Ausgabe 1/2013
Inhalt (47 Artikel)
Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice
Linghua Qiu, Tao Qiao, Melissa Beers, Weijia Tan, Hongyan Wang, Bin Yang, Zuoshang Xu
Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation
William A Eimer, Robert Vassar
Mitochondrial quality, dynamics and functional capacity in Parkinson’s disease cybrid cell lines selected for Lewy body expression
Emily N Cronin-Furman, M Kathleen Borland, Kristen E Bergquist, James P Bennett Jr, Patricia A Trimmer
In vivo functional brain mapping in a conditional mouse model of human tauopathy (taup301l) reveals reduced neural activity in memory formation structures
Pablo D Perez, Gabrielle Hall, Tetsuya Kimura, Yan Ren, Rachel M Bailey, Jada Lewis, Marcelo Febo, Naruhiko Sahara
Kinetics of neurodegeneration based on a risk-related biomarker in animal model of glaucoma
Takuya Hayashi, Masamitsu Shimazawa, Hiroshi Watabe, Takayuki Ose, Yuta Inokuchi, Yasushi Ito, Hajime Yamanaka, Shin-ichi Urayama, Yasuyoshi Watanabe, Hideaki Hara, Hirotaka Onoe
Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer’s disease
Francesca Fanelli, Sara Sepe, Marcello D’Amelio, Cinzia Bernardi, Loredana Cristiano, AnnaMaria Cimini, Francesco Cecconi, Maria Paola Ceru', Sandra Moreno
Aβ impairs nicotinic regulation of inhibitory synaptic transmission and interneuron excitability in prefrontal cortex
Guo-Jun Chen, Zhe Xiong, Zhen Yan
Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts
Badri Vardarajan, David Vergote, Fadel Tissir, Mark Logue, Jing Yang, Nathalie Daude, Kunie Ando, Ekaterina Rogaeva, Joseph Lee, Rong Cheng, Jean-Pierre Brion, Mahdi Ghani, Beipei Shi, Clinton T Baldwin, Satyabrata Kar, Richard Mayeux, Paul Fraser, André M Goffinet, Peter St George-Hyslop, Lindsay A Farrer, David Westaway
HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?
Claudia Simões-Pires, Vincent Zwick, Alessandra Nurisso, Esther Schenker, Pierre-Alain Carrupt, Muriel Cuendet
Simultaneous and independent detection of C9ORF72 alleles with low and high number of GGGGCC repeats using an optimised protocol of Southern blot hybridisation
Vladimir L Buchman, Johnathan Cooper-Knock, Natalie Connor-Robson, Adrian Higginbottom, Janine Kirby, Olga D Razinskaya, Natalia Ninkina, Pamela J Shaw
In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis
Jason D Ulrich, Jack M Burchett, Jessica L Restivo, Dorothy R Schuler, Philip B Verghese, Thomas E Mahan, Gary E Landreth, Joseph M Castellano, Hong Jiang, John R Cirrito, David M Holtzman
Behavioral characterization of the 6-hydroxidopamine model of Parkinson’s disease and pharmacological rescuing of non-motor deficits
Miguel M Carvalho, Filipa L Campos, Bárbara Coimbra, José M Pêgo, Carla Rodrigues, Rui Lima, Ana J Rodrigues, Nuno Sousa, António J Salgado
Normal cognition in transgenic BRI2-Aβ mice
Jungsu Kim, Paramita Chakrabarty, Amanda Hanna, Amelia March, Dennis W Dickson, David R Borchelt, Todd Golde, Christopher Janus
ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice
Ori Liraz, Anat Boehm-Cagan, Daniel M Michaelson
Conformational templating of α-synuclein aggregates in neuronal-glial cultures
Amanda N Sacino, Michael A Thomas, Carolina Ceballos-Diaz, Pedro E Cruz, Awilda M Rosario, Jada Lewis, Benoit I Giasson, Todd E Golde
TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease
Sruti Rayaprolu, Bianca Mullen, Matt Baker, Timothy Lynch, Elizabeth Finger, William W Seeley, Kimmo J Hatanpaa, Catherine Lomen-Hoerth, Andrew Kertesz, Eileen H Bigio, Carol Lippa, Keith A Josephs, David S Knopman, Charles L White III, Richard Caselli, Ian R Mackenzie, Bruce L Miller, Magdalena Boczarska-Jedynak, Grzegorz Opala, Anna Krygowska-Wajs, Maria Barcikowska, Steven G Younkin, Ronald C Petersen, Nilüfer Ertekin-Taner, Ryan J Uitti, James F Meschia, Kevin B Boylan, Bradley F Boeve, Neill R Graff-Radford, Zbigniew K Wszolek, Dennis W Dickson, Rosa Rademakers, Owen A Ross
Fluid biomarkers in Alzheimer’s disease – current concepts
Christoffer Rosén, Oskar Hansson, Kaj Blennow, Henrik Zetterberg
Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice
Katherine D LaClair, Kebreten F Manaye, Dexter L Lee, Joanne S Allard, Alena V Savonenko, Juan C Troncoso, Philip C Wong
Progressive morphological changes and impaired retinal function associated with temporal regulation of gene expression after retinal ischemia/reperfusion injury in mice
Byung-Jin Kim, Terry A Braun, Robert J Wordinger, Abbot F Clark
Voluntary exercise protects against methamphetamine-induced oxidative stress in brain microvasculature and disruption of the blood–brain barrier
Michal Toborek, Melissa J Seelbach, Cetewayo S Rashid, Ibolya E András, Lei Chen, Minseon Park, Karyn A Esser
The synaptic maintenance problem: membrane recycling, Ca2+homeostasis and late onset degeneration
Ilya Bezprozvanny, Peter Robin Hiesinger
Overcoming barriers and thresholds – signaling of oligomeric Aβ through the prion protein to Fyn
Hansen Wang, Carl He Ren, C Geeth Gunawardana, Gerold Schmitt-Ulms
LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype
Wladislaw Maier, Mariola Bednorz, Sabrina Meister, Anton Roebroek, Sascha Weggen, Ulrich Schmitt, Claus U Pietrzik
Autophagy is involved in oligodendroglial precursor-mediated clearance of amyloid peptide
Wenxia Li, Yifen Tang, Zhiqin Fan, Ya Meng, Guang Yang, Jia Luo, Zun-Ji Ke
S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson’s disease
Carmen R Sunico, Tomohiro Nakamura, Edward Rockenstein, Michael Mante, Anthony Adame, Shing Fai Chan, Traci Fang Newmeyer, Eliezer Masliah, Nobuki Nakanishi, Stuart A Lipton
Genetics of amyotrophic lateral sclerosis: an update
Sheng Chen, Pavani Sayana, Xiaojie Zhang, Weidong Le
Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics
Desiree M Baron, Laura J Kaushansky, Catherine L Ward, Reddy Ranjith K Sama, Ru-Ju Chian, Kristin J Boggio, Alexandre J C Quaresma, Jeffrey A Nickerson, Daryl A Bosco
Rapamycin increases survival in ALS mice lacking mature lymphocytes
Kim A Staats, Sara Hernandez, Susann Schönefeldt, André Bento-Abreu, James Dooley, Philip Van Damme, Adrian Liston, Wim Robberecht, Ludo Van Den Bosch
Heart fatty acid binding protein and Aβ-associated Alzheimer’s neurodegeneration
Rahul S Desikan, Wesley K Thompson, Dominic Holland, Christopher P Hess, James B Brewer, Henrik Zetterberg, Kaj Blennow, Ole A Andreassen, Linda K McEvoy, Bradley T Hyman, Anders M Dale
Dominant optic atrophy, OPA1, and mitochondrial quality control: understanding mitochondrial network dynamics
Marcel V Alavi, Nico Fuhrmann
Blood–brain-barriers in aging and in Alzheimer’s disease
Fernanda Marques, João Carlos Sousa, Nuno Sousa, Joana Almeida Palha
Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model
Carlotta E Duncan, Mahru C An, Theodora Papanikolaou, Caitlin Rugani, Cathy Vitelli, Lisa M Ellerby
Sustained, neuron-specific IKK/NF-κB activation generates a selective neuroinflammatory response promoting local neurodegeneration with aging
Ayesha Maqbool, Michael Lattke, Thomas Wirth, Bernd Baumann
Erratum to: treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice
Katherine D LaClair, Kebreten F Manaye, Dexter L Lee, Joanne S Allard, Alena V Savonenko, Juan C Troncoso, Philip C Wong
Drosophila melanogaster as a model organism for Alzheimer’s disease
Katja Prüßing, Aaron Voigt, Jörg B Schulz
rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration
Marusela Oliveras-Salvá, Anke Van der Perren, Nicolas Casadei, Stijn Stroobants, Silke Nuber, Rudi D’Hooge, Chris Van den Haute, Veerle Baekelandt
Heat shock factor 1 over-expression protects against exposure of hydrophobic residues on mutant SOD1 and early mortality in a mouse model of amyotrophic lateral sclerosis
Pei-Yi Lin, Sharotka M Simon, Won Kyun Koh, Oluwarotimi Folorunso, C Samuel Umbaugh, Anson Pierce
Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease
Rodrigo A Quintanilla, Youngnam N Jin, Rommy von Bernhardi, Gail VW Johnson
Features of wild-type human SOD1 limit interactions with misfolded aggregates of mouse G86R Sod1
David A Qualls, Mercedes Prudencio, Brittany LT Roberts, Keith Crosby, Hilda Brown, David R Borchelt
Behavioral and transcriptome alterations in male and female mice with postnatal deletion of TrkB in dorsal striatal medium spiny neurons
Ellen M Unterwald, Michelle E Page, Timothy B Brown, Jonathan S Miller, Marta Ruiz, Karen A Pescatore, Baoji Xu, Louis French Reichardt, Joel Beverley, Bin Tang, Heinz Steiner, Elizabeth A Thomas, Michelle E Ehrlich
Aggregation and neurotoxicity of recombinant α-synuclein aggregates initiated by dimerization
Alireza Roostaee, Simon Beaudoin, Antanas Staskevicius, Xavier Roucou
Endogenous expression of FAD-linked PS1 impairs proliferation, neuronal differentiation and survival of adult hippocampal progenitors
Karthikeyan Veeraraghavalu, Se Hoon Choi, Xiaoqiong Zhang, Sangram S Sisodia
Cross-talk of membrane lipids and Alzheimer-related proteins
Jochen Walter, Gerhild van Echten-Deckert
Current concepts in Alzheimer’s Disease: molecules, models and translational perspectives
Bart PF Rutten, Harry WM Steinbusch