Ausgabe 1/2014
Inhalt (61 Artikel)
Trafficking regulation of proteins in Alzheimer’s disease
Shangtong Jiang, Yanfang Li, Xian Zhang, Guojun Bu, Huaxi Xu, Yun-wu Zhang
Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation
Yu Ohki, Naoaki Shimada, Aya Tominaga, Satoko Osawa, Takuya Higo, Satoshi Yokoshima, Tohru Fukuyama, Taisuke Tomita, Takeshi Iwatsubo
Effects of the C57BL/6 strain background on tauopathy progression in the rTg4510 mouse model
Rachel M Bailey, John Howard, Joshua Knight, Naruhiko Sahara, Dennis W Dickson, Jada Lewis
Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk
Leon M Tai, Shipra Mehra, Varsha Shete, Steve Estus, G William Rebeck, Guojun Bu, Mary Jo LaDu
Stem cell derived basal forebrain cholinergic neurons from Alzheimer’s disease patients are more susceptible to cell death
Lishu Duan, Bula J Bhattacharyya, Abdelhak Belmadani, Liuliu Pan, Richard J Miller, John A Kessler
Amyloid peptides ABri and ADan show differential neurotoxicity in transgenic Drosophila models of familial British and Danish dementia
María S Marcora, Agata C Fernández-Gamba, Luz A Avendaño, Cecilia Rotondaro, Osvaldo L Podhajcer, Rubén Vidal, Laura Morelli, María F Ceriani, Eduardo M Castaño
BACE1 activity regulates cell surface contactin-2 levels
Vivek Gautam, Carla D’Avanzo, Matthias Hebisch, Dora M Kovacs, Doo Yeon Kim
A consecutive case series experience with [18 F] florbetapir PET imaging in an urban dementia center: impact on quality of life, decision making, and disposition
Effie M Mitsis, Heidi A Bender, Lale Kostakoglu, Josef Machac, Jane Martin, Jennifer L Woehr, Margaret C Sewell, Amy Aloysi, Martin A Goldstein, Clara Li, Mary Sano, Sam Gandy
Abundance of Aβ5-xlike immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer’s disease
Erika Avendaño Guzmán, Yvonne Bouter, Bernhard C Richard, Lars Lannfelt, Martin Ingelsson, Anders Paetau, Auli Verkkoniemi-Ahola, Oliver Wirths, Thomas A Bayer
U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer’s disease due to autosomal dominant genetic mutations and trisomy 21
Chadwick M Hales, Nicholas T Seyfried, Eric B Dammer, Duc Duong, Hong Yi, Marla Gearing, Juan C Troncoso, Elliott J Mufson, Madhav Thambisetty, Allan I Levey, James J Lah
The Parkinsonian mimetic, 6-OHDA, impairs axonal transport in dopaminergic axons
Xi Lu, Jeong Sook Kim-Han, Steve Harmon, Shelly E Sakiyama-Elbert, Karen L O'Malley
Optic nerve crush induces spatial and temporal gene expression patterns in retina and optic nerve of BALB/cJ mice
Tasneem P Sharma, Colleen M McDowell, Yang Liu, Alex H Wagner, David Thole, Benjamin P Faga, Robert J Wordinger, Terry A Braun, Abbot F Clark
Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer’s disease
Lokesh Kukreja, Gregory C Kujoth, Tomas A Prolla, Fred Van Leuven, Robert Vassar
Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5 – implications for dementia with Lewy bodies
Cassia R Overk, Anna Cartier, Gideon Shaked, Edward Rockenstein, Kiren Ubhi, Brian Spencer, Diana L Price, Christina Patrick, Paula Desplats, Eliezer Masliah
Simplified method to perform CLARITY imaging
Ekaterina Poguzhelskaya, Dmitry Artamonov, Anastasia Bolshakova, Olga Vlasova, Ilya Bezprozvanny
Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2
Jason D Ulrich, Mary Beth Finn, Yaming Wang, Alice Shen, Thomas E Mahan, Hong Jiang, Floy R Stewart, Laura Piccio, Marco Colonna, David M Holtzman
Identification of longitudinally dynamic biomarkers in Alzheimer’s disease cerebrospinal fluid by targeted proteomics
Kristin R Wildsmith, Stephen P Schauer, Ashley M Smith, David Arnott, Yuda Zhu, Joshua Haznedar, Surinder Kaur, W Rodney Mathews, Lee A Honigberg
Ryanodine receptors: physiological function and deregulation in Alzheimer disease
Dolores Del Prete, Frédéric Checler, Mounia Chami
Epigenetic regulation of adult neural stem cells: implications for Alzheimer’s disease
Carlos P Fitzsimons, Emma van Bodegraven, Marijn Schouten, Roy Lardenoije, Konstantinos Kompotis, Gunter Kenis, Mark van den Hurk, Marco P Boks, Caroline Biojone, Samia Joca, Harry WM Steinbusch, Katie Lunnon, Diego F Mastroeni, Jonathan Mill, Paul J Lucassen, Paul D Coleman, Daniel LA van den Hove, Bart PF Rutten
Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T)mice
Sarah Herdewyn, Carla Cirillo, Ludo Van Den Bosch, Wim Robberecht, Pieter Vanden Berghe, Philip Van Damme
Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats
Vez Repunte-Canonigo, Celine Lefebvre, Olivier George, Tomoya Kawamura, Marisela Morales, George F Koob, Andrea Califano, Eliezer Masliah, Pietro Paolo Sanna
Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson’s disease
Scott Ayton, Peng Lei, Paul A Adlard, Irene Volitakis, Robert A Cherny, Ashley I Bush, David I Finkelstein
Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow
Hongmei Li, Qinxi Guo, Taeko Inoue, Vinicia A Polito, Katsuhiko Tabuchi, Robert E Hammer, Robia G Pautler, George E Taffet, Hui Zheng
Motor and cognitive deficits in aged tau knockout mice in two background strains
Peng Lei, Scott Ayton, Steve Moon, Qihao Zhang, Irene Volitakis, David I Finkelstein, Ashley I Bush
Neuroinflammation and neurologic deficits in diabetes linked to brain accumulation of amylin
Sarah Srodulski, Savita Sharma, Adam B Bachstetter, Jennifer M Brelsfoard, Conrado Pascual, Xinmin Simon Xie, Kathryn E Saatman, Linda J Van Eldik, Florin Despa
An intronic PICALM polymorphism, rs588076, is associated with allelic expression of a PICALMisoform
Ishita Parikh, Christopher Medway, Steven Younkin, David W Fardo, Steven Estus
The transcription factor X-box binding protein-1 in neurodegenerative diseases
Julie Dunys, Eric Duplan, Frédéric Checler
Diet and exercise orthogonally alter the gut microbiome and reveal independent associations with anxiety and cognition
Silvia S Kang, Patricio R Jeraldo, Aishe Kurti, Margret E Berg Miller, Marc D Cook, Keith Whitlock, Nigel Goldenfeld, Jeffrey A Woods, Bryan A White, Nicholas Chia, John D Fryer
Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease
Véréna Landel, Kévin Baranger, Isabelle Virard, Béatrice Loriod, Michel Khrestchatisky, Santiago Rivera, Philippe Benech, François Féron
Chronic traumatic encephalopathy: clinical‐biomarker correlations and current concepts in pathogenesis
Sam Gandy, Milos D Ikonomovic, Effie Mitsis, Gregory Elder, Stephen T Ahlers, Jeffrey Barth, James R Stone, Steven T DeKosky
Molecular neurodegeneration: basic biology and disease pathways
Robert Vassar, Hui Zheng
Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene
Marka van Blitterswijk, Bianca Mullen, Aleksandra Wojtas, Michael G Heckman, Nancy N Diehl, Matthew C Baker, Mariely DeJesus-Hernandez, Patricia H Brown, Melissa E Murray, Ging-Yuek R Hsiung, Heather Stewart, Anna M Karydas, Elizabeth Finger, Andrew Kertesz, Eileen H Bigio, Sandra Weintraub, Marsel Mesulam, Kimmo J Hatanpaa, Charles L White III, Manuela Neumann, Michael J Strong, Thomas G Beach, Zbigniew K Wszolek, Carol Lippa, Richard Caselli, Leonard Petrucelli, Keith A Josephs, Joseph E Parisi, David S Knopman, Ronald C Petersen, Ian R Mackenzie, William W Seeley, Lea T Grinberg, Bruce L Miller, Kevin B Boylan, Neill R Graff-Radford, Bradley F Boeve, Dennis W Dickson, Rosa Rademakers
Histone deacetylase 3 (HDAC3) plays an important role in retinal ganglion cell death after acute optic nerve injury
Heather M Schmitt, Heather R Pelzel, Cassandra L Schlamp, Robert W Nickells
Altered synaptic structure in the hippocampus in a mouse model of Alzheimer’s disease with soluble amyloid-β oligomers and no plaque pathology
Katherine A Price, Merina Varghese, Allison Sowa, Frank Yuk, Hannah Brautigam, Michelle E Ehrlich, Dara L Dickstein
The role of tau protein in HIV-associated neurocognitive disorders
Lecia AM Brown, James Scarola, Adam J Smith, Paul R Sanberg, Jun Tan, Brian Giunta
Alpha-synuclein and tau: teammates in neurodegeneration?
Simon Moussaud, Daryl R Jones, Elisabeth L Moussaud-Lamodière, Marion Delenclos, Owen A Ross, Pamela J McLean
Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice
Scott A Yuzwa, Xiaoyang Shan, Bryan A Jones, Gang Zhao, Melissa L Woodward, Xiaojing Li, Yanping Zhu, Ernest J McEachern, Michael A Silverman, Neil V Watson, Cheng-Xin Gong, David J Vocadlo
Analysis of COQ2gene in multiple system atrophy
Kotaro Ogaki, Shinsuke Fujioka, Michael G Heckman, Sruti Rayaprolu, Alexandra I Soto-Ortolaza, Catherine Labbé, Ronald L Walton, Oswaldo Lorenzo-Betancor, Xue Wang, Yan Asmann, Rosa Rademakers, Neill Graff-Radford, Ryan Uitti, William P Cheshire, Zbigniew K Wszolek, Dennis W Dickson, Owen A Ross
Pathogenic polyglutamine expansion length correlates with polarity of the flanking sequences
Meewhi Kim
Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease
Shichun Tu, Shu-ichi Okamoto, Stuart A Lipton, Huaxi Xu
Increase of angiotensin II type 1 receptor auto-antibodies in Huntington’s disease
De-Hyung Lee, Harald Heidecke, Alexandra Schröder, Friedemann Paul, Rolf Wachter, Rainer Hoffmann, Gisa Ellrichmann, Duska Dragun, Anne Waschbisch, Johannes Stegbauer, Peter Klotz, Ralf Gold, Ralf Dechend, Dominik N Müller, Carsten Saft, Ralf A Linker
The impact of human and mouse differences in NOS2 gene expression on the brain’s redox and immune environment
Michael D Hoos, Michael P Vitek, Lisa A Ridnour, Joan Wilson, Marilyn Jansen, Angela Everhart, David A Wink, Carol A Colton
Tau deletion impairs intracellular β-amyloid-42 clearance and leads to more extracellular plaque deposition in gene transfer models
Irina Lonskaya, Michaeline Hebron, Wenqiang Chen, Joel Schachter, Charbel Moussa
SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer’s disease
Ann Brinkmalm, Gunnar Brinkmalm, William G Honer, Lutz Frölich, Lucrezia Hausner, Lennart Minthon, Oskar Hansson, Anders Wallin, Henrik Zetterberg, Kaj Blennow, Annika Öhrfelt
Models of β-amyloid induced Tau-pathology: the long and “folded” road to understand the mechanism
Ilie-Cosmin Stancu, Bruno Vasconcelos, Dick Terwel, Ilse Dewachter
Merging pathology with biomechanics using CHIMERA (Closed-Head Impact Model of Engineered Rotational Acceleration): a novel, surgery-free model of traumatic brain injury
Dhananjay R Namjoshi, Wai Hang Cheng, Kurt A McInnes, Kris M Martens, Michael Carr, Anna Wilkinson, Jianjia Fan, Jerome Robert, Arooj Hayat, Peter A Cripton, Cheryl L Wellington
The cognitive defects of neonatally irradiated mice are accompanied by changed synaptic plasticity, adult neurogenesis and neuroinflammation
Stefan J Kempf, Arianna Casciati, Sonja Buratovic, Dirk Janik, Christine von Toerne, Marius Ueffing, Frauke Neff, Simone Moertl, Bo Stenerlöw, Anna Saran, Michael J Atkinson, Per Eriksson, Simonetta Pazzaglia, Soile Tapio
Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40
Xiaoyan Hu, Xiaoling Li, Mingrui Zhao, Andrew Gottesdiener, Wenjie Luo, Steven Paul
Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer’s disease early phenotypes
Catherine Marquer, Jeanne Laine, Luce Dauphinot, Linda Hanbouch, Camille Lemercier-Neuillet, Nathalie Pierrot, Koen Bossers, Mickael Le, Fabian Corlier, Caroline Benstaali, Frédéric Saudou, Gopal Thinakaran, Nathalie Cartier, Jean-Noël Octave, Charles Duyckaerts, Marie-Claude Potier
Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice
Odochi Ohia-Nwoko, Saghi Montazari, Yuen-Sum Lau, Jason L Eriksen
Interleukin-1β causes excitotoxic neurodegeneration and multiple sclerosis disease progression by activating the apoptotic protein p53
Silvia Rossi, Caterina Motta, Valeria Studer, Giulia Macchiarulo, Elisabetta Volpe, Francesca Barbieri, Gabriella Ruocco, Fabio Buttari, Annamaria Finardi, Raffaele Mancino, Sagit Weiss, Luca Battistini, Gianvito Martino, Roberto Furlan, Jelena Drulovic, Diego Centonze
Associations between brain microstructures, metabolites, and cognitive deficits during chronic HIV-1 infection of humanized mice
Michael D Boska, Prasanta K Dash, Jaclyn Knibbe, Adrian A Epstein, Sidra P Akhter, Natasha Fields, Robin High, Edward Makarov, Stephen Bonasera, Harris A Gelbard, Larisa Y Poluektova, Howard E Gendelman, Santhi Gorantla
Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase
Virginie Buggia-Prévot, Celia G Fernandez, Sean Riordan, Kulandaivelu S Vetrivel, Jelita Roseman, Jack Waters, Vytautas P Bindokas, Robert Vassar, Gopal Thinakaran
Structural biology of presenilin 1 complexes
Yi Li, Christopher Bohm, Roger Dodd, Fusheng Chen, Seema Qamar, Gerold Schmitt-Ulms, Paul E Fraser, Peter H St George-Hyslop
Vacuolar protein sorting 35 (Vps35) rescues locomotor deficits and shortened lifespan in Drosophila expressing a Parkinson’s disease mutant of Leucine-rich repeat kinase 2 (LRRK2)
Radek Linhart, Sarah Anne Wong, Jieyun Cao, Melody Tran, Anne Huynh, Casey Ardrey, Jong Min Park, Christine Hsu, Saher Taha, Rentia Peterson, Shannon Shea, Jason Kurian, Katerina Venderova
ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer’s disease
Christopher W Medway, Samer Abdul-Hay, Tynickwa Mims, Li Ma, Gina Bisceglio, Fanggeng Zou, Shane Pankratz, Sigrid B Sando, Jan O Aasly, Maria Barcikowska, Joanna Siuda, Zbigniew K Wszolek, Owen A Ross, Minerva Carrasquillo, Dennis W Dickson, Neill Graff-Radford, Ronald C Petersen, Nilüfer Ertekin-Taner, Kevin Morgan, Guojun Bu, Steven G Younkin
Dysregulation of protein trafficking in neurodegeneration
Xin Wang, Timothy Huang, Guojun Bu, Huaxi Xu
Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 mice
Felipe G Serrano, Cheril Tapia-Rojas, Francisco J Carvajal, Juan Hancke, Waldo Cerpa, Nibaldo C Inestrosa
Erratum to: A glycine zipper motif mediates the formation of toxic beta-amyloid oligomers in vitro and in vivo
Virginia Fonte, Vishantie Dostal, Christine M Roberts, Patrick Gonzales, Pascale N Lacor, Pauline T Velasco, Jordi Magrane, Natalie Dingwell, Emily Y Fan, Michael A Silverman, Gretchen H Stein, Christopher D Link