cristiana Garisto, Isabella Favia, Paola Cogo

Quantification of urinary TIMP-2 and IGFBP-7: an adequate diagnostic test to predict acute kidney injury after cardiac surgery?

Anna J Wetz, Eva M Richardt, Saskia Wand, Nils Kunze, Hanna Schotola, Michael Quintel, Anselm Bräuer, Onnen Moerer

The relationship between serum potassium, potassium variability and in-hospital mortality in critically ill patients and a before-after analysis on the impact of computer-assisted potassium control

Lara Hessels, Miriam Hoekstra, Lisa J Mijzen, Mathijs Vogelzang, Wim Dieperink, Annemieke Oude Lansink, Maarten W Nijsten

Preload dependence indices to titrate volume expansion during septic shock: a randomized controlled trial

Jean-Christophe Richard, Frédérique Bayle, Gael Bourdin, Véronique Leray, Sophie Debord, Bertrand Delannoy, Alina Cividjian Stoian, Florent Wallet, Hodane Yonis, Claude Guerin

Rs1800625 in the receptor for advanced glycation end products gene predisposes to sepsis and multiple organ dysfunction syndrome in patients with major trauma

Ling Zeng, Juan Du, Wei Gu, An-qiang Zhang, Hai-yan Wang, Da-lin Wen, Lin Qiu, Xue-tao Yang, Jian-hui Sun, Mao Zhang, Jiang Hao, Jian-xin Jiang

Epidemiology of invasive aspergillosis in critically ill patients: clinical presentation, underlying conditions, and outcomes

Fabio Silvio Taccone, Anne-Marie Van den Abeele, Pierre Bulpa, Benoit Misset, Wouter Meersseman, Teresa Cardoso, José-Artur Paiva, Miguel Blasco-Navalpotro, Emmanuel De Laere, George Dimopoulos, Jordi Rello, Dirk Vogelaers, Stijn I Blot

Evaluation of lung recruitment maneuvers in acute respiratory distress syndrome using computer simulation

Anup Das, Oana Cole, Marc Chikhani, Wenfei Wang, Tayyba Ali, Mainul Haque, Declan G Bates, Jonathan G Hardman

Adjusting tidal volume to stress index in an open lung condition optimizes ventilation and prevents overdistension in an experimental model of lung injury and reduced chest wall compliance

Carlos Ferrando, Fernando Suárez-Sipmann, Andrea Gutierrez, Gerardo Tusman, Jose Carbonell, Marisa García, Laura Piqueras, Desamparados Compañ, Susanie Flores, Marina Soro, Alicia Llombart, Francisco Javier Belda

Preoperative intra-aortic balloon pump to reduce mortality in coronary artery bypass graft: a meta-analysis of randomized controlled trials

Alberto Zangrillo, Federico Pappalardo, Roberto Dossi, Ambra Licia Di Prima, Marta Eugenia Sassone, Teresa Greco, Fabrizio Monaco, Mario Musu, Gabriele Finco, Giovanni Landoni

Integration of metabolic and inflammatory mediator profiles as a potential prognostic approach for septic shock in the intensive care unit

Beata Mickiewicz, Patrick Tam, Craig N Jenne, Caroline Leger, Josee Wong, Brent W Winston, Christopher Doig, Paul Kubes, Hans J Vogel

Reintubation in critically ill patients: procedural complications and implications for care

Jonathan Elmer, Sean Lee, Jon C Rittenberger, James Dargin, Daniel Winger, Lillian Emlet

The association between the neutrophil-to-lymphocyte ratio and mortality in critical illness: an observational cohort study

Justin D Salciccioli, Dominic C Marshall, Marco AF Pimentel, Mauro D Santos, Tom Pollard, Leo Anthony Celi, Joseph Shalhoub

Dynamic arterial elastance predicts mean arterial pressure decrease associated with decreasing norepinephrine dosage in septic shock

Pierre-Grégoire Guinot, Eugénie Bernard, Mélanie Levrard, Hervé Dupont, Emmanuel Lorne

Optimal site for ultrasound-guided venous catheterisation in paediatric patients: an observational study to investigate predictors for catheterisation success and a randomised controlled study to determine the most successful site

Jun Takeshita, Yoshinobu Nakayama, Yasufumi Nakajima, Daniel I Sessler, Satoru Ogawa, Teiji Sawa, Toshiki Mizobe

The relationship between fasting plasma citrulline concentration and small intestinal function in the critically ill

Alexis Poole, Adam Deane, Matthew Summers, Janice Fletcher, Marianne Chapman

Is there a role for music in the ICU?

Jeffrey D DellaVolpe, David T Huang

Passive leg raising: five rules, not a drop of fluid!

Xavier Monnet, Jean-Louis Teboul

Extracorporeal life support as bridge to lung transplantation: a systematic review

Davide Chiumello, Silvia Coppola, Sara Froio, Andrea Colombo, Lorenzo Del Sorbo

Effects of glucose-dependent insulinotropic polypeptide on gastric emptying, glycaemia and insulinaemia during critical illness: a prospective, double blind, randomised, crossover study

Palash Kar, Caroline E Cousins, Christopher E Annink, Karen L Jones, Marianne J Chapman, Juris J Meier, Michael A Nauck, Michael Horowitz, Adam M Deane

Low-dose hydrocortisone reduces norepinephrine duration in severe burn patients: a randomized clinical trial

Fabienne Venet, Jonathan Plassais, Julien Textoris, Marie-Angélique Cazalis, Alexandre Pachot, Marc Bertin-Maghit, Christophe Magnin, Thomas Rimmelé, Guillaume Monneret, Sylvie Tissot

Gastric tonometry guided therapy in critical care patients: a systematic review and meta-analysis

Xin Zhang, Wei Xuan, Ping Yin, Linlin Wang, Xiaodan Wu, Qingping Wu

Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice

Holger C Müller-Redetzky, Matthias Felten, Katharina Hellwig, Sandra-Maria Wienhold, Jan Naujoks, Bastian Opitz, Olivia Kershaw, Achim D Gruber, Norbert Suttorp, Martin Witzenrath

The blind spot in high-dose tigecycline pharmacokinetics in critically ill patients: membrane adsorption during continuous extracorporeal treatment

Patrick M Honore, Rita Jacobs, Elisabeth De Waele, Viola Van Gorp, Herbert D Spapen

ICU vampires and anemia

Tamra Ranasinghe, William D Freeman

Glycocalyx and sepsis-induced alterations in vascular permeability

Cosimo Chelazzi, Gianluca Villa, Paola Mancinelli, A Raffaele De Gaudio, Chiara Adembri

Intraoperative renal near-infrared spectroscopy indicates developing acute kidney injury in infants undergoing cardiac surgery with cardiopulmonary bypass: a case–control study

Bettina Ruf, Vittorio Bonelli, Gunter Balling, Jürgen Hörer, Nicole Nagdyman, Siegmund Lorenz Braun, Peter Ewert, Karl Reiter

Are standard doses of piperacillin sufficient for critically ill patients with augmented creatinine clearance?

Andrew A Udy, Jeffrey Lipman, Paul Jarrett, Kerenaftali Klein, Steven C Wallis, Kashyap Patel, Carl MJ Kirkpatrick, Peter S Kruger, David L Paterson, Michael S Roberts, Jason A Roberts

Contradictory findings on one-year mortality following ICU delirium

Alison E Turnbull, Karin J Neufeld, Dale M Needham

Efficiency of hydrogen peroxide in improving disinfection of ICU rooms

Caroline Blazejewski, Frédéric Wallet, Anahita Rouzé, Rémi Le Guern, Sylvie Ponthieux, Julia Salleron, Saad Nseir

The relationship between arterial transducer level and pulse contour waveform-derived measurements

Huaiwu He, Dawei Liu, Yun Long, Xiaoting Wang, Yuan Yu, Xin Li, Hailing Guo, Jing Cai, Ning Fang

Evaluation of sulfobutylether-β-cyclodextrin (SBECD) accumulation and voriconazole pharmacokinetics in critically ill patients undergoing continuous renal replacement therapy

Tyree H Kiser, Douglas N Fish, Christina L Aquilante, Joseph E Rower, Michael F Wempe, Robert MacLaren, Isaac Teitelbaum

Pharmacokinetic variability and exposures of fluconazole, anidulafungin, and caspofungin in intensive care unit patients: Data from multinational Defining Antibiotic Levels in Intensive care unit (DALI) patients Study

Mahipal G Sinnollareddy, Jason A Roberts, Jeffrey Lipman, Murat Akova, Matteo Bassetti, Jan J De Waele, Kirsi-Maija Kaukonen, Despoina Koulenti, Claude Martin, Philippe Montravers, Jordi Rello, Andrew Rhodes, Therese Starr, Steven C Wallis, George Dimopoulos

Point accuracy and reliability of an interstitial continuous glucose-monitoring device in critically ill patients: a prospective study

Roosmarijn TM van Hooijdonk, Jan Hendrik Leopold, Tineke Winters, Jan M Binnekade, Nicole P Juffermans, Janneke Horn, Johan C Fischer, Edmée C van Dongen-Lases, Marcus J Schultz

Metabolic and nutritional support of critically ill patients: consensus and controversies

Jean-Charles Preiser, Arthur RH van Zanten, Mette M Berger, Gianni Biolo, Michael P Casaer, Gordon S Doig, Richard D Griffiths, Daren K Heyland, Michael Hiesmayr, Gaetano Iapichino, Alessandro Laviano, Claude Pichard, Pierre Singer, Greet Van den Berghe, Jan Wernerman, Paul Wischmeyer, Jean-Louis Vincent

Simplified lung ultrasound protocol shows excellent prediction of extravascular lung water in ventilated intensive care patients

Philipp Enghard, Sibylle Rademacher, Jens Nee, Dietrich Hasper, Ulrike Engert, Achim Jörres, Jan M Kruse

Successful treatment of severe sepsis and diarrhea after vagotomy utilizing fecal microbiota transplantation: a case report

Qiurong Li, Chenyang Wang, Chun Tang, Qin He, Xiaofan Zhao, Ning Li, Jieshou Li

Targeted screening for third-generation cephalosporin-resistant Enterobacteriaceae carriage among patients admitted to intensive care units: a quasi-experimental study

Cédric Dananché, Thomas Bénet, Bernard Allaouchiche, Romain Hernu, Laurent Argaud, Olivier Dauwalder, François Vandenesch, Philippe Vanhems

Platelet mitochondrial dysfunction in critically ill patients: comparison between sepsis and cardiogenic shock

Alessandro Protti, Francesco Fortunato, Andrea Artoni, Anna Lecchi, Giovanna Motta, Giovanni Mistraletti, Cristina Novembrino, Giacomo Pietro Comi, Luciano Gattinoni

Propofol, midazolam, vancomycin and cyclosporine therapeutic drug monitoring in extracorporeal membrane oxygenation circuits primed with whole human blood

Florian Lemaitre, Nesrine Hasni, Pascal Leprince, Emmanuel Corvol, Ghassen Belhabib, Pierre Fillâtre, Charles-Edouard Luyt, Cyril Leven, Robert Farinotti, Christine Fernandez, Alain Combes

Discharge diagnoses versus medical record review in the identification of community-acquired sepsis

Henry E Wang, Dylan R Addis, John P Donnelly, Nathan I Shapiro, Russell L Griffin, Monika M Safford, John W Baddley

Effect of high-dose dexamethasone on perioperative lactate levels and glucose control: a randomized controlled trial

Thomas H Ottens, Maarten WN Nijsten, Jan Hofland, Jan M Dieleman, Miriam Hoekstra, Diederik van Dijk, Joost MAA van der Maaten

Assessment of patient-ventilator breath contribution during neurally adjusted ventilatory assist in patients with acute respiratory failure

Ling Liu, Songqiao Liu, Jianfeng Xie, Yi Yang, Arthur S Slutsky, Jennifer Beck, Christer Sinderby, Haibo Qiu

Neurally adjusted ventilatory assist (NAVA) allows patient-ventilator synchrony during pediatric noninvasive ventilation: a crossover physiological study

Laurence Ducharme-Crevier, Jennifer Beck, Sandrine Essouri, Philippe Jouvet, Guillaume Emeriaud

Propofol increases morbidity and mortality in a rat model of sepsis

Martin Schläpfer, Tobias Piegeler, Randal O Dull, David E Schwartz, Mao Mao, Marcelo G Bonini, Birgit Roth Z’Graggen, Beatrice Beck-Schimmer, Richard D Minshall

Do corticosteroids reduce the mortality of influenza A (H1N1) infection? A meta-analysis

Yi Zhang, Wenjie Sun, Erik R Svendsen, Song Tang, Raina C MacIntyre, Peng Yang, Daitao Zhang, Quanyi Wang

Prospective validation of pediatric disease severity scores to predict mortality in Ugandan children presenting with malaria and non-malaria febrile illness

Andrea L Conroy, Michael Hawkes, Kyla Hayford, Sophie Namasopo, Robert O Opoka, Chandy C John, W Conrad Liles, Kevin C Kain

Automated versus non-automated weaning for reducing the duration of mechanical ventilation for critically ill adults and children: a cochrane systematic review and meta-analysis

Louise Rose, Marcus J Schultz, Chris R Cardwell, Philippe Jouvet, Danny F McAuley, Bronagh Blackwood

Erythropoietin improves long-term neurological outcome in acute ischemic stroke patients: a randomized, prospective, placebo-controlled clinical trial

Tzu-Hsien Tsai, Cheng-Hsien Lu, Christopher Glenn Wallace, Wen-Neng Chang, Shu-Feng Chen, Chi-Ren Huang, Nai-Wen Tsai, Min-Yu Lan, Pei-Hsun Sung, Chu-Feng Liu, Hon-Kan Yip

Some metabolic issues should not be neglected when using citrate for continuous renal replacement therapy!

Rita Jacobs, Patrick M Honore, Herbert D Spapen

Perceptions of the appropriateness of care in California adult intensive care units

Matthew H Anstey, John L Adams, Elizabeth A McGlynn

A new two-tier strength assessment approach to the diagnosis of weakness in intensive care: an observational study

Selina M Parry, Sue Berney, Catherine L Granger, Danielle L Dunlop, Laura Murphy, Doa El-Ansary, René Koopman, Linda Denehy

Neutralization of osteopontin attenuates neutrophil migration in sepsis-induced acute lung injury

Yohei Hirano, Monowar Aziz, Weng-Lang Yang, Zhimin Wang, Mian Zhou, Mahendar Ochani, Adam Khader, Ping Wang

MicroRNAs: new biomarkers and therapeutic targets after cardiac arrest?

Yvan Devaux, Pascal Stammet, Hans Friberg, Christian Hassager, Michael A Kuiper, Matt P Wise, Niklas Nielsen

Starling curves and central venous pressure

David A Berlin, Jan Bakker

Neurally adjusted ventilatory assist and proportional assist ventilation both improve patient-ventilator interaction

Matthieu Schmidt, Felix Kindler, Jérôme Cecchini, Tymothée Poitou, Elise Morawiec, Romain Persichini, Thomas Similowski, Alexandre Demoule

The diagnostic and prognostic significance of monitoring blood levels of immature neutrophils in patients with systemic inflammation

Tracey Anne Mare, David Floyd Treacher, Manu Shankar-Hari, Richard Beale, Sion Marc Lewis, David John Chambers, Kenneth Alun Brown

Selenium prevents microparticle-induced endothelial inflammation in patients after cardiopulmonary resuscitation

Katrin Fink, Monica Moebes, Caroline Vetter, Natascha Bourgeois, Bonaventura Schmid, Christoph Bode, Thomas Helbing, Hans-Jörg Busch

Endotracheal tube biofilm translocation in the lateral Trendelenburg position

Gianluigi Li Bassi, Laia Fernandez-Barat, Lina Saucedo, Valeria Giunta, Joan Daniel Marti, Otavio Tavares Ranzani, Eli Aguilera Xiol, Montserrat Rigol, Ignasi Roca, Laura Muñoz, Nestor Luque, Mariano Esperatti, Maria Adela Saco, Jose Ramirez, Jordi Vila, Miguel Ferrer, Antoni Torres

Can yeast isolation be predicted in complicated secondary non-postoperative intra-abdominal infections?

Hervé Dupont, Mathieu Guilbart, Alexandre Ntouba, Mélanie Perquin, Sandra Petiot, Jean-Marc Regimbeau, Taieb Chouaki, Yazine Mahjoub, Elie Zogheib

Metoclopramide or domperidone improves post-pyloric placement of spiral nasojejunal tubes in critically ill patients: a prospective, multicenter, open-label, randomized, controlled clinical trial

Bei Hu, Heng Ye, Cheng Sun, Yichen Zhang, Zhigang Lao, Fanghong Wu, Zhaohui Liu, Linxi Huang, Changchun Qu, Lewu Xian, Hao Wu, Yingjie Jiao, Junling Liu, Juyu Cai, Weiying Chen, Zhiqiang Nie, Zaiyi Liu, Chunbo Chen

Transferring the critically ill patient: are we there yet?

Joep M Droogh, Marije Smit, Anthony R Absalom, Jack JM Ligtenberg, Jan G Zijlstra

Incidence and outcome of inappropriate in-hospital empiric antibiotics for severe infection: a systematic review and meta-analysis

Kristel Marquet, An Liesenborgs, Jochen Bergs, Arthur Vleugels, Neree Claes

Comparison of ultrasound-guided modified Seldinger technique versus blind puncture for peripherally inserted central catheter: a meta-analysis of randomized controlled trials

ZhanZhan Li, LiZhang Chen

Dose of colistin: a work in progress?

Monica Rocco, Luca Montini, Gennaro De Pascale, Massimo Antonelli

Can heparin therapy reduce 28-day mortality in adult severe sepsis patients?

Li-bing Jiang, Yue-feng Ma, Xia Feng, Mao Zhang

Dexmedetomidine versus standard care sedation with propofol or midazolam in intensive care: an economic evaluation

Heidi Turunen, Stephan M Jakob, Esko Ruokonen, Kirsi-Maija Kaukonen, Toni Sarapohja, Marjo Apajasalo, Jukka Takala

Superior vena cava drainage improves upper body oxygenation during veno-arterial extracorporeal membrane oxygenation in sheep

Xiaotong Hou, Xiaofang Yang, Zhongtao Du, Jialin Xing, Hui Li, Chunjing Jiang, Jinhong Wang, Zhichen Xing, Shuanglei Li, Xiaokui Li, Feng Yang, Hong Wang, Hui Zeng

Levosimendan affects oxidative and inflammatory pathways in the diaphragm of ventilated endotoxemic mice

Willem-Jan M Schellekens, Hieronymus WH van Hees, Marianne Linkels, PN Richard Dekhuijzen, Gert Jan Scheffer, Johannes G van der Hoeven, Leo MA Heunks

Dynamic changes of microbial flora and therapeutic consequences in persistent peritonitis

Philippe Montravers, Guillaume Dufour, Jean Guglielminotti, Mathieu Desmard, Claudette Muller, Hamda Houissa, Nicolas Allou, Jean-Pierre Marmuse, Pascal Augustin

Human metabolic response to systemic inflammation: assessment of the concordance between experimental endotoxemia and clinical cases of sepsis/SIRS

Kubra Kamisoglu, Beatrice Haimovich, Steve E Calvano, Susette M Coyle, Siobhan A Corbett, Raymond J Langley, Stephen F Kingsmore, Ioannis P Androulakis

Local hemostasis, immunothrombosis, and systemic disseminated intravascular coagulation in trauma and traumatic shock

Satoshi Gando, Yasuhiro Otomo

An ADAM10 promoter polymorphism is a functional variant in severe sepsis patients and confers susceptibility to the development of sepsis

Lili Cui, Yan Gao, Yuliu Xie, Yan Wang, Yujie Cai, Xin Shao, Xiaotang Ma, You LI, Guoda Ma, Gen Liu, Wanwen Cheng, Yu Liu, Tingting Liu, Qunwen Pan, Hua Tao, Zhou Liu, Bin Zhao, Yiming Shao, Keshen Li

Prognostic value of procalcitonin in respiratory tract infections across clinical settings

Alexander Kutz, Matthias Briel, Mirjam Christ-Crain, Daiana Stolz, Lila Bouadma, Michel Wolff, Kristina B Kristoffersen, Long Wei, Olaf Burkhardt, Tobias Welte, Stefan Schroeder, Vandack Nobre, Michael Tamm, Neera Bhatnagar, Heiner C Bucher, Charles-Edouard Luyt, Jean Chastre, Florence Tubach, Beat Mueller, Philipp Schuetz

Early brain injury after aneurysmal subarachnoid hemorrhage: a multimodal neuromonitoring study

Raimund Helbok, Alois Josef Schiefecker, Ronny Beer, Anelia Dietmann, Ana Patrícia Antunes, Florian Sohm, Marlene Fischer, Werner Oskar Hackl, Paul Rhomberg, Peter Lackner, Bettina Pfausler, Claudius Thomé, Christian Humpel, Erich Schmutzhard

β1-adrenoceptor stimulation promotes LPS-induced cardiomyocyte apoptosis through activating PKA and enhancing CaMKII and IκBα phosphorylation

Yiyang Wang, Yuan Wang, Duomeng Yang, Xiaohui Yu, Hongmei Li, Xiuxiu Lv, Daxiang Lu, Huadong Wang

Safety evaluation on low-molecular-weight hydroxyethyl starch for volume expansion therapy in pediatric patients: a meta-analysis of randomized controlled trials

Lixia Li, Yongyang Li, Xiaoxing Xu, Bo Xu, Rongrong Ren, Yan Liu, Jian Zhang, Bin He

Benefit profile of recombinant human soluble thrombomodulin in sepsis-induced disseminated intravascular coagulation: a multicenter propensity score analysis

Jumpei Yoshimura, Kazuma Yamakawa, Hiroshi Ogura, Yutaka Umemura, Hiroki Takahashi, Miki Morikawa, Yoshiaki Inoue, Satoshi Fujimi, Hiroshi Tanaka, Toshimitsu Hamasaki, Takeshi Shimazu

Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock

Erin L Vanzant, Rachael E Hilton, Cecilia M Lopez, Jianyi Zhang, Ricardo F Ungaro, Lori F Gentile, Benjamin E Szpila, Ronald V Maier, Joseph Cuschieri, Azra Bihorac, Christiaan Leeuwenburgh, Frederick A Moore, Henry V Baker, Lyle L Moldawer, Scott C Brakenridge, Philip A Efron

Cathelicidin antimicrobial protein, vitamin D, and risk of death in critically ill patients

David E Leaf, Heather E Croy, Sara J Abrahams, Anas Raed, Sushrut S Waikar

Early mobilization and recovery in mechanically ventilated patients in the ICU: a bi-national, multi-centre, prospective cohort study

The ratio of Th17/Treg cells as a risk indicator in early acute respiratory distress syndrome

Zhi-xin Yu, Mu-sen Ji, Jun Yan, Yan Cai, Jing Liu, Hong-feng Yang, Yong Li, Zhao-chen Jin, Jin-xu Zheng

Trauma-induced coagulopathy: impact of the early coagulation support protocol on blood product consumption, mortality and costs

Giuseppe Nardi, Vanessa Agostini, Beatrice Rondinelli, Emanuele Russo, Barbara Bastianini, Giovanni Bini, Simona Bulgarelli, Emiliano Cingolani, Alessia Donato, Giorgio Gambale, Giulia Ranaldi

A multicenter study on the effect of continuous hemodiafiltration intensity on antibiotic pharmacokinetics

Darren M Roberts, Xin Liu, Jason A Roberts, Priya Nair, Louise Cole, Michael S Roberts, Jeffrey Lipman, Rinaldo Bellomo

An observational study of surface versus endovascular cooling techniques in cardiac arrest patients: a propensity-matched analysis

Sang Hoon Oh, Joo Suk Oh, Young-Min Kim, Kyu Nam Park, Seung Pill Choi, Gi Woon Kim, Kyung Woon Jeung, Tae Chang Jang, Yoo Seok Park, Yeon Young Kyong

A simple prognostic index based on admission vital signs data among patients with sepsis in a resource-limited setting

Stephen B Asiimwe, Amir Abdallah, Richard Ssekitoleko

Efficacy and safety of 6% hydroxyethyl starch 130/0.4 (Voluven) for perioperative volume replacement in children undergoing cardiac surgery: a propensity-matched analysis

Philippe Van der Linden, Melanie Dumoulin, Celine Van Lerberghe, Cristel Sanchez Torres, Ariane Willems, David Faraoni

Serum levels of apolipoprotein A-I and high-density lipoprotein can predict organ failure in acute pancreatitis

Yun-Shing Peng, Yung-Chang Chen, Ya-Chung Tian, Chih-Wei Yang, Jau-Min Lien, Ji-Tseng Fang, Cheng-Shyong Wu, Chien-Fu Hung, Tsan-Long Hwang, Ying-Huang Tsai, Mel S Lee, Ming-Hung Tsai

Does intermediate care improve patient outcomes or reduce costs?

Jean-Louis Vincent, Gordon D Rubenfeld

The original sins of clinical trials with intravenous immunoglobulins in sepsis

Raquel Almansa, Eduardo Tamayo, David Andaluz-Ojeda, Leonor Nogales, Jesús Blanco, Jose Maria Eiros, Jose Ignacio Gomez-Herreras, Jesus F Bermejo-Martin

Efficacy and safety of citrate-based anticoagulation compared to heparin in patients with acute kidney injury requiring continuous renal replacement therapy: a randomized controlled trial

Fabien Stucker, Belen Ponte, James Tataw, Pierre-Yves Martin, Hannah Wozniak, Jérome Pugin, Patrick Saudan

Hydroxyethyl starch versus other fluids for non-septic patients in the intensive care unit: a meta-analysis of randomized controlled trials

Bin He, Bo Xu, Xiaoxing Xu, Lixia Li, Rongrong Ren, Zhiyu Chen, Jian Xiao, Yingwei Wang, Bin Xu

Renal angina: concept and development of pretest probability assessment in acute kidney injury

Lakhmir S Chawla, Stuart L Goldstein, John A Kellum, Claudio Ronco

Closed-loop assisted versus manual goal-directed fluid therapy during high-risk abdominal surgery: a case–control study with propensity matching

Joseph Rinehart, Marc Lilot, Christine Lee, Alexandre Joosten, Trish Huynh, Cecilia Canales, David Imagawa, Aram Demirjian, Maxime Cannesson

Identification of haplotype tag single nucleotide polymorphisms within the nuclear factor-κB family genes and their clinical relevance in patients with major trauma

Wei Pan, An Qiang Zhang, Wei Gu, Jun Wei Gao, Ding Yuan Du, Lian Yang Zhang, Ling Zeng, Juan Du, Hai Yan Wang, Jian Xin Jiang

Timing for deep vein thrombosis chemoprophylaxis in traumatic brain injury: an evidence-based review

Hiba Abdel-Aziz, C Michael Dunham, Rema J Malik, Barbara M Hileman

Detection of acute traumatic coagulopathy and massive transfusion requirements by means of rotational thromboelastometry: an international prospective validation study

Jostein S Hagemo, Sarah C Christiaans, Simon J Stanworth, Karim Brohi, Pär I Johansson, J Carel Goslings, Paal A Naess, Christine Gaarder

Angiotensin II in septic shock

Thiago D Corrêa, Jukka Takala, Stephan M Jakob

Extracorporeal gas exchange for acute respiratory failure in adult patients: a systematic review

Matthieu Schmidt, Carol Hodgson, Alain Combes

Why intensivists want chest radiographs

Martijn Tolsma, Peter HJ van der Voort, Nardo JM van der Meer

Optimizing mean arterial pressure in septic shock: a critical reappraisal of the literature

Marc Leone, Pierre Asfar, Peter Radermacher, Jean-Louis Vincent, Claude Martin

Long-term sequelae from acute kidney injury: potential mechanisms for the observed poor renal outcomes

Matt Varrier, Lui G Forni, Marlies Ostermann

Cooling techniques for targeted temperature management post-cardiac arrest

Charudatt Vaity, Nawaf Al-Subaie, Maurizio Cecconi

Rapid response systems: are they really effective?

Claudio Sandroni, Sonia D’Arrigo, Massimo Antonelli

Exposure to high concentrations of inspired oxygen does not worsen lung injury after cardiac arrest

Jonathan Elmer, Bo Wang, Samer Melhem, Raghevesh Pullalarevu, Nishit Vaghasia, Jaya Buddineni, Bedda L Rosario, Ankur A Doshi, Clifton W Callaway, Cameron Dezfulian

Short-term amino acid infusion improves protein balance in critically ill patients

Felix Liebau, Martin Sundström, Luc JC van Loon, Jan Wernerman, Olav Rooyackers

Effects of terlipressin as early treatment for protection of brain in a model of haemorrhagic shock

Keila Kazue Ida, Denise Aya Otsuki, Adolfo Toshiro Cotarelli Sasaki, Emilyn Silva Borges, Letícia Urbano Cardoso Castro, Talita Rojas Sanches, Maria-Heloisa Massola Shimizu, Lúcia Conceição Andrade, José-Otávio Costa Auler Jr, Alex Dyson, Kenneth John Smith, Joel Avancini Rocha Filho, Luiz-Marcelo Sá Malbouisson

Mechanical ventilation modes for respiratory distress syndrome in infants: a systematic review and network meta-analysis

Changsong Wang, Libo Guo, Chunjie Chi, Xiaoyang Wang, Lei Guo, Weiwei Wang, Nana Zhao, Yibo Wang, Zhaodi Zhang, Enyou Li

Aspirin therapy in patients with acute respiratory distress syndrome (ARDS) is associated with reduced intensive care unit mortality: a prospective analysis

Andrew J Boyle, Stefania Di Gangi, Umar I Hamid, Linda-Jayne Mottram, Lia McNamee, Griania White, LJ Mark Cross, James J McNamee, Cecilia M O’Kane, Daniel F McAuley

Gastro-oesophageal reflux disease increases the risk of intensive care unit admittance and mechanical ventilation use among patients with chronic obstructive pulmonary disease: a nationwide population-based cohort study

Chen-Liang Tsai, Yu-Huei Lin, Meng-Ting Wang, Li-Nien Chien, Chii Jeng, Chih-Feng Chian, Wann-Cherng Perng, Chi-Huei Chiang, Hung-Yi Chiou

A regional trauma system to optimize the pre-hospital triage of trauma patients

Pierre Bouzat, François-Xavier Ageron, Julien Brun, Albrice Levrat, Marion Berthet, Elisabeth Rancurel, Jean-Marc Thouret, Frederic Thony, Catherine Arvieux, Jean-François Payen

Increase in cerebral oxygenation during advanced life support in out-of-hospital patients is associated with return of spontaneous circulation

Cornelia Genbrugge, Ingrid Meex, Willem Boer, Frank Jans, René Heylen, Bert Ferdinande, Jo Dens, Cathy De Deyne

Colistin and tobramycin resistance during long- term use of selective decontamination strategies in the intensive care unit: a post hoc analysis

Bastiaan HJ Wittekamp, Evelien AN Oostdijk, Anne Marie GA de Smet, Marc JM Bonten

Combatting resistance in intensive care: the multimodal approach of the Spanish ICU “Zero Resistance” program

José Garnacho Montero, Francisco Álvarez Lerma, Paula Ramírez Galleymore, Mercedes Palomar Martínez, Luis Álvarez Rocha, Fernando Barcenilla Gaite, Joaquín Álvarez Rodríguez, Mercedes Catalán González, Inmaculada Fernández Moreno, Jesús Rodríguez Baño, José Campos, Jesús Ma Aranaz Andrés, Yolanda Agra Varela, Carolina Rodríguez Gay, Miguel Sánchez García

Effects of earplugs and eye masks combined with relaxing music on sleep, melatonin and cortisol levels in ICU patients: a randomized controlled trial

Rong-Fang Hu, Xiao-Ying Jiang, Kathleen M Hegadoren, You-Hua Zhang

Postoperative pneumonia following cardiac surgery in non-ventilated patients versus mechanically ventilated patients: is there any difference?

Nicolas Allou, Jerome Allyn, Aurélie Snauwaert, Camille Welsch, Jean Christophe Lucet, Rita Kortbaoui, Mathieu Desmard, Pascal Augustin, Philippe Montravers

Update on the role of extracorporeal CO2 removal as an adjunct to mechanical ventilation in ARDS

Philippe Morimont, Andriy Batchinsky, Bernard Lambermont

State of the art review: the data revolution in critical care

Marzyeh Ghassemi, Leo Anthony Celi, David J Stone

β-blockers in critically ill patients: from physiology to clinical evidence

Silvia Coppola, Sara Froio, Davide Chiumello

Is epinephrine during cardiac arrest associated with worse outcomes in resuscitated patients? Effect of vasopressin and catecholamines on the migration of leukocytes

Franz J Wiedermann, Martina Stichlberger, Wolfgang Lederer

Prehospital endotracheal intubation: elemental or detrimental?

Paul E Pepe, Lynn P Roppolo, Raymond L Fowler

Strain echocardiography in septic shock – a comparison with systolic and diastolic function parameters, cardiac biomarkers and outcome

Lina De Geer, Jan Engvall, Anna Oscarsson

Doubling survival and improving clinical outcomes using a left ventricular assist device instead of chest compressions for resuscitation after prolonged cardiac arrest: a large animal study

Matthias Derwall, Anne Brücken, Christian Bleilevens, Andreas Ebeling, Philipp Föhr, Rolf Rossaint, Karl B Kern, Christoph Nix, Michael Fries

Effect of oral melatonin and wearing earplugs and eye masks on nocturnal sleep in healthy subjects in a simulated intensive care unit environment: which might be a more promising strategy for ICU sleep deprivation?

Hua-Wei Huang, Bo-Lu Zheng, Li Jiang, Zong-Tong Lin, Guo-Bin Zhang, Ling Shen, Xiu-Ming Xi

Predicting one-year mortality of critically ill patients with early acute kidney injury: data from the prospective multicenter FINNAKI study

Meri Poukkanen, Suvi T Vaara, Matti Reinikainen, Tuomas Selander, Sara Nisula, Sari Karlsson, Ilkka Parviainen, Juha Koskenkari, Ville Pettilä

Central venous-to-arterial carbon dioxide difference combined with arterial-to-venous oxygen content difference is associated with lactate evolution in the hemodynamic resuscitation process in early septic shock

Jaume Mesquida, Paula Saludes, Guillem Gruartmoner, Cristina Espinal, Eva Torrents, Francisco Baigorri, Antonio Artigas

Functional outcomes in ICU – what should we be using? - an observational study

Selina M Parry, Linda Denehy, Lisa J Beach, Sue Berney, Hannah C Williamson, Catherine L Granger

Resting energy expenditure and substrate oxidation rates correlate to temperature and outcome after cardiac arrest - a prospective observational cohort study

Ulrike Holzinger, Richard Brunner, Heidrun Losert, Valentin Fuhrmann, Harald Herkner, Christian Madl, Fritz Sterz, Bruno Schneeweiß

Gender differences in outcome and use of resources do exist in Swedish intensive care, but to no advantage for women of premenopausal age

Carolina Samuelsson, Folke Sjöberg, Göran Karlström, Thomas Nolin, Sten M Walther

A high mean arterial pressure target is associated with improved microcirculation in septic shock patients with previous hypertension: a prospective open label study

Jing-Yuan Xu, Si-Qing Ma, Chun Pan, Hong-Li He, Shi-Xia Cai, Shu-Ling Hu, Ai-Ran Liu, Ling Liu, Ying-Zi Huang, Feng-Mei Guo, Yi Yang, Hai-Bo Qiu

Trigger mechanisms of secondary sclerosing cholangitis in critically ill patients

Silke Leonhardt, Wilfried Veltzke-Schlieker, Andreas Adler, Eckart Schott, Roland Hetzer, Walter Schaffartzik, Michael Tryba, Peter Neuhaus, Daniel Seehofer

Copeptin levels are associated with organ dysfunction and death in the intensive care unit after out-of-hospital cardiac arrest

Giuseppe Ristagno, Roberto Latini, Mario Plebani, Martina Zaninotto, Jukka Vaahersalo, Serge Masson, Marjaana Tiainen, Jouni Kurola, Flavio Gaspari, Valentina Milani, Ville Pettilä, Markus Benedikt Skrifvars

Critical care capacity in Canada: results of a national cross-sectional study

Robert A Fowler, Philip Abdelmalik, Gordon Wood, Denise Foster, Noel Gibney, Natalie Bandrauk, Alexis F Turgeon, François Lamontagne, Anand Kumar, Ryan Zarychanski, Rob Green, Sean M Bagshaw, Henry T Stelfox, Ryan Foster, Peter Dodek, Susan Shaw, John Granton, Bernard Lawless, Andrea Hill, Louise Rose, Neill K Adhikari, Damon C Scales, Deborah J Cook, John C Marshall, Claudio Martin, Philippe Jouvet

Significant modification of traditional rapid sequence induction improves safety and effectiveness of pre-hospital trauma anaesthesia

Richard M Lyon, Zane B Perkins, Debamoy Chatterjee, David J Lockey, Malcolm Q Russell

Fluid overload at start of continuous renal replacement therapy is associated with poorer clinical condition and outcome: a prospective observational study on the combined use of bioimpedance vector analysis and serum N-terminal pro-B-type natriuretic peptide measurement

Haiyan Chen, Buyun Wu, Dehua Gong, Zhihong Liu

Clinical effectiveness of a sedation protocol minimizing benzodiazepine infusions and favoring early dexmedetomidine: a before-after study

Lee P Skrupky, Anne M Drewry, Brian Wessman, R Ryan Field, Richard E Fagley, Linda Varghese, Angela Lieu, Joshua Olatunde, Scott T Micek, Marin H Kollef, Walter A Boyle

Inhaled nitric oxide therapy and risk of renal dysfunction: a systematic review and meta-analysis of randomized trials

Sheng-Yuan Ruan, Tao-Min Huang, Hon-Yen Wu, Huey-Dong Wu, Chong-Jen Yu, Mei-Shu Lai

Tryptase is involved in the development of early ventilator-induced pulmonary fibrosis in sepsis-induced lung injury

Jesús Villar, Nuria E Cabrera-Benítez, Francisco Valladares, Sonia García-Hernández, Ángela Ramos-Nuez, José Luís Martín-Barrasa, Mercedes Muros, Robert M Kacmarek, Arthur S Slutsky

Validity of administrative data in recording sepsis: a systematic review

Rachel J Jolley, Keri Jo Sawka, Dean W Yergens, Hude Quan, Nathalie Jetté, Christopher J Doig

Continuous renal replacement therapy in critically ill patients does not affect urinary neutrophil gelatinase-associated lipocalin levels

Ioannis Vasileiadis, Chrysoula Pipili, Serafeim Nanas

Skeletal muscle oxygenation in severe trauma patients during haemorrhagic shock resuscitation

Jerome Duret, Julien Pottecher, Pierre Bouzat, Julien Brun, Anatole Harrois, Jean-Francois Payen, Jacques Duranteau

External validation of scores proposed for estimation of survival probability of patients with severe adult respiratory distress syndrome undergoing extracorporeal membrane oxygenation therapy: a retrospective study

Stephanie Klinzing, Urs Wenger, Peter Steiger, Christoph Thomas Starck, Markus Wilhelm, Reto A Schuepbach, Marco Maggiorini

Impact of active screening for methicillin-resistant Staphylococcus aureus (MRSA) and decolonization on MRSA infections, mortality and medical cost: a quasi-experimental study in surgical intensive care unit

Yuarn-Jang Lee, Jen-Zon Chen, Hsiu-Chen Lin, Hsin-Yi Liu, Shyr-Yi Lin, Hsien-Ho Lin, Chi-Tai Fang, Po-Ren Hsueh

Applicability of pulse pressure variation: how many shades of grey?

Frederic Michard, Denis Chemla, Jean-Louis Teboul

Intertwining extracorporeal membrane oxygenation and continuous renal replacement therapy: sense or nonsense?

Rita Jacobs, Patrick M Honore, Herbert D Spapen

Renal replacement therapy in acute kidney injury: controversy and consensus

Claudio Ronco, Zaccaria Ricci, Daniel De Backer, John A Kellum, Fabio S Taccone, Michael Joannidis, Peter Pickkers, Vincenzo Cantaluppi, Franco Turani, Patrick Saudan, Rinaldo Bellomo, Olivier Joannes-Boyau, Massimo Antonelli, Didier Payen, John R Prowle, Jean-Louis Vincent

MiR-181a: a potential biomarker of acute muscle wasting following elective high-risk cardiothoracic surgery

Susannah AA Bloch, Anna VJ Donaldson, Amy Lewis, Winston AS Banya, Michael I Polkey, Mark JD Griffiths, Paul R Kemp

Renal tubular acidosis is highly prevalent in critically ill patients

Richard Brunner, Andreas Drolz, Thomas-Matthias Scherzer, Katharina Staufer, Valentin Fuhrmann, Christian Zauner, Ulrike Holzinger, Bruno Schneeweiß

Human severe sepsis cytokine mixture increases β2-integrin-dependent polymorphonuclear leukocyte adhesion to cerebral microvascular endothelial cells in vitro

Chris Blom, Brittany L Deller, Douglas D Fraser, Eric K Patterson, Claudio M Martin, Bryan Young, Patricia C Liaw, Payam Yazdan-Ashoori, Angelica Ortiz, Brian Webb, Greg Kilmer, David E Carter, Gediminas Cepinskas

Nebulized antibiotics for ventilator-associated pneumonia: a systematic review and meta-analysis

Fernando G Zampieri, Antonio P Nassar Jr, Dimitri Gusmao-Flores, Leandro U Taniguchi, Antoni Torres, Otavio T Ranzani

Tracheal extubation and reintubation of the critically ill - challenges coming and going

Matteo Parotto, Richard M Cooper

The shock index for pre-hospital identification of trauma patients with early acute coagulopathy and massive bleeding

Pierre Pasquier, Clément Dubost, Brice Malgras, Kevin Kearns, Stéphane Mérat

Severe and multiple hypoglycemic episodes are associated with increased risk of death in ICU patients

Pierre Kalfon, Yannick Le Manach, Carole Ichai, Nicolas Bréchot, Raphaël Cinotti, Pierre-François Dequin, Béatrice Riu-Poulenc, Philippe Montravers, Djilalli Annane, Hervé Dupont, Michel Sorine, Bruno Riou

Unexpected death within 72 hours of emergency department visit: were those deaths preventable?

Hélène Goulet, Victor Guerand, Benjamin Bloom, Patricia Martel, Philippe Aegerter, Enrique Casalino, Bruno Riou, Yonathan Freund

A physiological sign that mimics lung point in critical care ultrasonography

Zhongheng Zhang, Lin Chen

Albumin infusion for the critically ill – is it beneficial and, if so, why and how?

Undurti N Das

A systematic review of implementation strategies for assessment, prevention, and management of ICU delirium and their effect on clinical outcomes

Zoran Trogrlić, Mathieu van der Jagt, Jan Bakker, Michele C Balas, E Wesley Ely, Peter HJ van der Voort, Erwin Ista

Systolic blood pressure and short-term mortality in the emergency department and prehospital setting: a hospital-based cohort study

Anders Kasper Bruun Kristensen, Jon Gitz Holler, Søren Mikkelsen, Jesper Hallas, Annmarie Lassen

Prolonged mechanical ventilation–induced neuroinflammation affects postoperative memory dysfunction in surgical mice

Chang Chen, Zongze Zhang, Ting Chen, Mian Peng, Xing Xu, Yanlin Wang

The administration of dextrose during in-hospital cardiac arrest is associated with increased mortality and neurologic morbidity

Teng J Peng, Lars W Andersen, Brian Z Saindon, Tyler A Giberson, Won Young Kim, Katherine Berg, Victor Novack, Michael W Donnino

Diaphragm ultrasound as indicator of respiratory effort in critically ill patients undergoing assisted mechanical ventilation: a pilot clinical study

Michele Umbrello, Paolo Formenti, Daniela Longhi, Andrea Galimberti, Ilaria Piva, Angelo Pezzi, Giovanni Mistraletti, John J Marini, Gaetano Iapichino

Paracetamol therapy and outcome of critically ill patients: a multicenter retrospective observational study

Satoshi Suzuki, Glenn M Eastwood, Michael Bailey, David Gattas, Peter Kruger, Manoj Saxena, John D Santamaria, Rinaldo Bellomo

Effect of transfusion of fresh frozen plasma on parameters of endothelial condition and inflammatory status in non-bleeding critically ill patients: a prospective substudy of a randomized trial

Marleen Straat, Marcella CA Müller, Joost CM Meijers, Mendi S Arbous, Angelique ME Spoelstra - de Man, Charlotte JP Beurskens, Margreeth B Vroom, Nicole P Juffermans

Protein-bound drugs are prone to sequestration in the extracorporeal membrane oxygenation circuit: results from an ex vivo study

Kiran Shekar, Jason A Roberts, Charles I Mcdonald, Sussan Ghassabian, Chris Anstey, Steven C Wallis, Daniel V Mullany, Yoke L Fung, John F Fraser

A pilot study of change in fracture risk in patients with acute respiratory distress syndrome

Jaikitry Rawal, Mark JW McPhail, Gamumu Ratnayake, Pearl Chan, John Moxham, Stephen DR Harridge, Nicholas Hart, Hugh E Montgomery, Zudin A Puthucheary

Hemopexin in severe inflammation and infection: mouse models and human diseases

Tian Lin, Dayana Maita, Sujatha R Thundivalappil, Frank E Riley, Jasmin Hambsch, Linda J Van Marter, Helen A Christou, Lorenzo Berra, Shawn Fagan, David C Christiani, H Shaw Warren

Intravenous fish oil lipid emulsions in critically ill patients: an updated systematic review and meta-analysis

William Manzanares, Pascal L Langlois, Rupinder Dhaliwal, Margot Lemieux, Daren K Heyland

High central venous saturation after cardiac surgery is associated with increased organ failure and long-term mortality: an observational cross-sectional study

Felix Balzer, Michael Sander, Mark Simon, Claudia Spies, Marit Habicher, Sascha Treskatsch, Viktor Mezger, Uwe Schirmer, Matthias Heringlake, Klaus-Dieter Wernecke, Herko Grubitzsch, Christian von Heymann

Acute kidney injury after cardiac arrest

Omar Tujjar, Giulia Mineo, Antonio Dell’Anna, Belen Poyatos-Robles, Katia Donadello, Sabino Scolletta, Jean-Louis Vincent, Fabio Silvio Taccone

Resuscitation strategies with different arterial pressure targets after surgical management of traumatic shock

Xiaowu Bai, Wenkui Yu, Wu Ji, Kaipeng Duan, Shanjun Tan, Zhiliang Lin, Lin Xu, Ning Li

2015, big data in healthcare: for whom the bell tolls?

Sven Van Poucke, Michiel Thomeer, Admir Hadzic

Does gastric tonometry-guided therapy reduce total mortality in critically ill patients?

Michael G Mythen

Performance and user evaluation of a novel capacitance-based automatic urinometer compared with a manual standard urinometer after elective cardiac surgery

Anton Eklund, Martin Slettengren, Jan van der Linden

Acute respiratory distress syndrome (ARDS)-associated acute cor pulmonale and patent foramen ovale: a multicenter noninvasive hemodynamic study

Annick Legras, Agnès Caille, Emmanuelle Begot, Gwenaëlle Lhéritier, Thierry Lherm, Armelle Mathonnet, Jean-Pierre Frat, Anne Courte, Laurent Martin-Lefèvre, Jean-Paul Gouëllo, Emmanuelle Mercier, Philippe Vignon

Hemodynamic consequences of severe lactic acidosis in shock states: from bench to bedside

Antoine Kimmoun, Emmanuel Novy, Thomas Auchet, Nicolas Ducrocq, Bruno Levy

Veno-venous extracorporeal CO2 removal for the treatment of severe respiratory acidosis

Matthew E Cove, William J Federspiel

Relationship between reduced albumin and inflammation in the critically ill

Marco Marano

Multicenter evaluation of a lateral-flow device test for diagnosing invasive pulmonary aspergillosis in ICU patients

Susanne Eigl, Juergen Prattes, Michaela Lackner, Birgit Willinger, Birgit Spiess, Mark Reinwald, Brigitte Selitsch, Michael Meilinger, Peter Neumeister, Frederike Reischies, Albert Wölfler, Reinhard B Raggam, Holger Flick, Stephan Eschertzhuber, Robert Krause, Dieter Buchheidt, Christopher R Thornton, Cornelia Lass-Flörl, Martin Hoenigl

Time in blood glucose range 70 to 140 mg/dl >80% is strongly associated with increased survival in non-diabetic critically ill adults

James S Krinsley, Jean-Charles Preiser

Effect of initial calorie intake via enteral nutrition in critical illness: a meta-analysis of randomised controlled trials

Feng Tian, Xinying Wang, Xuejin Gao, Xiao Wan, Chao Wu, Li Zhang, Ning Li, Jieshou Li

Urinary neutrophil gelatinase-associated lipocalin identifies critically ill young children with acute kidney injury following intensive care admission: a prospective cohort study

Alexandra JM Zwiers, Saskia N de Wildt, Joost van Rosmalen, Yolanda B de Rijke, Erik AB Buijs, Dick Tibboel, Karlien Cransberg

Association of gender to outcome after out-of-hospital cardiac arrest – a report from the International Cardiac Arrest Registry

Viktor Karlsson, Josef Dankiewicz, Niklas Nielsen, Karl B Kern, Michael R Mooney, Richard R Riker, Sten Rubertsson, David B Seder, Pascal Stammet, Kjetil Sunde, Eldar Søreide, Barbara T Unger, Hans Friberg

Does sodium bicarbonate infusion really have no effect on the incidence of acute kidney injury after cardiac surgery? A prospective observational trial

Anna J Wetz, Anselm Bräuer, Michael Quintel, Daniel Heise

Effects of inhalation of low-dose nitrite or carbon monoxide on post-reperfusion mitochondrial function and tissue injury in hemorrhagic shock swine

Håkon Haugaa, Hernando Gómez, Donald R Maberry, Andre Holder, Olufunmilayo Ogundele, Ana Maria B Quintero, Daniel Escobar, Tor Inge Tønnessen, Hannah Airgood, Cameron Dezfulian, Elizabeth Kenny, Sruti Shiva, Brian Zuckerbraun, Michael R Pinsky

Do alcohol use disorders impact on long term outcomes from intensive care?

Joanne M McPeake, Martin Shaw, Anna O’Neill, Ewan Forrest, Alex Puxty, Tara Quasim, John Kinsella

Neuroprotection in acute brain injury: an up-to-date review

Nino Stocchetti, Fabio S Taccone, Giuseppe Citerio, Paul E Pepe, Peter D Le Roux, Mauro Oddo, Kees H Polderman, Robert D Stevens, William Barsan, Andrew IR Maas, Geert Meyfroidt, Michael J Bell, Robert Silbergleit, Paul M Vespa, Alan I Faden, Raimund Helbok, Samuel Tisherman, Elisa R Zanier, Terence Valenzuela, Julia Wendon, David K Menon, Jean-Louis Vincent

Tetrastarch in cardiac surgery: error, confounding and bias in a meta-analysis of randomized trials

Roberta J Navickis, Gary R Haynes, Mahlon M Wilkes

Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion

Pablo Tapia, Dagoberto Soto, Alejandro Bruhn, Leyla Alegría, Nicolás Jarufe, Cecilia Luengo, Eduardo Kattan, Tomás Regueira, Arturo Meissner, Rodrigo Menchaca, María Ignacia Vives, Nicolas Echeverría, Gustavo Ospina-Tascón, Jan Bakker, Glenn Hernández

The increasing need for biomarkers in intensive care unit-acquired weakness - are microRNAs the solution?

Sebastian T Lugg, Phillip A Howells, David R Thickett

A single preoperative FGF23 measurement is a strong predictor of outcome in patients undergoing elective cardiac surgery: a prospective observational study

Timo Speer, Heinrich V Groesdonk, Beate Zapf, Vanessa Buescher, Miriam Beyse, Laura Duerr, Stella Gewert, Patrizia Krauss, Aaron Poppleton, Stefan Wagenpfeil, Danilo Fliser, Hans-Joachim Schaefers, Matthias Klingele

Association between biomarkers of endothelial injury and hypocoagulability in patients with severe sepsis: a prospective study

Sisse Rye Ostrowski, Nicolai Haase, Rasmus Beier Müller, Morten Hylander Møller, Frank Christian Pott, Anders Perner, Pär Ingemar Johansson

Serum substance P levels are associated with severity and mortality in patients with severe traumatic brain injury

Leonardo Lorente, María M Martín, Teresa Almeida, Mariano Hernández, Luis Ramos, Mónica Argueso, Juan J Cáceres, Jordi Solé-Violán, Alejandro Jiménez

Clinical impact of stress dose steroids in patients with septic shock: insights from the PROWESS-Shock trial

Pedro Póvoa, Jorge I F Salluh, Maria L Martinez, Raquel Guillamat-Prats, Dianne Gallup, Hussein R Al-Khalidi, B Taylor Thompson, V Marco Ranieri, Antonio Artigas

The association between time to antibiotics and relevant clinical outcomes in emergency department patients with various stages of sepsis: a prospective multi-center study

Bas de Groot, Annemieke Ansems, Daan H Gerling, Douwe Rijpsma, Paul van Amstel, Durk Linzel, Piet J Kostense, Marianne Jonker, Evert de Jonge

When do confounding by indication and inadequate risk adjustment bias critical care studies? A simulation study

Michael W Sjoding, Kaiyi Luo, Melissa A Miller, Theodore J Iwashyna

Impact of ICU-acquired weakness on post-ICU physical functioning: a follow-up study

Luuk Wieske, Daniela S Dettling-Ihnenfeldt, Camiel Verhamme, Frans Nollet, Ivo N van Schaik, Marcus J Schultz, Janneke Horn, Marike van der Schaaf

Early deep sedation is associated with decreased in-hospital and two-year follow-up survival

Felix Balzer, Björn Weiß, Oliver Kumpf, Sascha Treskatsch, Claudia Spies, Klaus-Dieter Wernecke, Alexander Krannich, Marc Kastrup

Impact of real-time ultrasound guidance on complications of percutaneous dilatational tracheostomy: a propensity score analysis

Venkatakrishna Rajajee, Craig A Williamson, Brady T West

Functional outcome of prolonged refractory status epilepticus

Alexandre Lai, Hervé D Outin, Julien Jabot, Bruno Mégarbane, Stéphane Gaudry, Rémi Coudroy, Guillaume Louis, Francis Schneider, Nicolas Barbarot, Antoine Roch, Nicolas Lerolle, David Luis, François Fourrier, Anne Renault, Laurent Argaud, Tarek Sharshar, Sébastien Gibot, Pierre-Edouard Bollaert

Kallistatin treatment attenuates lethality and organ injury in mouse models of established sepsis

Pengfei Li, Youming Guo, Grant Bledsoe, Zhi-Rong Yang, Hongkuan Fan, Lee Chao, Julie Chao

High-frequency oscillation ventilation for hypercapnic failure of conventional ventilation in pulmonary acute respiratory distress syndrome

Sigrun Friesecke, Stephanie-Susanne Stecher, Peter Abel

Restrictive and liberal red cell transfusion strategies in adult patients: reconciling clinical data with best practice

Marek A Mirski, Steven M Frank, Daryl J Kor, Jean-Louis Vincent, David R Holmes Jr

Updates in the perioperative and emergency management of non-vitamin K antagonist oral anticoagulants

David Faraoni, Jerrold H Levy, Pierre Albaladejo, Charles-Marc Samama

Plasma citrulline in the critically ill: intriguing biomarker, cautious interpretation

Gaël Piton, Gilles Capellier

Early mobilization on continuous renal replacement therapy is safe and may improve filter life

Frederic M Jacobs

Propensity matching cannot substitute for randomization in albumin studies

Christian J Wiedermann, Wolfgang Wiedermann

Mixed colloids and acute kidney injury: a case of selection bias?

AB Johan Groeneveld, Roberta J Navickis, Mahlon M Wilkes

Is fever control or improved survival the ‘risk factor’ for ventilator-associated pneumonia?

Matthew BA Harmon, Theis S Itenov, Jens U Jensen, Nicole P Juffermans

Acute kidney injury in cardiac surgery patients receiving hydroxyethyl starch solutions

Ole Bayer, Konrad Reinhart

Association between trends in clinical variables and outcome in intensive care patients with faecal peritonitis: analysis of the GenOSept cohort

Ascanio Tridente, Geraldine M Clarke, Andrew Walden, Anthony C Gordon, Paula Hutton, Jean-Daniel Chiche, Paul AH Holloway, Gary H Mills, Julian Bion, Frank Stüber, Christopher Garrard, Charles Hinds

The abdominal compartment syndrome: evolving concepts and future directions

Jan J De Waele, Manu LNG Malbrain, Andrew W Kirkpatrick

One-size MAP does not fit all

Mourad H Senussi

Clinical solutions: not always what they seem?

Anne Burke-Gaffney, Benedict C Creagh-Brown

A comprehensive method to develop a checklist to increase safety of intra-hospital transport of critically ill patients

Anja H Brunsveld-Reinders, M Sesmu Arbous, Sander G Kuiper, Evert de Jonge

Management and outcome of mechanically ventilated patients after cardiac arrest

Yuda Sutherasan, Oscar Peñuelas, Alfonso Muriel, Maria Vargas, Fernando Frutos-Vivar, Iole Brunetti, Konstantinos Raymondos, Davide D’Antini, Niklas Nielsen, Niall D Ferguson, Bernd W Böttiger, Arnaud W Thille, Andrew R Davies, Javier Hurtado, Fernando Rios, Carlos Apezteguía, Damian A Violi, Nahit Cakar, Marco González, Bin Du, Michael A Kuiper, Marco Antonio Soares, Younsuck Koh, Rui P Moreno, Pravin Amin, Vinko Tomicic, Luis Soto, Hans-Henrik Bülow, Antonio Anzueto, Andrés Esteban, Paolo Pelosi

Hydrogen peroxide room disinfection – ready for prime time?

Benedikt D Huttner, Stephan Harbarth

Propranolol attenuates hemorrhage and accelerates wound healing in severely burned adults

Arham Ali, David N Herndon, Ashish Mamachen, Samir Hasan, Clark R Andersen, Ro-Jon Grogans, Jordan L Brewer, Jong O Lee, Jamie Heffernan, Oscar E Suman, Celeste C Finnerty

Acquisition of Pseudomonas aeruginosa and its resistance phenotypes in critically ill medical patients: role of colonization pressure and antibiotic exposure

Nazaret Cobos-Trigueros, Mar Solé, Pedro Castro, Jorge Luis Torres, Cristina Hernández, Mariano Rinaudo, Sara Fernández, Álex Soriano, José María Nicolás, Josep Mensa, Jordi Vila, José Antonio Martínez

An international multicenter retrospective study of Pseudomonas aeruginosa nosocomial pneumonia: impact of multidrug resistance

Scott T Micek, Richard G Wunderink, Marin H Kollef, Catherine Chen, Jordi Rello, Jean Chastre, Massimo Antonelli, Tobias Welte, Bernard Clair, Helmut Ostermann, Esther Calbo, Antoni Torres, Francesco Menichetti, Garrett E Schramm, Vandana Menon

Cognitive screening among acute respiratory failure survivors: a cross-sectional evaluation of the Mini-Mental State Examination

Elizabeth R Pfoh, Kitty S Chan, Victor D Dinglas, Timothy D Girard, James C Jackson, Peter E Morris, Catherine L Hough, Pedro A Mendez-Tellez, E Wesley Ely, Minxuan Huang, Dale M Needham, Ramona O Hopkins

Evolution of chronic renal impairment and long-term mortality after de novo acute kidney injury in the critically ill; a Swedish multi-centre cohort study

Claire Rimes-Stigare, Paolo Frumento, Matteo Bottai, Johan Mårtensson, Claes-Roland Martling, Sten M Walther, Göran Karlström, Max Bell

Virtuous laughter: we should teach medical learners the art of humor

Simon Oczkowski

Diagnostic value of neutrophil gelatinase-associated lipocalin, cystatin C, and soluble triggering receptor expressed on myeloid cells-1 in critically ill patients with sepsis-associated acute kidney injury

Xingui Dai, Zhenhua Zeng, Chunlai Fu, Sheng’an Zhang, Yeping Cai, Zhongqing Chen

Perioperative cardiovascular monitoring of high-risk patients: a consensus of 12

Jean-Louis Vincent, Paolo Pelosi, Rupert Pearse, Didier Payen, Azriel Perel, Andreas Hoeft, Stefano Romagnoli, V Marco Ranieri, Carole Ichai, Patrice Forget, Giorgio Della Rocca, Andrew Rhodes

Experimental acute lung injury induces multi-organ epigenetic modifications in key angiogenic genes implicated in sepsis-associated endothelial dysfunction

Karol Bomsztyk, Daniel Mar, Dowon An, Roya Sharifian, Michal Mikula, Sina A Gharib, William A Altemeier, W Conrad Liles, Oleg Denisenko

Immunomodulation by lipid emulsions in pulmonary inflammation: a randomized controlled trial

Matthias Hecker, Tomke Linder, Juliane Ott, Hans-Dieter Walmrath, Jürgen Lohmeyer, István Vadász, Leigh M Marsh, Susanne Herold, Martin Reichert, Anja Buchbinder, Rory Edward Morty, Britta Bausch, Tobias Fischer, Richard Schulz, Friedrich Grimminger, Martin Witzenrath, Matt Barnes, Werner Seeger, Konstantin Mayer

Central venous-to-arterial carbon dioxide difference as a prognostic tool in high-risk surgical patients

Emmanuel Robin, Emmanuel Futier, Oscar Pires, Maher Fleyfel, Benoit Tavernier, Gilles Lebuffe, Benoit Vallet

Diffuse alveolar damage associated mortality in selected acute respiratory distress syndrome patients with open lung biopsy

Kuo-Chin Kao, Han-Chung Hu, Chih-Hao Chang, Chen-Yiu Hung, Li-Chung Chiu, Shih-Hong Li, Shih-Wei Lin, Li-Pang Chuang, Chih-Wei Wang, Li-Fu Li, Ning-Hung Chen, Cheng-Ta Yang, Chung-Chi Huang, Ying-Huang Tsai

Use of ultrasound guidance to improve the safety of percutaneous dilatational tracheostomy: a literature review

Mariam Alansari, Hadil Alotair, Zohair Al Aseri, Mohammed A Elhoseny

Nurses’ worry or concern and early recognition of deteriorating patients on general wards in acute care hospitals: a systematic review

Gooske Douw, Lisette Schoonhoven, Tineke Holwerda, Getty Huisman-de Waal, Arthur R H van Zanten, Theo van Achterberg, Johannes G van der Hoeven

Neuroprotective properties of dehydroepiandrosterone-sulfate and its relationship to interleukin 6 after aneurysmal subarachnoid hemorrhage: a prospective cohort study

Anke Höllig, Miriam Thiel, Birgit Stoffel-Wagner, Mark Coburn, Hans Clusmann

‘Biomarking’ infection during continuous renal replacement therapy: still relevant?

Patrick M Honore, Rita Jacobs, Inne Hendrickx, Elisabeth De Waele, Viola Van Gorp, Herbert D Spapen

Adequate application of recombinant thrombomodulin for sepsis-associated disseminated intravascular coagulation

Toshiaki Iba

Continuous renal replacement therapy for safe and adequate voriconazole intravenous treatment: enough reason to be confident?

Patrick M Honore, Rita Jacobs, Inne Hendrickx, Elisabeth De Waele, Viola Van Gorp, Herbert D Spapen

Higher colistin dose during continuous renal replacement therapy: look before leaping!

Patrick M. Honore, Rita Jacobs, Inne Hendrickx, Elisabeth De Waele, Viola Van Gorp, Herbert D. Spapen

Nebulized antibiotics for ventilator-associated pneumonia: misleading analysis and interpretation of the data

Wan-Jie Gu

Passive leg raising and compression stockings: a note of caution

Cyril Jacob Chacko, Matt P Wise, Paul J Frost

Critical care management of systemic mastocytosis: when every wasp is a killer bee

Hinke Y. van der Weide, David J. van Westerloo, Walter M. van den Bergh

How nanotechnology-enabled concepts could contribute to the prevention, diagnosis and therapy of bacterial infections

Inge K. Herrmann

The use of meta-analyses for benefit/risk re-evaluations of hydroxyethyl starch

Christian J Wiedermann

Gut and sublingual microvascular effect of esmolol during septic shock in a porcine model

Matthias Jacquet-Lagrèze, Bernard Allaouchiche, Damien Restagno, Christian Paquet, Jean-Yves Ayoub, Jêrome Etienne, François Vandenesch, Olivier Dauwalder, Jeanne-Marie Bonnet, Stéphane Junot

The pitfall of pulse pressure variation in the cardiac dysfunction condition

Huai-wu He, Da-wei Liu

Burn wound healing and treatment: review and advancements

Matthew P. Rowan, Leopoldo C. Cancio, Eric A. Elster, David M. Burmeister, Lloyd F. Rose, Shanmugasundaram Natesan, Rodney K. Chan, Robert J. Christy, Kevin K. Chung

Neural versus pneumatic control of pressure support in patients with chronic obstructive pulmonary diseases at different levels of positive end expiratory pressure: a physiological study

Ling Liu, Feiping Xia, Yi Yang, Federico Longhini, Paolo Navalesi, Jennifer Beck, Christer Sinderby, Haibo Qiu

Neutrophil CD64 expression as a diagnostic marker for sepsis in adult patients: a meta-analysis

Xiao Wang, Zhong-Yun Li, Ling Zeng, An-Qiang Zhang, Wei Pan, Wei Gu, Jian-Xin Jiang

Smart Care™ versus respiratory physiotherapy–driven manual weaning for critically ill adult patients: a randomized controlled trial

Corinne Taniguchi, Elivane S. Victor, Talita Pieri, Renata Henn, Carolina Santana, Erica Giovanetti, Cilene Saghabi, Karina Timenetsky, Raquel Caserta Eid, Eliezer Silva, Gustavo F. J. Matos, Guilherme P. P. Schettino, Carmen S. V. Barbas

A randomized controlled trial on the effects of goal-directed therapy on the inflammatory response open abdominal aortic aneurysm repair

Duane J. Funk, Kent T. HayGlass, Joshua Koulack, Greg Harding, April Boyd, Ryan Brinkman

Is critical care ready for an economic surrogate endpoint?

M Elizabeth Wilcox, Gordon D Rubenfeld

Anti-high mobility group box-1 monoclonal antibody treatment provides protection against influenza A virus (H1N1)-induced pneumonia in mice

Nobuyuki Nosaka, Masato Yashiro, Mutsuko Yamada, Yosuke Fujii, Hirokazu Tsukahara, Keyue Liu, Masahiro Nishibori, Akihiro Matsukawa, Tsuneo Morishima

Effects of fluid administration on renal perfusion in critically ill patients

Mouhamed Djahoum Moussa, Sabino Scolletta, David Fagnoul, Pierre Pasquier, Alexandre Brasseur, Fabio Silvio Taccone, Jean-Louis Vincent, Daniel De Backer

A positive fluid balance is an independent prognostic factor in patients with sepsis

Angela Acheampong, Jean-Louis Vincent

The potential utility of urinary biomarkers for risk prediction in combat casualties: a prospective observational cohort study

Ian J. Stewart, Kristen R. Glass, Jeffrey T. Howard, Benjamin D. Morrow, Jonathan A. Sosnov, Edward D. Siew, Nancy Wickersham, Wayne Latack, Hana K. Kwan, Kelly D. Heegard, Christina Diaz, Aaron T. Henderson, Kristin K. Saenz, T. Alp Ikizler, Kevin K. Chung

Bone - a casualty of ICU survival?

Karin Amrein, Astrid Fahrleitner-Pammer, Hans Peter Dimai

Rapid response systems: a systematic review and meta-analysis

Ritesh Maharaj, Ivan Raffaele, Julia Wendon

Hyperbaric oxygen therapy ameliorates acute brain injury after porcine intracerebral hemorrhage at high altitude

Hai-tao Zhu, Chen Bian, Ji-chao Yuan, Xiao-jun Liao, Wei Liu, Gang Zhu, Hua Feng, Jiang-kai Lin

Common variants of NFE2L2 gene predisposes to acute respiratory distress syndrome in patients with severe sepsis

Marialbert Acosta-Herrera, Maria Pino-Yanes, Jesús Blanco, Juan Carlos Ballesteros, Alfonso Ambrós, Almudena Corrales, Francisco Gandía, Carlés Subirá, David Domínguez, Aurora Baluja, José Manuel Añón, Ramón Adalia, Lina Pérez-Méndez, Carlos Flores, Jesus Villar

Incidence of and risk factors for severe cardiovascular collapse after endotracheal intubation in the ICU: a multicenter observational study

Sebastien Perbet, Audrey De Jong, Julie Delmas, Emmanuel Futier, Bruno Pereira, Samir Jaber, Jean-Michel Constantin

Endotracheal intubation in the ICU

Stephen E. Lapinsky

Selective decontamination and antibiotic resistance in ICUs

Nienke L. Plantinga, Marc JM Bonten

Management of septic shock: a protocol-less approach

Jorge L. Cabrera, Michael R. Pinsky

Perioperative goal-directed therapy and postoperative outcomes in patients undergoing high-risk abdominal surgery: a historical-prospective, comparative effectiveness study

Maxime Cannesson, Davinder Ramsingh, Joseph Rinehart, Aram Demirjian, Trung Vu, Shermeen Vakharia, David Imagawa, Zhaoxia Yu, Sheldon Greenfield, Zeev Kain

Early dynamic left intraventricular obstruction is associated with hypovolemia and high mortality in septic shock patients

Jean-Louis Chauvet, Shari El-Dash, Olivier Delastre, Bernard Bouffandeau, Dominique Jusserand, Jean-Baptiste Michot, Fabrice Bauer, Julien Maizel, Michel Slama

Meropenem therapy in extracorporeal membrane oxygenation patients: an ongoing pharmacokinetic challenge

Patrick M. Honore, Rita Jacobs, Inne Hendrickx, Elisabeth De Waele, Viola Van Gorp, Herbert D. Spapen

Arterial blood pressure targets in septic shock: is it time to move to an individualized approach?

Thiago Domingos Corrêa, Stephan Matthias Jakob, Jukka Takala

Nebulized colistin for treatment of ventilator-associated pneumonia caused by multidrug-resistant Gram-negative bacteria: we still need to straighten out the dose!

Patrick M. Honore, Rita Jacobs, Inne Hendrickx, Elisabeth De Waele, Jouke De Regt, Herbert D. Spapen

A conceptual framework: the early and late phases of skeletal muscle dysfunction in the acute respiratory distress syndrome

D. Clark Files, Michael A. Sanchez, Peter E. Morris

Regional pressure and temperature variations across the injured human brain: comparisons between paired intraparenchymal and ventricular measurements

Charmaine Childs, Liang Shen

Protocols for uncontrolled donation after circulatory death: a systematic review of international guidelines, practices and transplant outcomes

Iván Ortega-Deballon, Laura Hornby, Sam D. Shemie

One-year survival and resource use after critical illness: impact of organ failure and residual organ dysfunction in a cohort study in Brazil

Otavio T. Ranzani, Fernando G. Zampieri, Bruno A. M. P. Besen, Luciano C. P. Azevedo, Marcelo Park

Influence of a strict glucose protocol on serum potassium and glucose concentrations and their association with mortality in intensive care patients

Esther V. Uijtendaal, Jeannette E.F. Zwart-van Rijkom, Dylan W. de Lange, Arief Lalmohamed, Wouter W. van Solinge, Toine C.G. Egberts

Persistently elevated osteopontin serum levels predict mortality in critically ill patients

Christoph Roderburg, Fabian Benz, David Vargas Cardenas, Matthias Lutz, Hans-Joerg Hippe, Tom Luedde, Christian Trautwein, Norbert Frey, Alexander Koch, Frank Tacke, Mark Luedde

Pulse oximetry

Amal Jubran

Physician burnout: can we make a difference together?

Matthew Siedsma, Lillian Emlet

Clinical review: intensive care unit acquired weakness

Greet Hermans, Greet Van den Berghe

Ubiquinol (reduced Coenzyme Q10) in patients with severe sepsis or septic shock: a randomized, double-blind, placebo-controlled, pilot trial

Michael W. Donnino, Sharri J. Mortensen, Lars W. Andersen, Maureen Chase, Katherine M. Berg, Julia Balkema, Jeejabai Radhakrishnan, Raúl J. Gazmuri, Xiaowen Liu, Michael N. Cocchi

Quantifying the healthcare costs of treating severely bleeding major trauma patients: a national study for England

Helen E. Campbell, Elizabeth A. Stokes, Danielle N. Bargo, Nicola Curry, Fiona E. Lecky, Antoinette Edwards, Maralyn Woodford, Frances Seeney, Simon Eaglestone, Karim Brohi, Alastair M. Gray, Simon J. Stanworth

Shedding metabo‘light’ on the search for sepsis biomarkers

Claudia C. dos Santos

The Stockholm experience: interhospital transports on extracorporeal membrane oxygenation

L. Mikael Broman, Bernhard Holzgraefe, Kenneth Palmér, Björn Frenckner

Black-white racial disparities in sepsis: a prospective analysis of the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort

Justin Xavier Moore, John P. Donnelly, Russell Griffin, Monika M. Safford, George Howard, John Baddley, Henry E. Wang

Disrupting differential hypoxia in peripheral veno-arterial extracorporeal membrane oxygenation

Matthew Edward Cove

Urine sTREM-1 may be a valuable biomarker in diagnosis and prognosis of sepsis-associated acute kidney injury

Longxiang Su, Lixin Xie, Dawei Liu

Pulmonary ultrasound and pulse oximetry versus chest radiography and arterial blood gas analysis for the diagnosis of acute respiratory distress syndrome: a pilot study

Cameron M. Bass, Dana R. Sajed, Adeyinka A. Adedipe, T. Eoin West

Adverse events associated with poor neurological outcome during targeted temperature management and advanced critical care after out-of-hospital cardiac arrest

Young-Min Kim, Chun Song Youn, Soo Hyun Kim, Byung Kook Lee, In Soo Cho, Gyu Chong Cho, Kyung Woon Jeung, Sang Hoon Oh, Seung Pill Choi, Jong Hwan Shin, Kyoung-Chul Cha, Joo Suk Oh, Hyeon Woo Yim, Kyu Nam Park

Bench-to-bedside review: the effects of hyperoxia during critical illness

Hendrik J. F. Helmerhorst, Marcus J. Schultz, Peter H. J. van der Voort, Evert de Jonge, David J. van Westerloo

Why the C-statistic is not informative to evaluate early warning scores and what metrics to use

Santiago Romero-Brufau, Jeanne M. Huddleston, Gabriel J. Escobar, Mark Liebow

Early goal-directed resuscitation of patients with septic shock: current evidence and future directions

Ravi G. Gupta, Sarah M. Hartigan, Markos G. Kashiouris, Curtis N. Sessler, Gonzalo M. L. Bearman

Venous thromboembolism in the ICU: main characteristics, diagnosis and thromboprophylaxis

Clémence Minet, Leila Potton, Agnès Bonadona, Rébecca Hamidfar-Roy, Claire Ara Somohano, Maxime Lugosi, Jean-Charles Cartier, Gilbert Ferretti, Carole Schwebel, Jean-François Timsit

Hyperdynamic left ventricular ejection fraction in the intensive care unit

Joseph R. Paonessa, Thomas Brennan, Marco Pimentel, Daniel Steinhaus, Mengling Feng, Leo Anthony Celi

Long-term quality of life in critically ill patients with acute kidney injury treated with renal replacement therapy: a matched cohort study

Sandra Oeyen, Wouter De Corte, Dominique Benoit, Lieven Annemans, Annemieke Dhondt, Raymond Vanholder, Johan Decruyenaere, Eric Hoste

Bioelectrical impedance vector analysis in critically ill patients: a prospective, clinician-blinded investigation

Sarah L. Jones, Aiko Tanaka, Glenn M. Eastwood, Helen Young, Leah Peck, Rinaldo Bellomo, Johan Mårtensson

Tracheostomy procedures in the intensive care unit: an international survey

Maria Vargas, Yuda Sutherasan, Massimo Antonelli, Iole Brunetti, Antonio Corcione, John G. Laffey, Christian Putensen, Giuseppe Servillo, Paolo Pelosi

Physician report cards and rankings yield long-lasting hand hygiene compliance exceeding 90 %

John Adam Reich, Monica E. Goodstein, Susan E. Callahan, Kathleen M. Callahan, Lindsay W. Crossley, Shira I. Doron, David R. Snydman, Stanley A. Nasraway Jr

Timing of antibiotics, volume, and vasoactive infusions in children with sepsis admitted to intensive care

Bregje M. van Paridon, Cathy Sheppard, Garcia Guerra G, Ari R. Joffe

Enteral glutamine supplementation in critically ill patients: a systematic review and meta-analysis

Arthur R. H. van Zanten, Rupinder Dhaliwal, Dominique Garrel, Daren K. Heyland

Postextubation laryngeal edema and stridor resulting in respiratory failure in critically ill adult patients: updated review

Wouter A. Pluijms, Walther NKA van Mook, Bastiaan HJ Wittekamp, Dennis CJJ Bergmans

Loop diuretics in acute heart failure: beyond the decongestive relief for the kidney

Alberto Palazzuoli, Gaetano Ruocco, Claudio Ronco, Peter A. McCullough

Clinical study replicability and the pursuit of excellence

Michael J. Lanspa, Eliotte L. Hirshberg, Russell R. Miller III, Alan H. Morris

Importance of a registered and structured protocol when conducting systematic reviews: comments about nebulized antibiotics for ventilator-associated pneumonia

Fernando G. Zampieri, Antonio P. Nassar Jr, Dimitri Gusmao-Flores, Leandro U. Taniguchi, Antoni Torres, Otavio T. Ranzani

Pre-existing atrial fibrillation and risk of arterial thromboembolism and death in intensive care unit patients: a population-based cohort study

Jacob Gamst, Christian Fynbo Christiansen, Bodil Steen Rasmussen, Lars Hvilsted Rasmussen, Reimar Wernich Thomsen

Erratum: Prospective immune profiling in critically ill adults: before, during and after severe sepsis and septic shock

N. Layios, C. Gosset, C. Delierneux, A. Hego, J. Huart, A. Joly, P. Geurts, P. Damas, C. Oury, A. Gothot

Erratum: Elevated basal levels of circulating activated platelets predict ICU-acquired sepsis and mortality: a prospective study

N. Layios, C. Delierneux, A. Hego, J. Huart, A. Joly, P. Geurts, P. Damas, C. Lecut, A. Gothot, C. Oury

Adequate antibiotic therapy prior to ICU admission in patients with severe sepsis and septic shock reduces hospital mortality

José Garnacho-Montero, Antonio Gutiérrez-Pizarraya, Ana Escoresca-Ortega, Esperanza Fernández-Delgado, José María López-Sánchez

Rifampin use in acute community-acquired meningitis in intensive care units: the French retrospective cohort ACAM-ICU study

Cédric Bretonnière, Mathieu Jozwiak, Christophe Girault, Pascal Beuret, Jean-Louis Trouillet, Nadia Anguel, Jocelyne Caillon, Gilles Potel, Daniel Villers, David Boutoille, Christophe Guitton

Association of left ventricular longitudinal strain with central venous oxygen saturation and serum lactate in patients with early severe sepsis and septic shock

Michael J. Lanspa, Joel E. Pittman, Eliotte L. Hirshberg, Emily L. Wilson, Troy Olsen, Samuel M. Brown, Colin K. Grissom

Renal tubular acidosis with hyperchloremic acidosis: harmless with a sting?

Patrick M. Honore, Rita Jacobs, Inne Hendrickx, Elisabeth De Waele, Viola Van Gorp, Herbert D. Spapen

Is lactate clearance impaired in septic shock?

Thiago Domingos Corrêa, Jukka Takala, Stephan Matthias Jakob

Oxygen - a limiting factor for brain recovery

Amir Hadanny, Shai Efrati

Low B and T lymphocyte attenuator expression on CD4+ T cells in the early stage of sepsis is associated with the severity and mortality of septic patients: a prospective cohort study

Rui Shao, Chun-Sheng Li, Yingying Fang, Lianxing Zhao, Chenchen Hang

Subarachnoid hemorrhage: who dies, and why?

Hector Lantigua, Santiago Ortega-Gutierrez, J. Michael Schmidt, Kiwon Lee, Neeraj Badjatia, Sachin Agarwal, Jan Claassen, E. Sander Connolly, Stephan A. Mayer

Predictors for mechanical ventilation and short-term prognosis in patients with Guillain-Barré syndrome

Xiujuan Wu, Chunrong Li, Bing Zhang, Donghui Shen, Ting Li, Kangding Liu, Hong-Liang Zhang

Lung ultrasound in the critically ill (LUCI) and the lung point: a sign specific to pneumothorax which cannot be mimicked

German Moreno-Aguilar, Daniel Lichtenstein

Outcomes associated with bacteremia in the setting of methicillin-resistant Staphylococcus aureus pneumonia: a retrospective cohort study

Andrew F. Shorr, Marya D. Zilberberg, Scott T. Micek, Marin H. Kollef

Erratum to: Diminished adrenal sensitivity to endogenous and exogenous adrenocorticotropic hormone in critical illness: a prospective cohort study

Margriet FC de Jong, Nienke Molenaar, Albertus Beishuizen, AB Johan Groeneveld

Erratum to: can dynamic light improve melatonin production and quality of sleep?

HI Jensen, TD Thomsen, JW Larsen, J Markvart

Erratum to: Effect of insertion route on risk of central line-associated bloodstream infection in critically ill patients

N. Hassan, A. Hammodi, R. Alhubail, Ali Alazem, N. Rayyan

Microvascular reactivity and clinical outcomes in cardiac surgery

Tae Kyong Kim, Youn Joung Cho, Jeong Jin Min, John M. Murkin, Jae-Hyon Bahk, Deok Man Hong, Yunseok Jeon

The role of previously unmeasured organic acids in the pathogenesis of severe malaria

M. Trent Herdman, Natthida Sriboonvorakul, Stije J. Leopold, Sam Douthwaite, Sanjib Mohanty, M. Mahtab Uddin Hassan, Richard J. Maude, Hugh WF Kingston, Katherine Plewes, Prakaykaew Charunwatthana, Kamolrat Silamut, Charles J. Woodrow, Kesinee Chotinavich, Md. Amir Hossain, M. Abul Faiz, Saroj Mishra, Natchanun Leepipatpiboon, Nicholas J. White, Nicholas PJ Day, Joel Tarning, Arjen M. Dondorp

Automated drug dispensing systems in the intensive care unit: a financial analysis

Claire Chapuis, Pierrick Bedouch, Maxime Detavernier, Michel Durand, Gilles Francony, Pierre Lavagne, Luc Foroni, Pierre Albaladejo, Benoit Allenet, Jean-Francois Payen

Likelihood of infection in patients with presumed sepsis at the time of intensive care unit admission: a cohort study

Peter M. C. Klein Klouwenberg, Olaf L. Cremer, Lonneke A. van Vught, David S. Y. Ong, Jos F. Frencken, Marcus J. Schultz, Marc J. Bonten, Tom van der Poll

Development of metabolic and inflammatory mediator biomarker phenotyping for early diagnosis and triage of pediatric sepsis

Beata Mickiewicz, Graham C. Thompson, Jaime Blackwood, Craig N. Jenne, Brent W. Winston, Hans J. Vogel, Ari R. Joffe

Discrepant post filter ionized calcium concentrations by common blood gas analyzers in CRRT using regional citrate anticoagulation

Patrik Schwarzer, Sven-Olaf Kuhn, Sylvia Stracke, Matthias Gründling, Stephan Knigge, Sixten Selleng, Maximilian Helm, Sigrun Friesecke, Peter Abel, Anders Kallner, Matthias Nauck, Astrid Petersmann

Subsequent shock deliveries are associated with increased favorable neurological outcomes in cardiac arrest patients who had initially non-shockable rhythms

Nobuya Kitamura, Taka-aki Nakada, Koichiro Shinozaki, Yoshio Tahara, Atsushi Sakurai, Naohiro Yonemoto, Ken Nagao, Arino Yaguchi, Naoto Morimura

The accuracy of presepsin (sCD14-ST) for the diagnosis of sepsis in adults: a meta-analysis

Xin Zhang, Dan Liu, You-Ning Liu, Rui Wang, Li-Xin Xie

Daily estimation of the severity of organ dysfunctions in critically ill children by using the PELOD-2 score

Stéphane Leteurtre, Alain Duhamel, Valérie Deken, Jacques Lacroix, Francis Leclerc

Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study

Scott L. Weiss, Julie C. Fitzgerald, Frank A. Maffei, Jason M. Kane, Antonio Rodriguez-Nunez, Deyin D. Hsing, Deborah Franzon, Sze Ying Kee, Jenny L. Bush, Jason A. Roy, Neal J. Thomas, Vinay M. Nadkarni

Echocardiography for adult patients supported with extracorporeal membrane oxygenation

Ghislaine Douflé, Andrew Roscoe, Filio Billia, Eddy Fan

Differential expression of the Nrf2-linked genes in pediatric septic shock

Jocelyn R. Grunwell, Scott L. Weiss, Natalie Z. Cvijanovich, Geoffrey L. Allen, Neal J. Thomas, Robert J. Freishtat, Nick Anas, Keith Meyer, Paul A. Checchia, Thomas P. Shanley, Michael T. Bigham, Julie Fitzgerald, Kelli Howard, Erin Frank, Kelli Harmon, Hector R. Wong

Inhaled nitric oxide improves transpulmonary blood flow and clinical outcomes after prolonged cardiac arrest: a large animal study

Matthias Derwall, Andreas Ebeling, Kay Wilhelm Nolte, Joachim Weis, Rolf Rossaint, Fumito Ichinose, Christoph Nix, Michael Fries, Anne Brücken

Daily laxative therapy reduces organ dysfunction in mechanically ventilated patients: a phase II randomized controlled trial

Rodrigo Palacio de Azevedo, Flávio Geraldo Resende Freitas, Elaine Maria Ferreira, Luciano Cesar Pontes de Azevedo, Flávia Ribeiro Machado

Clinical classification of tissue perfusion based on the central venous oxygen saturation and the peripheral perfusion index

Huaiwu He, Yun Long, Dawei Liu, Xiaoting Wang, Xiang Zhou

THAM reduces CO2-associated increase in pulmonary vascular resistance – an experimental study in lung-injured piglets

Staffan Höstman, João Batista Borges, Fernando Suarez-Sipmann, Kerstin M. Ahlgren, Joakim Engström, Göran Hedenstierna, Anders Larsson

Estrogen administered after cardiac arrest and cardiopulmonary resuscitation ameliorates acute kidney injury in a sex- and age-specific manner

Mizuko Ikeda, Thomas Swide, Alexandra Vayl, Tim Lahm, Sharon Anderson, Michael P. Hutchens

A randomized controlled proof-of-concept trial of early sedation management using Responsiveness Index monitoring in mechanically ventilated critically ill patients

Markus Kaila, Kirsty Everingham, Petteri Lapinlampi, Petra Peltola, Mika O K Särkelä, Kimmo Uutela, Timothy S. Walsh

Impact of intravenous fluid composition on outcomes in patients with systemic inflammatory response syndrome

Andrew D. Shaw, Carol R. Schermer, Dileep N. Lobo, Sibyl H. Munson, Victor Khangulov, David K Hayashida, John A. Kellum

Improvement of antibiotic therapy and ICU survival in severe non-pneumococcal community-acquired pneumonia: a matched case–control study

Simone Gattarello, Leonel Lagunes, Loreto Vidaur, Jordi Solé-Violán, Rafael Zaragoza, Jordi Vallés, Antoni Torres, Rafael Sierra, Rosa Sebastian, Jordi Rello

Early mobilisation in intensive care units in Australia and Scotland: a prospective, observational cohort study examining mobilisation practises and barriers

Meg E. Harrold, Lisa G. Salisbury, Steve A. Webb, Garry T. Allison

Acute respiratory distress syndrome: does histology matter?

José A. Lorente, Aida Ballén-Barragán, Raquel Herrero, Andrés Esteban

Improving documentation and coding for acute organ dysfunction biases estimates of changing sepsis severity and burden: a retrospective study

Chanu Rhee, Michael V. Murphy, Lingling Li, Richard Platt, Michael Klompas

To beta block or not to beta block; that is the question

Can Ince

Dynamics of end expiratory lung volume after changing positive end-expiratory pressure in acute respiratory distress syndrome patients

Aude Garnero, David Tuxen, Gaëlle Corno, Jacques Durand-Gasselin, Carol Hodgson, Jean-Michel Arnal

Erratum to: Exposure to high concentrations of inspired oxygen does not worsen lung injury after cardiac arrest

Jonathan Elmer, Bo Wang, Samer Melhem, Raghavesh Pullalarevu, Nishit Vaghasia, Jaya Buddineni, Bedda L. Rosario, Ankur A. Doshi, Clifton W. Callaway, Cameron Dezfulian

Altering the mechanical scenario to decrease the driving pressure

João Batista Borges, Göran Hedenstierna, Anders Larsson, Fernando Suarez-Sipmann

Non-invasive monitoring of mitochondrial oxygenation and respiration in critical illness using a novel technique

Floor A. Harms, Sander I. A. Bodmer, Nicolaas J.H. Raat, Egbert G. Mik

Monitoring of serum lactate level during cardiopulmonary resuscitation in adult in-hospital cardiac arrest

Chih-Hung Wang, Chien-Hua Huang, Wei-Tien Chang, Min-Shan Tsai, Ping-Hsun Yu, Yen-Wen Wu, Kuan-Yu Hung, Wen-Jone Chen

Long-term outcome of severe herpes simplex encephalitis: a population-based observational study

Youenn Jouan, Leslie Grammatico-Guillon, Fabien Espitalier, Xavier Cazals, Patrick François, Antoine Guillon

Risk factors for delirium after on-pump cardiac surgery: a systematic review

Alex NC Gosselt, Arjen JC Slooter, Pascal RQ Boere, Irene J Zaal

The epidemiology of sepsis: questioning our understanding of the role of race

Thomas S. Valley, Colin R. Cooke

Associations of arterial carbon dioxide and arterial oxygen concentrations with hospital mortality after resuscitation from cardiac arrest

Hendrik J. F. Helmerhorst, Marie-José Roos-Blom, David J. van Westerloo, Ameen Abu-Hanna, Nicolette F. de Keizer, Evert de Jonge

Safety and efficacy of regional citrate anticoagulation in continuous venovenous hemodialysis in the presence of liver failure: the Liver Citrate Anticoagulation Threshold (L-CAT) observational study

Torsten Slowinski, Stanislao Morgera, Michael Joannidis, Thomas Henneberg, Reto Stocker, Elin Helset, Kirsti Andersson, Markus Wehner, Justyna Kozik-Jaromin, Sarah Brett, Julia Hasslacher, John F. Stover, Harm Peters, Hans-H. Neumayer, Detlef Kindgen-Milles

Relationship between a perioperative intravenous fluid administration strategy and acute kidney injury following off-pump coronary artery bypass surgery: an observational study

Ji-Yeon Kim, Kyoung-Woon Joung, Kyung-Mi Kim, Min-Ju Kim, Joon-Bum Kim, Sung-Ho Jung, Eun-Ho Lee, In-Cheol Choi

Diagnosis and management of inhalation injury: an updated review

Patrick F. Walker, Michelle F. Buehner, Leslie A. Wood, Nathan L. Boyer, Ian R. Driscoll, Jonathan B. Lundy, Leopoldo C. Cancio, Kevin K. Chung

Dehydroepiandrosterone sulphate: diabolical hormone or epiphenomenon in aneurysmal subarachnoid hemorrhage?

Santosh B. Murthy, Neeraj S. Naval

Trends in hospital and intensive care admissions in the Netherlands attributable to the very elderly in an ageing population

Lenneke E. M. Haas, Attila Karakus, Rebecca Holman, Sezgin Cihangir, Auke C. Reidinga, Nicolette F. de Keizer

Effect of end-stage renal disease on long-term survival after a first-ever mechanical ventilation: a population-based study

Chin-Ming Chen, Chih-Cheng Lai, Kuo-Chen Cheng, Shih-Feng Weng, Wei-Lun Liu, Hsiu-Nien Shen

Incidence and predisposing factors for the development of disturbed glucose metabolism and DIabetes mellitus AFter Intensive Care admission: the DIAFIC study

Sofie Van Ackerbroeck, Tom Schepens, Karolien Janssens, Philippe G. Jorens, Walter Verbrugghe, Sandra Collet, Viviane Van Hoof, Luc Van Gaal, Christophe De Block

Six-month quality-of-life and functional status of acute respiratory distress syndrome survivors compared to patients at risk: a population-based study

Michelle Biehl, Rahul Kashyap, Adil H. Ahmed, Martin K. Reriani, Uchenna R. Ofoma, Gregory A. Wilson, Guangxi Li, Michael Malinchoc, Jeff A. Sloan, Ognjen Gajic

Faulty risk-of-bias assessment in a meta-analysis of hydroxyethyl starch for nonseptic ICU patients

Ole Bayer, Konrad Reinhart

Epigenetic changes during sepsis: on your marks!

Aurélien Bataille, Pierre Galichon, Marie-Julia Ziliotis, Iman Sadia, Alexandre Hertig

Alleviating central venous oxygen saturation (ScvO2): a new approach of kidney protection after cardiac surgery?

Patrick M. Honore, Rita Jacobs, Inne Hendrickx, Elisabeth De Waele, Duc Nam Nguyen, Herbert D. Spapen

Fluid bolus therapy is a medical therapy or a diagnostic method?

Huaiwu He, Dawei Liu

Procalcitonin and mortality in status epilepticus: an observational cohort study

Raoul Sutter, Martina Valença, Sarah Tschudin-Sutter, Stephan Rüegg, Stephan Marsch

Glial fibrillary acidic protein as a biomarker in severe traumatic brain injury patients: a prospective cohort study

Jin Lei, Guoyi Gao, Junfeng Feng, Yichao Jin, Chuanfang Wang, Qing Mao, Jiyao Jiang

Management and outcome of patients supported with Impella 5.0 for refractory cardiogenic shock

Philippe Gaudard, Marc Mourad, Jacob Eliet, Norddine Zeroual, Geraldine Culas, Philippe Rouvière, Bernard Albat, Pascal Colson

Validation and analysis of prognostic scoring systems for critically ill patients with cirrhosis admitted to ICU

Joseph Campbell, Joanne McPeake, Martin Shaw, Alex Puxty, Ewan Forrest, Charlotte Soulsby, Philp Emerson, Sam J. Thomson, Tony M. Rahman, Tara Quasim, John Kinsella

Xenon triggers pro-inflammatory effects and suppresses the anti-inflammatory response compared to sevoflurane in patients undergoing cardiac surgery

Thomas Breuer, Christoph Emontzpohl, Mark Coburn, Carina Benstoem, Rolf Rossaint, Gernot Marx, Gereon Schälte, Juergen Bernhagen, Christian S. Bruells, Andreas Goetzenich, Christian Stoppe

Diagnostic accuracy of C-reactive protein and procalcitonin in suspected community-acquired pneumonia adults visiting emergency department and having a systematic thoracic CT scan

Josselin Le Bel, Pierre Hausfater, Camille Chenevier-Gobeaux, François-Xavier Blanc, Mikhael Benjoar, Cécile Ficko, Patrick Ray, Christophe Choquet, Xavier Duval, Yann-Erick Claessens

Prognostic significance of the angiopoietin-2/angiopoietin-1 and angiopoietin-1/Tie-2 ratios for early sepsis in an emergency department

Yingying Fang, Chunsheng Li, Rui Shao, Han Yu, Qing Zhang, Lianxing Zhao

Associations between single nucleotide polymorphisms in the FAS pathway and acute kidney injury

Pavan Bhatraju, Christine Hsu, Paramita Mukherjee, Bradford J. Glavan, Amber Burt, Carmen Mikacenic, Jonathan Himmelfarb, Mark Wurfel

The efficacy of recombinant human soluble thrombomodulin for obstetric disseminated intravascular coagulation: a retrospective study

Masato Yoshihara, Kaname Uno, Sho Tano, Michinori Mayama, Mayu Ukai, Shinya Kondo, Tetsuya Kokabu, Yasuyuki Kishigami, Hidenori Oguchi

Ventilator-derived carbon dioxide production to assess energy expenditure in critically ill patients: proof of concept

Sandra N. Stapel, Harm-Jan S. de Grooth, Hoda Alimohamad, Paul W G Elbers, Armand R J Girbes, Peter J M Weijs, Heleen M. Oudemans-van Straaten

Fluid balance and mortality in critically ill patients with acute kidney injury: a multicenter prospective epidemiological study

Na Wang, Li Jiang, Bo Zhu, Ying Wen, Xiu-Ming Xi

Decreased serum concentrations of sphingosine-1-phosphate in sepsis

Martin Sebastian Winkler, Axel Nierhaus, Maximilian Holzmann, Eileen Mudersbach, Antonia Bauer, Linda Robbe, Corinne Zahrte, Maria Geffken, Sven Peine, Edzard Schwedhelm, Guenter Daum, Stefan Kluge, Christian Zoellner

Inflammatory mediators in intra-abdominal sepsis or injury – a scoping review

Zhengwen Xiao, Crystal Wilson, Helen Lee Robertson, Derek J. Roberts, Chad G. Ball, Craig N. Jenne, Andrew W. Kirkpatrick

Aspirin as a potential treatment in sepsis or acute respiratory distress syndrome

Philip Toner, Danny Francis McAuley, Murali Shyamsundar

Milk fat globule epidermal growth factor-factor 8-derived peptide attenuates organ injury and improves survival in sepsis

Weng-Lang Yang, Archna Sharma, Fangming Zhang, Shingo Matsuo, Zhimin Wang, Haichao Wang, Ping Wang

Revised algorithm for heparin anticoagulation during continuous renal replacement therapy

Helen Dickie, Linda Tovey, William Berry, Marlies Ostermann

Biomarkers from distinct biological pathways improve early risk stratification in medical emergency patients: the multinational, prospective, observational TRIAGE study

Philipp Schuetz, Pierre Hausfater, Devendra Amin, Adina Amin, Sebastian Haubitz, Lukas Faessler, Alexander Kutz, Antoinette Conca, Barbara Reutlinger, Pauline Canavaggio, Gabrielle Sauvin, Maguy Bernard, Andreas Huber, Beat Mueller

Interleukin-27: a novel biomarker in predicting bacterial infection among the critically ill

William J. Hanna, Zachary Berrens, Travis Langner, Patrick Lahni, Hector R. Wong

Erratum to: Injurious mechanical ventilation affects neuronal activation in ventilated rats

María Elisa Quilez, Gemma Fuster, Jesús Villar, Carlos Flores, Octavi Martí-Sistac, Lluís Blanch, Josefina López-Aguilar

The effects of a 2-h trial of high-flow oxygen by nasal cannula versus Venturi mask in immunocompromised patients with hypoxemic acute respiratory failure: a multicenter randomized trial

Virginie Lemiale, Djamel Mokart, Julien Mayaux, Jérôme Lambert, Antoine Rabbat, Alexandre Demoule, Elie Azoulay

Extracorporeal decarboxylation in patients with severe traumatic brain injury and ARDS enables effective control of intracranial pressure

Christopher Munoz-Bendix, Kerim Beseoglu, Rainer Kram

Erratum to: the role of previously unmeasured organic acids in the pathogenesis of severe malaria

M. Trent Herdman, Natthida Sriboonvorakul, Stije J. Leopold, Sam Douthwaite, Sanjib Mohanty, M. Mahtab Uddin Hassan, Richard J. Maude, Hugh W. F. Kingston, Katherine Plewes, Prakaykaew Charunwatthana, Kamolrat Silamut, Charles J. Woodrow, Aniruddha Ghose, Kesinee Chotinavich, Md Amir Hossain, M. Abul Faiz, Saroj Mishra, Natchanun Leepipatpiboon, Nicholas J. White, Nicholas P. J. Day, Joel Tarning, Arjen M. Dondorp

Long-term mortality and risk factors for development of end-stage renal disease in critically ill patients with and without chronic kidney disease

Claire Rimes-Stigare, Paolo Frumento, Matteo Bottai, Johan Mårtensson, Claes-Roland Martling, Max Bell

Comparison of community-acquired, hospital-acquired, and intensive care unit-acquired acute respiratory distress syndrome: a prospective observational cohort study

Kuo-Chin Kao, Han-Chung Hu, Meng-Jer Hsieh, Ying-Huang Tsai, Chung-Chi Huang

How to understand the results of studies of glutamine supplementation

Jan Wernerman

Optimizing citrate dose for regional anticoagulation in continuous renal replacement therapy: measuring citrate concentrations instead of ionized calcium?

Patrick M. Honore, Rita Jacobs, Inne Hendrickx, Elisabeth De Waele, Viola Van Gorp, Herbert D. Spapen

Bioelectrical impedance vector analysis in the critically ill: cool tool or just another ‘toy’?

Lui G. Forni, Julia Hasslacher, Michael Joannidis

Qualitative real-time analysis by nurses of sublingual microcirculation in intensive care unit: the MICRONURSE study

Sébastien Tanaka, Anatole Harrois, Camille Nicolaï, Mélanie Flores, Sophie Hamada, Eric Vicaut, Jacques Duranteau

Sepsis impairs microvascular autoregulation and delays capillary response within hypoxic capillaries

Ryon M. Bateman, Michael D. Sharpe, Justin E. Jagger, Christopher G. Ellis

Diabetes-specific enteral nutrition formula in hyperglycemic, mechanically ventilated, critically ill patients: a prospective, open-label, blind-randomized, multicenter study

Alfonso Mesejo, Juan Carlos Montejo-González, Clara Vaquerizo-Alonso, Gabriela Lobo-Tamer, Mercedes Zabarte-Martinez, Jose Ignacio Herrero-Meseguer, Jose Acosta-Escribano, Antonio Blesa-Malpica, Fátima Martinez-Lozano

Difficulty interpreting the results of some trials: the case of therapeutic hypothermia after pediatric cardiac arrest

Jean-Louis Vincent, Fabio S. Taccone

Is neutrophil gelatinase-associated lipocalin unaffected by convective continuous renal replacement therapy? Definitely … maybe

Patrick M. Honore, Rita Jacobs, Inne Hendrickx, Elisabeth De Waele, Viola Van Gorp, Herbert D. Spapen

The rising incidence of severe sepsis based on administrative data — real change or coding-driven bias?

Lavi Oud

Timing of antibiotics, volume and vasoactive infusions in children with sepsis: it is all in the timing

Samiran Ray, Mark J. Peters

Erratum to: Development of the Post Cardiac Surgery (POCAS) prognostic score

Eduardo Tamayo, Inma Fierro, Juan Bustamante-Munguira, María Heredia-Rodríguez, Pablo Jorge-Monjas, Laura Maroto, Esther Gómez-Sánchez, Francisco Jesús Bermejo-Martín, Francisco Javier Álvarez, José Ignacio Gómez-Herreras

Argatroban in the management of heparin-induced thrombocytopenia: a multicenter clinical trial

Brigitte Tardy-Poncet, Philippe Nguyen, Jean-Claude Thiranos, Pierre-Emmanuel Morange, Christine Biron-Andréani, Yves Gruel, Jérome Morel, Alain Wynckel, Lelia Grunebaum, Judith Villacorta-Torres, Sandrine Grosjean, Emmanuel de Maistre

Extracorporeal therapies in pediatric severe sepsis: findings from the pediatric health-care information system

Amanda Ruth, Courtney E. McCracken, James D. Fortenberry, Kiran B. Hebbar

Propofol infusion syndrome: a structured review of experimental studies and 153 published case reports

Adéla Krajčová, Petr Waldauf, Michal Anděl, František Duška

Considerations for initial therapy in the treatment of acute heart failure

William F. Peacock, Chad M. Cannon, Adam J. Singer, Brian C. Hiestand

Does inferior vena cava respiratory variability predict fluid responsiveness in spontaneously breathing patients?

Norair Airapetian, Julien Maizel, Ola Alyamani, Yazine Mahjoub, Emmanuel Lorne, Melanie Levrard, Nacim Ammenouche, Aziz Seydi, François Tinturier, Eric Lobjoie, Hervé Dupont, Michel Slama

To counteract or to clear high-mobility group box-1 protein in influenza A (H1N1) infection? That may become the question

Patrick M. Honore, Rita Jacobs, Inne Hendrickx, Elisabeth De Waele, Viola Van Gorp, Herbert D. Spapen

The incretin effect in critically ill patients: a case–control study

Signe Tellerup Nielsen, Susanne Janum, Rikke Krogh-Madsen, Thomas P. Solomon, Kirsten Møller

Pain-related Somato Sensory Evoked Potentials: a potential new tool to improve the prognostic prediction of coma after cardiac arrest

Paolo Zanatta, Federico Linassi, Anna Paola Mazzarolo, Maria Aricò, Enrico Bosco, Matteo Bendini, Carlo Sorbara, Carlo Ori, Michele Carron, Bruno Scarpa

Impact of antibacterials on subsequent resistance and clinical outcomes in adult patients with viral pneumonia: an opportunity for stewardship

Matthew P. Crotty, Shelby Meyers, Nicholas Hampton, Stephanie Bledsoe, David J. Ritchie, Richard S. Buller, Gregory A. Storch, Marin H. Kollef, Scott T. Micek

Enteral glutamine supplementation in critically ill patients

Xu Tian, Guo-Min Song

What is the right temperature to cool post-cardiac arrest patients?

Premkumar Nattanmai Chandrasekaran, Cameron Dezfulian, Kees H. Polderman

Predictors for mechanical ventilation and short-term prognosis in patients with Guillain-Barré syndrome

Jingyan Yang, Linpei Jia

Brief inhalation of nitric oxide increases resuscitation success and improves 7-day-survival after cardiac arrest in rats: a randomized controlled animal study

Anne Brücken, Matthias Derwall, Christian Bleilevens, Christian Stoppe, Andreas Götzenich, Nadine T. Gaisa, Joachim Weis, Kay Wilhelm Nolte, Rolf Rossaint, Fumito Ichinose, Michael Fries

Risks and benefits of stress ulcer prophylaxis in adult neurocritical care patients: a systematic review and meta-analysis of randomized controlled trials

Bolin Liu, Shujuan Liu, Anan Yin, Javed Siddiqi

Neurological outcomes in children dead on hospital arrival

Yoshikazu Goto, Akira Funada, Yumiko Nakatsu-Goto

Effects of passive leg raising and volume expansion on mean systemic pressure and venous return in shock in humans

Laurent Guérin, Jean-Louis Teboul, Romain Persichini, Martin Dres, Christian Richard, Xavier Monnet

Plasma fractalkine is a sustained marker of disease severity and outcome in sepsis patients

Arie J. Hoogendijk, Maryse A. Wiewel, Lonneke A. van Vught, Brendon P. Scicluna, Hakima Belkasim-Bohoudi, Janneke Horn, Aeilko H. Zwinderman, Peter M. C. Klein Klouwenberg, Olaf L. Cremer, Marc J. Bonten, Marcus J. Schultz, Tom van der Poll

Intensive care at the end of life in patients dying due to non-cancer chronic diseases versus cancer: a nationwide study in Denmark

Thomas Lyngaa, Christian Fynbo Christiansen, Henrik Nielsen, Mette Asbjørn Neergaard, Anders Bonde Jensen, Kristina Grønborg Laut, Søren Paaske Johnsen

Improvement of prognostic performance in severely injured patients by integrated clinico-transcriptomics: a translational approach

Daniel Rittirsch, Veit Schoenborn, Sandro Lindig, Elisabeth Wanner, Kai Sprengel, Sebastian Günkel, Barbara Schaarschmidt, Sonja Märsmann, Hans-Peter Simmen, Paolo Cinelli, Michael Bauer, Ralf A. Claus, Guido A. Wanner

Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis

Espen W. Skjeflo, Caroline Sagatun, Knut Dybwik, Sturla Aam, Sven H. Urving, Miles A. Nunn, Hilde Fure, Corinna Lau, Ole-Lars Brekke, Markus Huber-Lang, Terje Espevik, Andreas Barratt-Due, Erik W. Nielsen, Tom E. Mollnes

Association between the TLR2 Arg753Gln polymorphism and the risk of sepsis: a meta-analysis

Jun-wei Gao, An-qiang Zhang, Xiao Wang, Zhong-yun Li, Jian-hua Yang, Ling Zeng, Wei Gu, Jian-xin Jiang

The effect of mild induced hypothermia on outcomes of patients after cardiac arrest: a systematic review and meta-analysis of randomised controlled trials

Xi Wen Zhang, Jian Feng Xie, Jian Xiao Chen, Ying Zi Huang, Feng Mei Guo, Yi Yang, Hai Bo Qiu

Ascorbate-dependent vasopressor synthesis: a rationale for vitamin C administration in severe sepsis and septic shock?

Anitra C. Carr, Geoffrey M. Shaw, Alpha A. Fowler, Ramesh Natarajan

Association of perioperative intravenous fluid strategy with acute kidney injury following off-pump coronary artery bypass surgery

Fu-Shan Xue, Gao-Pu Liu, Rui-Ping Li

Accuracy of intracranial pressure monitoring: systematic review and meta-analysis

Lucia Zacchetti, Sandra Magnoni, Federica Di Corte, Elisa R. Zanier, Nino Stocchetti

Putative invasive pulmonary aspergillosis in critically ill patients with chronic obstructive pulmonary disease: a matched cohort study

Claire Delsuc, Aurélie Cottereau, Emilie Frealle, Anne-Lise Bienvenu, Rodrigue Dessein, Sophie Jarraud, Oana Dumitrescu, Marion Le Maréchal, Florent Wallet, Arnaud Friggeri, Laurent Argaud, Thomas Rimmelé, Saad Nseir, Florence Ader

The course of diaphragm atrophy in ventilated patients assessed with ultrasound: a longitudinal cohort study

Tom Schepens, Walter Verbrugghe, Karolien Dams, Bob Corthouts, Paul M. Parizel, Philippe G. Jorens

European trauma guideline compliance assessment: the ETRAUSS study

Sophie Rym Hamada, Tobias Gauss, Jakob Pann, Martin Dünser, Marc Leone, Jacques Duranteau

Timing of tracheotomy in ICU patients: a systematic review of randomized controlled trials

Koji Hosokawa, Masaji Nishimura, Moritoki Egi, Jean-Louis Vincent

Combining multiple ECG features does not improve prediction of defibrillation outcome compared to single features in a large population of out-of-hospital cardiac arrests

Mi He, Yushun Gong, Yongqin Li, Tommaso Mauri, Francesca Fumagalli, Marcella Bozzola, Giancarlo Cesana, Roberto Latini, Antonio Pesenti, Giuseppe Ristagno

Biomarker validity in the critically ill: all must face the (continuous) renal replacement challenge!

Patrick M. Honore, Rita Jacobs, Inne Hendrickx, Elisabeth De Waele, Viola Van Gorp, Herbert D. Spapen

Ionized calcium measurements during regional citrate anticoagulation in CRRT: we need better blood gas analyzers

Detlef Kindgen-Milles, Marlies Ostermann, Torsten Slowinski

Presepsin and sepsis-induced acute kidney injury treated with continuous renal replacement therapy: will another promising biomarker bite the dust?

Patrick M. Honore, Rita Jacobs, Inne Hendrickx, Elisabeth De Waele, Viola Van Gorp, Herbert D. Spapen

Citrate anticoagulation for CRRT: don’t always trust the postfilter iCa results!

Heleen M. Oudemans-van Straaten, Marlies Ostermann

Should Reinke edema be considered a contributing factor to post-extubation failure?

Andrea Cortegiani, Vincenzo Russotto, Santi Maurizio Raineri, Antonino Giarratano

Extracorporeal membrane oxygenation (ECMO) for critically ill adults in the emergency department: history, current applications, and future directions

Jarrod M. Mosier, Melissa Kelsey, Yuval Raz, Kyle J. Gunnerson, Robyn Meyer, Cameron D. Hypes, Josh Malo, Sage P. Whitmore, Daniel W. Spaite

Predicting acute kidney injury in severe trauma. A biomarker breakthrough?

Patrick M. Honore, Rita Jacobs, Inne Hendrickx, Elisabeth De Waele, Viola Van Gorp, Herbert D. Spapen

Metabolic and coagulation effects of citrate: down to the last detail!

Patrick M. Honore, Rita Jacobs, Inne Hendrickx, Elisabeth De Waele, Viola Van Gorp, Herbert D. Spapen

Effects of different types of fluid resuscitation for hemorrhagic shock on splanchnic organ microcirculation and renal reactive oxygen species formation

Chun-Yu Wu, Kuang-Cheng Chan, Ya-Jung Cheng, Yu-Chang Yeh, Chiang-Ting Chien

Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study

Benjamin E. Orwoll, Aaron C. Spicer, Matt S. Zinter, Mustafa F. Alkhouli, Robinder G. Khemani, Heidi R. Flori, John M. Neuhaus, Carolyn S. Calfee, Michael A. Matthay, Anil Sapru

PEEP titration during prone positioning for acute respiratory distress syndrome

Jeremy R. Beitler, Claude Guérin, Louis Ayzac, Jordi Mancebo, Dina M. Bates, Atul Malhotra, Daniel Talmor

Can physicochemical properties of antimicrobials be used to predict their pharmacokinetics during extracorporeal membrane oxygenation? Illustrative data from ovine models

Kiran Shekar, Jason A. Roberts, Adrian G. Barnett, Sara Diab, Steven C. Wallis, Yoke L. Fung, John F. Fraser

Long-term remote organ consequences following acute kidney injury

Chih-Chung Shiao, Pei-Chen Wu, Tao-Min Huang, Tai-Shuan Lai, Wei-Shun Yang, Che-Hsiung Wu, Chun-Fu Lai, Vin-Cent Wu, Tzong-Shinn Chu, Kwan-Dun Wu

Reversal of neutrophil-to-lymphocyte count ratio in early versus late death from septic shock

Florence Riché, Etienne Gayat, Romain Barthélémy, Matthieu Le Dorze, Joaquim Matéo, Didier Payen

Plasma levels of microRNA are altered with the development of shock in human sepsis: an observational study

Andrew J. Goodwin, Changrun Guo, James A. Cook, Bethany Wolf, Perry V. Halushka, Hongkuan Fan

Conflicts between healthcare professionals and families of a multi-ethnic patient population during critical care: an ethnographic study

Rose-Lima Van Keer, Reginald Deschepper, Anneke L. Francke, Luc Huyghens, Johan Bilsen

Obituary: Mitchell P. Fink

Derek C. Angus

Fluid overload and acute kidney injury: cause or consequence?

Marlies Ostermann, Heleen M. Oudemans-van Straaten, Lui G. Forni

Faulty risk-of-bias assessment in a meta-analysis of hydroxyethyl starch for non-septic ICU patients: a rebuttal

Michael James, Ivan Joubert, William Lance Michell, Andrew Nicol, Pradeep Navsaria, Rencia Gillespie

Judging quality of current septic shock definitions and criteria

Manu Shankar-Hari, Guido Bertolini, Frank M. Brunkhorst, Rinaldo Bellomo, Djillali Annane, Clifford S. Deutschman, Mervyn Singer

Value of the cuff leak test is limited

Wei Wang, Yu Zhou, Hua-sheng Tong, Lei Su, Ling Zhao

Is the “golden age” of the “golden hour” in sepsis over?

Derek S. Wheeler

Mitochondrial function in skeletal muscle of patients with protracted critical illness and ICU-acquired weakness

Kateřina Jiroutková, Adéla Krajčová, Jakub Ziak, Michal Fric, Petr Waldauf, Valér Džupa, Jan Gojda, Vlasta Němcova-Fürstová, Jan Kovář, Moustafa Elkalaf, Jan Trnka, František Duška

Fenoldopam to prevent acute kidney injury after major surgery—a systematic review and meta-analysis

Michael A. Gillies, Vivek Kakar, Robert J. Parker, Patrick M. Honoré, Marlies Ostermann

Polymicrobial intensive care unit-acquired pneumonia: prevalence, microbiology and outcome

Miquel Ferrer, Leonardo Filippo Difrancesco, Adamantia Liapikou, Mariano Rinaudo, Marco Carbonara, Gianluigi Li Bassi, Albert Gabarrus, Antoni Torres

Incidence and outcome of adults with diabetic ketoacidosis admitted to ICUs in Australia and New Zealand

Balasubramanian Venkatesh, David Pilcher, John Prins, Rinaldo Bellomo, Thomas John Morgan, Michael Bailey

Acute kidney injury treated with renal replacement therapy and 5-year mortality after myocardial infarction-related cardiogenic shock: a nationwide population-based cohort study

Marie Dam Lauridsen, Henrik Gammelager, Morten Schmidt, Thomas Bøjer Rasmussen, Richard E. Shaw, Hans Erik Bøtker, Henrik Toft Sørensen, Christian Fynbo Christiansen

Peri-operative fluid strategy and post-operative acute kidney injury in cardiac surgery patients: any role for pre-operative statin therapy?

Patrick M. Honore, Rita Jacobs, Inne Hendrickx, Elisabeth De Waele, Viola Van Gorp, Herbert D. Spapen

Look at the patient—in sugar and infection

Sascha Tafelski, Claudia Spies, Irit Nachtigall

Cefepime-induced neurotoxicity in critically ill patients undergoing continuous renal replacement therapy: beware of dose reduction!

Patrick M. Honore, Herbert D. Spapen