Critical Care

Impact of prolonged assisted ventilation on diaphragmatic efficiency: NAVA versus PSV

Rosa Di mussi, Savino Spadaro, Lucia Mirabella, Carlo Alberto Volta, Gabriella Serio, Francesco Staffieri, Michele Dambrosio, Gilda Cinnella, Francesco Bruno, Salvatore Grasso

Molecular adsorbent recirculating system and single-pass albumin dialysis in liver failure – a prospective, randomised crossover study

Christoph Sponholz, Katja Matthes, Dina Rupp, Wolf Backaus, Sebastian Klammt, Diana Karailieva, Astrid Bauschke, Utz Settmacher, Matthias Kohl, Mark G. Clemens, Steffen Mitzner, Michael Bauer, Andreas Kortgen

Influence of different electrode belt positions on electrical impedance tomography imaging of regional ventilation: a prospective observational study

Jan Karsten, Thomas Stueber, Nicolas Voigt, Eckhard Teschner, Hermann Heinze

Influence of EMS-physician presence on survival after out-of-hospital cardiopulmonary resuscitation: systematic review and meta-analysis

Bernd W. Böttiger, Michael Bernhard, Jürgen Knapp, Peter Nagele

Safety and efficacy of prothrombin complex concentrate as first-line treatment in bleeding after cardiac surgery

Giangiuseppe Cappabianca, Giovanni Mariscalco, Fausto Biancari, Daniele Maselli, Francesca Papesso, Marzia Cottini, Sandro Crosta, Simona Banescu, Aamer B. Ahmed, Cesare Beghi

Nutrition support practices in critically ill head-injured patients: a global perspective

Lee-anne S. Chapple, Marianne J. Chapman, Kylie Lange, Adam M. Deane, Daren K. Heyland

A commentary on the 2015 Canadian Clinical Practice Guidelines in glutamine supplementation to parenteral nutrition

Alberto Leguina-Ruzzi

The leukocyte-stiffening property of plasma in early acute respiratory distress syndrome (ARDS) revealed by a microfluidic single-cell study: the role of cytokines and protection with antibodies

Pascal Preira, Jean-Marie Forel, Philippe Robert, Paulin Nègre, Martine Biarnes-Pelicot, Francois Xeridat, Pierre Bongrand, Laurent Papazian, Olivier Theodoly

Impact of documentation on interpretation of administrative data

Sam Antonios

Lactic acidosis and severe septic shock in metformin users: a cohort study

Keren Doenyas-Barak, Ilia Beberashvili, Ronit Marcus, Shai Efrati

Elevated high-sensitive troponin T on admission is an indicator of poor long-term outcome in patients with subarachnoid haemorrhage: a prospective observational study

Jonatan Oras, Christina Grivans, Andreas Bartley, Bertil Rydenhag, Sven-Erik Ricksten, Helene Seeman-Lodding

High incidence of adverse events during intra-hospital transport of critically ill patients and new related risk factors: a prospective, multicenter study in China

Liu Jia, Hongliang Wang, Yang Gao, Haitao Liu, Kaijiang Yu

The struggle to differentiate inflammation from infection in severely burned patients: time to send better biomarkers into the arena?

Patrick M. Honore, Herbert D. Spapen

Fondaparinux: another potential treatment for heparin-induced thrombocytopenia type II?

Patrick M. Honore, Rita Jacobs, Inne Hendrickx, Elisabeth De Waele, Viola Van Gorp, Herbert D. Spapen

T cells from patients with Candida sepsis display a suppressive immunophenotype

Andrej Spec, Yuichiro Shindo, Carey-Ann D. Burnham, Strother Wilson, Enyo A. Ablordeppey, Evan R. Beiter, Katherine Chang, Anne M. Drewry, Richard S. Hotchkiss

Reported burden on informal caregivers of ICU survivors: a literature review

Ilse van Beusekom, Ferishta Bakhshi-Raiez, Nicolette F. de Keizer, Dave A. Dongelmans, Marike van der Schaaf

Erratum to: Impact of intravenous fluid composition on outcomes in patients with systemic inflammatory response syndrome

Andrew D. Shaw, Carol R. Schermer, Dileep N. Lobo, Sibyl H. Munson, Victor Khangulov, David K Hayashida, John A. Kellum

Electrical impedance tomography (EIT) for quantification of pulmonary edema in acute lung injury

Constantin J. C. Trepte, Charles R. Phillips, Josep Solà, Andy Adler, Sebastian A. Haas, Michael Rapin, Stephan H. Böhm, Daniel A. Reuter

Treatment of Gram-negative pneumonia in the critical care setting: is the beta-lactam antibiotic backbone broken beyond repair?

Matteo Bassetti, Tobias Welte, Richard G. Wunderink

Dialysis with high-flux membranes significantly affects plasma levels of neutrophil gelatinase-associated lipocalin

Carlo Donadio

The critical care management of poor-grade subarachnoid haemorrhage

Airton Leonardo de Oliveira Manoel, Alberto Goffi, Tom R. Marotta, Tom A. Schweizer, Simon Abrahamson, R. Loch Macdonald

Stress ulcer prophylaxis in adult neurocritical care patients—no firm evidence for benefit or harm

Mette Krag, Anders Perner, Jørn Wetterslev, Morten Hylander Møller

Acute kidney stress—a useful term based on evolution in the understanding of acute kidney injury

Nevin Katz, Claudio Ronco

Erratum to: A commentary on the 2015 Canadian Clinical Practice Guidelines in glutamine supplementation to parenteral nutrition

Alberto Leguina-Ruzzi

Prediction of mortality and functional outcome from status epilepticus and independent external validation of STESS and EMSE scores

Bong Su Kang, Dong Wook Kim, Kwang Ki Kim, Hye Jin Moon, Young-Soo Kim, Hyun Kyung Kim, Seo-Young Lee, Yong Seo Koo, Jung-Won Shin, Jangsup Moon, Jun-Sang Sunwoo, Jung-Ick Byun, Yong Won Cho, Ki-Young Jung, Kon Chu, Sang Kun Lee

ICAT: a simple score predicting critical care needs after thrombolysis in stroke patients

Roland Faigle, Elisabeth B. Marsh, Rafael H. Llinas, Victor C. Urrutia, Rebecca F. Gottesman

Outcomes of patients admitted to intensive care units for acute manifestation of small-vessel vasculitis: a multicenter, retrospective study

Antoine Kimmoun, Elisabeth Baux, Vincent Das, Nicolas Terzi, Patrice Talec, Pierre Asfar, Stephan Ehrmann, Guillaume Geri, Steven Grange, Nadia Anguel, Alexandre Demoule, Anne Sophie Moreau, Elie Azoulay, Jean-Pierre Quenot, Julie Boisramé-Helms, Guillaume Louis, Romain Sonneville, Nicolas Girerd, Nicolas Ducrocq, Nelly Agrinier, Denis Wahl, Xavier Puéchal, Bruno Levy

Veno–veno–arterial extracorporeal membrane oxygenation treatment in patients with severe acute respiratory distress syndrome and septic shock

Hye Ju Yeo, Doosoo Jeon, Yun Seong Kim, Woo Hyun Cho, Dohyung Kim

Erratum to: Ventilator-associated pneumonia in the ICU

Atul Ashok Kalanuria, Wendy Ziai, Marek Mirski

Muscle mass, strength and functional outcomes in critically ill patients after cardiothoracic surgery: does neuromuscular electrical stimulation help? The Catastim 2 randomized controlled trial

Arabella Fischer, Matthias Spiegl, Klaus Altmann, Andreas Winkler, Anna Salamon, Michael Themessl-Huber, Mohamed Mouhieddine, Eva Maria Strasser, Arno Schiferer, Tatjana Paternostro-Sluga, Michael Hiesmayr

Early pneumonia and timing of antibiotic therapy in patients after nontraumatic out-of-hospital cardiac arrest

Kristian Hellenkamp, Sabrina Onimischewski, Jochen Kruppa, Martin Faßhauer, Alexander Becker, Helmut Eiffert, Mark Hünlich, Gerd Hasenfuß, Rolf Wachter

Assessment of central venous catheter colonization using surveillance culture of withdrawn connectors and insertion site skin

María Jesús Pérez-Granda, María Guembe, Raquel Cruces, José María Barrio, Emilio Bouza

Early and persistent high level of PS 100β is associated with increased poor neurological outcome in patients with SAH: is there a PS 100β threshold for SAH prognosis?

Hervé Quintard, Sébastien Leduc, Patricia Ferrari, Isabelle Petit, Carole Ichai

Erratum to: Echocardiography for adult patients supported with extracorporeal membrane oxygenation

Ghislaine Douflé, Andrew Roscoe, Filio Billia, Eddy Fan

A guide to human in vivo microcirculatory flow image analysis

Michael J. Massey, Nathan I. Shapiro

Feasibility and safety of low-flow extracorporeal carbon dioxide removal to facilitate ultra-protective ventilation in patients with moderate acute respiratory distress syndrome

Vito Fanelli, Marco V. Ranieri, Jordi Mancebo, Onnen Moerer, Michael Quintel, Scott Morley, Indalecio Moran, Francisco Parrilla, Andrea Costamagna, Marco Gaudiosi, Alain Combes

Tactical emergency medicine: lessons from Paris marauding terrorist attack

Urinary chitinase 3-like protein 1 for early diagnosis of acute kidney injury: a prospective cohort study in adult critically ill patients

Jorien De Loor, Johan Decruyenaere, Kristel Demeyere, Lieve Nuytinck, Eric AJ Hoste, Evelyne Meyer

Chemerin in peritoneal sepsis and its associations with glucose metabolism and prognosis: a translational cross-sectional study

Paul Horn, Uta Barbara Metzing, Ricardo Steidl, Bernd Romeike, Falk Rauchfuß, Christoph Sponholz, Daniel Thomas-Rüddel, Katrin Ludewig, Andreas L. Birkenfeld, Utz Settmacher, Michael Bauer, Ralf Alexander Claus, Christian von Loeffelholz

Pentraxin-3 as a marker of disease severity and risk of death in patients with necrotizing soft tissue infections: a nationwide, prospective, observational study

Marco Bo Hansen, Lars Simon Rasmussen, Peter Garred, Daniel Bidstrup, Martin Bruun Madsen, Ole Hyldegaard

Diagnosis and prognosis of neutrophil gelatinase-associated lipocalin for acute kidney injury with sepsis: a systematic review and meta-analysis

An Zhang, Ying Cai, Peng-Fei Wang, Jian-Ning Qu, Zhen-Chun Luo, Xiao-Dong Chen, Bin Huang, Yi Liu, Wen-Qi Huang, Jing Wu, Yue-Hui Yin

Ulinastatin administration is associated with a lower incidence of acute kidney injury after cardiac surgery: a propensity score matched study

Xin Wan, Xiangcheng Xie, Yasser Gendoo, Xin Chen, Xiaobing Ji, Changchun Cao

Daily urinary urea excretion to guide intermittent hemodialysis weaning in critically ill patients

Julien Aniort, Ali Ait Hssain, Bruno Pereira, Elisabeth Coupez, Pierre Antoine Pioche, Christophe Leroy, Anne Elisabeth Heng, Bertrand Souweine, Alexandre Lautrette

Prevalence and risk factors of hypotension associated with preload-dependence during intermittent hemodialysis in critically ill patients

Laurent Bitker, Frédérique Bayle, Hodane Yonis, Florent Gobert, Véronique Leray, Romain Taponnier, Sophie Debord, Alina Stoian-Cividjian, Claude Guérin, Jean-Christophe Richard

Prediction of functional outcome in patients with convulsive status epilepticus: the END-IT score

Qiong Gao, Tang-peng Ou-Yang, Xiao-long Sun, Feng Yang, Chen Wu, Tao Kang, Xiao-gang Kang, Wen Jiang

Problems in the management of mass casualties in the Tianjin explosion

Hong-Yu Wang, Hai Yan Wu

Easily identified at-risk patients for extubation failure may benefit from noninvasive ventilation: a prospective before-after study

Arnaud W. Thille, Florence Boissier, Hassen Ben-Ghezala, Keyvan Razazi, Armand Mekontso-Dessap, Christian Brun-Buisson, Laurent Brochard

Applying the termination of resuscitation rules to out-of-hospital cardiac arrests of both cardiac and non-cardiac etiologies: a prospective cohort study

Masahiro Kashiura, Yuichi Hamabe, Akiko Akashi, Atsushi Sakurai, Yoshio Tahara, Naohiro Yonemoto, Ken Nagao, Arino Yaguchi, Naoto Morimura

Algorithm-guided goal-directed haemodynamic therapy does not improve renal function after major abdominal surgery compared to good standard clinical care: a prospective randomised trial

Sebastian Schmid, Barbara Kapfer, Markus Heim, Ralph Bogdanski, Aida Anetsberger, Manfred Blobner, Bettina Jungwirth

Endothelial permeability following coronary artery bypass grafting: an observational study on the possible role of angiopoietin imbalance

Tobias Hilbert, Georg Daniel Duerr, Marwan Hamiko, Stilla Frede, Lynette Rogers, Georg Baumgarten, Andreas Hoeft, Markus Velten

Anaemia is not a risk factor for progression of acute kidney injury: a retrospective analysis

Jonah Powell-Tuck, Siobhan Crichton, Mario Raimundo, Luigi Camporota, Duncan Wyncoll, Marlies Ostermann

Characteristics and risk factors for 28-day mortality of hospital acquired fungemias in ICUs: data from the EUROBACT study

José-Artur Paiva, José Manuel Pereira, Alexis Tabah, Adam Mikstacki, Frederico Bruzzi de Carvalho, Despoina Koulenti, Stéphane Ruckly, Nahit Çakar, Benoit Misset, George Dimopoulos, Massimo Antonelli, Jordi Rello, Xiaochun Ma, Barbara Tamowicz, Jean-François Timsit

Measuring energy expenditure in the intensive care unit: a comparison of indirect calorimetry by E-sCOVX and Quark RMR with Deltatrac II in mechanically ventilated critically ill patients

Martin Sundström Rehal, Erik Fiskaare, Inga Tjäder, Åke Norberg, Olav Rooyackers, Jan Wernerman

Moderate hyperoxic versus near-physiological oxygen targets during and after coronary artery bypass surgery: a randomised controlled trial

Bob Smit, Yvo M. Smulders, Monique C. de Waard, Christa Boer, Alexander B. A. Vonk, Dennis Veerhoek, Suzanne Kamminga, Harm-Jan S. de Grooth, Juan J. García-Vallejo, Rene J. P. Musters, Armand R. J. Girbes, Heleen M. Oudemans - van Straaten, Angelique M. E. Spoelstra - de Man

The association between lactate, mean arterial pressure, central venous oxygen saturation and peripheral temperature and mortality in severe sepsis: a retrospective cohort analysis

Aletta P. I. Houwink, Saskia Rijkenberg, Rob J. Bosman, Peter H. J. van der Voort

Liver function predicts survival in patients undergoing extracorporeal membrane oxygenation following cardiovascular surgery

Christian Roth, Lore Schrutka, Christina Binder, Lukas Kriechbaumer, Gottfried Heinz, Irene M. Lang, Gerald Maurer, Herbert Koinig, Barbara Steinlechner, Alexander Niessner, Klaus Distelmaier, Georg Goliasch

Bedside myocardial perfusion assessment with contrast echocardiography

Sam Orde, Anthony McLean

Crystalloid fluid therapy

Sumeet Reddy, Laurence Weinberg, Paul Young

Abnormal movements in critical care patients with brain injury: a diagnostic approach

Yousef Hannawi, Michael S. Abers, Romergryko G. Geocadin, Marek A. Mirski

Detrimental cross-talk between sepsis and acute kidney injury: new pathogenic mechanisms, early biomarkers and targeted therapies

Sergio Dellepiane, Marita Marengo, Vincenzo Cantaluppi

Variable ventilation from bench to bedside

Robert Huhle, Paolo Pelosi, Marcelo Gama de Abreu

A word of caution on renal risks of prothrombin complex concentrate use in cardiac surgery

Christian J. Wiedermann

The impairment of small nerve fibers in severe sepsis and septic shock

Hubertus Axer, Alexander Grimm, Christine Pausch, Ulrike Teschner, Jan Zinke, Sven Eisenach, Sindy Beck, Orlando Guntinas-Lichius, Frank M. Brunkhorst, Otto W. Witte

Critically ill patients with Middle East respiratory syndrome coronavirus infection

Hasan M. Al-Dorzi, Sami Alsolamy, Yaseen M. Arabi

Mechanical circulatory support in the new era: an overview

Kiran Shekar, Shaun D. Gregory, John F. Fraser

The neglected role of abdominal compliance in organ-organ interactions

Manu L. N. G. Malbrain, Yannick Peeters, Robert Wise

Metabonomics and intensive care

David Antcliffe, Anthony C. Gordon

Creatinine-based definitions: from baseline creatinine to serum creatinine adjustment in intensive care

Silvia De Rosa, Sara Samoni, Claudio Ronco

Predicting cardiorespiratory instability

Michael R. Pinsky, Gilles Clermont, Marilyn Hravnak

Low Plasma Levels of Adiponectin Do Not Explain Acute Respiratory Distress Syndrome Risk: a Prospective Cohort Study of Patients with Severe Sepsis

Jessica A. Palakshappa, Brian J. Anderson, John P. Reilly, Michael G. S. Shashaty, Ryo Ueno, Qufei Wu, Caroline A. G. Ittner, Anna Tommasini, Thomas G. Dunn, Dudley Charles, Altaf Kazi, Jason D. Christie, Nuala J. Meyer

Simple equations for complex physiology: can we use VCO2 for calculating energy expenditure?

Pierre Singer

The role of neutrophils in immune dysfunction during severe inflammation

Pieter H. C. Leliefeld, Catharina M. Wessels, Luke P. H. Leenen, Leo Koenderman, Janesh Pillay

Postoperative blood pressure deficit and acute kidney injury progression in vasopressor-dependent cardiovascular surgery patients

Shinjiro Saito, Shigehiko Uchino, Masanori Takinami, Shoichi Uezono, Rinaldo Bellomo

The influence of corticosteroid treatment on the outcome of influenza A(H1N1pdm09)-related critical illness

Jesse W. Delaney, Ruxandra Pinto, Jennifer Long, François Lamontagne, Neill K. Adhikari, Anand Kumar, John C. Marshall, Deborah J. Cook, Philippe Jouvet, Niall D. Ferguson, Donald Griesdale, Lisa D. Burry, Karen E. A. Burns, Jamie Hutchison, Sangeeta Mehta, Kusum Menon, Robert A. Fowler

Long-term outcomes and healthcare utilization following critical illness – a population-based study

A. D. Hill, R. A. Fowler, R. Pinto, M. S. Herridge, B. H. Cuthbertson, D. C. Scales

Correlation of maximal inspiratory pressure to transdiaphragmatic twitch pressure in intensive care unit patients

Gerald S. Supinski, Phillip Westgate, Leigh A. Callahan

Erratum to: Erythropoietin improves long-term neurological outcome in acute ischemic stroke patients: a randomized, prospective, placebo-controlled clinical trial

Tzu-Hsien Tsai, Cheng-Hsien Lu, Christopher Glenn Wallace, Wen-Neng Chang, Shu-Feng Chen, Chi-Ren Huang, Nai-Wen Tsai, Min-Yu Lan, Pei-Hsun Sung, Chu-Feng Liu, Hon-Kan Yip

Piperacillin concentration in relation to therapeutic range in critically ill patients – a prospective observational study

Johannes Zander, Gundula Döbbeler, Dorothea Nagel, Barbara Maier, Christina Scharf, Mikayil Huseyn-Zada, Jette Jung, Lorenz Frey, Michael Vogeser, Michael Zoller

In-hospital mortality and successful weaning from venoarterial extracorporeal membrane oxygenation: analysis of 5,263 patients using a national inpatient database in Japan

Shotaro Aso, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga

Development of an algorithm to aid triage decisions for intensive care unit admission: a clinical vignette and retrospective cohort study

Joao Gabriel Rosa Ramos, Beatriz Perondi, Roger Daglius Dias, Leandro Costa Miranda, Claudio Cohen, Carlos Roberto Ribeiro Carvalho, Irineu Tadeu Velasco, Daniel Neves Forte

Corticosteroid therapy in refractory shock following cardiac arrest: a randomized, double-blind, placebo-controlled, trial

Michael W. Donnino, Lars W. Andersen, Katherine M. Berg, Maureen Chase, Robert Sherwin, Howard Smithline, Erin Carney, Long Ngo, Parth V. Patel, Xiaowen Liu, Donald Cutlip, Peter Zimetbaum, Michael N. Cocchi

Characteristics and outcomes of anti-infective de-escalation during health care-associated intra-abdominal infections

Philippe Montravers, Pascal Augustin, Nathalie Grall, Mathieu Desmard, Nicolas Allou, Jean-Pierre Marmuse, Jean Guglielminotti

Continuous capnography monitoring during transport of critically ill patients

Kumaresh Venkatesan

French Ministry of Health’s response to Paris attacks of 13 November 2015

Jean-Marc Philippe, Olivier Brahic, Pierre Carli, Jean-Pierre Tourtier, Bruno Riou, Benoit Vallet

How ARDS should be treated

Luciano Gattinoni, Michael Quintel

Neutrophil gelatinase-associated lipocalin elimination by renal replacement therapy: minding the membrane!

Patrick M. Honore, Herbert D. Spapen

Paris terrorist attack: early lessons from the intensivists

Diagnosing sepsis is subjective and highly variable: a survey of intensivists using case vignettes

Chanu Rhee, Sameer S. Kadri, Robert L. Danner, Anthony F. Suffredini, Anthony F. Massaro, Barrett T. Kitch, Grace Lee, Michael Klompas

Variable use of amiodarone is associated with a greater risk of recurrence of atrial fibrillation in the critically ill

Goran Mitrić, Andrew Udy, Hiran Bandeshe, Pierre Clement, Rob Boots

Speaking valves in tracheostomised ICU patients weaning off mechanical ventilation - do they facilitate lung recruitment?

Anna-Liisa Sutt, Lawrence R. Caruana, Kimble R. Dunster, Petrea L. Cornwell, Chris M. Anstey, John F. Fraser

Thiamine as an adjunctive therapy in cardiac surgery: a randomized, double-blind, placebo-controlled, phase II trial

Lars W. Andersen, Mathias J. Holmberg, Katherine M. Berg, Maureen Chase, Michael N. Cocchi, Christopher Sulmonte, Julia Balkema, Mary MacDonald, Sophia Montissol, Venkatachalam Senthilnathan, David Liu, Kamal Khabbaz, Adam Lerner, Victor Novack, Xiaowen Liu, Michael W. Donnino

Sepsis-induced long-term immune paralysis – results of a descriptive, explorative study

C. Arens, S. A. Bajwa, C. Koch, B. H. Siegler, E. Schneck, A. Hecker, S. Weiterer, C. Lichtenstern, M. A. Weigand, F. Uhle

Impact of hyperhydration on the mortality risk in critically ill patients admitted in intensive care units: comparison between bioelectrical impedance vector analysis and cumulative fluid balance recording

Sara Samoni, Valentina Vigo, Luis Ignacio Bonilla Reséndiz, Gianluca Villa, Silvia De Rosa, Federico Nalesso, Fiorenza Ferrari, Mario Meola, Alessandra Brendolan, Paolo Malacarne, Francesco Forfori, Raffaele Bonato, Carlo Donadio, Claudio Ronco

Effect of hemoadsorption during cardiopulmonary bypass surgery – a blinded, randomized, controlled pilot study using a novel adsorbent

Martin H. Bernardi, Harald Rinoesl, Klaus Dragosits, Robin Ristl, Friedrich Hoffelner, Philipp Opfermann, Christian Lamm, Falk Preißing, Dominik Wiedemann, Michael J. Hiesmayr, Andreas Spittler

Communication tools for end-of-life decision-making in the intensive care unit: a systematic review and meta-analysis

Simon J. W. Oczkowski, Han-Oh Chung, Louise Hanvey, Lawrence Mbuagbaw, John J. You

In vivo calibration of esophageal pressure in the mechanically ventilated patient makes measurements reliable

Francesco Mojoli, Giorgio Antonio Iotti, Francesca Torriglia, Marco Pozzi, Carlo Alberto Volta, Stefania Bianzina, Antonio Braschi, Laurent Brochard

Reliability of standard pupillometry practice in neurocritical care: an observational, double-blinded study

David Couret, Delphine Boumaza, Coline Grisotto, Thibaut Triglia, Lionel Pellegrini, Philippe Ocquidant, Nicolas J. Bruder, Lionel J. Velly

The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition

Rolf Rossaint, Bertil Bouillon, Vladimir Cerny, Timothy J. Coats, Jacques Duranteau, Enrique Fernández-Mondéjar, Daniela Filipescu, Beverley J. Hunt, Radko Komadina, Giuseppe Nardi, Edmund A. M. Neugebauer, Yves Ozier, Louis Riddez, Arthur Schultz, Jean-Louis Vincent, Donat R. Spahn

Evidence for a causal link between sepsis and long-term mortality: a systematic review of epidemiologic studies

Manu Shankar-Hari, Michael Ambler, Viyaasan Mahalingasivam, Andrew Jones, Kathryn Rowan, Gordon D. Rubenfeld

Use of intra-osseous access in adults: a systematic review

F. Petitpas, J. Guenezan, T. Vendeuvre, M. Scepi, D. Oriot, O. Mimoz

Strategies to optimize respiratory muscle function in ICU patients

Willem-Jan M. Schellekens, Hieronymus W. H. van Hees, Jonne Doorduin, Lisanne H. Roesthuis, Gert Jan Scheffer, Johannes G. van der Hoeven, Leo M. A. Heunks

Erratum to: ‘Measuring energy expenditure in the intensive care unit: a comparison of indirect calorimetry by E-sCOVX and Quark RMR with Deltatrac II in mechanically ventilated critically ill patients’

Martin Sundström Rehal, Erik Fiskaare, Inga Tjäder, Åke Norberg, Olav Rooyackers, Jan Wernerman

Multiple imputation is better than KDIGO guidelines to estimate unknown baseline renal function

Mathieu Jamme, Guillaume Geri

Future of sepsis therapies

Tom van der Poll

A recommended early goal-directed management guideline for the prevention of hypothermia-related transfusion, morbidity, and mortality in severely injured trauma patients

Ryan Perlman, Jeannie Callum, Claude Laflamme, Homer Tien, Barto Nascimento, Andrew Beckett, Asim Alam

The LUNG SAFE: a biased presentation of the prevalence of ARDS!

Jesús Villar, Marcus J. Schultz, Robert M. Kacmarek

Current evidence for the effectiveness of heated and humidified high flow nasal cannula supportive therapy in adult patients with respiratory failure

Oriol Roca, Gonzalo Hernández, Salvador Díaz-Lobato, José M. Carratalá, Rosa M. Gutiérrez, Joan R. Masclans

The interplay between teamwork, clinicians’ emotional exhaustion, and clinician-rated patient safety: a longitudinal study

Annalena Welp, Laurenz L. Meier, Tanja Manser

Protection of remote ischemic preconditioning against acute kidney injury: a systematic review and meta-analysis

Jiachang Hu, Shaopeng Liu, Ping Jia, Xialian Xu, Nana Song, Ting Zhang, Rongyi Chen, Xiaoqiang Ding

Does ulinastatin really reduce incidence of acute kidney injury after cardiac surgery?

Fu-Shan Xue, Gao-Pu Liu, Chao Sun

Leakage of albumin in major abdominal surgery

Åke Norberg, Olav Rooyackers, Ralf Segersvärd, Jan Wernerman

The paradox of the evidence about invasive fungal infections prevention

Andrea Cortegiani, Vincenzo Russotto, Santi Maurizio Raineri, Antonino Giarratano

Efficacy of prothrombin complex concentrates for the emergency reversal of dabigatran-induced anticoagulation

Oliver Grottke, James Aisenberg, Richard Bernstein, Patrick Goldstein, Menno V. Huisman, Dara G. Jamieson, Jerrold H. Levy, Charles V. Pollack Jr, Alex C. Spyropoulos, Thorsten Steiner, Gregory J. del Zoppo, John Eikelboom

Thoracic epidural analgesia: a new approach for the treatment of acute pancreatitis?

Olivier Windisch, Claudia-Paula Heidegger, Raphaël Giraud, Philippe Morel, Léo Bühler

Enteral versus parenteral nutrition in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials

Gunnar Elke, Arthur R. H. van Zanten, Margot Lemieux, Michele McCall, Khursheed N. Jeejeebhoy, Matthias Kott, Xuran Jiang, Andrew G. Day, Daren K. Heyland

Influence of temperature on thromboelastometry and platelet aggregation in cardiac arrest patients undergoing targeted temperature management

Anni Nørgaard Jeppesen, Hans Kirkegaard, Susanne Ilkjær, Anne Mette Hvas

Identification of regional overdistension, recruitment and cyclic alveolar collapse with electrical impedance tomography in an experimental ARDS model

Songqiao Liu, Li Tan, Knut Möller, Inez Frerichs, Tao Yu, Ling Liu, Yingzi Huang, Fengmei Guo, Jingyuan Xu, Yi Yang, Haibo Qiu, Zhanqi Zhao

Efficacy and safety of proton pump inhibitors for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis of randomized trials

Fayez Alshamsi, Emilie Belley-Cote, Deborah Cook, Saleh A. Almenawer, Zuhoor Alqahtani, Dan Perri, Lehana Thabane, Awad Al-Omari, Kim Lewis, Gordon Guyatt, Waleed Alhazzani

Assessment of dead-space ventilation in patients with acute respiratory distress syndrome: a prospective observational study

Jonne Doorduin, Joeke L. Nollet, Manon P. A. J. Vugts, Lisanne H. Roesthuis, Ferdi Akankan, Johannes G. van der Hoeven, Hieronymus W. H. van Hees, Leo M. A. Heunks

The impact of “early” versus “late” initiation of renal replacement therapy in critical care patients with acute kidney injury: a systematic review and evidence synthesis

Benjamin T. Wierstra, Sameer Kadri, Soha Alomar, Ximena Burbano, Glen W. Barrisford, Raymond L. C. Kao

Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients

Ghaleb A. Almekhlafi, Mohammed M. Albarrak, Yasser Mandourah, Sahar Hassan, Abid Alwan, Abdullah Abudayah, Sultan Altayyar, Mohamed Mustafa, Tareef Aldaghestani, Adnan Alghamedi, Ali Talag, Muhammad K. Malik, Ali S. Omrani, Yasser Sakr

Monocyte programmed death ligand-1 expression after 3–4 days of sepsis is associated with risk stratification and mortality in septic patients: a prospective cohort study

Rui Shao, Yingying Fang, Han Yu, Lianxing Zhao, Zhifeng Jiang, Chun-Sheng Li

Diagnosis and management of invasive candidiasis in the ICU: an updated approach to an old enemy

Thierry Calandra, Jason A. Roberts, Massimo Antonelli, Matteo Bassetti, Jean-Louis Vincent

Fluid management of the neurological patient: a concise review

Mathieu van der Jagt

Prognosis of extremely severe lactic acidosis in metformin-treated patients with septic shock: continuous (?) renal replacement therapy in the spotlight!

Patrick M. Honore, Herbert D. Spapen

Optimizing sedation in patients with acute brain injury

Mauro Oddo, Ilaria Alice Crippa, Sangeeta Mehta, David Menon, Jean-Francois Payen, Fabio Silvio Taccone, Giuseppe Citerio

Regulation of the cerebral circulation: bedside assessment and clinical implications

Joseph Donnelly, Karol P. Budohoski, Peter Smielewski, Marek Czosnyka

Ultra-protective ventilation and hypoxemia

Luciano Gattinoni

Muscle regeneration after sepsis

Adrien Bouglé, Pierre Rocheteau, Tarek Sharshar, Fabrice Chrétien

Severe hypoxemia: which strategy to choose

Davide Chiumello, Matteo Brioni

Advances in antibiotic therapy in the critically ill

Jean-Louis Vincent, Matteo Bassetti, Bruno François, George Karam, Jean Chastre, Antoni Torres, Jason A. Roberts, Fabio S. Taccone, Jordi Rello, Thierry Calandra, Daniel De Backer, Tobias Welte, Massimo Antonelli

Liver function during mechanical circulatory support: from witness to prognostic determinant

Christian Jung, Malte Kelm, Ralf Westenfeld

Beyond muscle destruction: a systematic review of rhabdomyolysis for clinical practice

Luis O. Chavez, Monica Leon, Sharon Einav, Joseph Varon

Antibiotic strategies in the era of multidrug resistance

George Karam, Jean Chastre, Mark H. Wilcox, Jean-Louis Vincent

The use of angiotensin II in distributive shock

Lakhmir S. Chawla, Laurence W. Busse, Ermira Brasha-Mitchell, Ziyad Alotaibi

New generation indirect calorimeters for measuring energy expenditure in the critically ill: a rampant or reticent revolution?

Elisabeth De Waele, Patrick M. Honore, Herbert D. Spapen

Does galactomannan testing increase diagnostic accuracy for IPA in the ICU? A prospective observational study

Maria Schroeder, Marcel Simon, Juri Katchanov, Charles Wijaya, Holger Rohde, Martin Christner, Azien Laqmani, Dominic Wichmann, Valentin Fuhrmann, Stefan Kluge

Hypotension and hypovolemia during hemodialysis: is the usual suspect innocent?

David Berger, Jukka Takala

Nighttime is associated with decreased survival and resuscitation efforts for out-of-hospital cardiac arrests: a prospective observational study

Yosuke Matsumura, Taka-aki Nakada, Koichiro Shinozaki, Takashi Tagami, Tomohisa Nomura, Yoshio Tahara, Atsushi Sakurai, Naohiro Yonemoto, Ken Nagao, Arino Yaguchi, Naoto Morimura

Do spontaneous and mechanical breathing have similar effects on average transpulmonary and alveolar pressure? A clinical crossover study

Giacomo Bellani, Giacomo Grasselli, Maddalena Teggia-Droghi, Tommaso Mauri, Andrea Coppadoro, Laurent Brochard, Antonio Pesenti

Prehospital administration of tranexamic acid in trauma patients

Arasch Wafaisade, Rolf Lefering, Bertil Bouillon, Andreas B. Böhmer, Michael Gäßler, Matthias Ruppert

Regional citrate versus heparin anticoagulation for continuous renal replacement therapy in critically ill patients: a meta-analysis with trial sequential analysis of randomized controlled trials

Chao Liu, Zhi Mao, Hongjun Kang, Jie Hu, Feihu Zhou

Speckle tracking echocardiography in patients with septic shock: a case control study (SPECKSS)

Pauline Yeung Ng, Wai Ching Sin, Andrew Kei-Yan Ng, Wai Ming Chan

Is venous congestion associated with reduced cerebral oxygenation and worse neurological outcome after cardiac arrest?

Koen Ameloot, Cornelia Genbrugge, Ingrid Meex, Ward Eertmans, Frank Jans, Cathy De Deyne, Joseph Dens, Wilfried Mullens, Bert Ferdinande, Matthias Dupont

Effect of the Cardio First Angel™ device on CPR indices: a randomized controlled clinical trial

Amir Vahedian-Azimi, Mohammadreza Hajiesmaeili, Ali Amirsavadkouhi, Hamidreza Jamaati, Morteza Izadi, Seyed J. Madani, Seyed M. R. Hashemian, Andrew C. Miller

Chronic impact of traumatic brain injury on outcome and quality of life: a narrative review

Nino Stocchetti, Elisa R. Zanier

Contribution of Candida biomarkers and DNA detection for the diagnosis of invasive candidiasis in ICU patients with severe abdominal conditions

Cristóbal León, Sergio Ruiz-Santana, Pedro Saavedra, Carmen Castro, Ana Loza, Ismail Zakariya, Alejandro Úbeda, Manuel Parra, Desirée Macías, José Ignacio Tomás, Antonio Rezusta, Alejandro Rodríguez, Frederic Gómez, Estrella Martín-Mazuelos

“Awake” extracorporeal membrane oxygenation (ECMO): pathophysiology, technical considerations, and clinical pioneering

Thomas Langer, Alessandro Santini, Nicola Bottino, Stefania Crotti, Andriy I. Batchinsky, Antonio Pesenti, Luciano Gattinoni

Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome

Anil Sapru, Kathleen D. Liu, Joseph Wiemels, Helen Hansen, Ludmilla Pawlikowska, Annie Poon, Eric Jorgenson, John S. Witte, Carolyn S. Calfee, Lorraine B. Ware, Michael A. Matthay

Anemia management after acute brain injury

Christophe Lelubre, Pierre Bouzat, Ilaria Alice Crippa, Fabio Silvio Taccone

Mechanical circulatory assist devices: a primer for critical care and emergency physicians

Ayan Sen, Joel S. Larson, Kianoush B. Kashani, Stacy L. Libricz, Bhavesh M. Patel, Pramod K. Guru, Cory M. Alwardt, Octavio Pajaro, J. Christopher Farmer

Improving the “urinary side” of acute kidney injury monitoring

Alexandre Toledo Maciel, Daniel Vitorio

Preload dependence and hypotension: One of the causes and one of the consequences of poor tolerance of intermittent hemodialysis in the ICU?

Jérôme Allyn, Laure Corradi, Nicolas Allou, Bernard Alex Gaüzère

An evaluation of the usefulness of single pass albumin dialysis: key role of dialysate flow rate

Mariusz Piechota, Anna Piechota

Acute kidney injury prediction in cardiac surgery patients by a urinary peptide pattern: a case-control validation study

Jochen Metzger, William Mullen, Holger Husi, Angelique Stalmach, Stefan Herget-Rosenthal, Heiner V. Groesdonk, Harald Mischak, Matthias Klingele

Metformin and lactic acidosis during shock: just the tip of the iceberg?

Rene A. Posma, Anthony R. Absalom, Daan J. Touw, Iwan C. C. van der Horst, Maarten W. N. Nijsten

Effects of non-severe acute kidney injury on clinical outcomes in critically ill patients

John A. Kellum, Raghavan Murugan

Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE

H. Bryant Nguyen, Anja Kathrin Jaehne, Namita Jayaprakash, Matthew W. Semler, Sara Hegab, Angel Coz Yataco, Geneva Tatem, Dhafer Salem, Steven Moore, Kamran Boka, Jasreen Kaur Gill, Jayna Gardner-Gray, Jacqueline Pflaum, Juan Pablo Domecq, Gina Hurst, Justin B. Belsky, Raymond Fowkes, Ronald B. Elkin, Steven Q. Simpson, Jay L. Falk, Daniel J. Singer, Emanuel P. Rivers

Portable infrared pupillometry in critical care

Merlin D. Larson, Vineeta Singh

Cardiac surgery, a right target for hyperoxia?

Julie Boisramé-Helms, Peter Radermacher, Pierre Asfar

We need to optimize piperacillin-tazobactam dosing in critically ill patients—but how?

Menino Osbert Cotta, Jason A. Roberts, Jeffrey Lipman

Bedside dressing changes for open abdomen in the intensive care unit is safe and time and staff efficient

Arne Seternes, Sigurd Fasting, Pål Klepstad, Skule Mo, Torbjørn Dahl, Martin Björck, Arne Wibe

Urine sodium concentration to predict fluid responsiveness in oliguric ICU patients: a prospective multicenter observational study

Matthieu Legrand, Brigitte Le Cam, Sébastien Perbet, Claire Roger, Michael Darmon, Philippe Guerci, Axelle Ferry, Véronique Maurel, Sabri Soussi, Jean-Michel Constantin, Etienne Gayat, Jean-Yves Lefrant, Marc Leone

Vascular catheter colonization: surveillance based on culture of needleless connectors

María Jesús Pérez-Granda, María Guembe, Raquel Cruces, Emilio Bouza

Use of CRB-65 and quick Sepsis-related Organ Failure Assessment to predict site of care and mortality in pneumonia patients in the emergency department: a retrospective study

Yun-Xia Chen, Jun-Yu Wang, Shu-Bin Guo

Unexpected versus all-cause mortality as the endpoint for investigating the effects of a Rapid Response System in hospitalized patients

Anja H. Brunsveld-Reinders, Jeroen Ludikhuize, Marcel G. W. Dijkgraaf, M. Sesmu Arbous, Evert de Jonge

From starting mechanical ventilation to ventilator-associated pneumonia, choosing the right moment to start antibiotic treatment

Paula Ramirez, Cristina Lopez-Ferraz, Monica Gordon, Alexandra Gimeno, Esther Villarreal, Jesús Ruiz, Rosario Menendez, Antoni Torres

Inflammasome and toll-like receptor signaling in human monocytes after successful cardiopulmonary resuscitation

Alexander Asmussen, Katrin Fink, Hans-Jörg Busch, Thomas Helbing, Natascha Bourgeois, Christoph Bode, Sebastian Grundmann

Structural equation modelling exploration of the key pathophysiological processes involved in cardiac surgery-related acute kidney injury in infants

Mirela Bojan, Maria Constanza Basto Duarte, Natalia Ermak, Vanessa Lopez-Lopez, Agnès Mogenet, Marc Froissart

Erratum to: ‘Neutrophil CD64 expression as a diagnostic marker for sepsis in adult patients: a meta-analysis’

Xiao Wang, Zhong-Yun Li, Ling Zeng, An-Qiang Zhang, Wei Pan, Wei Gu, Jian-Xin Jiang

Pentraxin-3 to better delineate necrotizing soft tissue infection: not really!

Patrick M. Honore, Herbert D. Spapen

Goal-directed therapy and acute kidney injury: as good as it gets?

James F. Doyle, Marlies Ostermann, Lui G. Forni

A prospective multicenter cohort study of frailty in younger critically ill patients

Sean M. Bagshaw, Sumit R. Majumdar, Darryl B. Rolfson, Quazi Ibrahim, Robert C. McDermid, H. Tom Stelfox

Early changes within the lymphocyte population are associated with the development of multiple organ dysfunction syndrome in trauma patients

Joanna Manson, Elaine Cole, Henry D. De’Ath, Paul Vulliamy, Ute Meier, Dan Pennington, Karim Brohi

The accuracy of blood pressure measured by arterial line and non-invasive cuff in critically ill children

Rachel Joffe, Jonathan Duff, Gonzalo Garcia Guerra, Jodie Pugh, Ari R. Joffe

Adrenomedullin and endothelin-1 are associated with myocardial injury and death in septic shock patients

Oscar H. M. Lundberg, Lill Bergenzaun, Jörgen Rydén, Mari Rosenqvist, Olle Melander, Michelle S. Chew

A novel cardiovascular risk stratification model incorporating ECG and heart rate variability for patients presenting to the emergency department with chest pain

Micah Liam Arthur Heldeweg, Nan Liu, Zhi Xiong Koh, Stephanie Fook-Chong, Weng Kit Lye, Mark Harms, Marcus Eng Hock Ong

The intensive care infection score – a novel marker for the prediction of infection and its severity

Patrick J. van der Geest, Mostafa Mohseni, Jo Linssen, Servet Duran, Robert de Jonge, A. B. Johan Groeneveld

Increased body mass index and adjusted mortality in ICU patients with sepsis or septic shock: a systematic review and meta-analysis

Dominique J. Pepper, Junfeng Sun, Judith Welsh, Xizhong Cui, Anthony F. Suffredini, Peter Q. Eichacker

Cardiopulmonary resuscitation quality and beyond: the need to improve real-time feedback and physiologic monitoring

Steve Lin, Damon C. Scales

Ulinastatin to prevent acute kidney injury after cardiopulmonary bypass surgery: does serum creatinine tell the whole story?

Patrick M. Honore, Herbert D. Spapen

Volumetric capnography: lessons from the past and current clinical applications

Sara Verscheure, Paul B. Massion, Franck Verschuren, Pierre Damas, Sheldon Magder

Genomics and pharmacogenomics of sepsis: so close and yet so far

James A. Russell

Sepsis in PD-1 light

Guillaume Monneret, Morgane Gossez, Fabienne Venet

Acute kidney injury following cardiac surgery: current understanding and future directions

Jason B. O’Neal, Andrew D. Shaw, Frederic T. Billings IV

Acute kidney injury: short-term and long-term effects

James F. Doyle, Lui G. Forni

Surrogate endpoints and competing risk of death in cardiac arrest research

Victoria A. McCredie, Damon C. Scales

Variable ventilation and Jensen's inequality: citation corrections

W. Alan C. Mutch, M. Ruth Graham, John F. Brewster

From bedside to bench: the missing brick for patients with fungal sepsis

Vincenzo Russotto, Andrea Cortegiani, Santi Maurizio Raineri, Antonino Giarratano

Lidocaine can reduce the pain of intra-osseous fluid infusion

Jonathan Ilicki, Jesper Scholander

Why you may need a neurologist to see a comatose patient in the ICU

Eelco F. M. Wijdicks

Erratum to: Multiple imputation is better than KDIGO guidelines for estimating unknown baseline renal function

Matthieu Jamme, Guillaume Geri

Hyperoxemia as a risk factor for ventilator-associated pneumonia

Sophie Six, Karim Jaffal, Geoffrey Ledoux, Emmanuelle Jaillette, Frédéric Wallet, Saad Nseir

The Dose Response Multicentre Investigation on Fluid Assessment (DoReMIFA) in critically ill patients

F. Garzotto, M. Ostermann, D. Martín-Langerwerf, M. Sánchez-Sánchez, J. Teng, R. Robert, A. Marinho, M. E. Herrera-Gutierrez, H. J. Mao, D. Benavente, E. Kipnis, A. Lorenzin, D. Marcelli, C. Tetta, C. Ronco, M Balciunas, B. S. Oliveira, L. Cachafeiro, E. G. Porcile, M. Ranieri, V. Cantaluppi, V. Schweiger, L. Montini, M. Gurjar, C. Liuzzo, N. Brienza, J. Silvestre

Propofol infusion syndrome: early blood purification to the rescue?

Patrick M. Honore, Herbert D. Spapen

An additional method for the prevention of hypothermia in severely injured trauma patients

Ellen Omi, Erik Kulstad

The neurological and cognitive consequences of hyperthermia

Edward James Walter, Mike Carraretto

The pathophysiological basis and consequences of fever

Edward James Walter, Sameer Hanna-Jumma, Mike Carraretto, Lui Forni

Acute kidney injury: from clinical to molecular diagnosis

Claudio Ronco

Is the 77.1 % rate of in-hospital mortality in patients receiving venoarterial extracorporeal membrane oxygenation really that high?

Kentaro Shimizu, Hiroshi Ogura

The value of polyurethane-cuffed endotracheal tubes to reduce microaspiration and intubation-related pneumonia: a systematic review of laboratory and clinical studies

Stijn I. Blot, Jordi Rello, Despoina Koulenti

Decreased CX3CR1 messenger RNA expression is an independent molecular biomarker of early and late mortality in critically ill patients

Arnaud Friggeri, Marie-Angélique Cazalis, Alexandre Pachot, Martin Cour, Laurent Argaud, Bernard Allaouchiche, Bernard Floccard, Zoé Schmitt, Olivier Martin, Thomas Rimmelé, Oriane Fontaine-Kesteloot, Mathieu Page, Vincent Piriou, Julien Bohé, Guillaume Monneret, Stéphane Morisset, Julien Textoris, Hélène Vallin, Sophie Blein, Delphine Maucort-Boulch, Alain Lepape, Fabienne Venet, Guillaume Marcotte, Christian Guillaume, Romain Hernu, Sylvie De La Salle, Marie Simon, Thomas Baudry, Elisabeth Cerrato, Emmanuelle Gallet-Gorius, Audrey Larue, Christine Alberti-Segui, Nathalie Panel, Marion Provent, Jean-Paul Viale, Anne Portier

Daily vancomycin dose requirements as a continuous infusion in obese versus non-obese SICU patients

Hsin Lin, Daniel Dante Yeh, Alexander R. Levine

Effects of dexmedetomidine and propofol on patient-ventilator interaction in difficult-to-wean, mechanically ventilated patients: a prospective, open-label, randomised, multicentre study

Giorgio Conti, Vito Marco Ranieri, Roberta Costa, Chris Garratt, Andrew Wighton, Giorgia Spinazzola, Rosario Urbino, Luciana Mascia, Giuliano Ferrone, Pasi Pohjanjousi, Gabriela Ferreyra, Massimo Antonelli

Association of markers of endothelial dysregulation Ang1 and Ang2 with acute kidney injury in critically ill patients

Cassianne Robinson-Cohen, Ronit Katz, Brenda L. Price, Susanna Harju-Baker, Carmen Mikacenic, Jonathan Himmelfarb, W. Conrad Liles, Mark M. Wurfel

Current real-life use of vasopressors and inotropes in cardiogenic shock - adrenaline use is associated with excess organ injury and mortality

Tuukka Tarvasmäki, Johan Lassus, Marjut Varpula, Alessandro Sionis, Reijo Sund, Lars Køber, Jindrich Spinar, John Parissis, Marek Banaszewski, Jose Silva Cardoso, Valentina Carubelli, Salvatore Di Somma, Alexandre Mebazaa, Veli-Pekka Harjola, Veli-Pekka Harjola, Marek Banaszewski, Lars Kober, Johan Lassus, Alexandre Mebazaa, Marco Metra, John Parissis, Jose Silva-Cardoso, Alessandro Sionis, Salvatore Di Somma, Jindrich Spinar, Katerina Koniari, Astrinos Voumvourakis, Apostolos Karavidas, Jordi Sans-Rosello, Montserrat Vila, Albert Duran-Cambra, Marco Metra, Michela Bulgari, Valentina Lazzarini, Jiri Parenica, Roman Stipal, Ondrej Ludka, Marie Palsuva, Eva Ganovska, Petr Kubena, Matias G. Lindholm, Christian Hassager, Tom Bäcklund, Raija Jurkko, Kristiina Järvinen, Tuomo Nieminen, Kari Pulkki, Leena Soininen, Reijo Sund, Ilkka Tierala, Jukka Tolonen, Marjut Varpula, Tuomas Korva, Anne Pitkälä, Rossella Marino, Alexandra Sousa, Carla Sousa, Mariana Paiva, Inês Rangel, Rui Almeida, Teresa Pinho, Maria Júlia Maciel, Janina Stepinska, Anna Skrobisz, Piotr Góral

Acute kidney injury in critically ill cancer patients: an update

Norbert Lameire, Raymond Vanholder, Wim Van Biesen, Dominique Benoit

qSOFA does not replace SIRS in the definition of sepsis

Jean-Louis Vincent, Greg S. Martin, Mitchell M. Levy

Possible significance of hemodynamic and immunomodulatory effects of early stress-dose steroids in cardiac arrest

Spyros D. Mentzelopoulos, Nicolas Mongardon, Theodoros Xanthos, Spyros G. Zakynthinos

A blueprint for improving undergraduate education in intensive care medicine

Enda O’Connor, Ignacio Martin-Loeches

Using noninvasive ventilation to prevent extubation failure: it is good news, but do we really know what “high risk” means?

Alastair J. Glossop, Antonio M. Esquinas

Dead space in acute respiratory distress syndrome: more than a feeling!

Lluis Blanch, Josefina López-Aguilar, Umberto Lucangelo

Your critical care patient may have HLH (hemophagocytic lymphohistiocytosis)

Rafal Machowicz, Gritta Janka, Wieslaw Wiktor-Jedrzejczak

Erratum to: Why you may need a neurologist to see a comatose patient in the ICU

Eelco F. M. Wijdicks

Ebola virus disease and critical illness

Aleksandra Leligdowicz, William A. Fischer II, Timothy M. Uyeki, Thomas E. Fletcher, Neill K. J. Adhikari, Gina Portella, Francois Lamontagne, Christophe Clement, Shevin T. Jacob, Lewis Rubinson, Abel Vanderschuren, Jan Hajek, Srinivas Murthy, Mauricio Ferri, Ian Crozier, Elhadj Ibrahima, Marie-Claire Lamah, John S. Schieffelin, David Brett-Major, Daniel G. Bausch, Nikki Shindo, Adrienne K. Chan, Tim O’Dempsey, Sharmistha Mishra, Michael Jacobs, Stuart Dickson, G. Marshall Lyon III, Robert A. Fowler

Individualizing endpoints in randomized clinical trials to better inform individual patient care: the TARGET proposal

Theodore J. Iwashyna, Adam M. Deane

Increasing survival after admission to UK critical care units following cardiopulmonary resuscitation

J. P. Nolan, P. Ferrando, J. Soar, J. Benger, M. Thomas, D. A. Harrison, G. D. Perkins

Absence of obvious link between supra-therapeutic serum levels of β lactams and clinical toxicity in ICU patients with acute renal failure treated with intermittent hemodialysis

Faten May, Najouah El-Helali, Jean-François Timsit, Benoît Misset

Multidrug resistance, inappropriate empiric therapy, and hospital mortality in Acinetobacter baumannii pneumonia and sepsis

Marya D. Zilberberg, Brian H. Nathanson, Kate Sulham, Weihong Fan, Andrew F. Shorr

Neutropenic sepsis is associated with distinct clinical and biological characteristics: a cohort study of severe sepsis

John P. Reilly, Brian J. Anderson, Kristin M. Hudock, Thomas G. Dunn, Altaf Kazi, Anna Tommasini, Dudley Charles, Michael G. S. Shashaty, Mark E. Mikkelsen, Jason D. Christie, Nuala J. Meyer

Erratum to: A prospective multicenter cohort study of frailty in younger critically ill patients

Sean M. Bagshaw, Sumit R. Majumdar, Darryl B. Rolfson, Quazi Ibrahim, Robert C. McDermid, H. Tom Stelfox

VCO2 calorimetry is a convenient method for improved assessment of energy expenditure in the intensive care unit

Ulrike Pielmeier, Steen Andreassen

In tribute to, in honor of, and with respectful memories of Professor William C. Shoemaker

Bart Chernow

Mechanical ventilation strategies for intensive care unit patients without acute lung injury or acute respiratory distress syndrome: a systematic review and network meta-analysis

Lei Guo, Weiwei Wang, Nana Zhao, Libo Guo, Chunjie Chi, Wei Hou, Anqi Wu, Hongshuang Tong, Yue Wang, Changsong Wang, Enyou Li

Ultrasonography in the emergency department

Micah R. Whitson, Paul H. Mayo

Critical care ultrasonography in acute respiratory failure

Philippe Vignon, Xavier Repessé, Antoine Vieillard-Baron, Eric Maury

Benefit profile of anticoagulant therapy in sepsis: a nationwide multicentre registry in Japan

Kazuma Yamakawa, Yutaka Umemura, Mineji Hayakawa, Daisuke Kudo, Masamitsu Sanui, Hiroki Takahashi, Yoshiaki Yoshikawa, Toshimitsu Hamasaki, Satoshi Fujimi, Shinjiro Saito, Shigehiko Uchino, Yusuke Iizuka, Wataru Matsunaga, Kohei Takimoto, Toshihiko Mayumi, Hideaki Arai, Takeo Azuhata, Fumihito Ito, Shodai Yoshihiro, Hayakawa Katsura, Tsuyoshi Nakashima, Takayuki Ogura, Eiichiro Noda, Yoshihiko Nakamura, Ryosuke Sekine, Motohiro Sekinao, Keiko Ueno, Yuko Okuda, Masayuki Watanabe, Akihito Tampo, Nobuyuki Saito, Yuya Kitai, Iwao Kobayashi, Yutaka Kondo, Sho Nachi, Toru Miike, Hiroshi Takahashi, Shuhei Takauji, Kensuke Umakoshi, Takafumi Todaka, Hiroshi Kodaira, Kohkichi Andoh, Takehiko Kasai, Yoshiaki Iwashita, Masato Murata, Masahiro Yamane, Kazuhiro Shiga, Naoto Hori

Guidewire exchange vs new site placement for temporary dialysis catheter insertion in ICU patients: is there a greater risk of colonization or dysfunction?

Elisabeth Coupez, Jean-François Timsit, Stéphane Ruckly, Carole Schwebel, Didier Gruson, Emmanuel Canet, Kada Klouche, Laurent Argaud, Julien Bohe, Maïté Garrouste-Orgeas, Christophe Mariat, François Vincent, Sophie Cayot, Olivier Cointault, Alain Lepape, Michael Darmon, Alexandre Boyer, Elie Azoulay, Lila Bouadma, Alexandre Lautrette, Bertrand Souweine

Respiratory weakness after mechanical ventilation is associated with one-year mortality - a prospective study

Clément Medrinal, Guillaume Prieur, Éric Frenoy, Aurora Robledo Quesada, Antoine Poncet, Tristan Bonnevie, Francis-Edouard Gravier, Bouchra Lamia, Olivier Contal

The effect of camicinal (GSK962040), a motilin agonist, on gastric emptying and glucose absorption in feed-intolerant critically ill patients: a randomized, blinded, placebo-controlled, clinical trial

Marianne J. Chapman, Adam M. Deane, Stephanie L. O’Connor, Nam Q. Nguyen, Robert J. L. Fraser, Duncan B. Richards, Kimberley E. Hacquoil, Lakshmi S. Vasist Johnson, Matthew E. Barton, George E. Dukes

Variation in diurnal sedation in mechanically ventilated patients who are managed with a sedation protocol alone or a sedation protocol and daily interruption

Sangeeta Mehta, Maureen Meade, Lisa Burry, Ranjeeta Mallick, Christina Katsios, Dean Fergusson, Peter Dodek, Karen Burns, Margaret Herridge, John W. Devlin, Maged Tanios, Robert Fowler, Michael Jacka, Yoanna Skrobik, Kendiss Olafson, Deborah Cook

Effects of dexmedetomidine and esmolol on systemic hemodynamics and exogenous lactate clearance in early experimental septic shock

Glenn Hernández, Pablo Tapia, Leyla Alegría, Dagoberto Soto, Cecilia Luengo, Jussara Gomez, Nicolas Jarufe, Pablo Achurra, Rolando Rebolledo, Alejandro Bruhn, Ricardo Castro, Eduardo Kattan, Gustavo Ospina-Tascón, Jan Bakker

Measurement of functional and morphodynamic neutrophil phenotypes in systemic inflammation and sepsis

Rens Zonneveld, G. Molema, Frans B. Plötz

Speckle tracking echocardiography: another step towards early detection of septic myocardial dysfunction?

Elio Antonucci, Sara Agosta

Severe community-acquired pneumonia: timely management measures in the first 24 hours

Jason Phua, Nathan C. Dean, Qi Guo, Win Sen Kuan, Hui Fang Lim, Tow Keang Lim

Latent AKI is… still AKI: the quantification of the burden of renal dysfunction

Zaccaria Ricci, Stefano Romagnoli, Luca Di Chiara

Does hyperoxia enhance susceptibility to secondary pulmonary infection in the ICU?

Benedikt Nußbaum, Peter Radermacher, Pierre Asfar, Clair Hartmann

Antibiotic dosing in obesity: a BIG challenge

Timothy P. Hanrahan, Jeffrey Lipman, Jason A. Roberts

Is it time to combine untargeted antifungal strategies to reach the goal of ‘early’ effective treatment?

Andrea Cortegiani, Vincenzo Russotto, Santi Maurizio Raineri, Antonino Giarratano

The predictive value of early acute kidney injury for long-term survival and quality of life of critically ill patients

Ivo W. Soliman, Jos F. Frencken, Linda M. Peelen, Arjen J. C. Slooter, Olaf L. Cremer, Johannes J. van Delden, Diederik van Dijk, Dylan W. de Lange

Application of a simplified definition of diastolic function in severe sepsis and septic shock

Michael J. Lanspa, Andrea R. Gutsche, Emily L. Wilson, Troy D. Olsen, Eliotte L. Hirshberg, Daniel B. Knox, Samuel M. Brown, Colin K. Grissom

Early identification of sepsis in hospital inpatients by ward nurses increases 30-day survival

Malvin Torsvik, Lise Tuset Gustad, Arne Mehl, Inger Lise Bangstad, Liv Jorun Vinje, Jan Kristian Damås, Erik Solligård

When to start renal replacement therapy in critically ill patients with acute kidney injury: comment on AKIKI and ELAIN

Sean M. Bagshaw, François Lamontagne, Michael Joannidis, Ron Wald

Is first-line antimicrobial therapy still adequate to treat MRSA in the ICU? A report from a highly endemic country

Matteo Bassetti, Elda Righi, Maddalena Peghin, Alessia Carnelutti, Filippo Ansaldi, Cecilia Trucchi, Cristiano Alicino, Enrico Maria Tricarichi, Paola Del Giacomo, Mario Tumbarello

Pyrexia: aetiology in the ICU

Daniel J. Niven, Kevin B. Laupland

Letter to the Editor: Lack of requirements for conducting meta-analysis to evaluate the association between the TLR2 Arg753Gln polymorphism and the risk of sepsis

Yasushi Tsujimoto, Yusuke Tsutsumi, Tatsuyoshi Ikenoue

Management of bleeding in patients treated with direct oral anticoagulants

Marcel Levi

Saline versus balanced solutions: are clinical trials comparing two crystalloid solutions really needed?

Jean-Louis Vincent, Daniel De Backer

Elevated plasma heparin-binding protein is associated with early death after resuscitation from cardiac arrest

Giuseppe Ristagno, Serge Masson, Marjaana Tiainen, Stepani Bendel, Roberto Bernasconi, Tero Varpula, Valentina Milani, Jukka Vaahersalo, Michela Magnoli, Eberhard Spanuth, Simona Barlera, Roberto Latini, Sanna Hoppu, Ville Pettilä, Markus B. Skrifvars

Association of diabetes and diabetes treatment with the host response in critically ill sepsis patients

Lonneke A. van Vught, Brendon P. Scicluna, Arie J. Hoogendijk, Maryse A. Wiewel, Peter M. C. Klein Klouwenberg, Olaf L. Cremer, Janneke Horn, Peter Nürnberg, Marc M. J. Bonten, Marcus J. Schultz, Tom van der Poll

Rapid response teams: how are they best used?

Thomas Rozen, Warwick Butt

Impaired Ca2+ release contributes to muscle weakness in a rat model of critical illness myopathy

Monica Llano-Diez, Arthur J. Cheng, William Jonsson, Niklas Ivarsson, Håkan Westerblad, Vic Sun, Nicola Cacciani, Lars Larsson, Joseph Bruton

External validation of a prehospital risk score for critical illness

Daniel R. Kievlan, Christian Martin-Gill, Jeremy M. Kahn, Clifton W. Callaway, Donald M. Yealy, Derek C. Angus, Christopher W. Seymour

Long-term outcome in ICU patients with acute kidney injury treated with renal replacement therapy: a prospective cohort study

Wouter De Corte, Annemieke Dhondt, Raymond Vanholder, Jan De Waele, Johan Decruyenaere, Veerle Sergoyne, Joke Vanhalst, Stefaan Claus, Eric A. J. Hoste

The value of blood lactate kinetics in critically ill patients: a systematic review

Jean-Louis Vincent, Amanda Quintairos e Silva, Lúcio Couto Jr, Fabio S. Taccone

Automatic detection of ventilatory modes during invasive mechanical ventilation

Gastón Murias, Jaume Montanyà, Encarna Chacón, Anna Estruga, Carles Subirà, Rafael Fernández, Bernat Sales, Candelaria de Haro, Josefina López-Aguilar, Umberto Lucangelo, Jesús Villar, Robert M. Kacmarek, Lluís Blanch

The efficacy and safety of prokinetic agents in critically ill patients receiving enteral nutrition: a systematic review and meta-analysis of randomized trials

Kim Lewis, Zuhoor Alqahtani, Lauralyn Mcintyre, Saleh Almenawer, Fayez Alshamsi, Andrew Rhodes, Laura Evans, Derek C. Angus, Waleed Alhazzani

Early initiation of continuous renal replacement therapy improves survival of elderly patients with acute kidney injury: a multicenter prospective cohort study

Jae Yoon Park, Jung Nam An, Jong Hyun Jhee, Dong Ki Kim, Hyung Jung Oh, Sejoong Kim, Kwon Wook Joo, Yun Kyu Oh, Chun-Soo Lim, Shin-Wook Kang, Yon Su Kim, Jung Tak Park, Jung Pyo Lee

The association of sleep quality, delirium, and sedation status with daily participation in physical therapy in the ICU

Biren B. Kamdar, Michael P. Combs, Elizabeth Colantuoni, Lauren M. King, Timothy Niessen, Karin J. Neufeld, Nancy A. Collop, Dale M. Needham

Probiotic and synbiotic therapy in critical illness: a systematic review and meta-analysis

William Manzanares, Margot Lemieux, Pascal L. Langlois, Paul E. Wischmeyer

The usability of ventilators: a comparative evaluation of use safety and user experience

Plinio P. Morita, Peter B. Weinstein, Christopher J. Flewwelling, Carleene A. Bañez, Tabitha A. Chiu, Mario Iannuzzi, Aastha H. Patel, Ashleigh P. Shier, Joseph A. Cafazzo

Intra-operative events during cardiac surgery are risk factors for the development of delirium in the ICU

Alain Rudiger, Hülya Begdeda, Daniela Babic, Bernard Krüger, Burkhardt Seifert, Maria Schubert, Donat R. Spahn, Dominique Bettex

Noninvasive ventilation with helmet versus control strategy in patients with acute respiratory failure: a systematic review and meta-analysis of controlled studies

Qi Liu, Yonghua Gao, Rongchang Chen, Zhe Cheng

The right ventricle: interaction with the pulmonary circulation

Michael R. Pinsky

New aspects in the management of pneumonia

Elena Prina, Adrian Ceccato, Antoni Torres

The LUNG SAFE study: a presentation of the prevalence of ARDS according to the Berlin Definition!

Giacomo Bellani, John G. Laffey, Tài Pham, Eddy Fan

Fundamentals of aerosol therapy in critical care

Jayesh Dhanani, John F. Fraser, Hak-Kim Chan, Jordi Rello, Jeremy Cohen, Jason A. Roberts

Left ventricular function: time-varying elastance and left ventricular aortic coupling

Keith R. Walley

Volume and its relationship to cardiac output and venous return

S. Magder

The critical care management of spontaneous intracranial hemorrhage: a contemporary review

Airton Leonardo de Oliveira Manoel, Alberto Goffi, Fernando Godinho Zampieri, David Turkel-Parrella, Abhijit Duggal, Thomas R. Marotta, R. Loch Macdonald, Simon Abrahamson

Nonvitamin K antagonist oral anticoagulant activity: challenges in measurement and reversal

Karen S. Brown, Hamim Zahir, Michael A. Grosso, Hans J. Lanz, Michele F. Mercuri, Jerrold H. Levy

Echocardiography as a guide for fluid management

John H. Boyd, Demetrios Sirounis, Julien Maizel, Michel Slama

Echocardiography in shock management

Anthony S. McLean

Airway driving pressure and lung stress in ARDS patients

Davide Chiumello, Eleonora Carlesso, Matteo Brioni, Massimo Cressoni

Management of delayed cerebral ischemia after subarachnoid hemorrhage

Charles L. Francoeur, Stephan A. Mayer

Retraction Note: Diacerhein attenuates the inflammatory response and improves survival in a model of severe sepsis

Kelly L Calisto, Angélica C Camacho, Francine C Mittestainer, Bruno M Carvalho, Dioze Guadagnini, José B Carvalheira, Mario J Saad

The digestive tract as the origin of systemic inflammation

Petrus R. de Jong, José M. González-Navajas, Nicolaas J. G. Jansen

Bronchoalveolar lavage fluid galactomannan as a diagnostic biomarker for IPA: still a long way to go

Yuetian Yu, Cheng Zhu, Yuan Gao

Association of polymorphisms in genes of factors involved in regulation of splicing of cystic fibrosis transmembrane conductance regulator mRNA with acute respiratory distress syndrome in children with pneumonia

Francesca Perez-Marques, Pippa Simpson, Ke Yan, Michael W. Quasney, Nadine Halligan, Daniel Merchant, Mary K. Dahmer

Outcome and predictors for successful resuscitation in the emergency room of adult patients in traumatic cardiorespiratory arrest

J. Zwingmann, R. Lefering, M. Feucht, N. P. Südkamp, P. C. Strohm, T. Hammer

Nomenclature for renal replacement therapy and blood purification techniques in critically ill patients: practical applications

Gianluca Villa, Mauro Neri, Rinaldo Bellomo, Jorge Cerda, A. Raffaele De Gaudio, Silvia De Rosa, Francesco Garzotto, Patrick M. Honore, John Kellum, Anna Lorenzin, Didier Payen, Zaccaria Ricci, Sara Samoni, Jean-Louis Vincent, Julia Wendon, Marta Zaccaria, Claudio Ronco, S. M. Bagshaw, A. Balducci, I. Baldwin, F. Barbarigo, R. Bellomo, P. Braganò, J. Braunsky, F. Calletti, J. Cerda, L. Chawla, S. De Rosa, S. Di Somma, K. Doi, P. Dosil Rosende, M. Emmett, L. Fecondini, D. Galavotti, F. Garzotto, N. Gibney, S. L. Goldstein, G. Guadagni, P. Honoré, E. Hoste, S. Inadome, K. Kashani, N. Katz, J. Kellum, R. Kenley, Y. Kobayashi, J. Lannoy, A. Lewington, A. Lorenzin, F. Mariano, P. A. McCullough, R. L. Mehta, J. Menneguerre, M. Mettifogo, M. Neri, M. Ostermann, A. Pani, P. Pirazzoli, R. Pohlmeier, D. Pouchoulin, Z. Ricci, C. Ronco, M. Rosner, M. Seamann, A. Shaw, A. Tolwani, G. Villa, J. L. Vincent, J. Wendon

The role of speckle tracking echocardiography for prognostication in patients with severe sepsis or septic shock

Filippo Sanfilippo, Cristina Santonocito, Giovanna Panarello, Antonio Arcadipane

Utility of neuron-specific enolase in traumatic brain injury; relations to S100B levels, outcome, and extracranial injury severity

Eric Peter Thelin, Emma Jeppsson, Arvid Frostell, Mikael Svensson, Stefania Mondello, Bo-Michael Bellander, David W. Nelson

High urinary excretion of kidney injury molecule-1 predicts adverse outcomes in acute kidney injury: a case control study

Yuanyuan Xie, Qin Wang, Chunlin Wang, Chaojun Qi, Zhaohui Ni, Shan Mou

Revision of the Japanese Association for Acute Medicine (JAAM) disseminated intravascular coagulation (DIC) diagnostic criteria using antithrombin activity

Toshiaki Iba, Marcello Di Nisio, Jecko Thachil, Hideo Wada, Hidesaku Asakura, Koichi Sato, Naoya Kitamura, Daizoh Saitoh

Plasma cytokines IL-6, IL-8, and IL-10 are associated with the development of acute respiratory distress syndrome in patients with severe traumatic brain injury

Imo P. Aisiku, Jose-Miguel Yamal, Pratik Doshi, Julia S. Benoit, Shankar Gopinath, Jerry C. Goodman, Claudia S. Robertson

Increased mortality with the use of adrenaline in shock: the evidence is still limited

Rodrigo Antonini Ribeiro, Luciane Maria Fabian Restelatto

The value of poly-urethane cuffed endotracheal tubes

Jan Poelaert

Work of breathing, not dysoxia, as the cause of low central venous blood O2 saturation in sepsis

Guillermo Gutierrez

Adrenaline use is associated with excess organ injury and mortality in cardiogenic shock: facts and fiction

Shou-Yin Jiang, Ye-Hua Shen, Xiao-Gang Zhao

Real-life use of vasopressors and inotropes in cardiogenic shock—observation is necessarily ‘theory-laden’

Samiran Ray, Mirjana Cvetkovic, Daniel H. Lutman, Nazima Pathan, Padmanabhan Ramnarayan, David P. Inwald, Mark J. Peters

Do we need new prokinetics to reduce enteral feeding intolerance during critical illness?

Arthur Raymond Hubert van Zanten

Electrical impedance tomography to determine optimal positive end-expiratory pressure in severe chronic obstructive pulmonary disease

Eirini Kostakou, Nicholas Barrett, Luigi Camporota

Concerns about LUNG-SAFE: response to the letter to the Editor of Critical Care by Bellani et al.

Jesús Villar, Robert M. Kacmarek

Prevalence of ketosis, ketonuria, and ketoacidosis during liberal glycemic control in critically ill patients with diabetes: an observational study

Nora Luethi, Luca Cioccari, Marco Crisman, Rinaldo Bellomo, Glenn M. Eastwood, Johan Mårtensson

Dexmedetomidine sedation reduces atrial fibrillation after cardiac surgery compared to propofol: a randomized controlled trial

Xu Liu, Kai Zhang, Wei Wang, Guohao Xie, Xiangming Fang

Acute kidney injury 2016: diagnosis and diagnostic workup

Marlies Ostermann, Michael Joannidis

Pre-emptive antibiotic therapy to reduce ventilator-associated pneumonia: “thinking outside the box”

Donald E. Craven, Jana Hudcova, Yuxiu Lei, Kathleen A. Craven, Ahsan Waqas

Stress hyperglycaemia in critically ill patients and the subsequent risk of diabetes: a systematic review and meta-analysis

Yasmine Ali Abdelhamid, Palash Kar, Mark E. Finnis, Liza K. Phillips, Mark P. Plummer, Jonathan E. Shaw, Michael Horowitz, Adam M. Deane

Vasopressors and inotropes in cardiogenic shock: is there room for “adrenaline resuscitation”?

Nuccia Morici, Miriam Stucchi, Alice Sacco, Maurizio A. Bottiroli, Fabrizio Oliva, Stefano Carugo, Diego Castini, Emanuele Catena, Manlio Cipriani, Elena Corrada, Maria Frigerio, Maria Pia Gagliardone, Andrea Garascia, Francesco Gentile, Antonio Mafrici, Filippo Milazzo, Marco Negrini, Federico Pappalardo, Claudio Russo, Michele Senni, Romano Giuseppe Seregni

Should we treat pyrexia? And how do we do it?

James F. Doyle, Frédérique Schortgen

Post-cardiac arrest mortality is declining in the UK

Saket Girotra

Can diaphragmatic ultrasonography performed during the T-tube trial predict weaning failure? The role of diaphragmatic rapid shallow breathing index

Savino Spadaro, Salvatore Grasso, Tommaso Mauri, Francesca Dalla Corte, Valentina Alvisi, Riccardo Ragazzi, Valentina Cricca, Giulia Biondi, Rossella Di Mussi, Elisabetta Marangoni, Carlo Alberto Volta

Iron supplementation to treat anaemia in adult critical care patients: a systematic review and meta-analysis

Akshay Shah, Noémi B. Roy, Stuart McKechnie, Carolyn Doree, Sheila A. Fisher, Simon J. Stanworth

Bleeding complications of anticoagulant therapy in sepsis-induced disseminated intravascular coagulation

Toshiaki Iba

Spinal cord injury: is monitoring from the injury site the future?

Samira Saadoun, Marios C. Papadopoulos

Decatecholaminisation during sepsis

Alain Rudiger, Mervyn Singer

Real-time point of care microcirculatory assessment of shock: design, rationale and application of the point of care microcirculation (POEM) tool

David N. Naumann, Clare Mellis, Shamus L. G. Husheer, Philip Hopkins, Jon Bishop, Mark J. Midwinter, Sam D. Hutchings

Near-infrared spectroscopy for assessing tissue oxygenation and microvascular reactivity in critically ill patients: a prospective observational study

Abele Donati, Elisa Damiani, Roberta Domizi, Claudia Scorcella, Andrea Carsetti, Stefania Tondi, Valentina Monaldi, Erica Adrario, Rocco Romano, Paolo Pelaia, Mervyn Singer

Dramatic reduction of mortality in pneumococcal meningitis

Grete Buchholz, Uwe Koedel, Hans-Walter Pfister, Stefan Kastenbauer, Matthias Klein

Use of explicit ICD9-CM codes to identify adult severe sepsis: impacts on epidemiological estimates

C. Bouza, T. Lopez-Cuadrado, J. M. Amate-Blanco

Urine biomarkers give early prediction of acute kidney injury and outcome after out-of-hospital cardiac arrest

Sigrid Beitland, Bård Endre Waldum-Grevbo, Espen Rostrup Nakstad, Jens-Petter Berg, Anne-Marie Siebke Trøseid, Berit Sletbakk Brusletto, Cathrine Brunborg, Geir Øystein Andersen, Kjetil Sunde

Hyperchloremia and moderate increase in serum chloride are associated with acute kidney injury in severe sepsis and septic shock patients

Bandarn Suetrong, Chawika Pisitsak, John H. Boyd, James A. Russell, Keith R. Walley

Noninvasive ventilation for avoidance of reintubation in patients with various cough strength

Jun Duan, Xiaoli Han, Shicong Huang, Linfu Bai

Preoperative plasma growth-differentiation factor-15 for prediction of acute kidney injury in patients undergoing cardiac surgery

Matthias Heringlake, Efstratios I. Charitos, Kira Erber, Astrid Ellen Berggreen, Hermann Heinze, Hauke Paarmann

Nomenclature for renal replacement therapy in acute kidney injury: basic principles

Mauro Neri, Gianluca Villa, Francesco Garzotto, Sean Bagshaw, Rinaldo Bellomo, Jorge Cerda, Fiorenza Ferrari, Silvia Guggia, Michael Joannidis, John Kellum, Jeong Chul Kim, Ravindra L. Mehta, Zaccaria Ricci, Alberto Trevisani, Silvio Marafon, William R. Clark, Jean-Louis Vincent, Claudio Ronco

Regulation of blood flow and volume exchange across the microcirculation

Matthias Jacob, Daniel Chappell, Bernhard F. Becker

Lung ultrasound: a promising tool to monitor ventilator-associated pneumonia in critically ill patients

Guyi Wang, Xiaoying Ji, Yongshan Xu, Xudong Xiang

Understanding the complex host response in sepsis: is diabetes the key?

Florian B. Mayr, Sachin Yende

Impact of HIV infection on the presentation, outcome and host response in patients admitted to the intensive care unit with sepsis; a case control study

Maryse A. Wiewel, Michaëla A. Huson, Lonneke A. van Vught, Arie J. Hoogendijk, Peter M. C. Klein Klouwenberg, Janneke Horn, René Lutter, Olaf L. Cremer, Marcus J. Schultz, Marc J. Bonten, Tom van der Poll, Friso M. de Beer, Lieuwe D. J. Bos, Jos F. Frencken, Gerie J. Glas, Roosmarijn T. M. van Hooijdonk, David S. Y. Ong, Laura R. A. Schouten, Brendon P. Scicluna, Marleen Straat, Esther Witteveen, Luuk Wieske

Positive impact of a clinical goal-directed protocol on reducing cardiac arrests during potential brain-dead donor maintenance

Glauco A. Westphal, Elisabeth Coll, Rafael L. de Souza, Silvana Wagner, Artur Montemezzo, Fernanda Carolina Cani de Souza, Gabriel Torres, Stefan Halla, Tiago C. Carnin, Míriam C. Machado, Eduardo Berbigier, Fernando Busetto, Ivonei Bittencourt, Karine Gerent, Bruno S. de Souza, Manoel Tassinari, Joel de Andrade

Response to: influence of EMS-physician presence on survival after out-of-hospital cardiopulmonary resuscitation

Johannes von Vopelius-Feldt, Jonathan Benger

Pharmacokinetics of anidulafungin during venovenous extracorporeal membrane oxygenation

Gerardo Aguilar, Rafael Ferriols, José A. Carbonell, Carlos Ezquer, José Miguel Alonso, Abigail Villena, Jaume Puig, David Navarro, Manuel Alós, F. Javier Belda

Nurse-performed screening for postextubation dysphagia: a retrospective cohort study in critically ill medical patients

Kay Choong See, Si Yu Peng, Jason Phua, Chew Lai Sum, Johncy Concepcion

What is the value of regional cerebral saturation in post-cardiac arrest patients? A prospective observational study

Cornelia Genbrugge, Ward Eertmans, Ingrid Meex, Margaretha Van Kerrebroeck, Noami Daems, An Creemers, Frank Jans, Willem Boer, Jo Dens, Cathy De Deyne

Risk factors, host response and outcome of hypothermic sepsis

Maryse A. Wiewel, Matthew B. Harmon, Lonneke A. van Vught, Brendon P. Scicluna, Arie J. Hoogendijk, Janneke Horn, Aeilko H. Zwinderman, Olaf L. Cremer, Marc J. Bonten, Marcus J. Schultz, Tom van der Poll, Nicole P. Juffermans, W. Joost Wiersinga

Hydrocortisone treatment in early sepsis-associated acute respiratory distress syndrome: results of a randomized controlled trial

Surat Tongyoo, Chairat Permpikul, Wasineenart Mongkolpun, Veerapong Vattanavanit, Suthipol Udompanturak, Mehmet Kocak, G. Umberto Meduri

Consensus development of core competencies in intensive and critical care medicine training in China

Xiaoyun Hu, Xiuming Xi, Penglin Ma, Haibo Qiu, Kaijiang Yu, Yaoqing Tang, Chuanyun Qian, Qiang Fang, Yushan Wang, Xiangyou Yu, Yuan Xu, Bin Du

N-acetylcysteine plus deferoxamine for patients with prolonged hypotension does not decrease acute kidney injury incidence: a double blind, randomized, placebo-controlled trial

Cassiana Mazon Fraga, Cristiane Damiani Tomasi, Danusa de Castro Damasio, Francieli Vuolo, Cristiane Ritter, Felipe Dal-Pizzol

Successful treatment with fecal microbiota transplantation in patients with multiple organ dysfunction syndrome and diarrhea following severe sepsis

Yanling Wei, Jun Yang, Jun Wang, Yang Yang, Juan Huang, Hao Gong, Hongli Cui, Dongfeng Chen

Communicating with conscious and mechanically ventilated critically ill patients: a systematic review

S. ten Hoorn, P. W. Elbers, A. R. Girbes, P. R. Tuinman

Comparison of monocyte human leukocyte antigen-DR expression and stimulated tumor necrosis factor alpha production as outcome predictors in severe sepsis: a prospective observational study

Anne M. Drewry, Enyo A. Ablordeppey, Ellen T. Murray, Evan R. Beiter, Andrew H. Walton, Mark W. Hall, Richard S. Hotchkiss

Bioavailable estradiol concentrations are elevated and predict mortality in septic patients: a prospective cohort study

Greg Tsang, Michael B. Insel, Justin M. Weis, Mary Anne M. Morgan, Michael S. Gough, Lauren M. Frasier, Cynthia M. Mack, Kathleen P. Doolin, Brian T. Graves, Michael J. Apostolakos, Anthony P. Pietropaoli

The modified SAVE score: predicting survival using urgent veno-arterial extracorporeal membrane oxygenation within 24 hours of arrival at the emergency department

Wei-Cheng Chen, Kuo-Yang Huang, Chih-Wei Yao, Cing-Feng Wu, Shinn-Jye Liang, Chia-Hsiang Li, Chih-Yeh Tu, Hung-Jen Chen

Delay in diagnosis of influenza A (H1N1)pdm09 virus infection in critically ill patients and impact on clinical outcome

Francisco Álvarez-Lerma, Judith Marín-Corral, Clara Vila, Joan Ramón Masclans, Francisco Javier González de Molina, Ignacio Martín Loeches, Sandra Barbadillo, Alejandro Rodríguez, Pedro Cobo, Javier Martins, Cecilia Carbayo, Emilio Robles-Musso, Antonio Cárdenas, Javier Fierro, Dolores Ocaña Fernández, Rafael Sierra, Ma Jesús Huertos, Ma Luz Carmona Pérez, Juan Carlos Pozo Laderas, R. Guerrero, Juan Carlos Robles, Melissa Echevarría León, Alberto Bermejo Gómez, Enrique Márquez, Manuel Rodríguez-Carvajal, Ángel Estella, José Pomares, José Luis Ballesteros, Olga Moreno Romero, Yolanda Fernández, Francisco Lobato, José F. Prieto, José Albofedo-Sánchez, Pilar Martínez, María Victoria de la Torre, María Nieto, Estefanía Cámara Sola, Miguel Ángel Díaz Castellanos, Guillermo Sevilla Soler, Carlos Ortiz Leyba, José Garnacho-Montero, Rafael Hinojosa, Esteban Fernández, Ana Loza, Cristóbal León, Samuel González López, Ángel Arenzana, Dolores Ocaña, Inés Navarrete, Medhi Zaheri Beryanaki, Ignacio Sánchez, Manuel Pérez Alé, Ana Ma Poullet Brea, Juan Francisco Machado Casas, Carlos Serón, Manuel Luis Avellanas, Arantxa Lander, S. Garrido Ramírez de Arellano, M. I. Marquina Lacueva, Pilar Luque, Elena Plumed Serrano, Juan Francisco Martín Lázaro, Carlos Sánchez Polo, Isabel Gutiérrez Cía, Belén Jiménez Bartolomé, Carlos López Núñez, Ignacio González, José Ignacio Tomás Marsilla, Clara Jaques Andrés, Pablo Gutiérrez Ibañes, Pilar Araujo Aguilar, Jose Ma Montón, Paloma Dorado Regil, Lisardo Iglesias, Carmen Pascual González, Brígida Quindós Fernández, Lorena Martín Iglesias, Lucía Viña Soria, Raquel Yano Escudero, Ma del Rosario Martínez Revuelta, José Ma Quiroga Ruiz, Águeda García-Rodríguez, Marta Martín Cuadrado, Ana Luz Balán Mariño, Lorenzo Socias, Pedro Ibáñez, Marcío Borges-Sa, A. Socias, A. Del Castillo, Ricard Jordà Marcos, Cristina Muñoz, José M. Bonell Goytisolo, José Antonio Morales Carbonero, Ignacio Ayestarán, M. Ángeles González López, Cecilia Vilanova Pàmies, Rossana Pérez Senoff, Marta Generelo López de Medrano, Sergio Ruiz-Santana, Juan José Díaz, Catalina Sánchez Ramírez, Montse Sisón, David Hernández, Ana Trujillo, Luis Regalado, Sonia Rodríguez Fernández, Leonardo Lorente, Judith Cabrera Rivero, Ma Luisa Mora Quintero, Mar Martín, Sergio Martínez, J. J. Cáceres, Manuel Sánchez Palacio, D. García Rodríguez, María Ripoll Leria, Borja Suberviola, P. Ugarte, Fernando García-López, Rafael Sánchez Iniesta, Ángel Álvaro Alonso, Antonio Padilla, Basi Martínez Palacios, Ma Luisa Gómez Grande, Ma Carmen Martín Rodríguez, Hasania Adbel-Hadi Álvarez, Alfonso Ambros Checa, Higinio Martín Hernández, Antonio Albaya, Alberto Silva Obregón, Carlos Marian Crespo, Carlos Armendáriz Estrella, Carmen Benito Puncel, Eduardo Quirós Oyargue, Alfonso Canabal, Luis Marina, Ismael López de Toro, Almudena Simón, José María Añón, Ma Jesús López Pueyo, María del Valle Ortiz, Sergio Ossa Echeverri, Zulema Ferreras, Juan C. Ballesteros Herraez, Santiago Macías, José Ángel Berezo, Jesús Blanco Varela, Pablo Blanco Schweizer, Ángela González Salamanca, Luis Tamayo Lomas, Andaluz Ojeda Anzález, Ramón Cicuéndez Ávila, G. Francisco Javier Pérez, Antonio Álvarez Terrero, Fabiola Tena Ezpeleta, Christian Sala, Oliverio López, Zulema Páez, Álvaro García, Demetrio Carriedo Ule, Miriam Riesco Crespo, Jesús Pino Rebolledo, Nicolás Hidalgo Andrés, Ana Carolina Caballero Zirena, Belén Román García, Juan Bautista López Messa, Rosa Ma Catalán, Miquel Ferrer, Antoni Torres, Catia Cilloniz, Sandra Barbadillo Ansorregui, Lluís Cabré, Ignacio Baeza, Assumpta Rovira, Francisco Álvarez-Lerma, Antonia Vázquez, Joan Nolla, Francisco Fernández, Joaquim Ramón Cervelló, Raquel Iglesia, Rafael Mañéz, J. Ballús, Rosa Ma Granada, Jordi Vallés, Emili Díaz, Marta Ortíz, C. Guía, Ignacio Martín-Loeches, Joaquim Páez, Jordi Almirall, Xavier Balanzó, Estel Güell, Juan Carlos Yébenes, Jordi Rello, Elena Arnau, Marcos Pérez, César Laborda, Jesica Souto, Leonel Lagunes, Iñaki Catalán, Josep Ma Sirvent, Nerea López de Arbina, Anna Baró Serra, Adriana Sánchez, Silvia M. Cuenca, Mariona Badía, Begonia Baseda-Garrido, Montserrat Valverdú-Vidal, Fernando Barcenilla, Mercedes Palomar, Xavier Nuvials, Pedro Garrido Benedicto, Ferrán Roche Campo, M. F. Esteban, José Luna, Gaspar Masdeu Eixarch, Angels Pascual Diago, Juan Ma Nava, J. González de Molina, Josep Trenado, Ricard Ferrer, Zoran Josic, Montserrat Casanovas, Francisco Gurri, Paula Rodríguez, Alejandro Rodríguez, Laura Claverías, Sandra Trefler, María Bodí, Mónica Magret, Cristina Ferri, Rosa María Díaz, Eduard Mesalles, Fernando Arméstar, Diego de Mendoza, Carmen Lomas Fernández, José Julián Berrade, Alfonso Bonet Saris, Marina Pechkova, Cristina Mora Jiménez, Santiago Picos Gil, Juliá-Narváez José, Manuel Robles Marcos, Vanessa Farje Mallqui, Ma Ángeles Santiago Triviño, Pablo Martínez García, Alberto Fernández-Zapata, Teresa Recio, Abilio Arrascaeta, Ma José García-Ramos, Elena Gallego, Esther Saiz Rodrigo, Fernando Bueno, Mercedes Díaz, Noemí Gil Pérez, David López Hormigo, Juan Diego Jiménez Delgado, Pérez Frutos, M. J. Rivera Pinna, Ma Lourdes Cordero, José A. Pastor, Luis Álvarez-Rocha, Alexandra Ceniceros Barros, Alejandra Virgós Pedreira, Dolores Vila, Carmen Fernández González, Eleuterio Merayo, Víctor José López-Ciudad, Juan Cortés Cañones, Eva Vilaboy, José Villar Chao, Francisco Savira Cid López, Pablo Vidal Cortés, Marcos A. Pérez Veloso, Eva María Saborido, Enrique Alemparte Pardavila, Ana Ortega Montes, Raúl José González, Santiago Freita, Enrique Alemparte, Ana Ortega, Ana María López, Julio Canabal, Enrique Ferres, Javier Blanco Pérez, M. Ortiz Piquer, Santiago Freitas Ramos, Lucas Lage Cendón, Vanesa Gómez Casal, Sabela Vara Adrio, Eva Menor Fernández, Susana González Prado, Antonio Varela Franco, José Luis Monzón, Félix Goñi, Frutos Del Nogal Sáez, M. Blasco Navalpotro, Ricardo Díaz Abad, José Luis Flordelis Lasierra, Ma Carmen García-Torrejón, César Pérez-Calvo, Diego López, Luis Arnaiz, S. Sánchez-Alonso, Carlos Velayos, Francisco del Río, Miguel Ángel González, Mercedes Nieto, Carmen Sánchez Cesteros, María Cruz Martín, José Ma Molina, Juan Carlos Montejo, Mercedes Catalán, Patricia Albert, Ana de Pablo, José Eugenio Guerrero, María Zurita, Jaime Benítez Peyrat, Miriam Díaz Cámara, Enrique Cerdá, Manuel Alvarez, Carlos Pey, Eva Manteiga Riestra, Concepción Martínez-Fidalgo, Montse Rodríguez, Eduardo Palencia, Rafael Caballero, Concepción Vaquero, Francisco Mariscal, S. García, Rico Cepeda, Nieves Carrasco, Isidro Prieto, A. Liétor, R. Ramos, Rosario Cuadra Casas, Cruz Soriano Cuesta, Susana Sánchez Alonso, Beatriz Galván, Juan C. Figueira, M. Cruz Soriano, Belen Civantos Martín, Alejandro Robles Caballero, P. Galdós, Bárbara Balandín Moreno, Sara Alcántara Carmona, Fernández del Cabo, Cecilia Hermosa, Federico Gordo, Alejandro Algora, Amparo Paredes, Teodoro Grau Carmona, J. A. Cambronero, Esther López Ramos, Yaiza Ortiz de Zárate, Sonia Gómez-Rosado, Margarita Mas Lodo, Nieves Franco Garrobo, Silvia Álvarez Hernández, Teresa Honrubia, Luis Miguel Prado López, Esteban A. Lorente, J. A. Nin, Carlos Jaramillo Sotomayor, Luis Arnaiz, Esperanza Molero Silvero, Eduardo Morales Fernández de la Reguera, Rosa Ma de la Casa Monje, Fátima Martín Serrano, Ma Victoria Trasmonte Martínez, M. Cruz Martín Delgado, Sofía Martínez, F. Felices Abad, Isabel Cremades Navalon, Martín Vigil Velis, Mariano Martínez, Domingo Martínez Baño, Enriqueta Andreu, Sergio Manuel Butí, Bernardo Gil Rueda, Francisco García, Noemí Llamas Fernández, Luis Herrera Para, Alejandro Ortín Freire, Ma Rosa Navarro Ruiz, C. R. Hernández Romero, Enrique Maraví-Poma, I. Jimenez Urra, Laura Macaya Redin, A. Tellería, Josu Insausti, Noelia Artesero García, Laura Macaya, Joaquín Lobo Palanco, Nagore González, Pilar Marco, Loreto Vidaur, Estibaliz Salas, Ruth Salaberría Udabe, B. Santamaría, Tomás Rodríguez, Juan Carlos Vergara, Jose Ramón Iruretagoyena Amiano, Iratí Garrido Santos, Alberto Manzano, Carlos Castillo Arenal, Pedro María Olaechea, Higinio Martín Hernández, Alejandro Martín López, Fernando Fonseca San Miguel, José Blanquer, Nieves Carbonell, José Ferreres Franco, Roberto Reig Valero, A. Belenger, Susana Altaba, Bernabé Álvarez-Sánchez, José Cánovas Robles, Jaime Sánchez Francisco, Mar Ruiz Sánchez, Santiago Alberto Picos, Abilio Arrascaeta Llanes, Eugenio Herrero Gutiérrez, Alberto Fernández Zapata, Ángel Sánchez-Miralles, José Luis Antón Pascual, Juan Bonastre, M. Palamo, Javier Cebrián, José Cuñat, Mónica Gordón Sahuquillo, Belén Romero, Santiago Borrás Pallé, Javier de León Belmar, Rafael Zaragoza, Constantino Tormo, Susana Sancho Chinesta, Virgilio Paricio, Asunción Marqués, S. Sánchez-Morcillo, S. Tormo, J. Latour, M. Ángel García, Manuel Palomo, Francisco Tarín Royo, Pedro Manzano Hinojosa, Ma Salomé Sánchez Pino, Concha Maragues Ribes, Rubén González Luis, Antolí Ribas

Does ventilator-associated event surveillance detect ventilator-associated pneumonia in intensive care units? A systematic review and meta-analysis

Yunzhou Fan, Fang Gao, Yanyan Wu, Jie Zhang, Ming Zhu, Lijuan Xiong

Survey of the training and use of echocardiography and lung ultrasound in Australasian intensive care units

Yang Yang, Colin Royse, Alistair Royse, Kacey Williams, David Canty

Early antibiotic treatment for gradual ventilator-associated pneumonia: yes or no?

Xuandong Jiang, Yanfei Shen

Benefit of prokinetics during enteral nutrition: still searching for a piece of evidence

Alain Dive

Mediation analysis to unravel mechanisms underlying association between platelet transfusion and postoperative delirium

Bingwen Zhang, Zhongheng Zhang

Cerebrospinal fluid penetration of meropenem in neurocritical care patients with proven or suspected ventriculitis: a prospective observational study

Ute Blassmann, Anka C. Roehr, Otto R. Frey, Cornelia Vetter-Kerkhoff, Niklas Thon, William Hope, Josef Briegel, Volker Huge

Microcirculatory assessment of patients under VA-ECMO

Atila Kara, Sakir Akin, Dinis dos Reis Miranda, Ard Struijs, Kadir Caliskan, Robert J. van Thiel, Eric A. Dubois, Wouter de Wilde, Felix Zijlstra, Diederik Gommers, Can Ince

Patient outcomes after critical illness: a systematic review of qualitative studies following hospital discharge

Mohamed D. Hashem, Aparna Nallagangula, Swaroopa Nalamalapu, Krishidhar Nunna, Utkarsh Nausran, Karen A. Robinson, Victor D. Dinglas, Dale M. Needham, Michelle N. Eakin

Spontaneous breathing trial and post-extubation work of breathing in morbidly obese critically ill patients

Martin Mahul, Boris Jung, Fabrice Galia, Nicolas Molinari, Audrey de Jong, Yannaël Coisel, Rosanna Vaschetto, Stefan Matecki, Gérald Chanques, Laurent Brochard, Samir Jaber

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

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Stephen Bonner, Nazir I. Lone

Not all β-lactams are equal regarding neurotoxicity

Khalil Chaïbi, Maïté Chaussard, Sabri Soussi, Matthieu Lafaurie, Matthieu Legrand

Should we continue to use prediction tools to identify patients at risk of Candida spp. infection? If yes, why?

A. Cortegiani, V. Russotto, S. M. Raineri, G. Gregoretti, A. Giarratano

The vulnerable microcirculation in the critically ill pediatric patient

J. W. Kuiper, D. Tibboel, C. Ince

Subglottic secretion suction for preventing ventilator-associated pneumonia: an updated meta-analysis and trial sequential analysis

Zhi Mao, Ling Gao, Guoqi Wang, Chao Liu, Yan Zhao, Wanjie Gu, Hongjun Kang, Feihu Zhou

Surviving critical illness: what is next? An expert consensus statement on physical rehabilitation after hospital discharge

M. E. Major, R. Kwakman, M. E. Kho, B. Connolly, D. McWilliams, L. Denehy, S. Hanekom, S. Patman, R. Gosselink, C. Jones, F. Nollet, D. M. Needham, R. H. H. Engelbert, M. van der Schaaf

National survey and point prevalence study of sedation practice in UK critical care

Alvin Richards-Belle, Ruth R. Canter, G. Sarah Power, Emily J. Robinson, Henrik Reschreiter, Hannah Wunsch, Sheila E. Harvey

High-dose intravenous selenium does not improve clinical outcomes in the critically ill: a systematic review and meta-analysis

William Manzanares, Margot Lemieux, Gunnar Elke, Pascal L. Langlois, Frank Bloos, Daren K. Heyland

Lower versus higher dose of enteral caloric intake in adult critically ill patients: a systematic review and meta-analysis

Hasan M. Al-Dorzi, Abdullah Albarrak, Mazen Ferwana, Mohammad Hassan Murad, Yaseen M. Arabi

Prehospital fibrinolysis versus primary percutaneous coronary intervention in ST-elevation myocardial infarction: a systematic review and meta-analysis of randomized controlled trials

Vincent Roule, Pierre Ardouin, Katrien Blanchart, Adrien Lemaitre, Julien Wain-Hobson, Damien Legallois, Joachim Alexandre, Rémi Sabatier, Paul Milliez, Farzin Beygui

Septic shock with no diagnosis at 24 hours: a pragmatic multicenter prospective cohort study

Damien Contou, Damien Roux, Sébastien Jochmans, Rémi Coudroy, Emmanuel Guérot, David Grimaldi, Sylvie Ricome, Eric Maury, Gaëtan Plantefève, Julien Mayaux, Armand Mekontso Dessap, Christian Brun-Buisson, Nicolas de Prost

Is the glutamine story over?

Marie Smedberg, Jan Wernerman

Pre-hospital management of mass casualty civilian shootings: a systematic literature review

Conor D. A. Turner, David J. Lockey, Marius Rehn

Mid-regional pro-adrenomedullin (MR-proADM), a marker of positive fluid balance in critically ill patients: results of the ENVOL study

Bernard Vigué, Pierre-Etienne Leblanc, Frédérique Moati, Eric Pussard, Hussam Foufa, Aurore Rodrigues, Samy Figueiredo, Anatole Harrois, Jean-Xavier Mazoit, Homa Rafi, Jacques Duranteau

Erratum to: The right ventricle: interaction with the pulmonary circulation

Michael R. Pinsky

Obituary: Professor AB Johan Groeneveld

Johannes P. C. van den Akker, Diederik A. M. P. J. Gommers

Hybrid blood purification strategy in pediatric septic shock

Gabriella Bottari, Fabio Silvio Taccone, Andrea Moscatelli

Resting energy expenditure, calorie and protein consumption in critically ill patients: a retrospective cohort study

Oren Zusman, Miriam Theilla, Jonathan Cohen, Ilya Kagan, Itai Bendavid, Pierre Singer

The impact of extracerebral organ failure on outcome of patients after cardiac arrest: an observational study from the ICON database

Leda Nobile, Fabio S. Taccone, Tamas Szakmany, Yasser Sakr, Stephan M. Jakob, Tommaso Pellis, Massimo Antonelli, Marc Leone, Xavier Wittebole, Peter Pickkers, Jean-Louis Vincent

Cardiac dysfunction induced by weaning from mechanical ventilation: incidence, risk factors, and effects of fluid removal

Jinglun Liu, Feng Shen, Jean-Louis Teboul, Nadia Anguel, Alexandra Beurton, Nadia Bezaz, Christian Richard, Xavier Monnet

Simultaneous assessment of the synthesis rate and transcapillary escape rate of albumin in inflammation and surgery

András Komáromi, Ulrika Estenberg, Folke Hammarqvist, Olav Rooyackers, Jan Wernerman, Åke Norberg

Development and validation of a prehospital prediction model for acute traumatic coagulopathy

Ithan D. Peltan, Ali Rowhani-Rahbar, Lisa K. Vande Vusse, Ellen Caldwell, Thomas D. Rea, Ronald V. Maier, Timothy R. Watkins

Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death

Pavan K. Bhatraju, Paramita Mukherjee, Cassianne Robinson-Cohen, Grant E. O’Keefe, Angela J. Frank, Jason D. Christie, Nuala J. Meyer, Kathleen D. Liu, Michael A. Matthay, Carolyn S. Calfee, David C. Christiani, Jonathan Himmelfarb, Mark M. Wurfel

Prognostic impact of restored sinus rhythm in patients with sepsis and new-onset atrial fibrillation

Wen Cheng Liu, Wen Yu Lin, Chin Sheng Lin, Han Bin Huang, Tzu Chiao Lin, Shu Meng Cheng, Shih Ping Yang, Jung Chung Lin, Wei Shiang Lin

Effects of continuous renal replacement therapy on linezolid pharmacokinetic/pharmacodynamics: a systematic review

Gianluca Villa, Paola Di Maggio, A. Raffaele De Gaudio, Andrea Novelli, Riccardo Antoniotti, Enrico Fiaccadori, Chiara Adembri

Viral-bacterial coinfection affects the presentation and alters the prognosis of severe community-acquired pneumonia

Guillaume Voiriot, Benoit Visseaux, Johana Cohen, Liem Binh Luong Nguyen, Mathilde Neuville, Caroline Morbieu, Charles Burdet, Aguila Radjou, François-Xavier Lescure, Roland Smonig, Laurence Armand-Lefèvre, Bruno Mourvillier, Yazdan Yazdanpanah, Jean-Francois Soubirou, Stephane Ruckly, Nadhira Houhou-Fidouh, Jean-François Timsit

The utility of biomarkers in traumatic brain injury clinical management

Ana Rodríguez-Rodríguez, Juan José Egea-Guerrero

Response to a trial on reversal of Death by Neurologic Criteria

Ariane Lewis, Arthur Caplan

Antipsychotic prescribing patterns during and after critical illness: a prospective cohort study

Jason E. Tomichek, Joanna L. Stollings, Pratik P. Pandharipande, Rameela Chandrasekhar, E. Wesley Ely, Timothy D. Girard

Chlorhexidine bathing and health care-associated infections among adult intensive care patients: a systematic review and meta-analysis

Steven A. Frost, Mari-Cris Alogso, Lauren Metcalfe, Joan M. Lynch, Leanne Hunt, Ritesh Sanghavi, Evan Alexandrou, Kenneth M. Hillman

Manual versus Automated moNitoring Accuracy of GlucosE II (MANAGE II)

Cláudia Righy Shinotsuka, Alexandre Brasseur, David Fagnoul, Timothy So, Jean-Louis Vincent, Jean-Charles Preiser

Intravascular versus surface cooling for targeted temperature management after out-of-hospital cardiac arrest – an analysis of the TTM trial data

Guy W. Glover, Richard M. Thomas, George Vamvakas, Nawaf Al-Subaie, Jules Cranshaw, Andrew Walden, Matthew P. Wise, Marlies Ostermann, Emma Thomas-Jones, Tobias Cronberg, David Erlinge, Yvan Gasche, Christian Hassager, Janneke Horn, Jesper Kjaergaard, Michael Kuiper, Tommaso Pellis, Pascal Stammet, Michael Wanscher, Jørn Wetterslev, Hans Friberg, Niklas Nielsen

Limited predictability of maximal muscular pressure using the difference between peak airway pressure and positive end-expiratory pressure during proportional assist ventilation (PAV)

Po-Lan Su, Pei-Shan Kao, Wei-Chieh Lin, Pei-Fang Su, Chang-Wen Chen

The involvement of regulatory non-coding RNAs in sepsis: a systematic review

Jeffery Ho, Hung Chan, Sunny H. Wong, Maggie H. T. Wang, Jun Yu, Zhangang Xiao, Xiaodong Liu, Gordon Choi, Czarina C. H. Leung, Wai T. Wong, Zheng Li, Tony Gin, Matthew T. V. Chan, William K. K. Wu

Effect of driving pressure on mortality in ARDS patients during lung protective mechanical ventilation in two randomized controlled trials

Claude Guérin, Laurent Papazian, Jean Reignier, Louis Ayzac, Anderson Loundou, Jean-Marie Forel

Lung ultrasound can be used to predict the potential of prone positioning and assess prognosis in patients with acute respiratory distress syndrome

Xiao-ting Wang, Xin Ding, Hong-min Zhang, Huan Chen, Long-xiang Su, Da-wei Liu

Skeletal muscle quality as assessed by CT-derived skeletal muscle density is associated with 6-month mortality in mechanically ventilated critically ill patients

Wilhelmus G. P. M. Looijaard, Ingeborg M. Dekker, Sandra N. Stapel, Armand R. J. Girbes, Jos W. R. Twisk, Heleen M. Oudemans-van Straaten, Peter J. M. Weijs

The inflammatory response to extracorporeal membrane oxygenation (ECMO): a review of the pathophysiology

Jonathan E. Millar, Jonathon P. Fanning, Charles I. McDonald, Daniel F. McAuley, John F. Fraser

Reassessing the death risk related to probiotics in critically ill patients

Alberto Enrico Maraolo

Inhaled nitric oxide and the risk of renal dysfunction in patients with acute respiratory distress syndrome: a propensity-matched cohort study

Sheng-Yuan Ruan, Hon-Yen Wu, Hsien-Ho Lin, Huey-Dong Wu, Chong-Jen Yu, Mei-Shu Lai

Association between time of discharge from ICU and hospital mortality: a systematic review and meta-analysis

Si Yang, Zheng Wang, Zhida Liu, Jinlai Wang, Lijun Ma

Immunomodulation after ischemic stroke: potential mechanisms and implications for therapy

Cynthia Santos Samary, Paolo Pelosi, Pedro Leme Silva, Patricia Rieken Macedo Rocco

Outcomes and survival prediction models for severe adult acute respiratory distress syndrome treated with extracorporeal membrane oxygenation

Sacha Rozencwajg, David Pilcher, Alain Combes, Matthieu Schmidt

Advances in antibiotic therapy in the critically ill

Rufu Jia, Linpei Jia

Coughing correlates: insights into an innovative study using cough peak expiratory flow to predict extubation failure

Chuan Jiang, Antonio M. Esquinas, Bushra Mina

Perioperative statin therapy in cardiac surgery: a meta-analysis of randomized controlled trials

Alessandro Putzu, Bruno Capelli, Alessandro Belletti, Tiziano Cassina, Enrico Ferrari, Michele Gallo, Gabriele Casso, Giovanni Landoni

Sepsis and the theory of relativity: measuring a moving target with a moving measuring stick

Michael Klompas, Chanu Rhee

Non-antibiotic treatments for bacterial diseases in an era of progressive antibiotic resistance

Steven M. Opal

Fecal microbiota transplantation for multiple organ dysfunction syndrome

Nathan J. Klingensmith, Craig M. Coopersmith

VCO2 calorimetry: stop tossing stones, it’s time for building!

Elisabeth De Waele, Patrick M. Honoré, Herbert D. Spapen

Resuscitative endovascular balloon occlusion of the aorta versus aortic cross clamping among patients with critical trauma: a nationwide cohort study in Japan

Toshikazu Abe, Masatoshi Uchida, Isao Nagata, Daizoh Saitoh, Nanako Tamiya

Hemodynamic monitoring in the era of evidence-based medicine

Bernd Saugel, Manu L. N. G. Malbrain, Azriel Perel

Interpretation of gene associations with risk of acute respiratory distress syndrome: P values, Bayes factors, positive predictive values, and need for replication

Sebastian Rimpau, Ari R. Joffe

Erratum to: The influence of N-acetyl-L-cysteine infusion on cytokine levels and gastric intramucosal pH during severe sepsis

Sayim Emet, Dilek Memis, Zafer Pamukcu

Rapid detection of carbapenem resistance: targeting a zero level of inadequate empiric antibiotic exposure?

Andrea Cortegiani, Vincenzo Russotto, Pasquale Iozzo, Santi Maurizio Raineri, Antonino Giarratano

Early-phase cumulative hypotension duration and severe-stage progression in oliguric acute kidney injury with and without sepsis: an observational study

Junichi Izawa, Tetsuhisa Kitamura, Taku Iwami, Shigehiko Uchino, Masanori Takinami, John A. Kellum, Takashi Kawamura

Blood transfusion improves renal oxygenation and renal function in sepsis-induced acute kidney injury in rats

Lara Zafrani, Bulent Ergin, Aysegul Kapucu, Can Ince

Effects of low doses of esmolol on cardiac and vascular function in experimental septic shock

Chaojie Wei, Huguette Louis, Margaux Schmitt, Eliane Albuisson, Sophie Orlowski, Bruno Levy, Antoine Kimmoun

Cholesterol levels and long-term rates of community-acquired sepsis

Faheem W. Guirgis, John P. Donnelly, Sunita Dodani, George Howard, Monika M. Safford, Emily B. Levitan, Henry E. Wang

qSOFA should replace SIRS as the screening tool for sepsis

Stefano Franchini, Andrea Duca