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Zeitschrift

Molecular Cancer

Molecular Cancer 1/2017

Ausgabe 1/2017

Inhaltsverzeichnis ( 179 Artikel )

01.12.2017 | Research | Ausgabe 1/2017 Open Access

SPAG6 and L1TD1 are transcriptionally regulated by DNA methylation in non-small cell lung cancers

Corinna Altenberger, Gerwin Heller, Barbara Ziegler, Erwin Tomasich, Maximilian Marhold, Thais Topakian, Leonhard Müllauer, Petra Heffeter, György Lang, Adelheid End-Pfützenreuter, Balazs Döme, Britt-Madeleine Arns, Walter Klepetko, Christoph C. Zielinski, Sabine Zöchbauer-Müller

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Understanding of leukemic stem cells and their clinical implications

Xuefei Wang, Shile Huang, Ji-Long Chen

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The role of autophagy in the cross-talk between epithelial-mesenchymal transitioned tumor cells and cancer stem-like cells

Fabrizio Marcucci, Pietro Ghezzi, Cristiano Rumio

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The evolving concept of liver cancer stem cells

Kouki Nio, Taro Yamashita, Shuichi Kaneko

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Long non-coding RNA TUG1 is involved in cell growth and chemoresistance of small cell lung cancer by regulating LIMK2b via EZH2

Yuchun Niu, Feng Ma, Weimei Huang, Shun Fang, Man Li, Ting Wei, Linlang Guo

01.12.2017 | Review | Ausgabe 1/2017 Open Access

IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights

Heming Li, Izhar Singh Batth, Xiujuan Qu, Ling Xu, Na Song, Ruoyu Wang, Yunpeng Liu

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Therapeutic implications of cellular and molecular biology of cancer stem cells in melanoma

Dhiraj Kumar, Mahadeo Gorain, Gautam Kundu, Gopal C. Kundu

01.12.2017 | Review | Ausgabe 1/2017 Open Access

EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression

Davide Pradella, Chiara Naro, Claudio Sette, Claudia Ghigna

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The lncRNA CRNDE promotes colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt/β-catenin signaling

Peng Han, Jing-wen Li, Bo-miao Zhang, Jia-chen Lv, Yong-min Li, Xin-yue Gu, Zhi-wei Yu, Yun-he Jia, Xue-feng Bai, Li Li, Yan-long Liu, Bin-bin Cui

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation

Su Yeon Lee, Eui Kyong Jeong, Min Kyung Ju, Hyun Min Jeon, Min Young Kim, Cho Hee Kim, Hye Gyeong Park, Song Iy Han, Ho Sung Kang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12/Sp1/survivin axis

Celia S. L. Mak, Mingo M. H. Yung, Lynn M. N. Hui, Leanne L. Leung, Rui Liang, Kangmei Chen, Stephanie S. Liu, Yiming Qin, Thomas H. Y. Leung, Kai-Fai Lee, Karen K. L. Chan, Hextan Y. S. Ngan, David W. Chan

01.12.2017 | Research | Ausgabe 1/2017 Open Access

miR-4775 promotes colorectal cancer invasion and metastasis via the Smad7/TGFβ-mediated epithelial to mesenchymal transition

Senlin Zhao, Hongcheng Sun, Weiliang Jiang, Yushuai Mi, Dongyuan Zhang, Yugang Wen, Dantong Cheng, Huamei Tang, Shaohan Wu, Yang Yu, Xisheng Liu, Weiyingqi Cui, Meng Zhang, Xiaofeng Sun, Zongguang Zhou, Zhihai Peng, Dongwang Yan

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Targeting acute myeloid leukemia stem cell signaling by natural products

Kodappully Sivaraman Siveen, Shahab Uddin, Ramzi M. Mohammad

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and β-Catenin and Akt activation

Abdullah Al-Dhfyan, Ali Alhoshani, Hesham M. Korashy

01.12.2017 | Review | Ausgabe 1/2017 Open Access

MicroRNA expression patterns and signalling pathways in the development and progression of childhood solid tumours

Anna L. Leichter, Michael J. Sullivan, Michael R. Eccles, Aniruddha Chatterjee

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Discovery and validation of immune-associated long non-coding RNA biomarkers associated with clinically molecular subtype and prognosis in diffuse large B cell lymphoma

Meng Zhou, Hengqiang Zhao, Wanying Xu, Siqi Bao, Liang Cheng, Jie Sun

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Long intergenic non-coding RNA 00152 promotes lung adenocarcinoma proliferation via interacting with EZH2 and repressing IL24 expression

Qin-nan Chen, Xin Chen, Zhen-yao Chen, Feng-qi Nie, Chen-chen Wei, Hong-wei Ma, Li Wan, Shuai Yan, Sheng-nan Ren, Zhao-xia Wang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Decreased expression of miR-939 contributes to chemoresistance and metastasis of gastric cancer via dysregulation of SLC34A2 and Raf/MEK/ERK pathway

Jia-Xing Zhang, Yi Xu, Ying Gao, Cui Chen, Zhou-San Zheng, Miao Yun, Hui-Wen Weng, Dan Xie, Sheng Ye

01.12.2017 | Short communication | Ausgabe 1/2017 Open Access

Interplay between CCR7 and Notch1 axes promotes stemness in MMTV-PyMT mammary cancer cells

Sarah T. Boyle, Krystyna A. Gieniec, Carly E. Gregor, Jessica W. Faulkner, Shaun R. McColl, Marina Kochetkova

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Up-regulated NRIP2 in colorectal cancer initiating cells modulates the Wnt pathway by targeting RORβ

Zhenzhen Wen, Tianhui Pan, Saisai Yang, Jingwen Liu, Haiying Tao, Yiming Zhao, Dingting Xu, Wei Shao, Jia Wu, Xiyong Liu, Yongjiang Wang, Jianshan Mao, Yongliang Zhu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Targeting CD133 improves chemotherapeutic efficacy of recurrent pediatric pilocytic astrocytoma following prolonged chemotherapy

Guifa Xi, Yuping Derek Li, Gordan Grahovac, Veena Rajaram, Nitin Wadhwani, Tatiana Pundy, Barbara Mania-Farnell, Charles David James, Tadanori Tomita

01.12.2017 | Research | Ausgabe 1/2017 Open Access

BAP1 dependent expression of long non-coding RNA NEAT-1 contributes to sensitivity to gemcitabine in cholangiocarcinoma

Mansi Parasramka, Irene K. Yan, Xue Wang, Phuong Nguyen, Akiko Matsuda, Sayantan Maji, Catherine Foye, Yan Asmann, Tushar Patel

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Quercetin-induced miR-200b-3p regulates the mode of self-renewing divisions in pancreatic cancer

Clifford C. Nwaeburu, Alia Abukiwan, Zhefu Zhao, Ingrid Herr

01.12.2017 | Research | Ausgabe 1/2017 Open Access

MiR-182 promotes cancer invasion by linking RET oncogene activated NF-κB to loss of the HES1/Notch1 regulatory circuit

Alf Spitschak, Claudia Meier, Bhavani Kowtharapu, David Engelmann, Brigitte M. Pützer

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Circular RNAs in human cancer

Yumin Wang, Yongzhen Mo, Zhaojian Gong, Xiang Yang, Mo Yang, Shanshan Zhang, Fang Xiong, Bo Xiang, Ming Zhou, Qianjin Liao, Wenling Zhang, Xiayu Li, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng, Wei Xiong

01.12.2017 | Research | Ausgabe 1/2017 Open Access

MiR-193b promoter methylation accurately detects prostate cancer in urine sediments and miR-34b/c or miR-129-2 promoter methylation define subsets of clinically aggressive tumors

Jorge Torres-Ferreira, João Ramalho-Carvalho, Antonio Gomez, Francisco Duarte Menezes, Rui Freitas, Jorge Oliveira, Luís Antunes, Maria José Bento, Manel Esteller, Rui Henrique, Carmen Jerónimo

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Osteoprotegerin mediates tumor-promoting effects of Interleukin-1beta in breast cancer cells

Stephanie Tsang Mui Chung, Dirk Geerts, Kim Roseman, Ashleigh Renaud, Linda Connelly

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Cancer stem cell niche models and contribution by mesenchymal stroma/stem cells

Catharina Melzer, Juliane von der Ohe, Hendrik Lehnert, Hendrik Ungefroren, Ralf Hass

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Epigenetics in cancer stem cells

Tan Boon Toh, Jhin Jieh Lim, Edward Kai-Hua Chow

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells

Parthasarathy Chandrakesan, Jiannan Yao, Dongfeng Qu, Randal May, Nathaniel Weygant, Yang Ge, Naushad Ali, Sripathi M. Sureban, Modhi Gude, Kenneth Vega, Eddie Bannerman-Menson, Lijun Xia, Michael Bronze, Guangyu An, Courtney W. Houchen

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Mesenchymal stem cells: key players in cancer progression

Sarah M. Ridge, Francis J. Sullivan, Sharon A. Glynn

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer

Sara Duhachek-Muggy, Yue Qi, Randi Wise, Linda Alyahya, Hui Li, Jacob Hodge, Anna Zolkiewska

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Targeting MUC1-C inhibits the AKT-S6K1-elF4A pathway regulating TIGAR translation in colorectal cancer

Rehan Ahmad, Maroof Alam, Masanori Hasegawa, Yasumitsu Uchida, Omar Al-Obaid, Surender Kharbanda, Donald Kufe

01.12.2017 | Research | Ausgabe 1/2017 Open Access

CD73/NT5E is a target of miR-30a-5p and plays an important role in the pathogenesis of non-small cell lung cancer

Jianjie Zhu, Yuanyuan Zeng, Wei Li, Hualong Qin, Zhe Lei, Dan Shen, Dongmei Gu, Jian-an Huang, Zeyi Liu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Hypoxia-inducible microRNA-224 promotes the cell growth, migration and invasion by directly targeting RASSF8 in gastric cancer

Chuan He, Libo Wang, Jiantao Zhang, Hong Xu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Doxycycline attenuates breast cancer related inflammation by decreasing plasma lysophosphatidate concentrations and inhibiting NF-κB activation

Xiaoyun Tang, Xianyan Wang, Yuan Y. Zhao, Jonathan M. Curtis, David N. Brindley

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Functional role of ALK-related signal cascades on modulation of epithelial-mesenchymal transition and apoptosis in uterine carcinosarcoma

H Inoue, M Hashimura, M Akiya, R Chiba, M Saegusa

01.12.2017 | Research | Ausgabe 1/2017 Open Access

HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells

Mansi Shah, Ryan Cardenas, Belinda Wang, Jenny Persson, Nigel P. Mongan, Anna Grabowska, Cinzia Allegrucci

01.12.2017 | Research | Ausgabe 1/2017 Open Access

LincRNAFEZF1-AS1 represses p21 expression to promote gastric cancer proliferation through LSD1-Mediated H3K4me2 demethylation

Yan-wen Liu, Rui Xia, Kai Lu, Min Xie, Fen Yang, Ming Sun, Wei De, Cailian Wang, Guozhong Ji

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies

Komal Qureshi-Baig, Pit Ullmann, Serge Haan, Elisabeth Letellier

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Intra-tumor heterogeneity from a cancer stem cell perspective

Pramudita R. Prasetyanti, Jan Paul Medema

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Linking long non-coding RNAs and SWI/SNF complexes to chromatin remodeling in cancer

Yanyan Tang, Jinpeng Wang, Yu Lian, Chunmei Fan, Ping Zhang, Yingfen Wu, Xiayu Li, Fang Xiong, Xiaoling Li, Guiyuan Li, Wei Xiong, Zhaoyang Zeng

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Catching moving targets: cancer stem cell hierarchies, therapy-resistance & considerations for clinical intervention

Claudia Gasch, Brendan Ffrench, John J. O’Leary, Michael F. Gallagher

01.12.2017 | Research | Ausgabe 1/2017 Open Access

ITIH5 mediates epigenetic reprogramming of breast cancer cells

Michael Rose, Vera Kloten, Erik Noetzel, Lukas Gola, Josef Ehling, Timon Heide, Steffen K. Meurer, Aljona Gaiko-Shcherbak, Antonio S. Sechi, Sebastian Huth, Ralf Weiskirchen, Oliver Klaas, Wiebke Antonopoulos, Qiong Lin, Wolfgang Wagner, Jürgen Veeck, Felix Gremse, Julia Steitz, Ruth Knüchel, Edgar Dahl

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Mechanistic added value of a trans-Sulfonamide-Platinum-Complex in human melanoma cell lines and synergism with cis-Platin

Alba Agudo-López, Elena Prieto-García, José Alemán, Carlos Pérez, C. Vanesa Díaz-García, Lucía Parrilla-Rubio, Silvia Cabrera, Carmen Navarro-Ranninger, Hernán Cortés-Funes, José A. López-Martín, M. Teresa Agulló-Ortuño

01.12.2017 | Research | Ausgabe 1/2017 Open Access

KCNMA1 cooperating with PTK2 is a novel tumor suppressor in gastric cancer and is associated with disease outcome

Gaoxiang Ma, Hanting Liu, Qiuhan Hua, Meilin Wang, Mulong Du, Yadi Lin, Yuqiu Ge, Weida Gong, Qinghong Zhao, Fulin Qiang, Guoquan Tao, Zhengdong Zhang, Haiyan Chu

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Mitochondrial DNA sequencing demonstrates clonality of peritoneal implants of borderline ovarian tumors

Giulia Girolimetti, Pierandrea De Iaco, Martina Procaccini, Riccardo Panzacchi, Ivana Kurelac, Laura Benedetta Amato, Giulia Dondi, Giacomo Caprara, Claudio Ceccarelli, Donatella Santini, Anna Maria Porcelli, Anna Myriam Perrone, Giuseppe Gasparre

01.12.2017 | Research | Ausgabe 1/2017 Open Access

MicroRNA-30d promotes angiogenesis and tumor growth via MYPT1/c-JUN/VEGFA pathway and predicts aggressive outcome in prostate cancer

Zhuo-yuan Lin, Guo Chen, Yan-qiong Zhang, Hui-chan He, Yu-xiang Liang, Jian-heng Ye, Ying-ke Liang, Ru-jun Mo, Jian-ming Lu, Yang-jia Zhuo, Yu Zheng, Fu-neng Jiang, Zhao-dong Han, Shu-lin Wu, Wei-de Zhong, Chin-Lee Wu

01.12.2017 | Short communication | Ausgabe 1/2017 Open Access

A loss of host-derived MMP-7 promotes myeloma growth and osteolytic bone disease in vivo

S. T. Lwin, J. A. Fowler, M. T. Drake, J. R. Edwards, C. C. Lynch, C. M. Edwards

01.12.2017 | Research | Ausgabe 1/2017 Open Access

MicroRNA-29c functions as a tumor suppressor by targeting VEGFA in lung adenocarcinoma

Lipin Liu, Nan Bi, Lihong Wu, Xiao Ding, Yu Men, Wei Zhou, Lin Li, Weimin Zhang, Susheng Shi, Yongmei Song, Luhua Wang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Regulation of stem-like cancer cells by glutamine through β-catenin pathway mediated by redox signaling

Jianwei Liao, Pan-Pan Liu, Guoxin Hou, Jiajia Shao, Jing Yang, Kaiyan Liu, Wenhua Lu, Shijun Wen, Yumin Hu, Peng Huang

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer

Pingting Zhou, Bo Li, Furao Liu, Meichao Zhang, Qian Wang, Yuanhua Liu, Yuan Yao, Dong Li

01.12.2017 | Research | Ausgabe 1/2017 Open Access

miR-19a promotes colorectal cancer proliferation and migration by targeting TIA1

Yanqing Liu, Rui Liu, Fei Yang, Rongjie Cheng, Xiaorui Chen, Shufang Cui, Yuanyuan Gu, Wu Sun, Chaoying You, Zhijian Liu, Feng Sun, Yanbo Wang, Zheng Fu, Chao Ye, Chenyu Zhang, Jing Li, Xi Chen

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Ion channels or aquaporins as novel molecular targets in gastric cancer

Jianling Xia, Hongqiang Wang, Shi Li, Qinghui Wu, Li Sun, Hongxiang Huang, Ming Zeng

01.12.2017 | Research | Ausgabe 1/2017 Open Access

MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability

Francesca Mancini, Emanuela Teveroni, Giusy Di Conza, Valentina Monteleone, Ivan Arisi, Marsha Pellegrino, Marianna Buttarelli, Luisa Pieroni, Mara D’Onofrio, Andrea Urbani, Alfredo Pontecorvi, Massimiliano Mazzone, Fabiola Moretti

01.12.2017 | Research | Ausgabe 1/2017 Open Access

BMI1, a new target of CK2α

Soumyajit Banerjee Mustafi, Prabir Kumar Chakraborty, Shailendra Kumar Dhar Dwivedi, Kai Ding, Katherine M. Moxley, Priyabrata Mukherjee, Resham Bhattacharya

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Syndecan-1 is a novel molecular marker for triple negative inflammatory breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways

Sherif Abdelaziz Ibrahim, Ramy Gadalla, Eslam A. El-Ghonaimy, Omnia Samir, Hossam Taha Mohamed, Hebatallah Hassan, Burkhard Greve, Mohamed El-Shinawi, Mona Mostafa Mohamed, Martin Götte

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Circles reshaping the RNA world: from waste to treasure

Jing Liu, Tian Liu, Xiaman Wang, Aili He

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Serum microRNA profiling in patients with glioblastoma: a survival analysis

Hua Zhao, Jie Shen, Tiffany R. Hodges, Renduo Song, Gregory N. Fuller, Amy B. Heimberger

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Cdk5 links with DNA damage response and cancer

Wan Liu, Jun Li, Yu-Shu Song, Yue Li, Yu-Hong Jia, Hai-Dong Zhao

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Overexpression of G protein-coupled receptor GPR87 promotes pancreatic cancer aggressiveness and activates NF-κB signaling pathway

Li Wang, Wei Zhou, Yunfeng Zhong, Yongbao Huo, Ping Fan, Sudong Zhan, Jun Xiao, Xin Jin, Shanmiao Gou, Tao Yin, Heshui Wu, Tao Liu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

SOX2 regulates multiple malignant processes of breast cancer development through the SOX2/miR-181a-5p, miR-30e-5p/TUSC3 axis

Kuancan Liu, Fuan Xie, Anding Gao, Rui Zhang, Long Zhang, Zhangwu Xiao, Qiong Hu, Weifeng Huang, Qiaojia Huang, Baoshun Lin, Jian Zhu, Haikun Wang, Jianwen Que, Xiaopeng Lan

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Mesothelin promotes epithelial-to-mesenchymal transition and tumorigenicity of human lung cancer and mesothelioma cells

Xiaoqing He, Liying Wang, Heimo Riedel, Kai Wang, Yong Yang, Cerasela Zoica Dinu, Yon Rojanasakul

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Ovarian cancer stem cells: still an elusive entity?

Michela Lupia, Ugo Cavallaro

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Vasculogenic mimicry signaling revisited: focus on non-vascular VE-cadherin

Daniel Delgado-Bellido, Santiago Serrano-Saenz, Mónica Fernández-Cortés, F. Javier Oliver

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Vasohibin 2 reduces chemosensitivity to gemcitabine in pancreatic cancer cells via Jun proto-oncogene dependent transactivation of ribonucleotide reductase regulatory subunit M2

Min Tu, Haifeng Li, Nan Lv, Chunhua Xi, Zipeng Lu, Jishu Wei, Jianmin Chen, Feng Guo, Kuirong Jiang, Guoxin Song, Wentao Gao, Yi Miao

01.12.2017 | Research | Ausgabe 1/2017 Open Access

TRIM8 restores p53 tumour suppressor function by blunting N-MYC activity in chemo-resistant tumours

Francesca Mastropasqua, Flaviana Marzano, Alessio Valletti, Italia Aiello, Giuseppe Di Tullio, Annalisa Morgano, Sabino Liuni, Elena Ranieri, Luisa Guerrini, Giuseppe Gasparre, Elisabetta Sbisà, Graziano Pesole, Antonio Moschetta, Mariano Francesco Caratozzolo, Apollonia Tullo

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Upregulation of the long noncoding RNA UCA1 affects the proliferation, invasion, and survival of hypopharyngeal carcinoma

Ye Qian, Dayu Liu, Shengda Cao, Ye Tao, Dongmin Wei, Wenming Li, Guojun Li, Xinliang Pan, Dapeng Lei

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and β-Catenin and Akt activation

Abdullah Al-Dhfyan, Ali Alhoshani, Hesham M. Korashy

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways

Jingkun Zhao, Baochi Ou, Dingpei Han, Puxiongzhi Wang, Yaping Zong, Congcong Zhu, Di Liu, Minhua Zheng, Jing Sun, Hao Feng, Aiguo Lu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Pregnane X receptor is associated with unfavorable survival and induces chemotherapeutic resistance by transcriptional activating multidrug resistance-related protein 3 in colorectal cancer

Yan Dong, Zhe Wang, Gan-feng Xie, Chong Li, Wen-wei Zuo, Gang Meng, Cheng-ping Xu, Jian-jun Li

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Hsp90β promoted endothelial cell-dependent tumor angiogenesis in hepatocellular carcinoma

Jing Meng, Yanrong Liu, Jingxia Han, Qiang Tan, Shuang Chen, Kailiang Qiao, Honggang Zhou, Tao Sun, Cheng Yang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Cellular organization and molecular differentiation model of breast cancer-associated fibroblasts

Susann Busch, Daniel Andersson, Eva Bom, Claire Walsh, Anders Ståhlberg, Göran Landberg

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The depletion of PinX1 involved in the tumorigenesis of non-small cell lung cancer promotes cell proliferation via p15/cyclin D1 pathway

Xiao-Peng Tian, Xiao-Han Jin, Mei Li, Wei-Juan Huang, Dan Xie, Jia-Xing Zhang

01.12.2017 | Short communication | Ausgabe 1/2017 Open Access

Serum HOTAIR as a novel diagnostic biomarker for esophageal squamous cell carcinoma

Wenjian Wang, Xiaotian He, Zehua Zheng, Xiaofan Ma, Xueting Hu, Duoguang Wu, Minghui Wang

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Emerging roles of lipid metabolism in cancer metastasis

Xiangjian Luo, Can Cheng, Zheqiong Tan, Namei Li, Min Tang, Lifang Yang, Ya Cao

01.12.2017 | Research | Ausgabe 1/2017 Open Access

IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis

Yuhang Zhou, Tingting Huang, Ho Lam Siu, Chi Chun Wong, Yujuan Dong, Feng Wu, Bin Zhang, William K. K. Wu, Alfred S. L. Cheng, Jun Yu, Ka Fai To, Wei Kang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

DC - SIGNR by influencing the lncRNA HNRNPKP2 upregulates the expression of CXCR4 in gastric cancer liver metastasis

Yu Zhang, Qianshi Zhang, Mengyang Zhang, Menglang Yuan, Zhaohui Wang, Jingbo Zhang, Xu Zhou, Yinan Zhang, Fang Lin, Heya NA, Shuangyi Ren, Yunfei Zuo

01.12.2017 | Review | Ausgabe 1/2017 Open Access

ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway

Yang Zhao, Xingbin Hu, Yajing Liu, Shumin Dong, Zhaowei Wen, Wanming He, Shuyi Zhang, Qiong Huang, Min Shi

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Liquid biopsy: a step forward towards precision medicine in urologic malignancies

Ashley Di Meo, Jenni Bartlett, Yufeng Cheng, Maria D. Pasic, George M. Yousef

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Cripto-1 acts as a functional marker of cancer stem-like cells and predicts prognosis of the patients in esophageal squamous cell carcinoma

Qiang Liu, Xiang Cui, Xi Yu, Bai-Shi-Jiao Bian, Feng Qian, Xu-gang Hu, Cheng-dong Ji, Lang Yang, Yong Ren, Wei Cui, Xia Zhang, Peng Zhang, Ji Ming Wang, You-hong Cui, Xiu-wu Bian

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Over-expressed long noncoding RNA HOXA11-AS promotes cell cycle progression and metastasis in gastric cancer

Zhili Liu, Zhenyao Chen, Ruihua Fan, Bin Jiang, Xin Chen, Qinnan Chen, Fengqi Nie, Kaihua Lu, Ming Sun

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Phosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancer

Qirong Geng, Jianjun Liu, Zhaohui Gong, Shangxiang Chen, Shuai Chen, Xiaoxing Li, Yue Lu, Xiaofeng Zhu, Hui-kuan Lin, Dazhi Xu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Human germ/stem cell-specific gene TEX19 influences cancer cell proliferation and cancer prognosis

Vicente Planells-Palop, Ali Hazazi, Julia Feichtinger, Jana Jezkova, Gerhard Thallinger, Naif O. Alsiwiehri, Mikhlid Almutairi, Lee Parry, Jane A. Wakeman, Ramsay J. McFarlane

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The landscape of BRAF transcript and protein variants in human cancer

Andrea Marranci, Zhijie Jiang, Marianna Vitiello, Elena Guzzolino, Laura Comelli, Samanta Sarti, Simone Lubrano, Cinzia Franchin, Ileabett Echevarría-Vargas, Andrea Tuccoli, Alberto Mercatanti, Monica Evangelista, Paolo Sportoletti, Giorgio Cozza, Ettore Luzi, Enrico Capobianco, Jessie Villanueva, Giorgio Arrigoni, Giovanni Signore, Silvia Rocchiccioli, Letizia Pitto, Nicholas Tsinoremas, Laura Poliseno

01.12.2017 | Research | Ausgabe 1/2017 Open Access

PARP1 expression drives the synergistic antitumor activity of trabectedin and PARP1 inhibitors in sarcoma preclinical models

Ymera Pignochino, Federica Capozzi, Lorenzo D’Ambrosio, Carmine Dell’Aglio, Marco Basiricò, Marta Canta, Annalisa Lorenzato, Francesca Vignolo Lutati, Sandra Aliberti, Erica Palesandro, Paola Boccone, Danilo Galizia, Sara Miano, Giulia Chiabotto, Lucia Napione, Loretta Gammaitoni, Dario Sangiolo, Maria Serena Benassi, Barbara Pasini, Giovanna Chiorino, Massimo Aglietta, Giovanni Grignani

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Epigenetic down regulation of G protein-coupled estrogen receptor (GPER) functions as a tumor suppressor in colorectal cancer

Qiao Liu, Zhuojia Chen, Guanmin Jiang, Yan Zhou, Xiangling Yang, Hongbin Huang, Huanliang Liu, Jun Du, Hongsheng Wang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Thymic Epithelial Tumors phenotype relies on miR-145-5p epigenetic regulation

Teresa Bellissimo, Federica Ganci, Enzo Gallo, Andrea Sacconi, Claudia Tito, Luciana De Angelis, Claudio Pulito, Silvia Masciarelli, Daniele Diso, Marco Anile, Vincenzo Petrozza, Felice Giangaspero, Edoardo Pescarmona, Francesco Facciolo, Federico Venuta, Mirella Marino, Giovanni Blandino, Francesco Fazi

01.12.2017 | Research | Ausgabe 1/2017 Open Access

ING5 suppresses breast cancer progression and is regulated by miR-24

Shufang Cui, Xin Liao, Chao Ye, Xin Yin, Minghui Liu, Yeting Hong, Mengchao Yu, Yanqing Liu, Hongwei Liang, Chen-Yu Zhang, Xi Chen

01.12.2017 | Research | Ausgabe 1/2017 Open Access

HN1 contributes to migration, invasion, and tumorigenesis of breast cancer by enhancing MYC activity

Chen Zhang, Bingfei Xu, Shi Lu, Ying Zhao, Pian Liu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy

Iris C. Salaroglio, Elisa Panada, Enrico Moiso, Ilaria Buondonno, Paolo Provero, Menachem Rubinstein, Joanna Kopecka, Chiara Riganti

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The emerging roles and therapeutic potential of exosomes in epithelial ovarian cancer

Xiaoduan Li, Xipeng Wang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

PIK3CA hotspot mutations differentially impact responses to MET targeting in MET-driven and non-driven preclinical cancer models

Lluís Nisa, Pascal Häfliger, Michaela Poliaková, Roland Giger, Paola Francica, Daniel Matthias Aebersold, Roch-Philippe Charles, Yitzhak Zimmer, Michaela Medová

01.12.2017 | Review | Ausgabe 1/2017 Open Access

CircRNA: functions and properties of a novel potential biomarker for cancer

Shujuan Meng, Hecheng Zhou, Ziyang Feng, Zihao Xu, Ying Tang, Peiyao Li, Minghua Wu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

C10ORF10/DEPP-mediated ROS accumulation is a critical modulator of FOXO3-induced autophagy

S. Salcher, M. Hermann, U. Kiechl-Kohlendorfer, M. J. Ausserlechner, P. Obexer

01.12.2017 | Research | Ausgabe 1/2017 Open Access

MicroRNA-608 inhibits proliferation of bladder cancer via AKT/FOXO3a signaling pathway

Zhen Liang, Xiao Wang, Xin Xu, Bo Xie, Alin Ji, Shuai Meng, Shiqi Li, Yi Zhu, Jian Wu, Zhenghui Hu, Yiwei Lin, Xiangyi Zheng, Liping Xie, Ben Liu

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Combination of paclitaxel, bevacizumab and MEK162 in second line treatment in platinum-relapsing patient derived ovarian cancer xenografts

Francesca Ricci, Federica Guffanti, Giovanna Damia, Massimo Broggini

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Differential expression analysis at the individual level reveals a lncRNA prognostic signature for lung adenocarcinoma

Fuduan Peng, Ruiping Wang, Yuanyuan Zhang, Zhangxiang Zhao, Wenbin Zhou, Zhiqiang Chang, Haihai Liang, Wenyuan Zhao, Lishuang Qi, Zheng Guo, Yunyan Gu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma

Si-Rui Ma, Wei-Wei Deng, Jian-Feng Liu, Liang Mao, Guang-Tao Yu, Lin-Lin Bu, Ashok B. Kulkarni, Wen-Feng Zhang, Zhi-Jun Sun

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Recent advances in the use of PI3K inhibitors for glioblastoma multiforme: current preclinical and clinical development

Hua-fu Zhao, Jing Wang, Wei Shao, Chang-peng Wu, Zhong-ping Chen, Shing-shun Tony To, Wei-ping Li

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Characterization of MED12, HMGA2, and FH alterations reveals molecular variability in uterine smooth muscle tumors

Netta Mäkinen, Kati Kämpjärvi, Norma Frizzell, Ralf Bützow, Pia Vahteristo

01.12.2017 | Research | Ausgabe 1/2017 Open Access

ROS production induced by BRAF inhibitor treatment rewires metabolic processes affecting cell growth of melanoma cells

Giulia Cesi, Geoffroy Walbrecq, Andreas Zimmer, Stephanie Kreis, Claude Haan

01.12.2017 | Research | Ausgabe 1/2017 Open Access

MicroRNA-1296 inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting SRPK1-mediated PI3K/AKT pathway

Qiuran Xu, Xin Liu, Zhikui Liu, Zhenyu Zhou, Yufeng Wang, Jianfeng Tu, Lijie Li, Hangxing Bao, Liu Yang, Kangsheng Tu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Oct4 transcriptionally regulates the expression of long non-coding RNAs NEAT1 and MALAT1 to promote lung cancer progression

Jayu Jen, Yen-An Tang, Ying-Hung Lu, Che-Chung Lin, Wu-Wei Lai, Yi-Ching Wang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

In vitro downregulated hypoxia transcriptome is associated with poor prognosis in breast cancer

Basel Abu-Jamous, Francesca M. Buffa, Adrian L. Harris, Asoke K. Nandi

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Antagonizing miR-455-3p inhibits chemoresistance and aggressiveness in esophageal squamous cell carcinoma

Aibin Liu, Jinrong Zhu, Geyan Wu, Lixue Cao, Zhanyao Tan, Shuxia Zhang, Lili Jiang, Jueheng Wu, Mengfeng Li, Libing Song, Jun Li

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Dysregulated expression of long noncoding RNAs in gynecologic cancers

Elahe Seyed Hosseini, Matthieu Meryet-Figuiere, Hamed Sabzalipoor, Hamed Haddad Kashani, Hossein Nikzad, Zatollah Asemi

01.12.2017 | Research | Ausgabe 1/2017 Open Access

PRC1 contributes to tumorigenesis of lung adenocarcinoma in association with the Wnt/β-catenin signaling pathway

Ping Zhan, Bin Zhang, Guang-min Xi, Ying Wu, Hong-bing Liu, Ya-fang Liu, Wu-jian Xu, Qing-qing Zhu, Feng Cai, Ze-jun Zhou, Ying-ying Miu, Xiao-xia Wang, Jia-jia Jin, Qian Li, Li-ping Qian, Tang-feng Lv, Yong Song

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The long non-coding RNA BC200 (BCYRN1) is critical for cancer cell survival and proliferation

Evan P. Booy, Ewan KS McRae, Amit Koul, Francis Lin, Sean A. McKenna

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Linc00152 promotes malignant progression of glioma stem cells by regulating miR-103a-3p/FEZF1/CDC25A pathway

Mingjun Yu, Yixue Xue, Jian Zheng, Xiaobai Liu, Hai Yu, Libo Liu, Zhen Li, Yunhui Liu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Long noncoding RNA MRCCAT1 promotes metastasis of clear cell renal cell carcinoma via inhibiting NPR3 and activating p38-MAPK signaling

Jia-Kuan Li, Cheng Chen, Jia-Yi Liu, Jia-Zi Shi, Shu-Peng Liu, Bing Liu, Deng-Shuang Wu, Zi-Yu Fang, Yi Bao, Ming-Ming Jiang, Ji-Hang Yuan, Le Qu, Lin-Hui Wang

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

PLX8394, a new generation BRAF inhibitor, selectively inhibits BRAF in colonic adenocarcinoma cells and prevents paradoxical MAPK pathway activation

Candani S. A. Tutuka, Miles C. Andrews, John M. Mariadason, Paul Ioannidis, Christopher Hudson, Jonathan Cebon, Andreas Behren

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Dual role for p16 in the metastasis process of HPV positive head and neck cancers

Rüveyda Dok, Mary Glorieux, Karolina Holacka, Marieke Bamps, Sandra Nuyts

01.12.2017 | Review | Ausgabe 1/2017 Open Access

11q deletion in neuroblastoma: a review of biological and clinical implications

Vid Mlakar, Simona Jurkovic Mlakar, Gonzalo Lopez, John M. Maris, Marc Ansari, Fabienne Gumy-Pause

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

New somatic BRAF splicing mutation in Langerhans cell histiocytosis

Sébastien Héritier, Zofia Hélias-Rodzewicz, Rikhia Chakraborty, Amel G. Sengal, Christine Bellanné-Chantelot, Caroline Thomas, Anne Moreau, Sylvie Fraitag, Carl E. Allen, Jean Donadieu, Jean-François Emile

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies

Kaja C. G. Berg, Peter W. Eide, Ina A. Eilertsen, Bjarne Johannessen, Jarle Bruun, Stine A. Danielsen, Merete Bjørnslett, Leonardo A. Meza-Zepeda, Mette Eknæs, Guro E. Lind, Ola Myklebost, Rolf I. Skotheim, Anita Sveen, Ragnhild A. Lothe

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Oncogenic miR-210-3p promotes prostate cancer cell EMT and bone metastasis via NF-κB signaling pathway

Dong Ren, Qing Yang, Yuhu Dai, Wei Guo, Hong Du, Libing Song, Xinsheng Peng

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Long non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150-5p

Wei Lu, Honghe Zhang, Yuequn Niu, Yongfeng Wu, Wenjie Sun, Hongyi Li, Jianlu Kong, Kefeng Ding, Han-Ming Shen, Han Wu, Dajing Xia, Yihua Wu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Hypoxia-inducible factor-2α promotes tumor progression and has crosstalk with Wnt/β-catenin signaling in pancreatic cancer

Qi Zhang, Yu Lou, Jingying Zhang, Qihan Fu, Tao Wei, Xu Sun, Qi Chen, Jiaqi Yang, Xueli Bai, Tingbo Liang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Clonal competition in BcrAbl-driven leukemia: how transplantations can accelerate clonal conversion

Kerstin Cornils, Lars Thielecke, Doreen Winkelmann, Tim Aranyossy, Mathias Lesche, Andreas Dahl, Ingo Roeder, Boris Fehse, Ingmar Glauche

01.12.2017 | Retraction Note | Ausgabe 1/2017 Open Access

Retraction Note to: Extranuclear ERα is associated with regression of T47D PKCα-overexpressing, tamoxifen-resistant breast cancer

Bethany Perez White, Mary Ellen Molloy, Huiping Zhao, Yiyun Zhang, Debra A. Tonetti

01.12.2017 | Research | Ausgabe 1/2017 Open Access

MiR-661 promotes tumor invasion and metastasis by directly inhibiting RB1 in non small cell lung cancer

Feiye Liu, Yanjun Cai, Xiaoxiang Rong, Jinzhang Chen, Dayong Zheng, Lu Chen, Junyi Zhang, Rongcheng Luo, Peng Zhao, Jian Ruan

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Long non-coding RNA CASC2 suppresses epithelial-mesenchymal transition of hepatocellular carcinoma cells through CASC2/miR-367/FBXW7 axis

Yufeng Wang, Zhikui Liu, Bowen Yao, Qing Li, Liang Wang, Cong Wang, Changwei Dou, Meng Xu, Qingguang Liu, Kangsheng Tu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

FOXP3 promotes tumor growth and metastasis by activating Wnt/β-catenin signaling pathway and EMT in non-small cell lung cancer

Shucai Yang, Yi Liu, Ming-Yue Li, Calvin S. H. Ng, Sheng-li Yang, Shanshan Wang, Chang Zou, Yujuan Dong, Jing Du, Xiang Long, Li-Zhong Liu, Innes Y. P. Wan, Tony Mok, Malcolm J. Underwood, George G. Chen

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The noncoding RNA HOXD-AS1 is a critical regulator of the metastasis and apoptosis phenotype in human hepatocellular carcinoma

Shan Lu, Jiansheng Zhou, Yimin Sun, Nan Li, Mingyong Miao, Binghua Jiao, Huan Chen

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The lncRNA CASC15 regulates SOX4 expression in RUNX1-rearranged acute leukemia

Thilini R. Fernando, Jorge R. Contreras, Matteo Zampini, Norma I. Rodriguez-Malave, Michael O. Alberti, Jaime Anguiano, Tiffany M. Tran, Jayanth K. Palanichamy, Jasmine Gajeton, Nolan M. Ung, Cody J. Aros, Ella V. Waters, David Casero, Giuseppe Basso, Martina Pigazzi, Dinesh S. Rao

01.12.2017 | Research | Ausgabe 1/2017 Open Access

EGFR modulates monounsaturated fatty acid synthesis through phosphorylation of SCD1 in lung cancer

Jiqin Zhang, Fei Song, Xiaojing Zhao, Hua Jiang, Xiuqi Wu, Biao Wang, Min Zhou, Mi Tian, Bizhi Shi, Huamao Wang, Yuanhui Jia, Hai Wang, Xiaorong Pan, Zonghai Li

01.12.2017 | Review | Ausgabe 1/2017 Open Access

WW domain-binding protein 2: an adaptor protein closely linked to the development of breast cancer

Shuai Chen, Han Wang, Yu-Fan Huang, Ming-Li Li, Jiang-Hong Cheng, Peng Hu, Chuan-Hui Lu, Ya Zhang, Na Liu, Chi-Meng Tzeng, Zhi-Ming Zhang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Oncogenic long noncoding RNA landscape in breast cancer

Shouping Xu, Dejia Kong, Qianlin Chen, Yanyan Ping, Da Pang

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Role of long non-coding RNAs in glucose metabolism in cancer

Chunmei Fan, Yanyan Tang, Jinpeng Wang, Fang Xiong, Can Guo, Yumin Wang, Shanshan Zhang, Zhaojian Gong, Fang Wei, Liting Yang, Yi He, Ming Zhou, Xiaoling Li, Guiyuan Li, Wei Xiong, Zhaoyang Zeng

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer

Ke Chen, Weikun Qian, Zhengdong Jiang, Liang Cheng, Jie Li, Liankang Sun, Cancan Zhou, Luping Gao, Meng Lei, Bin Yan, Junyu Cao, Wanxing Duan, Qingyong Ma

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Exosomes derived from gemcitabine-resistant cells transfer malignant phenotypic traits via delivery of miRNA-222-3p

Feng Wei, Chengyuan Ma, Tong Zhou, Xuechao Dong, Qinghua Luo, Li Geng, Lijuan Ding, Yandong Zhang, Li Zhang, Nan Li, Yang Li, Yan Liu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

MEG2 is regulated by miR-181a-5p and functions as a tumour suppressor gene to suppress the proliferation and migration of gastric cancer cells

Zhijian Liu, Feng Sun, Yeting Hong, Yanqing Liu, Min Fen, Kai Yin, Xiaolong Ge, Feng Wang, Xi Chen, Wenxian Guan

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Nano-based delivery of RNAi in cancer therapy

Yong Xin, Min Huang, Wen Wen Guo, Qian Huang, Long zhen Zhang, Guan Jiang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis

Yu-Chan Chang, Chia-Yi Su, Ming-Huang Chen, Wei-Shone Chen, Chi-Long Chen, Michael Hsiao

01.12.2017 | Research | Ausgabe 1/2017 Open Access

STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4

Hui Wang, Xisong Huo, Xin-Rong Yang, Jia He, Lijun Cheng, Na Wang, Xuan Deng, Haojie Jin, Ning Wang, Cun Wang, Fangyu Zhao, Jingyuan Fang, Ming Yao, Jia Fan, Wenxin Qin

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Neutrophils in cancer: prognostic role and therapeutic strategies

Alberto Ocana, Cristina Nieto-Jiménez, Atanasio Pandiella, Arnoud J Templeton

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Role of the lncRNA ABHD11-AS1 in the tumorigenesis and progression of epithelial ovarian cancer through targeted regulation of RhoC

Dan-Dan Wu, Xi Chen, Kai-Xuan Sun, Li-Li Wang, Shuo Chen, Yang Zhao

01.12.2017 | Research | Ausgabe 1/2017 Open Access

miR-140-5p suppresses the proliferation, migration and invasion of gastric cancer by regulating YES1

Zheng Fang, Shuai Yin, Ruochuan Sun, Shangxin Zhang, Min Fu, Youliang Wu, Tao Zhang, Junaid Khaliq, Yongxiang Li

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Role of MEK partner-1 in cancer stemness through MEK/ERK pathway in cancerous neural stem cells, expressing EGFRviii

Soo-Jung Kwon, Ok-Seon Kwon, Keun-Tae Kim, Young-Hyun Go, Si-in Yu, Byeong-ha Lee, Hiroyuki Miyoshi, Eunsel Oh, Seung-Ju Cho, Hyuk-Jin Cha

01.12.2017 | Research | Ausgabe 1/2017 Open Access

MicroRNA-218 functions as a tumor suppressor in lung cancer by targeting IL-6/STAT3 and negatively correlates with poor prognosis

Yan Yang, Lili Ding, Qun Hu, Jia Xia, Junjie Sun, Xudong Wang, Hua Xiong, Deepak Gurbani, Lianbo Li, Yan Liu, Aiguo Liu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Long noncoding RNA ZEB1-AS1 epigenetically regulates the expressions of ZEB1 and downstream molecules in prostate cancer

Wenjing Su, Miao Xu, Xueqin Chen, Ni Chen, Jing Gong, Ling Nie, Ling Li, Xinglan Li, Mengni Zhang, Qiao Zhou

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Hypoxic exosomes facilitate bladder tumor growth and development through transferring long non-coding RNA-UCA1

Mei Xue, Wei Chen, An Xiang, Ruiqi Wang, He Chen, Jingjing Pan, Huan Pang, Hongli An, Xiang Wang, Huilian Hou, Xu Li

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Long non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150-5p

Wei Lu, Honghe Zhang, Yuequn Niu, Yongfeng Wu, Wenjie Sun, Hongyi Li, Jianlu Kong, Kefeng Ding, Han-Ming Shen, Han Wu, Dajing Xia, Yihua Wu

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Role of exosomal proteins in cancer diagnosis

Weihua Li, Chuanyun Li, Tong Zhou, Xiuhong Liu, Xiaoni Liu, Xiuhui Li, Dexi Chen

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The oncogenic role of the In1-ghrelin splicing variant in prostate cancer aggressiveness

Daniel Hormaechea-Agulla, Manuel D. Gahete, Juan M. Jiménez-Vacas, Enrique Gómez-Gómez, Alejandro Ibáñez-Costa, Fernando L-López, Esther Rivero-Cortés, André Sarmento-Cabral, José Valero-Rosa, Julia Carrasco-Valiente, Rafael Sánchez-Sánchez, Rosa Ortega-Salas, María M. Moreno, Natia Tsomaia, Steve M. Swanson, Michael D. Culler, María J. Requena, Justo P. Castaño, Raúl M. Luque

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Phospholipid Phosphatase 4 promotes proliferation and tumorigenesis, and activates Ca2+-permeable Cationic Channel in lung carcinoma cells

Xin Zhang, Lan Zhang, Bihua Lin, Xingxing Chai, Ronggang Li, Yuehua Liao, Xinghui Deng, Qiongru Liu, Wenli Yang, Yubo Cai, Wei Zhou, Zhichao Lin, Wenhai Huang, Meigong Zhong, Fangyong Lei, Jinhua Wu, Shuaishuai Yu, Xiaoping Li, Shangren Li, Yueyue Li, Jincheng Zeng, Wansheng Long, Dong Ren, Yanming Huang

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Exosomal miRNAs and miRNA dysregulation in cancer-associated fibroblasts

Fengming Yang, Zhiqiang Ning, Ling Ma, Weitao Liu, Chuchu Shao, Yongqian Shu, Hua Shen

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The biology of Hepatocellular carcinoma: implications for genomic and immune therapies

Galina Khemlina, Sadakatsu Ikeda, Razelle Kurzrock

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Up-regulation of lncRNA CASC9 promotes esophageal squamous cell carcinoma growth by negatively regulating PDCD4 expression through EZH2

Yuanyuan Wu, Liwen Hu, Yan Liang, Juan Li, Kai Wang, Xuedan Chen, Hui Meng, Xingying Guan, Kang Yang, Yun Bai

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression

Jing Zhang, Hui Liu, Lidan Hou, Ge Wang, Rui Zhang, Yanxia Huang, Xiaoyu Chen, Jinshui Zhu

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer

Hui Wang, Liang Zou, Ke Ma, Jiankun Yu, Huizhe Wu, Minjie Wei, Qinghuan Xiao

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Tumor-related interleukins: old validated targets for new anti-cancer drug development

Sarra Setrerrahmane, Hanmei Xu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Overexpression of lncRNA IGFBP4–1 reprograms energy metabolism to promote lung cancer progression

Binyao Yang, Lisha Zhang, Yi Cao, Shuai Chen, Jun Cao, Di Wu, Jiansong Chen, Huali Xiong, Zihua Pan, Fuman Qiu, Jinbin Chen, Xiaoxuan Ling, Maosheng Yan, Suli Huang, Shiyu Zhou, Tiegang Li, Lei Yang, Yunchao Huang, Jiachun Lu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

A novel mechanism of lncRNA and miRNA interaction: CCAT2 regulates miR-145 expression by suppressing its maturation process in colon cancer cells

Yingjie Yu, Pratima Nangia-Makker, Lulu Farhana, Adhip P. N. Majumdar

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Identification of non-invasive miRNAs biomarkers for prostate cancer by deep sequencing analysis of urinary exosomes

Marta Rodríguez, Cristina Bajo-Santos, Nina P. Hessvik, Susanne Lorenz, Bastian Fromm, Viktor Berge, Kirsten Sandvig, Aija Linē, Alicia Llorente

01.12.2017 | Research | Ausgabe 1/2017 Open Access

SUMO1 modification of KHSRP regulates tumorigenesis by preventing the TL-G-Rich miRNA biogenesis

Haihua Yuan, Rong Deng, Xian Zhao, Ran Chen, Guofang Hou, Hailong Zhang, Yanli Wang, Ming Xu, Bin Jiang, Jianxiu Yu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Downregulation of NMI promotes tumor growth and predicts poor prognosis in human lung adenocarcinomas

Jingshu Wang, Kun Zou, Xu Feng, Miao Chen, Cong Li, Ranran Tang, Yang Xuan, Meihua Luo, Wangbing Chen, Huijuan Qiu, Ge Qin, Yixin Li, Changlin Zhang, Binyi Xiao, Lan Kang, Tiebang Kang, Wenlin Huang, Xinfa Yu, Xiaojun Wu, Wuguo Deng

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Monitoring multiple myeloma by idiotype-specific peptide binders of tumor-derived exosomes

Enrico Iaccino, Selena Mimmi, Vincenzo Dattilo, Fabiola Marino, Patrizio Candeloro, Antonio Di Loria, Danilo Marimpietri, Antonio Pisano, Francesco Albano, Eleonora Vecchio, Simona Ceglia, Gaetanina Golino, Antonio Lupia, Giuseppe Fiume, Ileana Quinto, Giuseppe Scala

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Evaluation on the diagnostic and prognostic values of long non-coding RNA BLACAT1 in common types of human cancer

Xiaoli Chen, Meiyu Dai, Hongzhen Zhu, Jinwan Li, Zhizhuo Huang, Xuexiang Liu, Yujie Huang, Jingfan Chen, Shengming Dai

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Linc-RoR promotes MAPK/ERK signaling and confers estrogen-independent growth of breast cancer

Wan-xin Peng, Jian-guo Huang, Liu Yang, Ai-hua Gong, Yin-Yuan Mo

01.12.2017 | Research | Ausgabe 1/2017 Open Access

A long non-coding RNA HOTTIP expression is associated with disease progression and predicts outcome in small cell lung cancer patients

Yanqin Sun, Yuanyuan Zhou, Yifeng Bai, Qiongyao Wang, Jiarong Bao, Yingshan Luo, Ying Guo, Linlang Guo

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Reprogramming of stromal fibroblasts by SNAI2 contributes to tumor desmoplasia and ovarian cancer progression

Zongyuan Yang, Xin Yang, Sen Xu, Ping Jin, Xiaoting Li, Xiao Wei, Dan Liu, Kecheng Huang, Sixiang Long, Ya Wang, Chaoyang Sun, Gang Chen, Junbo Hu, Li Meng, Ding Ma, Qinglei Gao

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Profiling, clinicopathological correlation and functional validation of specific long non-coding RNAs for hepatocellular carcinoma

Jian Yao, Lingjiao Wu, Xiaohua Meng, Huanxia Yang, Shujun Ni, Qiangfeng Wang, Jiawei Zhou, Qiong Zhang, Kunkai Su, Li Shao, Qingyi Cao, Mingding Li, Fusheng Wu, Lanjuan Li

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Dysregulated long noncoding RNAs (lncRNAs) in hepatocellular carcinoma: implications for tumorigenesis, disease progression, and liver cancer stem cells

Xiaoqi Huo, Shuanglin Han, Guang Wu, Olivier Latchoumanin, Gang Zhou, Lionel Hebbard, Jacob George, Liang Qiao

01.12.2017 | Research | Ausgabe 1/2017 Open Access

LncRNA RP11-436H11.5, functioning as a competitive endogenous RNA, upregulates BCL-W expression by sponging miR-335-5p and promotes proliferation and invasion in renal cell carcinoma

Kefeng Wang, Wei Jin, Yan Song, Xiang Fei

01.12.2017 | Research | Ausgabe 1/2017 Open Access

miR-92b-3p acts as a tumor suppressor by targeting Gabra3 in pancreatic cancer

Manmei Long, Ming Zhan, Sunwang Xu, Ruimeng Yang, Wei Chen, Shilei Zhang, Yongheng Shi, Qiao He, Man Mohan, Qiang Liu, Jian Wang

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Validation and comparison of the molecular classifications of pancreatic carcinomas

David J. Birnbaum, Pascal Finetti, Daniel Birnbaum, Emilie Mamessier, François Bertucci

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Long noncoding RNA NORAD, a novel competing endogenous RNA, enhances the hypoxia-induced epithelial-mesenchymal transition to promote metastasis in pancreatic cancer

Hongzhe Li, Xinjing Wang, Chenlei Wen, Zhen Huo, Weishen Wang, Qian Zhan, Dongfeng Cheng, Hao Chen, Xiaxing Deng, Chenghong Peng, Baiyong Shen

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Hdac7 promotes lung tumorigenesis by inhibiting Stat3 activation

Yubin Lei, Lingling Liu, Shujing Zhang, Shicheng Guo, Xiaoqing Li, Jiucun Wang, Bo Su, Yuchao Fang, Xiaofeng Chen, Hengning Ke, Wufan Tao

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Knockdown of SOX2OT inhibits the malignant biological behaviors of glioblastoma stem cells via up-regulating the expression of miR-194-5p and miR-122

Rui Su, Shuo Cao, Jun Ma, Yunhui Liu, Xiaobai Liu, Jian Zheng, Jiajia Chen, Libo Liu, Heng Cai, Zhen Li, Lini Zhao, Qianru He, Yixue Xue

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Bi-directional exosome-driven intercommunication between the hepatic niche and cancer cells

Nikolina Dioufa, Amanda M. Clark, Bo Ma, Colin H. Beckwitt, Alan Wells

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Novel insights into chromosomal conformations in cancer

Ruobing Jia, Peiwei Chai, He Zhang, Xianqun Fan

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Long noncoding RNA MALAT1 regulates autophagy associated chemoresistance via miR-23b-3p sequestration in gastric cancer

Hu YiRen, Yu YingCong, You Sunwu, Li Keqin, Tong Xiaochun, Chen Senrui, Chen Ende, Lin XiZhou, Chen Yanfan

01.12.2017 | Research | Ausgabe 1/2017 Open Access

JMJD6 promotes melanoma carcinogenesis through regulation of the alternative splicing of PAK1, a key MAPK signaling component

Xujun Liu, Wenzhe Si, Xinhua Liu, Lin He, Jie Ren, Ziran Yang, Jianguo Yang, Wanjin Li, Shumeng Liu, Fei Pei, Xiaohan Yang, Luyang Sun

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Factors involved in cancer metastasis: a better understanding to “seed and soil” hypothesis

Qiang Liu, Hongfei Zhang, Xiaoli Jiang, Caiyun Qian, Zhuoqi Liu, Daya Luo

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Generation of stable PDX derived cell lines using conditional reprogramming

Alexandra Borodovsky, Travis J. McQuiston, Daniel Stetson, Ambar Ahmed, David Whitston, Jingwen Zhang, Michael Grondine, Deborah Lawson, Sharon S. Challberg, Michael Zinda, Brian A. Pollok, Brian A. Dougherty, Celina M. D’Cruz

01.12.2017 | Research | Ausgabe 1/2017 Open Access

HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

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