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Zeitschrift

BMC Medicine

BMC Medicine 1/2018

Ausgabe 1/2018

Inhaltsverzeichnis ( 243 Artikel )

01.12.2018 | Opinion | Ausgabe 1/2018 Open Access

The health impacts of climate-related migration

Patricia Schwerdtle, Kathryn Bowen, Celia McMichael

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Identifying older adults at risk of harm following elective surgery: a systematic review and meta-analysis

Jennifer Watt, Andrea C. Tricco, Catherine Talbot-Hamon, Ba’ Pham, Patricia Rios, Agnes Grudniewicz, Camilla Wong, Douglas Sinclair, Sharon E. Straus

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Influence of demographic changes on the impact of vaccination against varicella and herpes zoster in Germany – a mathematical modelling study

Johannes Horn, Oliver Damm, Wolfgang Greiner, Hartmut Hengel, Mirjam E. Kretzschmar, Anette Siedler, Bernhard Ultsch, Felix Weidemann, Ole Wichmann, André Karch, Rafael T. Mikolajczyk

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Risk of fracture among patients with polymyalgia rheumatica and giant cell arteritis: a population-based study

Zoe Paskins, Rebecca Whittle, Alyshah Abdul Sultan, Sara Muller, Milica Blagojevic-Bucknall, Toby Helliwell, Samantha Hider, Edward Roddy, Christian Mallen

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Deprescribing preventive cardiovascular medication in patients with predicted low cardiovascular disease risk in general practice – the ECSTATIC study: a cluster randomised non-inferiority trial

Clare H. Luymes, Rosalinde K. E. Poortvliet, Nan van Geloven, Margot W. M. de Waal, Yvonne M. Drewes, Jeanet W. Blom, Nynke Smidt, Willem J. J. Assendelft, Wilbert B. van den Hout, Wouter de Ruijter, Mattijs E. Numans

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Antidepressant use during pregnancy and risk of autism spectrum disorder and attention deficit hyperactivity disorder: systematic review of observational studies and methodological considerations

Daniel R. Morales, Jim Slattery, Stephen Evans, Xavier Kurz

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Micronutrient powders to combat anaemia in young children: do they work?

Hans Verhoef, Emily Teshome, Andrew M. Prentice

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Efficacy of melatonin for sleep disturbance following traumatic brain injury: a randomised controlled trial

Natalie A. Grima, Shantha M. W. Rajaratnam, Darren Mansfield, Tracey L. Sletten, Gershon Spitz, Jennie L. Ponsford

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin

Richard G. Brown, Julian R. Marchesi, Yun S. Lee, Ann Smith, Benjamin Lehne, Lindsay M. Kindinger, Vasso Terzidou, Elaine Holmes, Jeremy K. Nicholson, Phillip R. Bennett, David A. MacIntyre

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Rotavirus vaccine impact and socioeconomic deprivation: an interrupted time-series analysis of gastrointestinal disease outcomes across primary and secondary care in the UK

Daniel Hungerford, Roberto Vivancos, Jonathan M. Read, Miren Iturriza-Gόmara, Neil French, Nigel A. Cunliffe

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria – a proposed model-derived age-based regimen for sub-Saharan Africa

W. Robert Taylor, Htee Khu Naw, Kathryn Maitland, Thomas N. Williams, Melissa Kapulu, Umberto D’Alessandro, James A. Berkley, Philip Bejon, Joseph Okebe, Jane Achan, Alfred Ngwa Amambua, Muna Affara, Davis Nwakanma, Jean-Pierre van Geertruyden, Muhindo Mavoko, Pascal Lutumba, Junior Matangila, Philipe Brasseur, Patrice Piola, Rindra Randremanana, Estrella Lasry, Caterina Fanello, Marie Onyamboko, Birgit Schramm, Zolia Yah, Joel Jones, Rick M. Fairhurst, Mahamadou Diakite, Grace Malenga, Malcolm Molyneux, Claude Rwagacondo, Charles Obonyo, Endalamaw Gadisa, Abraham Aseffa, Mores Loolpapit, Marie-Claire Henry, Grant Dorsey, Chandy John, Sodiomon B. Sirima, Karen I. Barnes, Peter Kremsner, Nicholas P. Day, Nicholas J. White, Mavuto Mukaka

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Built environmental characteristics and diabetes: a systematic review and meta-analysis

N. R. den Braver, J. Lakerveld, F. Rutters, L. J. Schoonmade, J. Brug, J. W. J. Beulens

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Elucidating the impact of the pneumococcal conjugate vaccine programme on pneumonia, sepsis and otitis media hospital admissions in England using a composite control

Dominic Thorrington, Nick Andrews, Julia Stowe, Elizabeth Miller, Albert Jan van Hoek

01.12.2018 | Debate | Ausgabe 1/2018 Open Access

Rethinking Disability

Alarcos Cieza, Carla Sabariego, Jerome Bickenbach, Somnath Chatterji

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Near-death experiences, attacks by family members, and absence of health care in their home countries affect the quality of life of refugee women in Germany: a multi-region, cross-sectional, gender-sensitive study

Jenny Jesuthasan, Ekin Sönmez, Ingar Abels, Christine Kurmeyer, Jana Gutermann, Renate Kimbel, Antje Krüger, Guenter Niklewski, Kneginja Richter, Ulrich Stangier, Anja Wollny, Ulrike Zier, Sabine Oertelt-Prigione, Meryam Shouler-Ocak, on behalf of the Female Refugee Study (FRS) Investigators

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Economic evaluation of type 2 diabetes prevention programmes: Markov model of low- and high-intensity lifestyle programmes and metformin in participants with different categories of intermediate hyperglycaemia

Samantha Roberts, Dawn Craig, Amanda Adler, Klim McPherson, Trisha Greenhalgh

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Metabolic characterization of menopause: cross-sectional and longitudinal evidence

Qin Wang, Diana L. Santos Ferreira, Scott M. Nelson, Naveed Sattar, Mika Ala-Korpela, Debbie A. Lawlor

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Melatonin and health: an umbrella review of health outcomes and biological mechanisms of action

Pawel P. Posadzki, Ram Bajpai, Bhone Myint Kyaw, Nicola J. Roberts, Amnon Brzezinski, George I. Christopoulos, Ushashree Divakar, Shweta Bajpai, Michael Soljak, Gerard Dunleavy, Krister Jarbrink, Ei Ei Khaing Nang, Chee Kiong Soh, Josip Car

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Chronic morbidity, deprivation and primary medical care spending in England in 2015-16: a cross-sectional spatial analysis

Evangelos Kontopantelis, Mamas A. Mamas, Harm van Marwijk, Andrew M. Ryan, Peter Bower, Bruce Guthrie, Tim Doran

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Circadian pathway genetic variation and cancer risk: evidence from genome-wide association studies

Simone Mocellin, Saveria Tropea, Clara Benna, Carlo Riccardo Rossi

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

International core outcome set for clinical trials of medication review in multi-morbid older patients with polypharmacy

Jean-Baptiste Beuscart, Wilma Knol, Shane Cullinan, Claudio Schneider, Olivia Dalleur, Benoit Boland, Stefanie Thevelin, Paul A. F. Jansen, Denis O’Mahony, Nicolas Rodondi, Anne Spinewine

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Geographic variation in sexual behavior can explain geospatial heterogeneity in the severity of the HIV epidemic in Malawi

Laurence Palk, Sally Blower

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester

Zoe C. Johnston, Michelle Bellingham, Panagiotis Filis, Ugo Soffientini, Denise Hough, Siladitya Bhattacharya, Marc Simard, Geoffrey L. Hammond, Peter King, Peter J. O’Shaughnessy, Paul A. Fowler

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Second-line treatment for advanced NSCLC without actionable mutations: is immunotherapy the ‘panacea’ for all patients?

Alessandro Morabito

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Genomic screening for monogenic forms of diabetes

Leslie G. Biesecker

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Reproducibility of clinical research in critical care: a scoping review

Daniel J. Niven, T. Jared McCormick, Sharon E. Straus, Brenda R. Hemmelgarn, Lianne Jeffs, Tavish R. M. Barnes, Henry T. Stelfox

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Multidrug-resistant tuberculosis treatment adherence in migrants: a systematic review and meta-analysis

Laura B. Nellums, Kieran Rustage, Sally Hargreaves, Jon S. Friedland

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A personalized intervention to prevent depression in primary care: cost-effectiveness study nested into a clustered randomized trial

Anna Fernández, Juan M. Mendive, Sonia Conejo-Cerón, Patricia Moreno-Peral, Michael King, Irwin Nazareth, Carlos Martín-Pérez, Carmen Fernández-Alonso, Antonina Rodríguez-Bayón, Jose Maria Aiarzaguena, Carmen Montón-Franco, Antoni Serrano-Blanco, Inmaculada Ibañez-Casas, Emiliano Rodríguez-Sánchez, Luis Salvador-Carulla, Paola Bully Garay, María Isabel Ballesta-Rodríguez, Pilar LaFuente, María del Mar Muñoz-García, Pilar Mínguez-Gonzalo, Luz Araujo, Diego Palao, María Cruz Gómez, Fernando Zubiaga, Desirée Navas-Campaña, Jose Manuel Aranda-Regules, Alberto Rodriguez-Morejón, Juan de Dios Luna, Juan Ángel Bellón

01.12.2018 | Correspondence | Ausgabe 1/2018 Open Access

Adaptive designs in clinical trials: why use them, and how to run and report them

Philip Pallmann, Alun W. Bedding, Babak Choodari-Oskooei, Munyaradzi Dimairo, Laura Flight, Lisa V. Hampson, Jane Holmes, Adrian P. Mander, Lang’o Odondi, Matthew R. Sydes, Sofía S. Villar, James M. S. Wason, Christopher J. Weir, Graham M. Wheeler, Christina Yap, Thomas Jaki

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Class-modeling analysis reveals T-cell homeostasis disturbances involved in loss of immune control in elite controllers

José M. Benito, María C. Ortiz, Agathe León, Luis A. Sarabia, José M. Ligos, María Montoya, Marcial Garcia, Ezequiel Ruiz-Mateos, Rosario Palacios, Alfonso Cabello, Clara Restrepo, Carmen Rodriguez, Jorge del Romero, Manuel Leal, María A. Muñoz-Fernández, José Alcamí, Felipe García, Miguel Górgolas, Norma Rallón, On behalf of ECRIS integrated in the Spanish AIDS Research Network

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The Cambridge Prognostic Groups for improved prediction of disease mortality at diagnosis in primary non-metastatic prostate cancer: a validation study

V. J. Gnanapragasam, O. Bratt, K. Muir, L. S. Lee, H. H. Huang, P. Stattin, A. Lophatananon

01.12.2018 | Debate | Ausgabe 1/2018 Open Access

Hospital Mortality – a neglected but rich source of information supporting the transition to higher quality health systems in low and middle income countries

Mike English, Paul Mwaniki, Thomas Julius, Mercy Chepkirui, David Gathara, Paul O. Ouma, Peter Cherutich, Emelda A. Okiro, Robert W. Snow

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Large-scale external validation and comparison of prognostic models: an application to chronic obstructive pulmonary disease

Beniamino Guerra, Sarah R. Haile, Bernd Lamprecht, Ana S. Ramírez, Pablo Martinez-Camblor, Bernhard Kaiser, Inmaculada Alfageme, Pere Almagro, Ciro Casanova, Cristóbal Esteban-González, Juan J. Soler-Cataluña, Juan P. de-Torres, Marc Miravitlles, Bartolome R. Celli, Jose M. Marin, Gerben ter Riet, Patricia Sobradillo, Peter Lange, Judith Garcia-Aymerich, Josep M. Antó, Alice M. Turner, Meilan K. Han, Arnulf Langhammer, Linda Leivseth, Per Bakke, Ane Johannessen, Toru Oga, Borja Cosio, Julio Ancochea-Bermúdez, Andres Echazarreta, Nicolas Roche, Pierre-Régis Burgel, Don D. Sin, Joan B. Soriano, Milo A. Puhan, for the 3CIA collaboration

01.12.2018 | Opinion | Ausgabe 1/2018 Open Access

Are dementia with Lewy bodies and Parkinson’s disease dementia the same disease?

Kurt A. Jellinger, Amos D. Korczyn

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Prevalence, risk factors and behavioural and emotional comorbidity of acute seizures in young Kenyan children: a population-based study

Symon M. Kariuki, Amina Abubakar, Martha Kombe, Michael Kazungu, Rachael Odhiambo, Alan Stein, Charles R. J. C. Newton

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Antidepressant use and risk of adverse outcomes in people aged 20–64 years: cohort study using a primary care database

Carol Coupland, Trevor Hill, Richard Morriss, Michael Moore, Antony Arthur, Julia Hippisley-Cox

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa

A. Aramburo, Jim Todd, Elizabeth C. George, Sarah Kiguli, Peter Olupot-Olupot, Robert O. Opoka, Charles Engoru, Samuel O. Akech, Richard Nyeko, George Mtove, Diana M. Gibb, Abdel G. Babiker, Kathryn Maitland

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Outcomes of notifications to health practitioner boards: a retrospective cohort study

Matthew J. Spittal, David M. Studdert, Ron Paterson, Marie M. Bismark

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Genetic variation in clusterin and risk of dementia and ischemic vascular disease in the general population: cohort studies and meta-analyses of 362,338 individuals

Liv Tybjærg Nordestgaard, Anne Tybjærg-Hansen, Katrine Laura Rasmussen, Børge G. Nordestgaard, Ruth Frikke-Schmidt

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Syrian refugees in Greece: experience with violence, mental health status, and access to information during the journey and while in Greece

Jihane Ben Farhat, Karl Blanchet, Pia Juul Bjertrup, Apostolos Veizis, Clément Perrin, Rebecca M. Coulborn, Philippe Mayaud, Sandra Cohuet

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Fatty fish intake and cognitive function: FINS-KIDS, a randomized controlled trial in preschool children

Jannike Øyen, Ingrid Kvestad, Lisa Kolden Midtbø, Ingvild Eide Graff, Mari Hysing, Kjell Morten Stormark, Maria Wik Markhus, Valborg Baste, Livar Frøyland, Berthold Koletzko, Hans Demmelmair, Lisbeth Dahl, Øyvind Lie, Marian Kjellevold

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Impact of atopy on risk of glioma: a Mendelian randomisation study

Linden Disney-Hogg, Alex J. Cornish, Amit Sud, Philip J. Law, Ben Kinnersley, Daniel I. Jacobs, Quinn T. Ostrom, Karim Labreche, Jeanette E. Eckel-Passow, Georgina N. Armstrong, Elizabeth B. Claus, Dora Il’yasova, Joellen Schildkraut, Jill S. Barnholtz-Sloan, Sara H. Olson, Jonine L. Bernstein, Rose K. Lai, Minouk J. Schoemaker, Matthias Simon, Per Hoffmann, Markus M. Nöthen, Karl-Heinz Jöckel, Stephen Chanock, Preetha Rajaraman, Christoffer Johansen, Robert B. Jenkins, Beatrice S. Melin, Margaret R. Wrensch, Marc Sanson, Melissa L. Bondy, Richard S. Houlston

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Clinical assessment is a neglected component of outbreak preparedness: evidence from refugee camps in Greece

Amanda M. Rojek, Kassiani Gkolfinopoulou, Apostolos Veizis, Angeliki Lambrou, Lyndsey Castle, Theano Georgakopoulou, Karl Blanchet, Takis Panagiotopoulos, Peter W. Horby, The Epidemic Diseases Research Group field team

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Sleep deficiency and motor vehicle crash risk in the general population: a prospective cohort study

Daniel J. Gottlieb, Jeffrey M. Ellenbogen, Matt T. Bianchi, Charles A. Czeisler

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Comparison of treatment effect sizes from pivotal and postapproval trials of novel therapeutics approved by the FDA based on surrogate markers of disease: a meta-epidemiological study

Joshua D. Wallach, Oriana Ciani, Alison M. Pease, Gregg S. Gonsalves, Harlan M. Krumholz, Rod S. Taylor, Joseph S. Ross

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study

Conor Duncan Tweed, Genevieve Helen Wills, Angela M. Crook, Rodney Dawson, Andreas H. Diacon, Cheryl E. Louw, Timothy D. McHugh, Carl Mendel, Sarah Meredith, Lerato Mohapi, Michael E. Murphy, Stephen Murray, Sara Murthy, Andrew J. Nunn, Patrick P. J. Phillips, Kasha Singh, M. Spigelman, S. H. Gillespie

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Hepatitis B in Moroccan-Dutch: a quantitative study into determinants of screening participation

Nora Hamdiui, Mart L. Stein, Aura Timen, Danielle Timmermans, Albert Wong, Maria E. T. C. van den Muijsenbergh, Jim E. van Steenbergen

01.12.2018 | Correspondence | Ausgabe 1/2018 Open Access

The perceived organizational impact of the gender gap across a Canadian department of medicine and proposed strategies to combat it: a qualitative study

Reena Pattani, Christine Marquez, Camellia Dinyarian, Malika Sharma, Julie Bain, Julia E. Moore, Sharon E. Straus

01.12.2018 | Debate | Ausgabe 1/2018 Open Access

Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic?

Rafael Dal-Ré, Perrine Janiaud, John P. A. Ioannidis

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Consumption of meat in relation to physical functioning in the Seniors-ENRICA cohort

Ellen A. Struijk, José R. Banegas, Fernando Rodríguez-Artalejo, Esther Lopez-Garcia

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

General and disease-specific pain trajectories as predictors of social and political outcomes in arthritis and cancer

Richard J. E. James, David A. Walsh, Eamonn Ferguson

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Small contribution of gold mines to the ongoing tuberculosis epidemic in South Africa: a modeling-based study

Stewart T. Chang, Violet N. Chihota, Katherine L. Fielding, Alison D. Grant, Rein M. Houben, Richard G. White, Gavin J. Churchyard, Philip A. Eckhoff, Bradley G. Wagner

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Prediction of autonomic dysreflexia during urodynamics: a prospective cohort study

Matthias Walter, Stephanie C. Knüpfer, Jacquelyn J. Cragg, Lorenz Leitner, Marc P. Schneider, Ulrich Mehnert, Andrei V. Krassioukov, Martin Schubert, Armin Curt, Thomas M. Kessler

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Medical end-of-life practices in Swiss cultural regions: a death certificate study

Samia A. Hurst, Ueli Zellweger, Georg Bosshard, Matthias Bopp, for the Swiss Medical End-of-Life Decisions Study Group

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Ethnic minority inequalities in access to treatments for schizophrenia and schizoaffective disorders: findings from a nationally representative cross-sectional study

Jayati Das-Munshi, Dinesh Bhugra, Mike J. Crawford

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Performance of InSilicoVA for assigning causes of death to verbal autopsies: multisite validation study using clinical diagnostic gold standards

Abraham D. Flaxman, Jonathan C. Joseph, Christopher J. L. Murray, Ian Douglas Riley, Alan D. Lopez

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Differences in the health transition patterns of migrants and non-migrants aged 50 and older in southern and western Europe (2004–2015)

Matias Reus-Pons, Clara H. Mulder, Eva U. B. Kibele, Fanny Janssen

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The cost-effectiveness of oral HIV pre-exposure prophylaxis and early antiretroviral therapy in the presence of drug resistance among men who have sex with men in San Francisco

Mingwang Shen, Yanni Xiao, Libin Rong, Lauren Ancel Meyers, Steven E. Bellan

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Efficacy and safety of methylene blue in the treatment of malaria: a systematic review

G. Lu, M. Nagbanshi, N. Goldau, M. Mendes Jorge, P. Meissner, A. Jahn, F. P. Mockenhaupt, O. Müller

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Clinical trial registration and reporting: a survey of academic organizations in the United States

Evan Mayo-Wilson, James Heyward, Anthony Keyes, Jesse Reynolds, Sarah White, Nidhi Atri, G. Caleb Alexander, Audrey Omar, Daniel E. Ford, on behalf of the National Clinical Trials Registration and Results Reporting Taskforce Survey Subcommittee

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children

Liriye Kurtovic, Marije C. Behet, Gaoqian Feng, Linda Reiling, Kiprotich Chelimo, Arlene E. Dent, Ivo Mueller, James W. Kazura, Robert W. Sauerwein, Freya J. I. Fowkes, James G. Beeson

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Migration and tuberculosis transmission in a middle-income country: a cross-sectional study in a central area of São Paulo, Brazil

Julia Moreira Pescarini, Vera Simonsen, Lucilaine Ferrazoli, Laura C. Rodrigues, Rosangela S. Oliveira, Eliseu Alves Waldman, Rein Houben

01.12.2018 | Opinion | Ausgabe 1/2018 Open Access

When complexity science meets implementation science: a theoretical and empirical analysis of systems change

Jeffrey Braithwaite, Kate Churruca, Janet C. Long, Louise A. Ellis, Jessica Herkes

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The Daily Mile makes primary school children more active, less sedentary and improves their fitness and body composition: a quasi-experimental pilot study

Ross A. Chesham, Josephine N. Booth, Emma L. Sweeney, Gemma C. Ryde, Trish Gorely, Naomi E. Brooks, Colin N. Moran

01.12.2018 | Opinion | Ausgabe 1/2018 Open Access

The Syrian conflict: a case study of the challenges and acute need for medical humanitarian operations for women and children internally displaced persons

Rahma Aburas, Amina Najeeb, Laila Baageel, Tim K. Mackey

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Analysing the role of complexity in explaining the fortunes of technology programmes: empirical application of the NASSS framework

Trisha Greenhalgh, Joe Wherton, Chrysanthi Papoutsi, Jenni Lynch, Gemma Hughes, Christine A’Court, Sue Hinder, Rob Procter, Sara Shaw

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Guillain–Barré syndrome risk among individuals infected with Zika virus: a multi-country assessment

Luis Mier-y-Teran-Romero, Mark J. Delorey, James J. Sejvar, Michael A. Johansson

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Serum magnesium levels and risk of coronary artery disease: Mendelian randomisation study

Susanna C. Larsson, Stephen Burgess, Karl Michaëlsson

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Healthcare costs and utilization associated with high-risk prescription opioid use: a retrospective cohort study

Hsien-Yen Chang, Hadi Kharrazi, Dave Bodycombe, Jonathan P. Weiner, G. Caleb Alexander

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

High burden of birthweight-lowering genetic variants in Africans and Asians

Fasil Tekola-Ayele, Tsegaselassie Workalemahu, Azmeraw T. Amare

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Spatio-temporal mapping of Madagascar’s Malaria Indicator Survey results to assess Plasmodium falciparum endemicity trends between 2011 and 2016

Su Yun Kang, Katherine E. Battle, Harry S. Gibson, Arsène Ratsimbasoa, Milijaona Randrianarivelojosia, Stéphanie Ramboarina, Peter A. Zimmerman, Daniel J. Weiss, Ewan Cameron, Peter W. Gething, Rosalind E. Howes

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Effective coverage of essential inpatient care for small and sick newborns in a high mortality urban setting: a cross-sectional study in Nairobi City County, Kenya

Georgina A. V. Murphy, David Gathara, Jacintah Mwachiro, Nancy Abuya, Jalemba Aluvaala, Mike English, on behalf of the Health Services that Deliver for Newborns Expert Group

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Pretreatment chest x-ray severity and its relation to bacterial burden in smear positive pulmonary tuberculosis

S. E. Murthy, F. Chatterjee, A. Crook, R. Dawson, C. Mendel, M. E. Murphy, S. R. Murray, A. J. Nunn, P. P. J. Phillips, Kasha P. Singh, T. D. McHugh, S. H. Gillespie, On behalf of the REMoxTB Consortium

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A cut-off of daily sedentary time and all-cause mortality in adults: a meta-regression analysis involving more than 1 million participants

Po-Wen Ku, Andrew Steptoe, Yung Liao, Ming-Chun Hsueh, Li-Jung Chen

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Patterns of adiposity, vascular phenotypes and cognitive function in the 1946 British Birth Cohort

Stefano Masi, Georgios Georgiopoulos, Tauseef Khan, William Johnson, Andrew Wong, Marietta Charakida, Peter Whincup, Alun D. Hughes, Marcus Richards, Rebecca Hardy, John Deanfield

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Informing real-world practice with real-world evidence: the value of PRECIS-2

Gila Neta, Karin E. Johnson

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Associations of discretionary screen time with mortality, cardiovascular disease and cancer are attenuated by strength, fitness and physical activity: findings from the UK Biobank study

Carlos A. Celis-Morales, Donald M. Lyall, Lewis Steell, Stuart R. Gray, Stamatina Iliodromiti, Jana Anderson, Daniel F. Mackay, Paul Welsh, Thomas Yates, Jill P. Pell, Naveed Sattar, Jason M. R. Gill

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Measuring and mapping the global burden of antimicrobial resistance

Simon I. Hay, Puja C. Rao, Christiane Dolecek, Nicholas P. J. Day, Andy Stergachis, Alan D. Lopez, Christopher J. L. Murray

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Switching to dual/monotherapy determines an increase in CD8+ in HIV-infected individuals: an observational cohort study

Cristina Mussini, Patrizia Lorenzini, Alessandro Cozzi-Lepri, Giulia Marchetti, Stefano Rusconi, Andrea Gori, Silvia Nozza, Miriam Lichtner, Andrea Antinori, Andrea Cossarizza, Antonella d’Arminio Monforte, for the Icona Foundation Study Group

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Is telephone health coaching a useful population health strategy for supporting older people with multimorbidity? An evaluation of reach, effectiveness and cost-effectiveness using a ‘trial within a cohort’

Maria Panagioti, David Reeves, Rachel Meacock, Beth Parkinson, Karina Lovell, Mark Hann, Kelly Howells, Amy Blakemore, Lisa Riste, Peter Coventry, Thomas Blakeman, Mark Sidaway, Peter Bower

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Efficacy and safety of ascending doses of praziquantel against Schistosoma haematobium infection in preschool-aged and school-aged children: a single-blind randomised controlled trial

Jean T. Coulibaly, Gordana Panic, Richard B. Yapi, Jana Kovač, Beatrice Barda, Yves K. N’Gbesso, Jan Hattendorf, Jennifer Keiser

01.12.2018 | Opinion | Ausgabe 1/2018 Open Access

Using flawed, uncertain, proximate and sparse (FUPS) data in the context of complexity: learning from the case of child mental health

Miranda Wolpert, Harry Rutter

01.12.2018 | Minireview | Ausgabe 1/2018 Open Access

Transient portal vein thrombosis in liver cirrhosis

Xingshun Qi, Xiaozhong Guo, Eric M. Yoshida, Nahum Méndez-Sánchez, Valerio De Stefano, Frank Tacke, Andrea Mancuso, Yasuhiko Sugawara, Sien-Sing Yang, Rolf Teschke, Ankur Arora, Dominique-Charles Valla

01.12.2018 | Opinion | Ausgabe 1/2018 Open Access

Zika vaccines and therapeutics: landscape analysis and challenges ahead

Annelies Wilder-Smith, Kirsten Vannice, Anna Durbin, Joachim Hombach, Stephen J. Thomas, Irani Thevarjan, Cameron P. Simmons

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Trends in, and factors associated with, HIV infection amongst tuberculosis patients in the era of anti-retroviral therapy: a retrospective study in England, Wales and Northern Ireland

Joanne R. Winter, Helen R. Stagg, Colette J. Smith, Maeve K. Lalor, Jennifer A. Davidson, Alison E. Brown, James Brown, Dominik Zenner, Marc Lipman, Anton Pozniak, Ibrahim Abubakar, Valerie Delpech

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Four-year effects of exercise on fatigue and physical activity in patients with cancer

Lenja Witlox, Anouk E. Hiensch, Miranda J. Velthuis, Charlotte N. Steins Bisschop, Maartje Los, Frans L. G. Erdkamp, Haiko J. Bloemendal, Marlies Verhaar, Daan ten Bokkel Huinink, Elsken van der Wall, Petra H. M. Peeters, Anne M. May

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Avoidable waste of research related to outcome planning and reporting in clinical trials

Youri Yordanov, Agnes Dechartres, Ignacio Atal, Viet-Thi Tran, Isabelle Boutron, Perrine Crequit, Philippe Ravaud

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Abortion-related emergency department visits in the United States: An analysis of a national emergency department sample

Ushma D. Upadhyay, Nicole E. Johns, Rebecca Barron, Alice F. Cartwright, Chantal Tapé, Alyssa Mierjeski, Alyson J. McGregor

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Perinatal health outcomes and care among asylum seekers and refugees: a systematic review of systematic reviews

Nicola Heslehurst, Heather Brown, Augustina Pemu, Hayley Coleman, Judith Rankin

01.12.2018 | Debate | Ausgabe 1/2018 Open Access

Innovative health financing for refugees

Paul Spiegel, Rebecca Chanis, Antonio Trujillo

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Developing a measure of polypharmacy appropriateness in primary care: systematic review and expert consensus study

Jenni Burt, Natasha Elmore, Stephen M. Campbell, Sarah Rodgers, Anthony J. Avery, Rupert A. Payne

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Simple rules for evidence translation in complex systems: A qualitative study

Julie E. Reed, Cathy Howe, Cathal Doyle, Derek Bell

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Chronic hepatitis B virus infection and risk of chronic kidney disease: a population-based prospective cohort study of 0.5 million Chinese adults

Jiahui Si, Canqing Yu, Yu Guo, Zheng Bian, Chenxi Qin, Ling Yang, Yiping Chen, Li Yin, Hui Li, Jian Lan, Junshi Chen, Zhengming Chen, Jun Lv, Liming Li, on behalf of the China Kadoorie Biobank Collaborative Group

01.12.2018 | Opinion | Ausgabe 1/2018 Open Access

Being pragmatic about healthcare complexity: our experiences applying complexity theory and pragmatism to health services research

Katrina M. Long, Fiona McDermott, Graham N. Meadows

01.12.2018 | Editorial | Ausgabe 1/2018 Open Access

Studying complexity in health services research: desperately seeking an overdue paradigm shift

Trisha Greenhalgh, Chrysanthi Papoutsi

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Outcomes of neonates born following transfers of frozen-thawed cleavage-stage embryos with blastomere loss: a prospective, multicenter, cohort study

Yan-Ting Wu, Cheng Li, Yi-Min Zhu, Shu-Hua Zou, Qiong-Fang Wu, Li-Ping Wang, Yan Wu, Rong Yin, Chao-Yi Shi, Jing Lin, Zi-Ru Jiang, Yi-Jing Xu, Yun-Fei Su, Jian Zhang, Jian-Zhong Sheng, William D. Fraser, Zhi-Wei Liu, He-Feng Huang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The socioeconomic profile of alcohol-attributable mortality in South Africa: a modelling study

Charlotte Probst, Charles D. H. Parry, Hans-Ulrich Wittchen, Jürgen Rehm

01.12.2018 | Correspondence | Ausgabe 1/2018 Open Access

Cross-border movement, economic development and malaria elimination in the Kingdom of Saudi Arabia

Mohammed H. Al Zahrani, Abdiasiis I. Omar, Abdelmohsin M. O. Abdoon, Ali Adam Ibrahim, Abdullah Alhogail, Mohamed Elmubarak, Yousif Eldirdiry Elamin, Mohammed A. AlHelal, Ali M. Alshahrani, Tarig M. Abdelgader, Ibrahim Saeed, Tageddin B. El Gamri, Mohammed S. Alattas, Abdu A. Dahlan, Abdullah M. Assiri, Joseph Maina, Xiao Hong Li, Robert W. Snow

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Nordic diet, Mediterranean diet, and the risk of chronic diseases: the EPIC-Potsdam study

Cecilia Galbete, Janine Kröger, Franziska Jannasch, Khalid Iqbal, Lukas Schwingshackl, Carolina Schwedhelm, Cornelia Weikert, Heiner Boeing, Matthias B. Schulze

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Cost-effectiveness of a potential Zika vaccine candidate: a case study for Colombia

Affan Shoukat, Thomas Vilches, Seyed M. Moghadas

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Recurrence quantification analysis of resting state EEG signals in autism spectrum disorder – a systematic methodological exploration of technical and demographic confounders in the search for biomarkers

T. Heunis, C. Aldrich, J. M. Peters, S. S. Jeste, M. Sahin, C. Scheffer, P. J. de Vries

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Estimating the distribution of morbidity and mortality of childhood diarrhea, measles, and pneumonia by wealth group in low- and middle-income countries

Angela Y. Chang, Carlos Riumallo-Herl, Joshua A. Salomon, Stephen C. Resch, Logan Brenzel, Stéphane Verguet

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Optimising first- and second-line treatment strategies for untreated major depressive disorder — the SUN☺D study: a pragmatic, multi-centre, assessor-blinded randomised controlled trial

Tadashi Kato, Toshi A. Furukawa, Akio Mantani, Ken’ichi Kurata, Hajime Kubouchi, Susumu Hirota, Hirotoshi Sato, Kazuyuki Sugishita, Bun Chino, Kahori Itoh, Yoshio Ikeda, Yoshihiro Shinagawa, Masaki Kondo, Yasumasa Okamoto, Hirokazu Fujita, Motomu Suga, Shingo Yasumoto, Naohisa Tsujino, Takeshi Inoue, Noboru Fujise, Tatsuo Akechi, Mitsuhiko Yamada, Shinji Shimodera, Norio Watanabe, Masatoshi Inagaki, Kazuhira Miki, Yusuke Ogawa, Nozomi Takeshima, Yu Hayasaka, Aran Tajika, Kiyomi Shinohara, Naohiro Yonemoto, Shiro Tanaka, Qi Zhou, Gordon H. Guyatt, for the SUN☺D Investigators

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Genotype-guided versus traditional clinical dosing of warfarin in patients of Asian ancestry: a randomized controlled trial

Nicholas L. Syn, Andrea Li-Ann Wong, Soo-Chin Lee, Hock-Luen Teoh, James Wei Luen Yip, Raymond CS Seet, Wee Tiong Yeo, William Kristanto, Ping-Chong Bee, LM Poon, Patrick Marban, Tuck Seng Wu, Michael D. Winther, Liam R. Brunham, Richie Soong, Bee-Choo Tai, Boon-Cher Goh

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Translating evidence to patient care through caregivers: a systematic review of caregiver-mediated interventions

Kirsten M. Fiest, Christiane Job McIntosh, Danielle Demiantschuk, Jeanna Parsons Leigh, Henry T. Stelfox

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Can community health worker home visiting improve care-seeking and maternal and newborn care practices in fragile states such as Afghanistan? A population-based intervention study

Karen M. Edmond, Khaksar Yousufi, Zelaikha Anwari, Sayed Masoud Sadat, Shah Mansoor Staniczai, Ariel Higgins-Steele, Alexandra L. Bellows, Emily R. Smith

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

How can we teach medical students to choose wisely? A randomised controlled cross-over study of video- versus text-based case scenarios

Sascha Ludwig, Nikolai Schuelper, Jamie Brown, Sven Anders, Tobias Raupach

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Clinical utility of the S3-score for molecular prediction of outcome in non-metastatic and metastatic clear cell renal cell carcinoma

Florian Büttner, Stefan Winter, Steffen Rausch, Jörg Hennenlotter, Stephan Kruck, Arnulf Stenzl, Marcus Scharpf, Falko Fend, Abbas Agaimy, Arndt Hartmann, Jens Bedke, Matthias Schwab, Elke Schaeffeler

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Modelling population-level impact to inform target product profiles for childhood malaria vaccines

Alexandra B. Hogan, Peter Winskill, Robert Verity, Jamie T. Griffin, Azra C. Ghani

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Efficacy, effectiveness and safety of vaccination against human papillomavirus in males: a systematic review

Thomas Harder, Ole Wichmann, Stefanie J. Klug, Marianne A. B. van der Sande, Miriam Wiese-Posselt

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A longitudinal, observational study of the features of transitional healthcare associated with better outcomes for young people with long-term conditions

A. Colver, H. McConachie, A. Le Couteur, G. Dovey-Pearce, K. D. Mann, J. E. McDonagh, M. S. Pearce, L. Vale, H. Merrick, J. R. Parr, On behalf of the Transition Collaborative Group

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The association of depression and all-cause and cause-specific mortality: an umbrella review of systematic reviews and meta-analyses

Myrela O. Machado, Nicola Veronese, Marcos Sanches, Brendon Stubbs, Ai Koyanagi, Trevor Thompson, Ioanna Tzoulaki, Marco Solmi, Davy Vancampfort, Felipe B. Schuch, Michael Maes, Giovanni A. Fava, John P. A. Ioannidis, André F. Carvalho

01.12.2018 | Opinion | Ausgabe 1/2018 Open Access

Management of patients with liver diseases on the waiting list for transplantation: a major impact to the success of liver transplantation

Didier Samuel, Audrey Coilly

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The impact of dementia on service use by individuals with a comorbid health condition: a comparison of two cross-sectional analyses conducted approximately 10 years apart

Holly Q. Bennett, Sam Norton, Frances Bunn, Louise Robinson, Greta Rait, Claire Goodman, Carol Brayne, Fiona E. Matthews

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Medications that reduce emergency hospital admissions: an overview of systematic reviews and prioritisation of treatments

Niklas Bobrovitz, Carl Heneghan, Igho Onakpoya, Benjamin Fletcher, Dylan Collins, Alice Tompson, Joseph Lee, David Nunan, Rebecca Fisher, Brittney Scott, Jack O’Sullivan, Oliver Van Hecke, Brian D. Nicholson, Sarah Stevens, Nia Roberts, Kamal R. Mahtani

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Changes in HbA1c and weight, and treatment persistence, over the 18 months following initiation of second-line therapy in patients with type 2 diabetes: results from the United Kingdom Clinical Practice Research Datalink

John Wilding, Thomas Godec, Kamlesh Khunti, Stuart Pocock, Robin Fox, Liam Smeeth, Per Clauson, Peter Fenici, Niklas Hammar, Jesús Medina

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The impact of demographic changes, exogenous boosting and new vaccination policies on varicella and herpes zoster in Italy: a modelling and cost-effectiveness study

Alessia Melegaro, Valentina Marziano, Emanuele Del Fava, Piero Poletti, Marcello Tirani, Caterina Rizzo, Stefano Merler

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The potential impact of the demographic transition in the Senegal-Gambia region of sub-Saharan Africa on the burden of infectious disease and its potential synergies with control programmes: the case of hepatitis B

John R. Williams, Piero Manfredi, Alessia Melegaro

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Breaking bread: examining the impact of policy changes in access to state-funded provisions of gluten-free foods in England

Myles-Jay Linton, Tim Jones, Amanda Owen-Smith, Rupert A. Payne, Joanna Coast, Joel Glynn, William Hollingworth

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Poor reporting of multivariable prediction model studies: towards a targeted implementation strategy of the TRIPOD statement

Pauline Heus, Johanna A. A. G. Damen, Romin Pajouheshnia, Rob J. P. M. Scholten, Johannes B. Reitsma, Gary S. Collins, Douglas G. Altman, Karel G. M. Moons, Lotty Hooft

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

How are health-related behaviours influenced by a diagnosis of pre-diabetes? A meta-narrative review

Eleanor Barry, Trisha Greenhalgh, Nicholas Fahy

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Investigating spillover of multidrug-resistant tuberculosis from a prison: a spatial and molecular epidemiological analysis

Joshua L. Warren, Louis Grandjean, David A. J. Moore, Anna Lithgow, Jorge Coronel, Patricia Sheen, Jonathan L. Zelner, Jason R. Andrews, Ted Cohen

01.12.2018 | Opinion | Ausgabe 1/2018 Open Access

How and why weight stigma drives the obesity ‘epidemic’ and harms health

A. Janet Tomiyama, Deborah Carr, Ellen M. Granberg, Brenda Major, Eric Robinson, Angelina R. Sutin, Alexandra Brewis

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Association of longitudinal alcohol consumption trajectories with coronary heart disease: a meta-analysis of six cohort studies using individual participant data

Dara O’Neill, Annie Britton, Mary K. Hannah, Marcel Goldberg, Diana Kuh, Kay Tee Khaw, Steven Bell

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Stratified survival of resected and overall pancreatic cancer patients in Europe and the USA in the early twenty-first century: a large, international population-based study

Lei Huang, Lina Jansen, Yesilda Balavarca, Masoud Babaei, Lydia van der Geest, Valery Lemmens, Liesbet Van Eycken, Harlinde De Schutter, Tom B. Johannesen, Maja Primic-Žakelj, Vesna Zadnik, Marc G. Besselink, Petra Schrotz-King, Hermann Brenner

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Resistance decay in individuals after antibiotic exposure in primary care: a systematic review and meta-analysis

Mina Bakhit, Tammy Hoffmann, Anna Mae Scott, Elaine Beller, John Rathbone, Chris Del Mar

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Epidemiological and genomic determinants of tuberculosis outbreaks in First Nations communities in Canada

Alexander Doroshenko, Caitlin S. Pepperell, Courtney Heffernan, Mary Lou Egedahl, Tatum D. Mortimer, Tracy M. Smith, Hailey E. Bussan, Gregory J. Tyrrell, Richard Long

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Simultaneously characterizing the comparative economics of routine female adolescent nonavalent human papillomavirus (HPV) vaccination and assortativity of sexual mixing in Hong Kong Chinese: a modeling analysis

Horace C. W. Choi, Mark Jit, Gabriel M. Leung, Kwok-Leung Tsui, Joseph T. Wu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Neighbourhood level real-time forecasting of dengue cases in tropical urban Singapore

Yirong Chen, Janet Hui Yi Ong, Jayanthi Rajarethinam, Grace Yap, Lee Ching Ng, Alex R. Cook

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Real-world data reveal a diagnostic gap in non-alcoholic fatty liver disease

Myriam Alexander, A. Katrina Loomis, Jolyon Fairburn-Beech, Johan van der Lei, Talita Duarte-Salles, Daniel Prieto-Alhambra, David Ansell, Alessandro Pasqua, Francesco Lapi, Peter Rijnbeek, Mees Mosseveld, Paul Avillach, Peter Egger, Stuart Kendrick, Dawn M. Waterworth, Naveed Sattar, William Alazawi

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Differential relationship between waist circumference and mortality according to age, sex, and body mass index in Koreans with age of 30–90 years; a nationwide health insurance database study

Geum Joon Cho, Hye Jin Yoo, Soon Young Hwang, Jun Choi, Kyu-Min Lee, Kyung Mook Choi, Sei Hyun Baik, Sung Won Han, Tak Kim

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Cardiovascular medicine in China: what can we do to achieve the Healthy China 2030 plan?

Yihua Bei, Tingting Yang, Junjie Xiao

01.12.2018 | Retraction Note | Ausgabe 1/2018 Open Access

Retraction Note: The impact of repeated vaccination on influenza vaccine effectiveness: a systematic review and meta-analysis

Lauren C. Ramsay, Sarah A. Buchan, Robert G. Stirling, Benjamin J. Cowling, Shou Feng, Jeffrey C. Kwong, Bryna F. Warshawsky

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Actigraphy assessments of circadian sleep-wake cycles in the Vegetative and Minimally Conscious States

D. Cruse, A. Thibaut, A. Demertzi, J. C. Nantes, M. A. Bruno, O. Gosseries, A. Vanhaudenhuyse, T. A. Bekinschtein, A. M. Owen, S. Laureys

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Modelling the cost-effectiveness of pay-for-performance in primary care in the UK

Ankur Pandya, Tim Doran, Jinyi Zhu, Simon Walker, Emily Arntson, Andrew M. Ryan

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Validity of an online 24-h recall tool (myfood24) for dietary assessment in population studies: comparison with biomarkers and standard interviews

Petra A. Wark, Laura J. Hardie, Gary S. Frost, Nisreen A. Alwan, Michelle Carter, Paul Elliott, Heather E. Ford, Neil Hancock, Michelle A. Morris, Umme Z. Mulla, Essra A. Noorwali, K. Petropoulou, David Murphy, Gregory D. M. Potter, Elio Riboli, Darren C. Greenwood, Janet E. Cade

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Quantifying where human acquisition of antibiotic resistance occurs: a mathematical modelling study

Gwenan M. Knight, Céire Costelloe, Sarah R. Deeny, Luke S. P. Moore, Susan Hopkins, Alan P. Johnson, Julie V. Robotham, Alison H. Holmes

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Do healthcare services behave as complex systems? Analysis of patterns of attendance and implications for service delivery

Christopher Burton, Alison Elliott, Amanda Cochran, Tom Love

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Cost-benefit analysis of vaccination: a comparative analysis of eight approaches for valuing changes to mortality and morbidity risks

Minah Park, Mark Jit, Joseph T. Wu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Dementia subtype and living well: results from the Improving the experience of Dementia and Enhancing Active Life (IDEAL) study

Yu-Tzu Wu, Linda Clare, John V. Hindle, Sharon M. Nelis, Anthony Martyr, Fiona E. Matthews, on behalf of the Improving the experience of Dementia and Enhancing Active Life study

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Fast and expensive (PCR) or cheap and slow (culture)? A mathematical modelling study to explore screening for carbapenem resistance in UK hospitals

Gwenan M. Knight, Eleonora Dyakova, Siddharth Mookerjee, Frances Davies, Eimear T. Brannigan, Jonathan A. Otter, Alison H. Holmes

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Exploring causality in the association between circulating 25-hydroxyvitamin D and colorectal cancer risk: a large Mendelian randomisation study

Yazhou He, Maria Timofeeva, Susan M. Farrington, Peter Vaughan-Shaw, Victoria Svinti, Marion Walker, Lina Zgaga, Xiangrui Meng, Xue Li, Athina Spiliopoulou, Xia Jiang, Elina Hyppönen, Peter Kraft, Douglas P. Kiel, Caroline Hayward, Archie Campbell, David Porteous, Katarina Vucic, Iva Kirac, Masa Filipovic, Sarah E. Harris, Ian J. Deary, Richard Houlston, Ian P. Tomlinson, Harry Campbell, Evropi Theodoratou, Malcolm G. Dunlop, The SUNLIGHT consortium

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Infectious disease testing of UK-bound refugees: a population-based, cross-sectional study

Alison F. Crawshaw, Manish Pareek, John Were, Steffen Schillinger, Olga Gorbacheva, Kolitha P. Wickramage, Sema Mandal, Valerie Delpech, Noel Gill, Hilary Kirkbride, Dominik Zenner

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Progress toward eliminating TB and HIV deaths in Brazil, 2001–2015: a spatial assessment

Jennifer M. Ross, Nathaniel J. Henry, Laura A. Dwyer-Lindgren, Andrea de Paula Lobo, Fatima Marinho de Souza, Molly H. Biehl, Sarah E. Ray, Robert C. Reiner Jr, Rebecca W. Stubbs, Kirsten E. Wiens, Lucas Earl, Michael J. Kutz, Natalia V. Bhattacharjee, Hmwe H. Kyu, Mohsen Naghavi, Simon I. Hay

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Global incidence of suicide among Indigenous peoples: a systematic review

Nathaniel J. Pollock, Kiyuri Naicker, Alex Loro, Shree Mulay, Ian Colman

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Childhood trauma and the enduring consequences of forcibly separating children from parents at the United States border

Martin H. Teicher

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

The heart of the matter: in search of causal effects of depression on somatic diseases

Annelieke M. Roest, Peter de Jonge

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Putting non-alcoholic fatty liver disease on the radar for primary care physicians: how well are we doing?

Arun J. Sanyal

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Recently resettled refugee women-at-risk in Australia evidence high levels of psychiatric symptoms: individual, trauma and post-migration factors predict outcomes

Robert D. Schweitzer, Lyn Vromans, Mark Brough, Mary Asic-Kobe, Ignacio Correa-Velez, Kate Murray, Caroline Lenette

01.12.2018 | Debate | Ausgabe 1/2018 Open Access

From hype to reality: data science enabling personalized medicine

Holger Fröhlich, Rudi Balling, Niko Beerenwinkel, Oliver Kohlbacher, Santosh Kumar, Thomas Lengauer, Marloes H. Maathuis, Yves Moreau, Susan A. Murphy, Teresa M. Przytycka, Michael Rebhan, Hannes Röst, Andreas Schuppert, Matthias Schwab, Rainer Spang, Daniel Stekhoven, Jimeng Sun, Andreas Weber, Daniel Ziemek, Blaz Zupan

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Impact of preventive primary care on children’s unplanned hospital admissions: a population-based birth cohort study of UK children 2000–2013

Elizabeth Cecil, Alex Bottle, Richard Ma, Dougal S. Hargreaves, Ingrid Wolfe, Arch G. Mainous III, Sonia Saxena

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Local and regional dynamics of chikungunya virus transmission in Colombia: the role of mismatched spatial heterogeneity

Sean M. Moore, Quirine A. ten Bosch, Amir S. Siraj, K. James Soda, Guido España, Alfonso Campo, Sara Gómez, Daniela Salas, Benoit Raybaud, Edward Wenger, Philip Welkhoff, T. Alex Perkins

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Gestational weight gain across continents and ethnicity: systematic review and meta-analysis of maternal and infant outcomes in more than one million women

Rebecca F. Goldstein, Sally K. Abell, Sanjeeva Ranasinha, Marie L. Misso, Jacqueline A. Boyle, Cheryce L. Harrison, Mary Helen Black, Nan Li, Gang Hu, Francesco Corrado, Hanne Hegaard, Young Ju Kim, Margaretha Haugen, Won O. Song, Min Hyoung Kim, Annick Bogaerts, Roland Devlieger, Judith H. Chung, Helena J. Teede

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Trauma and perceived social rejection among Yazidi women and girls who survived enslavement and genocide

Hawkar Ibrahim, Verena Ertl, Claudia Catani, Azad Ali Ismail, Frank Neuner

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Bayesian adaptive algorithms for locating HIV mobile testing services

Gregg S. Gonsalves, J. Tyler Copple, Tyler Johnson, A. David Paltiel, Joshua L. Warren

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Iron deficiency during pregnancy is associated with a reduced risk of adverse birth outcomes in a malaria-endemic area in a longitudinal cohort study

Freya J. I. Fowkes, Kerryn A. Moore, D. Herbert Opi, Julie A. Simpson, Freya Langham, Danielle I. Stanisic, Alice Ura, Christopher L. King, Peter M. Siba, Ivo Mueller, Stephen J. Rogerson, James G. Beeson

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Adjustment of refugee children and adolescents in Australia: outcomes from wave three of the Building a New Life in Australia study

Winnie Lau, Derrick Silove, Ben Edwards, David Forbes, Richard Bryant, Alexander McFarlane, Dusan Hadzi-Pavlovic, Zachary Steel, Angela Nickerson, Miranda Van Hooff, Kim Felmingham, Sean Cowlishaw, Nathan Alkemade, Dzenana Kartal, Meaghan O’Donnell

01.12.2018 | Opinion | Ausgabe 1/2018 Open Access

Practical issues in clinical scenarios involving CKD patients requiring antithrombotic therapy in light of the 2017 ESC guideline recommendations

Adrian Covic, Simonetta Genovesi, Patrick Rossignol, Philip A. Kalra, Alberto Ortiz, Maciej Banach, Alexandru Burlacu

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: In vitro prediction of stop-codon suppression by intravenous gentamicin in patients with cystic fibrosis: a pilot study

I. Sermet-Gaudelus, M. Renouil, A. Fajac, L. Bidou, B. Parbaille, S. Pierrot, N. Davy, E. Bismuth, P. Reinert, G. Lenoir, J. F. Lesure, J. P. Rousset, A. Edelman

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Do hotspots fuel malaria transmission: a village-scale spatio-temporal analysis of a 2-year cohort study in The Gambia

Gillian H. Stresman, Julia Mwesigwa, Jane Achan, Emanuele Giorgi, Archibald Worwui, Musa Jawara, Gian Luca Di Tanna, Teun Bousema, Jean-Pierre Van Geertruyden, Chris Drakeley, Umberto D’Alessandro

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Inflammation and micronutrient biomarkers predict clinical HIV treatment failure and incident active TB in HIV-infected adults: a case-control study

Rupak Shivakoti, Nikhil Gupte, Srikanth Tripathy, Selvamuthu Poongulali, Cecilia Kanyama, Sima Berendes, Sandra W. Cardoso, Breno R. Santos, Alberto La Rosa, Noluthando Mwelase, Sandy Pillay, Wadzanai Samaneka, Cynthia Riviere, Patcharaphan Sugandhavesa, Robert C. Bollinger, Ashwin Balagopal, Richard D. Semba, Parul Christian, Thomas B. Campbell, Amita Gupta, for the NWCS 319 and PEARLS Study Team

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Quantifying the impact of social groups and vaccination on inequalities in infectious diseases using a mathematical model

James D. Munday, Albert Jan van Hoek, W. John Edmunds, Katherine E. Atkins

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Healthcare service delivery to refugee children from the Democratic Republic of Congo living in Durban, South Africa: a caregivers’ perspective

Anna Meyer-Weitz, Kwaku Oppong Asante, Bukenge J. Lukobeka

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Refugees and the post-migration environment

Mina Fazel

01.12.2018 | Correspondence | Ausgabe 1/2018 Open Access

Data sharing from pharmaceutical industry sponsored clinical studies: audit of data availability

Ashley M. Hopkins, Andrew Rowland, Michael J. Sorich

01.12.2018 | Opinion | Ausgabe 1/2018 Open Access

Utility of circulating tumor DNA in cancer diagnostics with emphasis on early detection

Clare Fiala, Eleftherios P. Diamandis

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Musculoskeletal conditions may increase the risk of chronic disease: a systematic review and meta-analysis of cohort studies

Amanda Williams, Steven J. Kamper, John H. Wiggers, Kate M. O’Brien, Hopin Lee, Luke Wolfenden, Sze Lin Yoong, Emma Robson, James H. McAuley, Jan Hartvigsen, Christopher M. Williams

01.12.2018 | Correspondence | Ausgabe 1/2018 Open Access

Updated cost-effectiveness and risk-benefit analysis of two infant rotavirus vaccination strategies in a high-income, low-endemic setting

P. Bruijning-Verhagen, J. A. P. van Dongen, J. D. M. Verberk, R. Pijnacker, R. D. van Gaalen, D. Klinkenberg, H. E. de Melker, M.-J. J. Mangen

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Balancing feasibility and comprehensiveness: examining medications for reducing emergency hospital admissions

Michael R. Gionfriddo

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

An exploratory study examining how nano-liquid chromatography–mass spectrometry and phosphoproteomics can differentiate patients with advanced fibrosis and higher percentage collagen in non-alcoholic fatty liver disease

Zobair M. Younossi, Azza Karrar, Mariaelena Pierobon, Aybike Birerdinc, Maria Stepanova, Dinan Abdelatif, Zahra Younoszai, Thomas Jeffers, Sean Felix, Kianoush Jeiran, Alex Hodge, Weidong Zhou, Fanny Monge, Lakshmi Alaparthi, Vikas Chandhoke, Zachary D. Goodman, Emanuel F. Petricoin

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Frailty trajectories to identify end of life: a longitudinal population-based study

Daniel Stow, Fiona E. Matthews, Barbara Hanratty

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Back to the future, again: greater leadership, collaboration and accountability to accelerate progress to end TB

Diana Weil, Kristijan Marinkovic, Tereza Kasaeva

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Registration of published randomized trials: a systematic review and meta-analysis

Ludovic Trinquart, Adam G. Dunn, Florence T. Bourgeois

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Participatory design of an improvement intervention for the primary care management of possible sepsis using the Functional Resonance Analysis Method

Duncan McNab, John Freestone, Chris Black, Andrew Carson-Stevens, Paul Bowie

01.12.2018 | Debate | Ausgabe 1/2018 Open Access

Pathways to ensure universal and affordable access to hepatitis C treatment

Caitlin H. Douglass, Alisa Pedrana, Jeffrey V. Lazarus, Ellen F. M. ‘t Hoen, Radi Hammad, Ricardo Baptista Leite, Andrew Hill, Margaret Hellard

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

External validation of the Scandinavian guidelines for management of minimal, mild and moderate head injuries in children

Johan Undén, Stuart R. Dalziel, Meredith L. Borland, Natalie Phillips, Amit Kochar, Mark D. Lyttle, Silvia Bressan, John A. Cheek, Jocelyn Neutze, Susan Donath, Stephen Hearps, Ed Oakley, Sarah Dalton, Yuri Gilhotra, Franz E. Babl, on behalf of the Paediatric Research in Emergency Departments International Collaborative (PREDICT)

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The hidden burden of measles in Ethiopia: how distance to hospital shapes the disease mortality rate

Piero Poletti, Stefano Parlamento, Tafarraa Fayyisaa, Rattaa Feyyiss, Marta Lusiani, Ademe Tsegaye, Giulia Segafredo, Giovanni Putoto, Fabio Manenti, Stefano Merler

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Racial differences in comorbidity profile among patients with chronic obstructive pulmonary disease

Hyun Lee, Sun Hye Shin, Seonhye Gu, Di Zhao, Danbee Kang, Yeong Rae Joi, Gee Young Suh, Roberto Pastor-Barriuso, Eliseo Guallar, Juhee Cho, Hye Yun Park

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Specific microRNA signatures in exosomes of triple-negative and HER2-positive breast cancer patients undergoing neoadjuvant therapy within the GeparSixto trial

Ines Stevic, Volkmar Müller, Karsten Weber, Peter A. Fasching, Thomas Karn, Frederic Marmé, Christian Schem, Elmar Stickeler, Carsten Denkert, Marion van Mackelenbergh, Christoph Salat, Andreas Schneeweiss, Klaus Pantel, Sibylle Loibl, Michael Untch, Heidi Schwarzenbach

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Projecting the end of the Zika virus epidemic in Latin America: a modelling analysis

Kathleen M. O’Reilly, Rachel Lowe, W. John Edmunds, Philippe Mayaud, Adam Kucharski, Rosalind M. Eggo, Sebastian Funk, Deepit Bhatia, Kamran Khan, Moritz U. G. Kraemer, Annelies Wilder-Smith, Laura C. Rodrigues, Patricia Brasil, Eduardo Massad, Thomas Jaenisch, Simon Cauchemez, Oliver J. Brady, Laith Yakob

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

High-level artemisinin-resistance with quinine co-resistance emerges in P. falciparum malaria under in vivo artesunate pressure

Rajeev K. Tyagi, Patrick J. Gleeson, Ludovic Arnold, Rachida Tahar, Eric Prieur, Laurent Decosterd, Jean-Louis Pérignon, Piero Olliaro, Pierre Druilhe

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A model of access combining triage with initial management reduced waiting time for community outpatient services: a stepped wedge cluster randomised controlled trial

Katherine E. Harding, Sandra G. Leggat, Jennifer J. Watts, Bridie Kent, Luke Prendergast, Michelle Kotis, Mary O’Reilly, Leila Karimi, Annie K. Lewis, David A. Snowdon, Nicholas F. Taylor

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Malaria elimination in remote communities requires integration of malaria control activities into general health care: an observational study and interrupted time series analysis in Myanmar

Alistair R. D. McLean, Hla Phyo Wai, Aung Myat Thu, Zay Soe Khant, Chanida Indrasuta, Elizabeth A. Ashley, Thar Tun Kyaw, Nicholas P. J. Day, Arjen Dondorp, Nicholas J. White, Frank M. Smithuis

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Vaccination with chemically attenuated Plasmodium falciparum asexual blood-stage parasites induces parasite-specific cellular immune responses in malaria-naïve volunteers: a pilot study

Danielle I. Stanisic, James Fink, Johanna Mayer, Sarah Coghill, Letitia Gore, Xue Q. Liu, Ibrahim El-Deeb, Ingrid B. Rodriguez, Jessica Powell, Nicole M. Willemsen, Sai Lata De, Mei-Fong Ho, Stephen L. Hoffman, John Gerrard, Michael F. Good

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Effect of 24-month physical activity on cognitive frailty and the role of inflammation: the LIFE randomized clinical trial

Zuyun Liu, Fang-Chi Hsu, Andrea Trombetti, Abby C. King, Christine K. Liu, Todd M. Manini, Roger A. Fielding, Marco Pahor, Anne B. Newman, Stephen Kritchevsky, Thomas M. Gill, for the LIFE Study investigators

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Complex interactions between malaria and malnutrition: a systematic literature review

D Das, R F Grais, E A Okiro, K Stepniewska, R Mansoor, S van der Kam, D J Terlouw, J Tarning, K I Barnes, P J Guerin

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Adult height and risk of 50 diseases: a combined epidemiological and genetic analysis

Florence Y. Lai, Mintu Nath, Stephen E. Hamby, John R. Thompson, Christopher P. Nelson, Nilesh J. Samani

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Frailty, nutrition-related parameters, and mortality across the adult age spectrum

Kulapong Jayanama, Olga Theou, Joanna M Blodgett, Leah Cahill, Kenneth Rockwood

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Gender differences in tuberculosis treatment outcomes: a post hoc analysis of the REMoxTB study

M. E. Murphy, G. H. Wills, S. Murthy, C. Louw, A. L. C. Bateson, R. D. Hunt, T. D. McHugh, A. J. Nunn, S. K. Meredith, C. M. Mendel, M. Spigelman, A. M. Crook, S. H. Gillespie, for the REMoxTB consortium

01.12.2018 | Opinion | Ausgabe 1/2018 Open Access

Mapping malaria by combining parasite genomic and epidemiologic data

Amy Wesolowski, Aimee R Taylor, Hsiao-Han Chang, Robert Verity, Sofonias Tessema, Jeffrey A Bailey, T Alex Perkins, Daniel E Neafsey, Bryan Greenhouse, Caroline O Buckee

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Designs of trials assessing interventions to improve the peer review process: a vignette-based survey

Amytis Heim, Philippe Ravaud, Gabriel Baron, Isabelle Boutron

01.12.2018 | Editorial | Ausgabe 1/2018 Open Access

Spatial infectious disease epidemiology: on the cusp

G Chowell, R Rothenberg

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Methods used in the spatial analysis of tuberculosis epidemiology: a systematic review

Debebe Shaweno, Malancha Karmakar, Kefyalew Addis Alene, Romain Ragonnet, Archie CA Clements, James M. Trauer, Justin T. Denholm, Emma S. McBryde

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Maternal smoking and high BMI disrupt thyroid gland development

Panagiotis Filis, Sabine Hombach-Klonisch, Pierre Ayotte, Nalin Nagrath, Ugo Soffientini, Thomas Klonisch, Peter O’Shaughnessy, Paul A. Fowler

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Quantifying the risk of local Zika virus transmission in the contiguous US during the 2015–2016 ZIKV epidemic

Kaiyuan Sun, Qian Zhang, Ana Pastore-Piontti, Matteo Chinazzi, Dina Mistry, Natalie E Dean, Diana Patricia Rojas, Stefano Merler, Piero Poletti, Luca Rossi, M Elizabeth Halloran, Ira M Longini Jr, Alessandro Vespignani

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Global variation in bacterial strains that cause tuberculosis disease: a systematic review and meta-analysis

Kirsten E Wiens, Lauren P Woyczynski, Jorge R Ledesma, Jennifer M Ross, Roberto Zenteno-Cuevas, Amador Goodridge, Irfan Ullah, Barun Mathema, Joel Fleury Djoba Siawaya, Molly H Biehl, Sarah E Ray, Natalia V Bhattacharjee, Nathaniel J Henry, Robert C Reiner Jr, Hmwe H Kyu, Christopher J L Murray, Simon I Hay

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Baseline exposure, antibody subclass, and hepatitis B response differentially affect malaria protective immunity following RTS,S/AS01E vaccination in African children

Itziar Ubillos, Aintzane Ayestaran, Augusto J Nhabomba, David Dosoo, Marta Vidal, Alfons Jiménez, Chenjerai Jairoce, Hèctor Sanz, Ruth Aguilar, Nana Aba Williams, Núria Díez-Padrisa, Maximilian Mpina, Hermann Sorgho, Selidji Todagbe Agnandji, Simon Kariuki, Benjamin Mordmüller, Claudia Daubenberger, Kwaku Poku Asante, Seth Owusu-Agyei, Jahit Sacarlal, Pedro Aide, John J Aponte, Sheetij Dutta, Ben Gyan, Joseph J Campo, Clarissa Valim, Gemma Moncunill, Carlota Dobaño

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Modulation of innate immune responses at birth by prenatal malaria exposure and association with malaria risk during the first year of life

Hamtandi Magloire Natama, Gemma Moncunill, Eduard Rovira-Vallbona, Héctor Sanz, Hermann Sorgho, Ruth Aguilar, Maminata Coulibaly-Traoré, M. Athanase Somé, Susana Scott, Innocent Valéa, Petra F. Mens, Henk D. F. H. Schallig, Luc Kestens, Halidou Tinto, Carlota Dobaño, Anna Rosanas-Urgell

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Thresholds of socio-economic and environmental conditions necessary to escape from childhood malnutrition: a natural experiment in rural Gambia

Mayya Husseini, Momodou K Darboe, Sophie E Moore, Helen M Nabwera, Andrew M Prentice

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The arrhythmogenic cardiotoxicity of the quinoline and structurally related antimalarial drugs: a systematic review

Ilsa L. Haeusler, Xin Hui S. Chan, Philippe J. Guérin, Nicholas J. White

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania

Susana Santos, Iris Eekhout, Ellis Voerman, Romy Gaillard, Henrique Barros, Marie-Aline Charles, Leda Chatzi, Cécile Chevrier, George P. Chrousos, Eva Corpeleijn, Nathalie Costet, Sarah Crozier, Myriam Doyon, Merete Eggesbø, Maria Pia Fantini, Sara Farchi, Francesco Forastiere, Luigi Gagliardi, Vagelis Georgiu, Keith M. Godfrey, Davide Gori, Veit Grote, Wojciech Hanke, Irva Hertz-Picciotto, Barbara Heude, Marie-France Hivert, Daniel Hryhorczuk, Rae-Chi Huang, Hazel Inskip, Todd A. Jusko, Anne M. Karvonen, Berthold Koletzko, Leanne K. Küpers, Hanna Lagström, Debbie A. Lawlor, Irina Lehmann, Maria-Jose Lopez-Espinosa, Per Magnus, Renata Majewska, Johanna Mäkelä, Yannis Manios, Sheila W. McDonald, Monique Mommers, Camilla S. Morgen, George Moschonis, Ľubica Murínová, John Newnham, Ellen A. Nohr, Anne-Marie Nybo Andersen, Emily Oken, Adriëtte J. J. M. Oostvogels, Agnieszka Pac, Eleni Papadopoulou, Juha Pekkanen, Costanza Pizzi, Kinga Polanska, Daniela Porta, Lorenzo Richiardi, Sheryl L. Rifas-Shiman, Nel Roeleveld, Loreto Santa-Marina, Ana C. Santos, Henriette A. Smit, Thorkild I. A. Sørensen, Marie Standl, Maggie Stanislawski, Camilla Stoltenberg, Elisabeth Thiering, Carel Thijs, Maties Torrent, Suzanne C. Tough, Tomas Trnovec, Marleen M. H. J. van Gelder, Lenie van Rossem, Andrea von Berg, Martine Vrijheid, Tanja G. M. Vrijkotte, Oleksandr Zvinchuk, Stef van Buuren, Vincent W. V. Jaddoe

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Determinants of the urinary and serum metabolome in children from six European populations

Chung-Ho E. Lau, Alexandros P. Siskos, Léa Maitre, Oliver Robinson, Toby J. Athersuch, Elizabeth J. Want, Jose Urquiza, Maribel Casas, Marina Vafeiadi, Theano Roumeliotaki, Rosemary R. C. McEachan, Rafaq Azad, Line S. Haug, Helle M. Meltzer, Sandra Andrusaityte, Inga Petraviciene, Regina Grazuleviciene, Cathrine Thomsen, John Wright, Remy Slama, Leda Chatzi, Martine Vrijheid, Hector C. Keun, Muireann Coen

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Gestational diabetes and ultrasound-assessed fetal growth in South Asian and White European women: findings from a prospective pregnancy cohort

Judith S. Brand, Jane West, Derek Tuffnell, Philippa K. Bird, John Wright, Kate Tilling, Debbie A. Lawlor

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

A step forward for an attenuated blood-stage malaria vaccine

James M. Burns Jr.

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Selective serotonin reuptake inhibitor use during early pregnancy and congenital malformations: a systematic review and meta-analysis of cohort studies of more than 9 million births

Shan-Yan Gao, Qi-Jun Wu, Ce Sun, Tie-Ning Zhang, Zi-Qi Shen, Cai-Xia Liu, Ting-Ting Gong, Xin Xu, Chao Ji, Dong-Hui Huang, Qing Chang, Yu-Hong Zhao

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Are smokers who are regularly exposed to e-cigarette use by others more or less motivated to stop or to make a quit attempt? A cross-sectional and longitudinal survey

Sarah E. Jackson, Emma Beard, Susan Michie, Lion Shahab, Tobias Raupach, Robert West, Jamie Brown

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Communicating health risks in science publications: time for everyone to take responsibility

Alexandra L. J. Freeman, David J. Spiegelhalter

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Offspring outcomes after prenatal interventions for common mental disorders: a meta-analysis

Marlies E. Brouwer, Alishia D. Williams, Sam E. van Grinsven, Pim Cuijpers, Mijke P. Lambregtse-van den Berg, Huibert Burger, Claudi L. H. Bockting

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Innovation to impact in spatial epidemiology

Andrew J. Tatem

01.12.2018 | Guideline | Ausgabe 1/2018 Open Access

Development process of a consensus-driven CONSORT extension for randomised trials using an adaptive design

Munyaradzi Dimairo, Elizabeth Coates, Philip Pallmann, Susan Todd, Steven A. Julious, Thomas Jaki, James Wason, Adrian P. Mander, Christopher J. Weir, Franz Koenig, Marc K. Walton, Katie Biggs, Jon Nicholl, Toshimitsu Hamasaki, Michael A. Proschan, John A. Scott, Yuki Ando, Daniel Hind, Douglas G. Altman

01.12.2018 | Question and Answer | Ausgabe 1/2018 Open Access

Q&A: Scaling up delivery of mental health treatments in low and middle income countries: interviews with Retha Arjadi and Vikram Patel

Retha Arjadi, Vikram Patel

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

How does malaria in pregnancy impact malaria risk in infants?

Prasanna Jagannathan

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Guideline developers are not the only experts: Utilising the FRAM method in sepsis pathways

Damian Roland

01.12.2018 | Editorial | Ausgabe 1/2018 Open Access

Pancreatic cancer: challenges and opportunities

Huiyun Zhu, Tuo Li, Yiqi Du, Min Li

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A cluster randomised controlled trial of two rounds of mass drug administration in Zanzibar, a malaria pre-elimination setting—high coverage and safety, but no significant impact on transmission

Ulrika Morris, Mwinyi I. Msellem, Humphrey Mkali, Atiqul Islam, Berit Aydin-Schmidt, Irina Jovel, Shija Joseph Shija, Mwinyi Khamis, Safia Mohammed Ali, Lamija Hodzic, Ellinor Magnusson, Eugenie Poirot, Adam Bennett, Michael C. Sachs, Joel Tarning, Andreas Mårtensson, Abdullah S. Ali, Anders Björkman

01.12.2018 | Editorial | Ausgabe 1/2018 Open Access

Universal health coverage for refugees and migrants in the twenty-first century

Ibrahim Abubakar, Alimuddin Zumla

01.12.2018 | Editorial | Ausgabe 1/2018 Open Access

Patient, study thyself

Paul Wicks

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Geographical and temporal trends and seasonal relapse in Plasmodium ovale spp. and Plasmodium malariae infections imported to the UK between 1987 and 2015

Laura E. B. Nabarro, Debbie Nolder, Claire Broderick, Behzad Nadjm, Valerie Smith, Marie Blaze, Anna M. Checkley, Peter L. Chiodini, Colin J. Sutherland, Christopher J. M. Whitty

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Sauna bathing is associated with reduced cardiovascular mortality and improves risk prediction in men and women: a prospective cohort study

Tanjaniina Laukkanen, Setor K. Kunutsor, Hassan Khan, Peter Willeit, Francesco Zaccardi, Jari A. Laukkanen

01.12.2018 | Editorial | Ausgabe 1/2018 Open Access

Fifteen years of progress in understanding frailty and health in aging

Kenneth Rockwood, Susan E. Howlett

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Improving access to multi-drug resistant tuberculosis diagnostic and health services for refugees and migrants

Alimuddin Zumla, Ibrahim Abubakar

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Quantitative characterization of the urine and serum metabolomes of children is essential for ‘omics’ studies

Alicia DiBattista, Pranesh Chakraborty

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Ethnic inequalities and pathways to care in psychosis in England: a systematic review and meta-analysis

Kristoffer Halvorsrud, James Nazroo, Michaela Otis, Eva Brown Hajdukova, Kamaldeep Bhui

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The growth of assisted reproductive treatment-conceived children from birth to 5 years: a national cohort study

Mark Hann, Stephen A. Roberts, Stephen W. D’Souza, Peter Clayton, Nick Macklon, Daniel R. Brison

01.12.2018 | Opinion | Ausgabe 1/2018 Open Access

How can clinicians, specialty societies and others evaluate and improve the quality of apps for patient use?

Jeremy C. Wyatt

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Spatiotemporal analysis of malaria for new sustainable control strategies

Jordi Landier, Stanislas Rebaudet, Renaud Piarroux, Jean Gaudart

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Intensity of perinatal care, extreme prematurity and sensorimotor outcome at 2 years corrected age: evidence from the EPIPAGE-2 cohort study

Andrei S. Morgan, Laurence Foix L’Helias, Caroline Diguisto, Laetitia Marchand-Martin, Monique Kaminski, Babak Khoshnood, Jennifer Zeitlin, Gérard Bréart, Xavier Durrmeyer, François Goffinet, Pierre-Yves Ancel

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Cost-effectiveness of vaccination of immunocompetent older adults against herpes zoster in the Netherlands: a comparison between the adjuvanted subunit and live-attenuated vaccines

Pieter T. de Boer, Alies van Lier, Hester de Melker, Albert J. M. van Wijck, Jan C. Wilschut, Albert Jan van Hoek, Maarten J. Postma

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Practice variation in the use of tests in UK primary care: a retrospective analysis of 16 million tests performed over 3.3 million patient years in 2015/16

Jack W. O’Sullivan, Sarah Stevens, Jason Oke, F. D. Richard Hobbs, Chris Salisbury, Paul Little, Ben Goldacre, Clare Bankhead, Jeffrey K. Aronson, Carl Heneghan, Rafael Perera

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Fitness to practise sanctions in UK doctors are predicted by poor performance at MRCGP and MRCP(UK) assessments: data linkage study

Richard Wakeford, Kasia Ludka, Katherine Woolf, I. C. McManus

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Living at home after emergency hospital admission: prospective cohort study in older adults with and without cognitive spectrum disorder

Jennifer K. Burton, Bruce Guthrie, Simona M. Hapca, Vera Cvoro, Peter T. Donnan, Emma L. Reynish

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Insulin translates unfavourable lifestyle into obesity

Hubert Kolb, Michael Stumvoll, Werner Kramer, Kerstin Kempf, Stephan Martin

01.12.2018 | Editorial | Ausgabe 1/2018 Open Access

Reporting guidelines: doing better for readers

David Moher

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Treatment of chronic hepatitis B in sub-Saharan Africa: 1-year results of a pilot program in Ethiopia

Hailemichael Desalegn, Hanna Aberra, Nega Berhe, Bitsatab Mekasha, Kathrine Stene-Johansen, Henrik Krarup, Andre Puntervold Pereira, Svein Gunnar Gundersen, Asgeir Johannessen

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Frailty, nutrition-related parameters, and mortality across the adult age spectrum

Kulapong Jayanama, Olga Theou, Joanna M. Blodgett, Leah Cahill, Kenneth Rockwood

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES’ trial)

Felice N. Jacka, Adrienne O’Neil, Rachelle Opie, Catherine Itsiopoulos, Sue Cotton, Mohammedreza Mohebbi, David Castle, Sarah Dash, Cathrine Mihalopoulos, Mary Lou Chatterton, Laima Brazionis, Olivia M. Dean, Allison M. Hodge, Michael Berk

01.12.2018 | Correspondence | Ausgabe 1/2018 Open Access

The SMILES trial: an important first step

Felice N. Jacka, Adrienne O’Neil, Catherine Itsiopoulos, Rachelle Opie, Sue Cotton, Mohammadreza Mohebbi, David Castle, Sarah Dash, Cathrine Mihalopoulos, Mary Lou Chatterton, Laima Brazionis, Olivia M. Dean, Allison Hodge, Michael Berk

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Avoiding rash decisions about zoster vaccination: insights from cost-effectiveness evidence

Chester B. Good, Natasha Parekh, Inmaculada Hernandez

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Mass drug administration for malaria elimination: do we understand the settings well enough?

Manuel W. Hetzel, Blaise Genton

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Addressing ethnic inequalities in the pathways to care for psychosis

James B. Kirkbride

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Mapping malaria by combining parasite genomic and epidemiologic data

Amy Wesolowski, Aimee R. Taylor, Hsiao-Han Chang, Robert Verity, Sofonias Tessema, Jeffrey A. Bailey, T. Alex Perkins, Daniel E. Neafsey, Bryan Greenhouse, Caroline O. Buckee

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Small contribution of gold mines to the ongoing tuberculosis epidemic in South Africa: a modeling-based study

Stewart T. Chang, Violet N. Chihota, Katherine L. Fielding, Alison D. Grant, Rein M. Houben, Richard G. White, Gavin J. Churchyard, Philip A. Eckhoff, Bradley G. Wagner

01.12.2018 | Correspondence | Ausgabe 1/2018 Open Access

The SMILES trial: do undisclosed recruitment practices explain the remarkably large effect?

Marc L. Molendijk, Eiko I. Fried, Willem Van der Does

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