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Zeitschrift

Respiratory Research

Respiratory Research 1/2018

Ausgabe 1/2018

Inhaltsverzeichnis ( 261 Artikel )

01.12.2018 | Letter to the Editor | Ausgabe 1/2018 Open Access

Upregulation of Mas-related G Protein coupled receptor X2 in asthmatic lung mast cells and its activation by the novel neuropeptide hemokinin-1

Wichayapha Manorak, Chizobam Idahosa, Kshitij Gupta, Saptarshi Roy, Reynold Panettieri Jr, Hydar Ali

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inhibition of histone-deacetylase activity rescues inflammatory cystic fibrosis lung disease by modulating innate and adaptive immune responses

Manish Bodas, Steven Mazur, Taehong Min, Neeraj Vij

01.12.2018 | Research | Ausgabe 1/2018 Open Access

GM-CSF overexpression after influenza a virus infection prevents mortality and moderates M1-like airway monocyte/macrophage polarization

E. Scott Halstead, Todd M. Umstead, Michael L. Davies, Yuka Imamura Kawasawa, Patricia Silveyra, Judie Howyrlak, Linlin Yang, Weichao Guo, Sanmei Hu, Eranda Kurundu Hewage, Zissis C. Chroneos

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Role and regulation of Abelson tyrosine kinase in Crk-associated substrate/profilin-1 interaction and airway smooth muscle contraction

Yinna Wang, Alyssa C. Rezey, Ruping Wang, Dale D. Tang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Urban particulate matter (PM) suppresses airway antibacterial defence

Xiaoyan Chen, Jinguo Liu, Jian Zhou, Jian Wang, Cuicui Chen, Yuanlin Song, Jue Pan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Biomarkers of inflammation in infants with cystic fibrosis

Theresa A. Laguna, Cynthia B. Williams, Myra G. Nunez, Cole Welchlin-Bradford, Catherine E. Moen, Cavan S. Reilly, Chris H. Wendt

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Serum metabolic profiling identified a distinct metabolic signature in patients with idiopathic pulmonary fibrosis – a potential biomarker role for LysoPC

Barbara Rindlisbacher, Cornelia Schmid, Thomas Geiser, Cédric Bovet, Manuela Funke-Chambour

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

The association of the N-terminal pro-brain-type natriuretic peptide response to exercise with disease severity in therapy-naive pulmonary arterial hypertension: a cohort study

J. Kutsch, C. Faul, W. von Scheidt, M. Schwaiblmair, T. M. Berghaus

01.12.2018 | Letter to the Editor | Ausgabe 1/2018 Open Access

Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF)

Shaney L. Barratt, Thomas Blythe, Khadija Ourradi, Caroline Jarrett, Gavin I. Welsh, David O. Bates, Ann B. Millar

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Critical inhaler errors in asthma and COPD: a systematic review of impact on health outcomes

Omar Sharif Usmani, Federico Lavorini, Jonathan Marshall, William Christopher Nigel Dunlop, Louise Heron, Emily Farrington, Richard Dekhuijzen

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Chronic obstructive pulmonary disease guidelines in Europe: a look into the future

Marc Miravitlles, Nicolas Roche, João Cardoso, David Halpin, Zaurbek Aisanov, Hannu Kankaanranta, Vladimir Kobližek, Paweł Śliwiński, Leif Bjermer, Michael Tamm, Francesco Blasi, Claus F. Vogelmeier

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Prevalence and management of severe asthma in primary care: an observational cohort study in Sweden (PACEHR)

Kjell Larsson, Björn Ställberg, Karin Lisspers, Gunilla Telg, Gunnar Johansson, Marcus Thuresson, Christer Janson

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Comparative analysis of COPD associated with tobacco smoking, biomass smoke exposure or both

Jordi Olloquequi, Sergio Jaime, Viviana Parra, Elizabeth Cornejo-Córdova, Gonzalo Valdivia, Àlvar Agustí, Rafael Silva O.

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Radiation-induced pulmonary gene expression changes are attenuated by the CTGF antibody Pamrevlumab

Mark D. Sternlicht, Ute Wirkner, Sebastian Bickelhaupt, Ramon Lopez Perez, Alexandra Tietz, Kenneth E. Lipson, Todd W. Seeley, Peter E. Huber

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Accumulation mode particles and LPS exposure induce TLR-4 dependent and independent inflammatory responses in the lung

Angela M. Fonceca, Graeme R. Zosky, Elizabeth M. Bozanich, Erika N. Sutanto, Anthony Kicic, Paul S. McNamara, Darryl A. Knight, Peter D. Sly, Debra J. Turner, Stephen M. Stick

01.12.2018 | Research | Ausgabe 1/2018 Open Access

IL-1β mediates lung neutrophilia and IL-33 expression in a mouse model of viral-induced asthma exacerbation

Irma Mahmutovic Persson, Mandy Menzel, Sangeetha Ramu, Samuel Cerps, Hamid Akbarshahi, Lena Uller

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Molecular imaging of pulmonary diseases

Julien Dimastromatteo, Eric J. Charles, Victor E. Laubach

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Long-acting bronchodilators improve exercise capacity in COPD patients: a systematic review and meta-analysis

Fabiano Di Marco, Giovanni Sotgiu, Pierachille Santus, Denis E. O’Donnell, Kai-Michael Beeh, Simone Dore, Maria Adelaide Roggi, Lisa Giuliani, Francesco Blasi, Stefano Centanni

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Single-inhaler fluticasone furoate/umeclidinium/vilanterol versus fluticasone furoate/vilanterol plus umeclidinium using two inhalers for chronic obstructive pulmonary disease: a randomized non-inferiority study

Peter R. Bremner, Ruby Birk, Noushin Brealey, Afisi S. Ismaila, Chang-Qing Zhu, David A. Lipson

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Association of thrombocytosis with COPD morbidity: the SPIROMICS and COPDGene cohorts

Ashraf Fawzy, Nirupama Putcha, Laura M. Paulin, Carrie P. Aaron, Wassim W. Labaki, MeiLan K. Han, Robert A. Wise, Richard E. Kanner, Russell P. Bowler, R. Graham Barr, Nadia N. Hansel, for the SPIROMICS and COPDGene Investigators

01.12.2018 | Research | Ausgabe 1/2018 Open Access

miR-34a is involved in CSE-induced apoptosis of human pulmonary microvascular endothelial cells by targeting Notch-1 receptor protein

Ying-Jiao Long, Xiao-Peng Liu, Shan-Shan Chen, Dan-Dan Zong, Yan Chen, Ping Chen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Long-term preservation of planar cell polarity in reversed tracheal epithelium

Takuya Tsuji, Ryosuke Nakamura, Tatsuya Katsuno, Yo Kishimoto, Atsushi Suehiro, Masaru Yamashita, Ryuji Uozumi, Tatsuo Nakamura, Ichiro Tateya, Koichi Omori

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Differential effects of innate immune variants of surfactant protein-A1 (SFTPA1) and SP-A2 (SFTPA2) in airway function after Klebsiella pneumoniae infection and sex differences

Nithyananda Thorenoor, Xuesheng Zhang, Todd M. Umstead, E. Scott Halstead, David S. Phelps, Joanna Floros

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The JAK2 pathway is activated in idiopathic pulmonary fibrosis

Javier Milara, Gracia Hernandez, Beatriz Ballester, Anselm Morell, Inés Roger, P. Montero, Juan Escrivá, José M. Lloris, Maria Molina-Molina, Esteban Morcillo, Julio Cortijo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The topical study of inhaled drug (salbutamol) delivery in idiopathic pulmonary fibrosis

Omar S. Usmani, Martyn F. Biddiscombe, Shuying Yang, Sally Meah, Eunice Oballa, Juliet K. Simpson, William A. Fahy, Richard P. Marshall, Pauline T. Lukey, Toby M. Maher

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Characterizing undiagnosed chronic obstructive pulmonary disease: a systematic review and meta-analysis

Kate M. Johnson, Stirling Bryan, Shahzad Ghanbarian, Don D. Sin, Mohsen Sadatsafavi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury

Jiawen Lv, Junchao Zeng, Fukun Guo, Yiran Li, Mengying Xu, Yuanxiong Cheng, Lin Zhang, Shaoxi Cai, Yinghua Chen, Yi Zheng, Guodong Hu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Intermittent hypoxia promotes melanoma lung metastasis via oxidative stress and inflammation responses in a mouse model of obstructive sleep apnea

Lian Li, Fangyuan Ren, Chao Qi, Leiqian Xu, Yinshan Fang, Maoli Liang, Jing Feng, Baoyuan Chen, Wen Ning, Jie Cao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia

Maurizio Turzo, Julian Vaith, Felix Lasitschka, Markus A. Weigand, Cornelius J. Busch

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Serum IgG subclass levels and risk of exacerbations and hospitalizations in patients with COPD

Fernando Sergio Leitao Filho, Seung Won Ra, Andre Mattman, Robert S. Schellenberg, Gerard J. Criner, Prescott G. Woodruff, Stephen C. Lazarus, Richard Albert, John E. Connett, Meilan K. Han, Fernando J. Martinez, Janice M. Leung, S. F. Paul Man, Shawn D. Aaron, Robert M. Reed, Don D. Sin, for the Canadian Respiratory Research Network (CRRN)

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Relationship of CT-quantified emphysema, small airways disease and bronchial wall dimensions with physiological, inflammatory and infective measures in COPD

Kristoffer Ostridge, Nicholas P. Williams, Viktoriya Kim, Stephen Harden, Simon Bourne, Stuart C. Clarke, Emmanuel Aris, Sonia Mesia-Vela, Jeanne-Marie Devaster, Andrew Tuck, Anthony Williams, Stephen Wootton, Karl J. Staples, Tom M. A. Wilkinson, on behalf of the AERIS Study Group

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Idiopathic pulmonary fibrosis: pathogenesis and management

Giacomo Sgalla, Bruno Iovene, Mariarosaria Calvello, Margherita Ori, Francesco Varone, Luca Richeldi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Modulation of human airway smooth muscle biology by human adipocytes

Amanda Giesler, Manali Mukherjee, Katherine Radford, Luke Janssen, Parameswaran Nair

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Impaired diversity of the lung microbiome predicts progression of idiopathic pulmonary fibrosis

Youhei Takahashi, Atsushi Saito, Hirofumi Chiba, Koji Kuronuma, Kimiyuki Ikeda, Tomofumi Kobayashi, Shigeru Ariki, Motoko Takahashi, Yasushi Sasaki, Hiroki Takahashi

01.12.2018 | Letter to the Editor | Ausgabe 1/2018 Open Access

Commenting on “Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from ACE 2 study” by Jacob A. Winther and colleagues

Luigi Mario Castello, Mattia Bellan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Favorable longitudinal change of lung function in patients with asthma-COPD overlap from a COPD cohort

Hye Yun Park, Suh-Young Lee, Danbee Kang, Juhee Cho, Hyun Lee, Seong Yong Lim, Ho Il Yoon, Seung Won Ra, Ki Uk Kim, Yeon-Mok Oh, Don D. Sin, Sang-Do Lee, Yong Bum Park

01.12.2018 | Research | Ausgabe 1/2018 Open Access

PM2.5 promotes human bronchial smooth muscle cell migration via the sonic hedgehog signaling pathway

Xiuqin Ye, Wei Hong, Binwei Hao, Gongyong Peng, Lingmei Huang, Zhuxiang Zhao, Yumin Zhou, Mengning Zheng, Chenglong Li, Chunxiao Liang, Erkang Yi, Jinding Pu, Bing Li, Pixin Ran

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A phase IIb randomized, chronic-dosing, incomplete block, cross-over study of glycopyrronium, delivered via metered dose inhaler, compared with a placebo and an active control in patients with moderate-to-severe COPD

Edward M. Kerwin, Selwyn Spangenthal, Christine Kollar, Earl St Rose, Colin Reisner

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Proteomic profiling of lung immune cells reveals dysregulation of phagocytotic pathways in female-dominated molecular COPD phenotype

Mingxing Yang, Maxie Kohler, Tina Heyder, Helena Forsslund, Hilde K. Garberg, Reza Karimi, Johan Grunewald, Frode S. Berven, Sven Nyrén, C. Magnus Sköld, Åsa M. Wheelock

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Long-term smoking alters abundance of over half of the proteome in bronchoalveolar lavage cell in smokers with normal spirometry, with effects on molecular pathways associated with COPD

Mingxing Yang, Maxie Kohler, Tina Heyder, Helena Forsslund, Hilde K. Garberg, Reza Karimi, Johan Grunewald, Frode S. Berven, C. Magnus Sköld, Åsa M. Wheelock

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inhibition of cell-adhesion protein DPYSL3 promotes metastasis of lung cancer

Yang Yang, Yan Jiang, Dong Xie, Ming Liu, Nan Song, Junjie Zhu, Jiang Fan, Chenfang Zhu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Airway surface liquid from smokers promotes bacterial growth and biofilm formation via iron-lactoferrin imbalance

Luis G. Vargas Buonfiglio, Jennifer A. Borcherding, Mark Frommelt, Gavin J. Parker, Bryce Duchman, Oriana G. Vanegas Calderón, Ruth Fernandez-Ruiz, Julio E. Noriega, Elizabeth A. Stone, Alicia K. Gerke, Joseph Zabner, Alejandro P. Comellas

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Factors associated with bronchiectasis in patients with uncontrolled asthma; the NOPES score: a study in 398 patients

A. Padilla-Galo, C. Olveira, L. Fernández de Rota-Garcia, I. Marco-Galve, A. J. Plata, A. Alvarez, F. Rivas-Ruiz, A. Carmona-Olveira, J. J. Cebrian-Gallardo, M. A. Martinez-Garcia

01.12.2018 | Research | Ausgabe 1/2018 Open Access

G908R NOD2 variant in a family with sarcoidosis

Valérie Besnard, Alain Calender, Diane Bouvry, Yves Pacheco, Catherine Chapelon-Abric, Florence Jeny, Hilario Nunes, Carole Planès, Dominique Valeyre

01.12.2018 | Letter to the Editor | Ausgabe 1/2018 Open Access

Increased circulating desmosine and age-dependent elastinolysis in idiopathic pulmonary fibrosis

Bart de Brouwer, Marjolein Drent, Jody M. W. van den Ouweland, Petal A. Wijnen, Coline H. M. van Moorsel, Otto Bekers, Jan C. Grutters, Eric S. White, Rob Janssen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Integrative genomics identifies new genes associated with severe COPD and emphysema

Phuwanat Sakornsakolpat, Jarrett D. Morrow, Peter J. Castaldi, Craig P. Hersh, Yohan Bossé, Edwin K. Silverman, Ani Manichaikul, Michael H. Cho

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Plasma YKL-40 and NGAL are useful in distinguishing ACO from asthma and COPD

Jing Wang, Huajie Lv, Zhuang Luo, Shan Mou, Jing Liu, Chang Liu, Shiying Deng, Youfan Jiang, Jiachen Lin, Chengzhou Wu, Xianhong Liu, Jinzhi He, Depeng Jiang

01.12.2018 | Letter to the Editor | Ausgabe 1/2018 Open Access

Prediction equations of forced oscillation technique: the insidious role of collinearity

Hassib Narchi, Afaf AlBlooshi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Physical activity in the morning and afternoon is lower in patients with chronic obstructive pulmonary disease with morning symptoms

Amanda R. van Buul, Marise J. Kasteleyn, Niels H. Chavannes, Christian Taube

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Regulation of alveolar macrophage death in acute lung inflammation

Erica K Y Fan, Jie Fan

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Evaluation of oxidative stress biomarkers in idiopathic pulmonary fibrosis and therapeutic applications: a systematic review

Alessandro G. Fois, Panagiotis Paliogiannis, Salvatore Sotgia, Arduino A. Mangoni, Elisabetta Zinellu, Pietro Pirina, Ciriaco Carru, Angelo Zinellu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Oxidative stress enhances the expression of IL-33 in human airway epithelial cells

Hiroyuki Aizawa, Akira Koarai, Yutaka Shishikura, Satoru Yanagisawa, Mutsuo Yamaya, Hisatoshi Sugiura, Tadahisa Numakura, Mitsuhiro Yamada, Tomohiro Ichikawa, Naoya Fujino, Masafumi Noda, Yoshinori Okada, Masakazu Ichinose

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The dopamine D1 receptor is expressed and induces CREB phosphorylation and MUC5AC expression in human airway epithelium

Nao Matsuyama, Sumire Shibata, Atsuko Matoba, Tada-aki Kudo, Jennifer Danielsson, Atsushi Kohjitani, Eiji Masaki, Charles W. Emala, Kentaro Mizuta

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Airway disease phenotypes in animal models of cystic fibrosis

Alexandra McCarron, Martin Donnelley, David Parsons

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A GATA3-specific DNAzyme attenuates sputum eosinophilia in eosinophilic COPD patients: a feasibility randomized clinical trial

Timm Greulich, Jens M. Hohlfeld, Petra Neuser, Katrin Lueer, Andreas Klemmer, Carmen Schade-Brittinger, Susanne Harnisch, Holger Garn, Harald Renz, Ursula Homburg, Jonas Renz, Anne Kirsten, Frauke Pedersen, Meike Müller, Claus F. Vogelmeier, Henrik Watz

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The inhibition of human lung fibroblast proliferation and differentiation by Gs-coupled receptors is not predicted by the magnitude of cAMP response

Maxine J. Roberts, Rebecca E. Broome, Toby C. Kent, Steven J. Charlton, Elizabeth M. Rosethorne

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Acute lung injury by gastric fluid instillation: activation of myofibroblast apoptosis during injury resolution

Pedro Ayala, Jorge Torres, Raúl Vivar, Manuel Meneses, Pablo Olmos, Tamara San Martin, Gisella R. Borzone

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Crocin attenuates cigarette smoke-induced lung injury and cardiac dysfunction by anti-oxidative effects: the role of Nrf2 antioxidant system in preventing oxidative stress

Mahin Dianat, Maryam Radan, Mohammad Badavi, Seyyed Ali Mard, Vahid Bayati, Masoumeh Ahmadizadeh

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The genetics of smoking in individuals with chronic obstructive pulmonary disease

Ma’en Obeidat, Guohai Zhou, Xuan Li, Nadia N. Hansel, Nicholas Rafaels, Rasika Mathias, Ingo Ruczinski, Terri H. Beaty, Kathleen C. Barnes, Peter D. Paré, Don D. Sin

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Associations of the plasma lipidome with mortality in the acute respiratory distress syndrome: a longitudinal cohort study

Michael D. Maile, Theodore J. Standiford, Milo C. Engoren, Kathleen A. Stringer, Elizabeth S. Jewell, Thekkelnaycke M. Rajendiran, Tanu Soni, Charles F. Burant

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Effect of continuous positive airway pressure on long-term cardiovascular outcomes in patients with coronary artery disease and obstructive sleep apnea: a systematic review and meta-analysis

Xiao Wang, Ying Zhang, Zhimin Dong, Jingyao Fan, Shaoping Nie, Yongxiang Wei

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Pectoralis muscle area and mortality in smokers without airflow obstruction

Alejandro A. Diaz, Carlos H. Martinez, Rola Harmouche, Thomas P. Young, Merry-Lynn McDonald, James C. Ross, Mei Lan Han, Russell Bowler, Barry Make, Elizabeth A. Regan, Edwin K. Silverman, James Crapo, Aladin M. Boriek, Gregory L. Kinney, John E. Hokanson, Raul San Jose Estepar, George R. Washko

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Assessing the healthcare resource use associated with inappropriate prescribing of inhaled corticosteroids for people with chronic obstructive pulmonary disease (COPD) in GOLD groups A or B: an observational study using the Clinical Practice Research Datalink (CPRD)

James D. Chalmers, Chris Poole, Samantha Webster, Abigail Tebboth, Scott Dickinson, Alicia Gayle

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Proteolytic biomarkers are related to prognosis in COPD- report from a population-based cohort

Robert Linder, Eva Rönmark, Jamshid Pourazar, Annelie F. Behndig, Anders Blomberg, Anne Lindberg

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Beclomethasone dipropionate and formoterol fumarate synergistically interact in hyperresponsive medium bronchi and small airways

Luigino Calzetta, Maria Gabriella Matera, Francesco Facciolo, Mario Cazzola, Paola Rogliani

01.12.2018 | Letter to the Editor | Ausgabe 1/2018 Open Access

Human alveolar macrophages predominately express combined classical M1 and M2 surface markers in steady state

Elena Mitsi, Raphael Kamng’ona, Jamie Rylance, Carla Solórzano, J. Jesus Reiné, Henry C. Mwandumba, Daniela M. Ferreira, Kondwani C. Jambo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

FK506-binding protein 10 (FKBP10) regulates lung fibroblast migration via collagen VI synthesis

Larissa Knüppel, Katharina Heinzelmann, Michael Lindner, Rudolf Hatz, Jürgen Behr, Oliver Eickelberg, Claudia A. Staab-Weijnitz

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Expression of MATE1, P-gp, OCTN1 and OCTN2, in epithelial and immune cells in the lung of COPD and healthy individuals

Tove Berg, Tove Hegelund-Myrbäck, Johan Öckinger, Xiao-Hong Zhou, Marie Brännström, Michael Hagemann-Jensen, Viktoria Werkström, Janeric Seidegård, Johan Grunewald, Magnus Nord, Lena Gustavsson

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Recurrent inhibition of mitochondrial complex III induces chronic pulmonary vasoconstriction and glycolytic switch in the rat lung

Olga Rafikova, Anup Srivastava, Ankit A. Desai, Ruslan Rafikov, Stevan P. Tofovic

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Long-acting bronchodilators improve exercise capacity in COPD patients: a systematic review and meta-analysis

Fabiano Di Marco, Giovanni Sotgiu, Pierachille Santus, Denis E. O’Donnell, Kai-Michael Beeh, Simone Dore, Maria Adelaide Roggi, Lisa Giuliani, Francesco Blasi, Stefano Centanni

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Resolution of bleomycin-induced murine pulmonary fibrosis via a splenic lymphocyte subpopulation

Koichiro Kamio, Arata Azuma, Kuniko Matsuda, Jiro Usuki, Minoru Inomata, Akemi Morinaga, Takeru Kashiwada, Nobuhiko Nishijima, Shioto Itakura, Nariaki Kokuho, Kenichiro Atsumi, Hiroki Hayashi, Tomoyoshi Yamaguchi, Kazue Fujita, Yoshinobu Saito, Shinji Abe, Kaoru Kubota, Akihiko Gemma

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Abnormal pulmonary function tests predict the development of radiation-induced pneumonitis in advanced non-small cell lung Cancer

L. Torre-Bouscoulet, W. R. Muñoz-Montaño, D. Martínez-Briseño, F. J. Lozano-Ruiz, R. Fernández-Plata, J. A. Beck-Magaña, C. García-Sancho, A. Guzmán-Barragán, E. Vergara, M. Blake-Cerda, L. Gochicoa-Rangel, F. Maldonado, M. Arroyo-Hernández, O. Arrieta

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Associations between comorbidities, their treatment and survival in patients with interstitial lung diseases – a claims data analysis

Larissa Schwarzkopf, Sabine Witt, Julia Waelscher, Markus Polke, Michael Kreuter

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Rituximab for auto-immune alveolar proteinosis, a real life cohort study

Berenice Soyez, Raphael Borie, Cedric Menard, Jacques Cadranel, Leonidas Chavez, Vincent Cottin, Emmanuel Gomez, Sylvain Marchand-Adam, Sylvie Leroy, Jean-Marc Naccache, Hilario Nunes, Martine Reynaud-Gaubert, Laurent Savale, Abdellatif Tazi, Lidwine Wemeau-Stervinou, Marie-Pierre Debray, Bruno Crestani

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Adverse events profile of oral corticosteroids among asthma patients in the UK: cohort study with a nested case-control analysis

Marlene Bloechliger, Daphne Reinau, Julia Spoendlin, Shih-Chen Chang, Klaus Kuhlbusch, Liam G. Heaney, Susan S. Jick, Christoph R. Meier

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Prenatal fine particulate exposure associated with reduced childhood lung function and nasal epithelia GSTP1 hypermethylation: Sex-specific effects

Alison G. Lee, Blake Le Grand, Hsiao-Hsien Leon Hsu, Yueh-Hsiu Mathilda Chiu, Kasey J. Brennan, Sonali Bose, Maria José Rosa, Kelly J. Brunst, Itai Kloog, Ander Wilson, Joel Schwartz, Wayne Morgan, Brent A. Coull, Robert O. Wright, Andrea A. Baccarelli, Rosalind J. Wright

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Comparative analysis of COPD associated with tobacco smoking, biomass smoke exposure or both

Jordi Olloquequi, Sergio Jaime, Viviana Parra, Elizabeth Cornejo-Córdova, Gonzalo Valdivia, Àlvar Agustí, Rafael O. Silva

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Altered lung biology of healthy never smokers following acute inhalation of E-cigarettes

Michelle R. Staudt, Jacqueline Salit, Robert J. Kaner, Charleen Hollmann, Ronald G. Crystal

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Pollution and respiratory disease: can diet or supplements help? A review

T. Whyand, J. R. Hurst, M. Beckles, M. E. Caplin

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Pulmonary inflammation-induced loss and subsequent recovery of skeletal muscle mass require functional poly-ubiquitin conjugation

Judith J. M. Ceelen, Annemie M. W. J. Schols, Nathalie G. M. Thielen, Astrid Haegens, Douglas A. Gray, Marco C. J. M. Kelders, Chiel C. de Theije, Ramon C. J. Langen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Trends in mortality from pneumonia in the Europe union: a temporal analysis of the European detailed mortality database between 2001 and 2014

Dominic C. Marshall, Ross J. Goodson, Yiwang Xu, Matthieu Komorowski, Joseph Shalhoub, Mahiben Maruthappu, Justin D. Salciccioli

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A Serological Biomarker of Versican Degradation is Associated with Mortality Following Acute Exacerbations of Idiopathic Interstitial Pneumonia

Jannie M. B. Sand, Yoshinori Tanino, Morten A. Karsdal, Takefumi Nikaido, Kenichi Misa, Yuki Sato, Ryuichi Togawa, Xintao Wang, Diana J. Leeming, Mitsuru Munakata

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Immunohistological features related to functional impairment in lymphangioleiomyomatosis

Ellen Caroline Toledo do Nascimento, Bruno Guedes Baldi, Alessandro Wasum Mariani, Raquel Annoni, Ronaldo Adib Kairalla, Suzana Pinheiro Pimenta, Luiz Fernando Ferraz da Silva, Carlos Roberto Ribeiro Carvalho, Marisa Dolhnikoff

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Cost-effectiveness of lung volume reduction coil treatment in patients with severe emphysema: results from the 2-year follow-up crossover REVOLENS study (REVOLENS-2 study)

Julie Bulsei, Sylvie Leroy, Jeanne-Marie Perotin, Hervé Mal, Charles-Hugo Marquette, Hervé Dutau, Arnaud Bourdin, Jean-Michel Vergnon, Christophe Pison, Romain Kessler, Vincent Jounieaux, Mathieu Salaün, Armelle Marceau, Sylvain Dukic, Coralie Barbe, Margaux Bonnaire, Gaëtan Deslee, Isabelle Durand-Zaleski, the REVOLENS study group

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The anti-proliferative and anti-inflammatory response of COPD airway smooth muscle cells to hydrogen sulfide

Mark M. Perry, Bernadett Tildy, Alberto Papi, Paolo Casolari, Gaetano Caramori, Karen Limbert Rempel, Andrew J. Halayko, Ian Adcock, Kian Fan Chung

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Arterial stiffness in adults with steady-state bronchiectasis: association with clinical indices and disease severity

Yong-hua Gao, Juan-juan Cui, Ling-yun Wang, Ke-qin Yin, Li Wang, Guo-jun Zhang, Shao-xia Liu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Genetic analyses in a cohort of 191 pulmonary arterial hypertension patients

Hang Yang, Qixian Zeng, Yanyun Ma, Bingyang Liu, Qianlong Chen, Wenke Li, Changming Xiong, Zhou Zhou

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Association between oncogenic status and risk of venous thromboembolism in patients with non-small cell lung cancer

Feifei Dou, Huiqiao Li, Min Zhu, Lirong Liang, Yuan Zhang, Jiawen Yi, Yuhui Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Modelling the asthma phenotype: impact of cigarette smoke exposure

Maria G. Belvisi, Katie Baker, Nicole Malloy, Kristof Raemdonck, Bilel Dekkak, Michael Pieper, Anthony T. Nials, Mark A. Birrell

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Fibrocytes are increased in lung and peripheral blood of patients with idiopathic pulmonary fibrosis

P. Heukels, J. A. C. van Hulst, M. van Nimwegen, C. E. Boorsma, B. N. Melgert, L. M. van den Toorn, K. A. T. Boomars, M. S. Wijsenbeek, H. Hoogsteden, J. H. von der Thüsen, R. W. Hendriks, M. Kool, B. van den Blink

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli

Amos E. Dodi, Iyabode O. Ajayi, Christine Chang, Meghan Beard, Shanna L. Ashley, Steven K. Huang, Victor J. Thannickal, Daniel J. Tschumperlin, Thomas H. Sisson, Jeffrey C. Horowitz

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A candidate gene identification strategy utilizing mouse to human big-data mining: “3R-tenet” in COPD genetic research

Sangeetha Vishweswaraiah, Leema George, Natarajan Purushothaman, Koustav Ganguly

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Effects and molecular mechanisms of intrauterine infection/inflammation on lung development

Jiarong Pan, Canyang Zhan, Tianming Yuan, Weiyan Wang, Ying Shen, Yi Sun, Tai Wu, Weizhong Gu, Lihua Chen, Huimin Yu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Metabolic reprogramming of the urea cycle pathway in experimental pulmonary arterial hypertension rats induced by monocrotaline

Hai-Kuo Zheng, Jun-Han Zhao, Yi Yan, Tian-Yu Lian, Jue Ye, Xiao-Jian Wang, Zhe Wang, Zhi-Cheng Jing, Yang-Yang He, Ping Yang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The aging lung: tissue telomere shortening in health and disease

Stephanie Everaerts, Elise J. Lammertyn, Dries S. Martens, Laurens J. De Sadeleer, Karen Maes, Aernoud A. van Batenburg, Roel Goldschmeding, Coline H. M. van Moorsel, Lieven J. Dupont, Wim A. Wuyts, Robin Vos, Ghislaine Gayan-Ramirez, Naftali Kaminski, James C. Hogg, Wim Janssens, Geert M. Verleden, Tim S. Nawrot, Stijn E. Verleden, John E. McDonough, Bart M. Vanaudenaerde

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Knockdown of annexin A5 restores gefitinib sensitivity by promoting G2/M cell cycle arrest

Jian Zhou, Meijia Chang, Jing Li, Tao Fang, Jie Hu, Chunxue Bai

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Soluble urokinase plasminogen activator receptor predicts mortality in exacerbated COPD

Nina S. Godtfredsen, Ditte V. Jørgensen, Kristoffer Marsaa, Charlotte S. Ulrik, Ove Andersen, Jesper Eugen-Olsen, Line J. H. Rasmussen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Hypoargininemia exacerbates airway hyperresponsiveness in a mouse model of asthma

Roy H. E. Cloots, Matthew E. Poynter, Els Terwindt, Wouter H. Lamers, S. Eleonore Köhler

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Association of serum bilirubin level with lung function decline: a Korean community-based cohort study

Ah Young Leem, Ha Yan Kim, Young Sam Kim, Moo Suk Park, Joon Chang, Ji Ye Jung

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Vascular inflammation and aortic stiffness: potential mechanisms of increased vascular risk in chronic obstructive pulmonary disease

Marie Fisk, Joseph Cheriyan, Divya Mohan, Carmel M. McEniery, Julia Forman, John R. Cockcroft, James H. F. Rudd, Ruth Tal-Singer, Nicholas S. Hopkinson, Michael I. Polkey, Ian B. Wilkinson

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Quality of life assessment in interstitial lung diseases:a comparison of the disease-specific K-BILD with the generic EQ-5D-5L

Boglárka Lilla Szentes, Michael Kreuter, Thomas Bahmer, Surinder S. Birring, Martin Claussen, Julia Waelscher, Reiner Leidl, Larissa Schwarzkopf

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Sequential broncho-alveolar lavages reflect distinct pulmonary compartments: clinical and research implications in lung transplantation

Liran Levy, Stephen C. Juvet, Kristen Boonstra, Lianne G. Singer, Sassan Azad, Betty Joe, Marcelo Cypel, Shaf Keshavjee, Tereza Martinu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Is the purinergic pathway involved in the pathology of COPD? Decreased lung CD39 expression at initial stages of COPD

Elisabet Aliagas, Mariana Muñoz-Esquerre, Ester Cuevas, Oriol Careta, Daniel Huertas, Marta López-Sánchez, Ignacio Escobar, Jordi Dorca, Salud Santos

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Therapeutic effects of adipose-tissue-derived mesenchymal stromal cells and their extracellular vesicles in experimental silicosis

Elga Bandeira, Helena Oliveira, Johnatas D. Silva, Rubem F. S. Menna-Barreto, Christina M. Takyia, Jung S. Suk, Kenneth W. Witwer, Michael E. Paulaitis, Justin Hanes, Patricia R. M. Rocco, Marcelo M. Morales

01.12.2018 | Letter to the Editor | Ausgabe 1/2018 Open Access

A home monitoring program including real-time wireless home spirometry in idiopathic pulmonary fibrosis: a pilot study on experiences and barriers

C. C. Moor, M. Wapenaar, J. R. Miedema, J. J. M. Geelhoed, P. P. Chandoesing, M. S. Wijsenbeek

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Anti-bacterial antibody and T cell responses in bronchiectasis are differentially associated with lung colonization and disease

Fathia G. Jaat, Sajidah F. Hasan, Audrey Perry, Sharon Cookson, Santosh Murali, John D. Perry, Clare V. Lanyon, Anthony De Soyza, Stephen M. Todryk

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury

Kevin Ni, Amar Gill, Victor Tseng, Andrew M. Mikosz, Kengo Koike, Erica L. Beatman, Cassie Y. Xu, Danting Cao, Fabienne Gally, Kara J. Mould, Karina A. Serban, Kelly S. Schweitzer, Keith L. March, William J. Janssen, Eva Nozik-Grayck, Stavros Garantziotis, Irina Petrache

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The association between airway eosinophilic inflammation and IL-33 in stable non-atopic COPD

Damian Tworek, Sebastian Majewski, Karolina Szewczyk, Justyna Kiszałkiewicz, Zofia Kurmanowska, Paweł Górski, Ewa Brzeziańska-Lasota, Piotr Kuna, Adam Antczak

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Human antigen R enhances the epithelial-mesenchymal transition via regulation of ZEB-1 in the human airway epithelium

Jian Sun, Xianmin Gu, Nan Wu, Pengju Zhang, Yi Liu, Shujuan Jiang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Uric acid, lung function, physical capacity and exacerbation frequency in patients with COPD: a multi-dimensional approach

Kathrin Kahnert, Peter Alter, Tobias Welte, Rudolf M. Huber, Jürgen Behr, Frank Biertz, Henrik Watz, Robert Bals, Claus F. Vogelmeier, Rudolf A. Jörres

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Parthenolide attenuated bleomycin-induced pulmonary fibrosis via the NF-κB/Snail signaling pathway

Xiao-he Li, Ting Xiao, Jia-huan Yang, Yuan Qin, Jing-jing Gao, Hui-juan Liu, Hong-gang Zhou

01.12.2018 | Letter to the Editor | Ausgabe 1/2018 Open Access

Serum periostin does not reflect type 2-driven inflammation in COPD

O. A. Carpaij, F. O. W. Muntinghe, M. B. Wagenaar, J. W. Habing, W. Timens, H. A. M. Kerstjens, M. C. Nawijn, L. I. Z. Kunz, P. S. Hiemstra, G. W. Tew, C. T. J. Holweg, C. A. Brandsma, M. van den Berge

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Is IgE or eosinophils the key player in allergic asthma pathogenesis? Are we asking the right question?

Andrea Matucci, Alessandra Vultaggio, Enrico Maggi, Ismail Kasujee

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The therapeutic effect of mesenchymal stem cells on pulmonary myeloid cells following neonatal hyperoxic lung injury in mice

Ali Al-Rubaie, Andrea F. Wise, Foula Sozo, Robert De Matteo, Chrishan S. Samuel, Richard Harding, Sharon D. Ricardo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Hsa_circ_0046264 up-regulated BRCA2 to suppress lung cancer through targeting hsa-miR-1245

Liu Yang, Jun Wang, Yaodong Fan, Kun Yu, Baowei Jiao, Xiaosan Su

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Oxidative stress enhances the expression of IL-33 in human airway epithelial cells

Hiroyuki Aizawa, Akira Koarai, Yutaka Shishikura, Satoru Yanagisawa, Mutsuo Yamaya, Hisatoshi Sugiura, Tadahisa Numakura, Mitsuhiro Yamada, Tomohiro Ichikawa, Naoya Fujino, Masafumi Noda, Yoshinori Okada, Masakazu Ichinose

01.12.2018 | Letter to the Editor | Ausgabe 1/2018 Open Access

Decreased telomere length in the small airway epithelium suggests accelerated aging in the lungs of persons living with human immunodeficiency virus (HIV)

Stella Xu, Emily A. Vucic, Tawimas Shaipanich, Stephen Lam, Wan Lam, Julio S. Montaner, Don D. Sin, S. F. Paul Man, Janice M. Leung

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Bone marrow characterization in COPD: a multi-level network analysis

Nuria Toledo-Pons, Guillaume Noell, Andreas Jahn, Amanda Iglesias, Maria Antonia Duran, Julio Iglesias, Angel Rios, Sergio Scrimini, Rosa Faner, Orlando Gigirey, Alvar Agustí, Borja G. Cosío

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Microorganisms resistant to conventional antimicrobials in acute exacerbations of chronic obstructive pulmonary disease

Cristina Estirado, Adrian Ceccato, Monica Guerrero, Arturo Huerta, Catia Cilloniz, Olivia Vilaró, Albert Gabarrús, Joaquim Gea, Ernesto Crisafulli, Nestor Soler, Antoni Torres

01.12.2018 | Research | Ausgabe 1/2018 Open Access

PDGF-BB regulates the pulmonary vascular tone: impact of prostaglandins, calcium, MAPK- and PI3K/AKT/mTOR signalling and actin polymerisation in pulmonary veins of guinea pigs

Annette D. Rieg, Said Suleiman, Carolin Anker, Eva Verjans, Rolf Rossaint, Stefan Uhlig, Christian Martin

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Indacaterol/glycopyrronium versus salmeterol/fluticasone in the prevention of clinically important deterioration in COPD: results from the FLAME study

Antonio R. Anzueto, Konstantinos Kostikas, Karen Mezzi, Steven Shen, Michael Larbig, Francesco Patalano, Robert Fogel, Donald Banerji, Jadwiga A. Wedzicha

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Landscape of transcription and long non-coding RNAs reveals new insights into the inflammatory and fibrotic response following ventilator-induced lung injury

Lu Wang, Nannan Zhang, Yi Zhang, Jingen Xia, Qingyuan Zhan, Chen Wang

01.12.2018 | Review | Ausgabe 1/2018 Open Access

The human viral challenge model: accelerating the evaluation of respiratory antivirals, vaccines and novel diagnostics

Rob Lambkin-Williams, Nicolas Noulin, Alex Mann, Andrew Catchpole, Anthony S. Gilbert

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Interleukin-32: its role in asthma and potential as a therapeutic agent

Tong Xin, Mo Chen, Liwei Duan, Yanling Xu, Peng Gao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Ciliated conical epithelial cell protrusions point towards a diagnosis of primary ciliary dyskinesia

Chris O’Callaghan, Andrew Rutman, Gwyneth Williams, Neeta Kulkarni, Joseph Hayes, Robert A. Hirst

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Comparison of pro- and anti-inflammatory responses in paired human primary airway epithelial cells and alveolar macrophages

Reem Al Mubarak, Nicole Roberts, Robert J. Mason, Scott Alper, Hong Wei Chu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Changes in pulmonary endothelial cell properties during bleomycin-induced pulmonary fibrosis

Shinpei Kato, Naoki Inui, Akio Hakamata, Yuzo Suzuki, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Hiroshi Watanabe, Takafumi Suda

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Circulating microRNAs and prediction of asthma exacerbation in childhood asthma

Alvin T. Kho, Michael J. McGeachie, Kip G. Moore, Jody M. Sylvia, Scott T. Weiss, Kelan G. Tantisira

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Prevalence of asthma, aspirin sensitivity and allergy in chronic rhinosinusitis: data from the UK National Chronic Rhinosinusitis Epidemiology Study

Carl M. Philpott, Sally Erskine, Claire Hopkins, Nirmal Kumar, Shahram Anari, Naveed Kara, Sankalp Sunkaraneni, Jaydip Ray, Allan Clark, Andrew Wilson, Sally Erskine, Carl Philpott, Allan Clark, Claire Hopkins, Alasdair Robertson, Shahzada Ahmed, Naveed Kara, Sean Carrie, Vishnu Sunkaraneni, Jaydip Ray, Shahram Anari, Paul Jervis, Jaan Panesaar, Amir Farboud, Nirmal Kumar, Russell Cathcart, Robert Almeyda, Hisham Khalil, Peter Prinsley, Nicolas Mansell, Mahmoud Salam, Jonathan Hobson, Jane Woods, Emma Coombes, On behalf of the CRES group

01.12.2018 | Research | Ausgabe 1/2018 Open Access

An attempt at modeling COPD epidemiological trends in France

Pierre-Régis Burgel, Caroline Laurendeau, Chantal Raherison, Claire Fuhrman, Nicolas Roche

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Impact of immunization against OxLDL on the pulmonary response to cigarette smoke exposure in mice

Maude Talbot, Mélanie Hamel-Auger, Marie-Josée Beaulieu, Morgan Gazzola, Ariane Lechasseur, Sophie Aubin, Marie-Ève Paré, David Marsolais, Ynuk Bossé, Mathieu C. Morissette

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A role for telomere length and chromosomal damage in idiopathic pulmonary fibrosis

John E. McDonough, Dries S. Martens, Naoya Tanabe, Farida Ahangari, Stijn E. Verleden, Karen Maes, Geert M. Verleden, Naftali Kaminski, James C. Hogg, Tim S. Nawrot, Wim A. Wuyts, Bart M. Vanaudenaerde

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Anti-inflammatory duration of action of fluticasone furoate/vilanterol trifenatate in asthma: a cross-over randomised controlled trial

George Bardsley, Peter Daley-Yates, Amanda Baines, Rodger Kempsford, Mathew Williams, Tony Mallon, Irene Braithwaite, Kylie Riddell, Shashidhar Joshi, Philippe Bareille, Richard Beasley, James Fingleton, on behalf of the study team

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Serial blood eosinophils and clinical outcome in patients with chronic obstructive pulmonary disease

Sun Hye Shin, Hye Yun Park, Danbee Kang, Juhee Cho, Sung Ok Kwon, Joo Hun Park, Jae Seung Lee, Yeon-Mok Oh, Don D. Sin, Woo Jin Kim, Sang-Do Lee, KOLD Study Group

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Cryobiopsies are diagnostic in Pleuroparenchymal and Airway-centered Fibroelastosis

Sissel Kronborg-White, Claudia Ravaglia, Alessandra Dubini, Sara Piciucchi, Sara Tomassetti, Elisabeth Bendstrup, Venerino Poletti

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Epithelial mesenchymal transition (EMT): a universal process in lung diseases with implications for cystic fibrosis pathophysiology

Nathan Rout-Pitt, Nigel Farrow, David Parsons, Martin Donnelley

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Health status decline in α-1 antitrypsin deficiency: a feasible outcome for disease modifying therapies?

Robert A. Stockley, Ross G. Edgar, Sian Starkey, Alice M. Turner

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Human alveolar epithelial cells type II are capable of TGFβ-dependent epithelial-mesenchymal-transition and collagen-synthesis

Torsten Goldmann, Gernot Zissel, Henrik Watz, Daniel Drömann, Martin Reck, Christian Kugler, Klaus F. Rabe, Sebastian Marwitz

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Lower respiratory tract microbial composition was diversified in Pseudomonas aeruginosa ventilator-associated pneumonia patients

Xiaoling Qi, Hongping Qu, Dandan Yang, Lian Zhou, Ya-Wen He, Yuetian Yu, Jieming Qu, Jialin Liu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Decreased microbiome diversity in the HIV small airway epithelium

Stella Xu, Amy Tsai, Marc A. Sze, Emily A. Vucic, Tawimas Shaipanich, Marianne Harris, Silvia Guillemi, Julia Yang, Sunita Sinha, Corey Nislow, Julio Montaner, Wan Lam, Stephen Lam, Don D. Sin, S. F. Paul Man, Janice M. Leung

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The European IPF registry (eurIPFreg): baseline characteristics and survival of patients with idiopathic pulmonary fibrosis

Andreas Guenther, Ekaterina Krauss, Silke Tello, Jasmin Wagner, Bettina Paul, Stefan Kuhn, Olga Maurer, Sabine Heinemann, Ulrich Costabel, María Asunción Nieto Barbero, Veronika Müller, Philippe Bonniaud, Carlo Vancheri, Athol Wells, Martina Vasakova, Alberto Pesci, Matteo Sofia, Walter Klepetko, Werner Seeger, Fotios Drakopanagiotakis, Bruno Crestani

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Adenosine 5’-triphosphate’s role in bradycardia and syncope associated with pulmonary embolism

Amir Pelleg, Edward S. Schulman, Peter J. Barnes

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Impact of radiologically stratified exacerbations: insights into pneumonia aetiology in COPD

Nicholas P. Williams, Kristoffer Ostridge, Jeanne-Marie Devaster, Viktoriya Kim, Ngaire A. Coombs, Simon Bourne, Stuart C. Clarke, Stephen Harden, Ausami Abbas, Emmanuel Aris, Christophe Lambert, Andrew Tuck, Anthony Williams, Stephen Wootton, Karl J. Staples, Tom M. A. Wilkinson, on behalf of the AERIS Study Group

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Regulatory role of heme oxygenase-1 in silica-induced lung injury

Kentaro Nakashima, Takashi Sato, Suguru Shigemori, Takeshi Shimosato, Masaharu Shinkai, Takeshi Kaneko

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Influenza A virus infection dysregulates the expression of microRNA-22 and its targets; CD147 and HDAC4, in epithelium of asthmatics

Fatemeh Moheimani, Jorinke Koops, Teresa Williams, Andrew T. Reid, Philip M. Hansbro, Peter A. Wark, Darryl A. Knight

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Asthmatic bronchial epithelial cells promote the establishment of a Hyaluronan-enriched, leukocyte-adhesive extracellular matrix by lung fibroblasts

Stephen R. Reeves, Inkyung Kang, Christina K. Chan, Kaitlyn A. Barrow, Tessa K. Kolstad, Maria P. White, Steven F. Ziegler, Thomas N. Wight, Jason S. Debley

01.12.2018 | Letter to the Editor | Ausgabe 1/2018 Open Access

The diagnostic performance of patient symptoms in screening for COPD

Kate M. Johnson, Wan C. Tan, Jean Bourbeau, Don D. Sin, Mohsen Sadatsafavi, for the Canadian Cohort of Obstructive Lung Disease (CanCOLD) study and the Canadian Respiratory Research Network

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Understanding alveolarization to induce lung regeneration

José Alberto Rodríguez-Castillo, David Bravo Pérez, Aglaia Ntokou, Werner Seeger, Rory E. Morty, Katrin Ahlbrecht

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Neuropeptides in asthma, chronic obstructive pulmonary disease and cystic fibrosis

Kalina R. Atanasova, Leah R. Reznikov

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Augmented expression of Ki-67 is correlated with clinicopathological characteristics and prognosis for lung cancer patients: an up-dated systematic review and meta-analysis with 108 studies and 14,732 patients

Dan-ming Wei, Wen-jie Chen, Rong-mei Meng, Na Zhao, Xiang-yu Zhang, Dan-yu Liao, Gang Chen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Real world evaluation of a novel lateral flow assay (AlphaKit® QuickScreen) for the detection of alpha-1-antitrypsin deficiency

Timm Greulich, Francisco Rodríguez-Frias, Irene Belmonte, Andreas Klemmer, Claus F. Vogelmeier, Marc Miravitlles

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Age and African-American race impact the validity and reliability of the asthma control test in persistent asthmatics

Allison J. Burbank, Krista Todoric, Pamela Steele, Jonathan Rosen, Haibo Zhou, Marcia Frye, Ceila E. Loughlin, Sally Ivins, Katherine Mills, Lauren Dembnicki Massey, Bryce B. Reeve, Michelle L. Hernandez

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Comprehensive gene expression profiling identifies distinct and overlapping transcriptional profiles in non-specific interstitial pneumonia and idiopathic pulmonary fibrosis

Matthew J. Cecchini, Karishma Hosein, Christopher J. Howlett, Mariamma Joseph, Marco Mura

01.12.2018 | Review | Ausgabe 1/2018 Open Access

The use of intravenous versus subcutaneous monoclonal antibodies in the treatment of severe asthma: a review

Andrea Matucci, Alessandra Vultaggio, Romano Danesi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Glucocorticoids influence versican and chondroitin sulphate proteoglycan levels in the fetal sheep lung

Annie R. A. McDougall, Amanda J. Fosang, Jessica Faggian, Megan J. Wallace, Kelly J. Crossley, Timothy J. Cole, Stuart B. Hooper

01.12.2018 | Research | Ausgabe 1/2018 Open Access

SERPINA1 methylation and lung function in tobacco-smoke exposed European children and adults: a meta-analysis of ALEC population-based cohorts

Anna Beckmeyer-Borowko, Medea Imboden, Faisal I. Rezwan, Matthias Wielscher, Andre F. S. Amaral, Ayoung Jeong, Emmanuel Schaffner, Juha Auvinen, Sylvain Sebert, Ville Karhunen, Robert Bettschart, Alexander Turk, Marco Pons, Daiana Stolz, Florian Kronenberg, Ryan Arathimos, Gemma C. Sharp, Caroline Relton, Alexander J. Henderson, Marjo-Riitta Jarvelin, Deborah Jarvis, John W. Holloway, Nicole M. Probst-Hensch

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Protein kinase R-like endoplasmic reticulum kinase is a mediator of stretch in ventilator-induced lung injury

Tamás Dolinay, Chanat Aonbangkhen, William Zacharias, Edward Cantu, Jennifer Pogoriler, Alec Stablow, Gladys G. Lawrence, Yoshikazu Suzuki, David M. Chenoweth, Edward Morrisey, Jason D. Christie, Michael F. Beers, Susan S. Margulies

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Prevalence and incidence of sarcoidosis in Korea: a nationwide population-based study

Hee-Young Yoon, Hyeong Min Kim, Ye-Jee Kim, Jin Woo Song

01.12.2018 | Editorial | Ausgabe 1/2018 Open Access

The underestimated danger of E-cigarettes - also in the absence of nicotine

Martina Korfei

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Transforming growth factor beta1 targets estrogen receptor signaling in bronchial epithelial cells

L. Cody Smith, Santiago Moreno, Lauren Robertson, Sarah Robinson, Kristal Gant, Andrew J. Bryant, Tara Sabo-Attwood

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Primary data, claims data, and linked data in observational research: the case of COPD in Germany

Sabrina Mueller, Fraence Gottschalk, Antje Groth, Wilhelmine Meeraus, Maurice Driessen, Thomas Kohlmann, Thomas Wilke

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Clinical significance of radiological pleuroparenchymal fibroelastosis pattern in interstitial lung disease patients registered for lung transplantation: a retrospective cohort study

Kiminobu Tanizawa, Tomohiro Handa, Takeshi Kubo, Toyofumi F. Chen-Yoshikawa, Akihiro Aoyama, Hideki Motoyama, Kyoko Hijiya, Akihiko Yoshizawa, Yohei Oshima, Kohei Ikezoe, Shinsaku Tokuda, Yoshinari Nakatsuka, Yuko Murase, Sonoko Nagai, Shigeo Muro, Toru Oga, Kazuo Chin, Toyohiro Hirai, Hiroshi Date

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Better approach for autoimmune pulmonary alveolar proteinosis treatment: inhaled or subcutaneous granulocyte-macrophage colony-stimulating factor: a meta-analyses

Gaohong Sheng, Peng Chen, Yanqiu Wei, Jiaojiao Chu, Xiaolei Cao, Hui-Lan Zhang

01.12.2018 | Letter to the Editor | Ausgabe 1/2018 Open Access

Carbon monoxide levels after inhalation from new generation heated tobacco products

Pasquale Caponnetto, Marilena Maglia, Gaetano Prosperini, Barbara Busà, Riccardo Polosa

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Elastin degradation products in acute lung injury induced by gastric contents aspiration

Pedro Ayala, Raúl Vivar, Rebeca Montalva, Pablo Olmos, Manuel Meneses, Gisella R. Borzone

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Relationship of systemic IL-10 levels with proinflammatory cytokine responsiveness and lung function in agriculture workers

Tricia D. LeVan, Debra J. Romberger, Mohammad Siahpush, Brandon L. Grimm, Athena K. Ramos, Patrik L. Johansson, Tzeyu L. Michaud, Art J. Heires, Todd A. Wyatt, Jill A. Poole

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Anti-acid therapy in idiopathic pulmonary fibrosis: insights from the INPULSIS® trials

Ulrich Costabel, Jürgen Behr, Bruno Crestani, Wibke Stansen, Rozsa Schlenker-Herceg, Susanne Stowasser, Ganesh Raghu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Health care resource utilization and cost for asthma patients regularly treated with oral corticosteroids – a Swedish observational cohort study (PACEHR)

Christer Janson, Karin Lisspers, Björn Ställberg, Gunnar Johansson, Gunilla Telg, Marcus Thuresson, Helene Nordahl Christensen, Kjell Larsson

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Serum sST2 levels predict severe exacerbation of asthma

Masato Watanabe, Keitaro Nakamoto, Toshiya Inui, Mitsuru Sada, Kojiro Honda, Masaki Tamura, Yukari Ogawa, Takuma Yokoyama, Takeshi Saraya, Daisuke Kurai, Haruyuki Ishii, Hajime Takizawa

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Macrophages: friend or foe in idiopathic pulmonary fibrosis?

Lei Zhang, Yi Wang, Guorao Wu, Weining Xiong, Weikuan Gu, Cong-Yi Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Combined diffusing capacity for nitric oxide and carbon monoxide as predictor of bronchiolitis obliterans syndrome following lung transplantation

Anna Winkler, Kathrin Kahnert, Jürgen Behr, Claus Neurohr, Nikolaus Kneidinger, Rudolf Hatz, Holger Dressel, Thomas Radtke, Rudolf A. Jörres

01.12.2018 | Research | Ausgabe 1/2018 Open Access

 Identifying the associated risks of pneumonia in COPD patients: ARCTIC an observational study

Christer Janson, Gunnar Johansson, Björn Ställberg, Karin Lisspers, Petter Olsson, Dorothy L. Keininger, Milica Uhde, Florian S. Gutzwiller, Leif Jörgensen, Kjell Larsson

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Impairment of respiratory muscle strength in Berardinelli-Seip congenital lipodystrophy subjects

Jorge Luiz Dantas de Medeiros, Bruno Carneiro Bezerra, Thiago Anderson Brito de Araújo, Aquiles Sales Craveiro Sarmento, Lázaro Batista de Azevedo Medeiros, Lucien Peroni Gualdi, Maria do Socorro Luna Cruz, Thaiza Teixeira Xavier Nobre, Josivan Gomes Lima, Julliane Tamara Araújo de Melo Campos

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Smoking is associated with quantifiable differences in the human lung DNA virome and metabolome

Ann C. Gregory, Matthew B. Sullivan, Leopoldo N. Segal, Brian C. Keller

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis

Mareike Lehmann, Lara Buhl, Hani N. Alsafadi, Stephan Klee, Sarah Hermann, Kathrin Mutze, Chiharu Ota, Michael Lindner, Jürgen Behr, Anne Hilgendorff, Darcy E. Wagner, Melanie Königshoff

01.12.2018 | Letter to the Editor | Ausgabe 1/2018 Open Access

Steroid insensitive fixed airflow obstruction is not related to airway inflammation in older non-smokers with asthma

K. O. Tonga, G. G. King, C. S. Farah, C. Thamrin, F. S. Tang, J. Santos, P. Sharma, D. G. Chapman, B. G. Oliver

01.12.2018 | Review | Ausgabe 1/2018 Open Access

What have we learned from observational studies and clinical trials of mild to moderate COPD?

Miriam Barrecheguren, Cruz González, Marc Miravitlles

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Imaging-based clusters in current smokers of the COPD cohort associate with clinical characteristics: the SubPopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)

Babak Haghighi, Sanghun Choi, Jiwoong Choi, Eric A. Hoffman, Alejandro P. Comellas, John D. Newell Jr, R. Graham Barr, Eugene Bleecker, Christopher B. Cooper, David Couper, Mei Lan Han, Nadia N. Hansel, Richard E. Kanner, Ella A. Kazerooni, Eric A. C. Kleerup, Fernando J. Martinez, Wanda O’Neal, Stephen I. Rennard, Prescott G. Woodruff, Ching-Long Lin

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Leptin receptor gene polymorphisms and sex modify the association between acetaminophen use and asthma among young adults: results from two observational studies

Ali H. Ziyab, Nandini Mukherjee, Ramesh J. Kurukulaaratchy, Hongmei Zhang, Susan Ewart, Hasan Arshad, Wilfried Karmaus

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Proteinase 3; a potential target in chronic obstructive pulmonary disease and other chronic inflammatory diseases

Helena Crisford, Elizabeth Sapey, Robert A. Stockley

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inhaled furosemide for relief of air hunger versus sense of breathing effort: a randomized controlled trial

Joanna C. Grogono, Clare Butler, Hooshang Izadi, Shakeeb H. Moosavi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Short and long-term effects of pulmonary rehabilitation in interstitial lung diseases: a randomised controlled trial

Silvia Perez-Bogerd, Wim Wuyts, Veronica Barbier, Heleen Demeyer, Alain Van Muylem, Wim Janssens, Thierry Troosters

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Serum phosphate and phosphate-regulatory hormones in COPD patients

Alexandra Stroda, Vincent Brandenburg, Ayham Daher, Christian Cornelissen, Claudia Goettsch, András Keszei, Michael Dreher

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The impact of HIV on the prevalence of asthma in Uganda: a general population survey

Bruce J. Kirenga, Levicatus Mugenyi, Corina de Jong, J. Lucian Davis, Winceslaus Katagira, Thys van der Molen, Moses R. Kamya, Marike Boezen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Significant predictors of medically diagnosed chronic obstructive pulmonary disease in patients with preserved ratio impaired spirometry: a 3-year cohort study

Hye Jung Park, Min Kwang Byun, Chin Kook Rhee, Kyungjoo Kim, Hyung Jung Kim, Kwang-Ha Yoo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A circulating cell population showing both M1 and M2 monocyte/macrophage surface markers characterizes systemic sclerosis patients with lung involvement

Amelia Chiara Trombetta, Stefano Soldano, Paola Contini, Veronica Tomatis, Barbara Ruaro, Sabrina Paolino, Renata Brizzolara, Paola Montagna, Alberto Sulli, Carmen Pizzorni, Vanessa Smith, Maurizio Cutolo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

PrtA immunization fails to protect against pulmonary and invasive infection by Streptococcus pneumoniae

Chen-Fang Hsu, Chen-Hao Hsiao, Shun-Fu Tseng, Jian-Ru Chen, Yu-Jou Liao, Sy-Jou Chen, Chin-Sheng Lin, Huey-Kang Sytwu, Yi-Ping Chuang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

IL-32γ attenuates airway fibrosis by modulating the integrin-FAK signaling pathway in fibroblasts

Gyong Hwa Hong, So-Young Park, Hyouk-Soo Kwon, Bo-Ram Bang, Jaechun Lee, Sang-Yeob Kim, Chan-Gi Pack, Soohyun Kim, Keun-Ai Moon, Tae-Bum Kim, Hee-Bom Moon, You Sook Cho

01.12.2018 | Review | Ausgabe 1/2018 Open Access

The prostaglandin D2 receptor 2 pathway in asthma: a key player in airway inflammation

Christian Domingo, Oscar Palomares, David A. Sandham, Veit J. Erpenbeck, Pablo Altman

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Dual effects of human neutrophil peptides in a mouse model of pneumonia and ventilator-induced lung injury

Junbo Zheng, Yongbo Huang, Diana Islam, Xiao-Yan Wen, Sulong Wu, Catherine Streutker, Alice Luo, Manshu Li, Julie Khang, Bing Han, Nanshan Zhong, Yimin Li, Kaijiang Yu, Haibo Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Rectal, central venous, gastric and bladder pressures versus esophageal pressure for the measurement of cough strength: a prospective clinical comparison

Lluís G. Aguilera, Lluís Gallart, Juan C. Álvarez, Jordi Vallès, Joaquim Gea

01.12.2018 | Letter to the Editor | Ausgabe 1/2018 Open Access

Good response to PAH-targeted drugs in a PVOD patient carrying Biallelic EIF2AK4 mutation

Li Liang, Hua Su, Xiuqing Ma, Ruifeng Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The moderate predictive value of serial serum CRP and PCT levels for the prognosis of hospitalized community-acquired pneumonia

Shuren Guo, Xiaohuan Mao, Ming Liang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

MiRNA expression profiles in healthy OSAHS and OSAHS with arterial hypertension: potential diagnostic and early warning markers

Xiuping Yang, Xun Niu, Ying Xiao, Kun Lin, Xiong Chen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Characteristics of lung cancer among patients with idiopathic pulmonary fibrosis and interstitial lung disease – analysis of institutional and population data

Joo Heung Yoon, Mehdi Nouraie, Xiaoping Chen, Richard H Zou, Jacobo Sellares, Kristen L Veraldi, Jared Chiarchiaro, Kathleen Lindell, David O Wilson, Naftali Kaminski, Timothy Burns, Humberto Trejo Bittar, Samuel Yousem, Kevin Gibson, Daniel J Kass

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Concomitant inhaled corticosteroid use and the risk of pneumonia in COPD: a matched-subgroup post hoc analysis of the UPLIFT® trial

Donald P. Tashkin, Marc Miravitlles, Bartolomé R. Celli, Norbert Metzdorf, Achim Mueller, David M. G. Halpin, Antonio Anzueto

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Elevated serum soluble programmed cell death ligand 1 concentration as a potential marker for poor prognosis in small cell lung cancer patients with chemotherapy

Jianjun Jin, Jiming Si, Yuanhua Liu, Huanqin Wang, Ran Ni, Jing Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Antiestrogen- and tamoxifen-induced effects on calcium-activated chloride currents in epithelial cells carrying the ∆F508-CFTR point mutation

Roberto Imberti, Maria Lisa Garavaglia, Ivan Verduci, Gaetano Cannavale, Giorgio Balduzzi, Sara Papetti, Michele Mazzanti

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A biomarker basing on radiomics for the prediction of overall survival in non–small cell lung cancer patients

Bo He, Wei Zhao, Jiang-Yuan Pi, Dan Han, Yuan-Ming Jiang, Zhen-Guang Zhang, Wei Zhao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Upregulation of microRNA-17-5p contributes to hypoxia-induced proliferation in human pulmonary artery smooth muscle cells through modulation of p21 and PTEN

Guangjie Liu, Peng Hao, Jie Xu, Liming Wang, Yuchuan Wang, Ruifang Han, Ming Ying, Shuangshuang Sui, Jinghua Liu, Xuan Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

cGMP interacts with tropomyosin and downregulates actin-tropomyosin-myosin complex interaction

Lihui Zou, Junhua Zhang, Jingli Han, Wenqing Li, Fei Su, Xiaomao Xu, Zhenguo Zhai, Fei Xiao

01.12.2018 | Review | Ausgabe 1/2018 Open Access

High-flow nasal cannula in adults with acute respiratory failure and after extubation: a systematic review and meta-analysis

Zhiheng Xu, Yimin Li, Jianmeng Zhou, Xi Li, Yongbo Huang, Xiaoqing Liu, Karen E. A. Burns, Nanshan Zhong, Haibo Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Efficacy and safety of nintedanib in advanced idiopathic pulmonary fibrosis

Hee-Young Yoon, Sojung Park, Dong Soon Kim, Jin Woo Song

01.12.2018 | Letter to the editor | Ausgabe 1/2018 Open Access

Culture of human alveolar epithelial type II cells by sprouting

Petra Khan, Kleanthis Fytianos, Luca Tamò, Michael Roth, Michael Tamm, Thomas Geiser, Amiq Gazdhar, Katrin E Hostettler

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Efficacy and effectiveness of Ceftaroline Fosamil in patients with pneumonia: a systematic review and meta-analysis

Giovanni Sotgiu, Stefano Aliberti, Andrea Gramegna, Marco Mantero, Marta Di Pasquale, Federica Trogu, Laura Saderi, Francesco Blasi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

FBXO17 promotes cell proliferation through activation of Akt in lung adenocarcinoma cells

Tomeka L. Suber, Ina Nikolli, Michael E. O’Brien, James Londino, Jing Zhao, Kong Chen, Rama K. Mallampalli, Yutong Zhao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Selective activation and proliferation of a quiescent stem cell population in the neuroepithelial body microenvironment

Line Verckist, Isabel Pintelon, Jean-Pierre Timmermans, Inge Brouns, Dirk Adriaensen

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Modulation of airway hyperresponsiveness by rhinovirus exposure

Dennis Lo, Joshua L. Kennedy, Richard C. Kurten, Reynold A. Panettieri Jr, Cynthia J. Koziol-White

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study

Lystra P. Hayden, Michael H. Cho, Benjamin A. Raby, Terri H. Beaty, Edwin K. Silverman, Craig P. Hersh, on behalf of the COPDGene Investigators

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The utility of biomarkers in diagnosis of aspirin exacerbated respiratory disease

Suzy A. A. Comhair, Grazyna Bochenek, Sara Baicker-McKee, Zeneng Wang, Tomasz Stachura, Marek Sanak, Jeffrey P. Hammel, Stanley L. Hazen, Serpil C. Erzurum, Ewa Nizankowska-Mogilnicka

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Dietary ω-6 polyunsaturated fatty acid arachidonic acid increases inflammation, but inhibits ECM protein expression in COPD

Sandra Rutting, Michael Papanicolaou, Dia Xenaki, Lisa G. Wood, Alexander M. Mullin, Philip M. Hansbro, Brian G. Oliver

01.12.2018 | Research | Ausgabe 1/2018 Open Access

From blood to lung tissue: effect of cigarette smoke on DNA methylation and lung function

Maaike de Vries, Diana A van der Plaat, Ivana Nedeljkovic, Rikst Nynke Verkaik-Schakel, Wierd Kooistra, Najaf Amin, Cornelia M van Duijn, Corry-Anke Brandsma, Cleo C van Diemen, Judith M Vonk, H Marike Boezen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Quantitative CT analysis using functional imaging is superior in describing disease progression in idiopathic pulmonary fibrosis compared to forced vital capacity

J. Clukers, M. Lanclus, B. Mignot, C. Van Holsbeke, J. Roseman, S. Porter, E. Gorina, E. Kouchakji, K. E. Lipson, W. De Backer, J. De Backer

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Association of lung function with cardiovascular risk: a cohort study

Bin Wang, Yun Zhou, Lili Xiao, Yanjun Guo, Jixuan Ma, Min Zhou, Tingming Shi, Aijun Tan, Jing Yuan, Weihong Chen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Serum AGE/RAGEs as potential biomarker in idiopathic pulmonary fibrosis

Carlos Machahua, Ana Montes-Worboys, Lurdes Planas-Cerezales, Raquel Buendia-Flores, Maria Molina-Molina, Vanesa Vicens-Zygmunt

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Right heart size and function significantly correlate in patients with pulmonary arterial hypertension – a cross-sectional study

Lukas Fischer, Nicola Benjamin, Norbert Blank, Benjamin Egenlauf, Christine Fischer, Satenik Harutyunova, Maria Koegler, Hanns-Martin Lorenz, Alberto M. Marra, Christian Nagel, Panagiota Xanthouli, Eduardo Bossone, Ekkehard Grünig

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Efficacy and safety of antagonists for chemoattractant receptor-homologous molecule expressed on Th2 cells in adult patients with asthma: a meta-analysis and systematic review

Jing Yang, Jian Luo, Ling Yang, Dan Yang, Dan Wang, Bicui Liu, Tingxuan Huang, Xiaohu Wang, Binmiao Liang, Chuntao Liu

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Therapeutic potential of products derived from mesenchymal stem/stromal cells in pulmonary disease

Arezoo Mohammadipoor, Ben Antebi, Andriy I. Batchinsky, Leopoldo C. Cancio

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Primary immunodeficiency diseases in lung disease: warning signs, diagnosis and management

Pere Soler-Palacín, Javier de Gracia, Luis Ignacio González-Granado, Carlos Martín, Carlos Rodríguez-Gallego, Silvia Sánchez-Ramón, Lung ID-Signal Group

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Unfractionated heparin ameliorates pulmonary microvascular endothelial barrier dysfunction via microtubule stabilization in acute lung injury

Shengtian Mu, Yina Liu, Jing Jiang, Renyu Ding, Xu Li, Xin Li, Xiaochun Ma

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Role of SOD3 in silica-related lung fibrosis and pulmonary vascular remodeling

Igor N. Zelko, Jianxin Zhu, Jesse Roman

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Long-term outcomes following first short-term clinically important deterioration in COPD

Ian P. Naya, Lee Tombs, Hana Muellerova, Christopher Compton, Paul W. Jones

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Heterogeneous burden of lung disease in smokers with borderline airflow obstruction

Cheryl S. Pirozzi, Tian Gu, Pedro M. Quibrera, Elizabeth E. Carretta, MeiLan K. Han, Susan Murray, Christopher B. Cooper, Donald P. Tashkin, Eric C. Kleerup, Igor Barjaktarevic, Eric A. Hoffman, Carlos H. Martinez, Stephanie A. Christenson, Nadia N. Hansel, R. Graham Barr, Eugene R. Bleecker, Victor E. Ortega, Fernando J. Martinez, Richard E. Kanner, Robert Paine III, for the NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS)

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Cost-effectiveness analysis of umeclidinium bromide/vilanterol 62.5/25 mcg versus tiotropium/olodaterol 5/5 mcg in symptomatic patients with chronic obstructive pulmonary disease: a Spanish National Healthcare System perspective

M. T. Driessen, J. Whalen, B. Seewoodharry Buguth, L. A. Vallejo-Aparicio, I. P. Naya, Y. Asukai, B. Alcázar-Navarrete, M. Miravitlles, F. García-Río, N. A. Risebrough

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Combination of inspiratory and expiratory muscle training in same respiratory cycle versus different cycles in COPD patients: a randomized trial

Wenhui Xu, Rui Li, Lili Guan, Kai Wang, Yuhe Hu, Limei Xu, Luqian Zhou, Rongchang Chen, Xin Chen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

MUC1 deficiency mediates corticosteroid resistance in chronic obstructive pulmonary disease

Javier Milara, Lucía Díaz-Platas, Sonia Contreras, Pilar Ribera, Inés Roger, Beatriz Ballester, Paula Montero, Ángel Cogolludo, Esteban Morcillo, Julio Cortijo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Nebulization versus standard application for topical anaesthesia during flexible bronchoscopy under moderate sedation – a randomized controlled trial

Tobias Müller, Christian Cornelissen, Michael Dreher

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Influence of viral infection on the relationships between airway cytokines and lung function in asthmatic children

Toby C. Lewis, Ediri E. Metitiri, Graciela B. Mentz, Xiaodan Ren, Ashley R. Carpenter, Adam M. Goldsmith, Kyra E. Wicklund, Breanna N. Eder, Adam T. Comstock, Jeannette M. Ricci, Sean R. Brennan, Ginger L. Washington, Kendall B. Owens, Bhramar Mukherjee, Thomas G. Robins, Stuart A. Batterman, Marc B. Hershenson, the Community Action Against Asthma Steering Committee

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Alterations in VASP phosphorylation and profilin1 and cofilin1 expression in hyperoxic lung injury and BPD

Mehboob Ali, Kathryn Heyob, Trent E. Tipple, Gloria S. Pryhuber, Lynette K. Rogers

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Roles of mitochondrial ROS and NLRP3 inflammasome in multiple ozone-induced lung inflammation and emphysema

Feng Li, Mengmeng Xu, Muyun Wang, Lei Wang, Hanying Wang, Hai Zhang, Yuqing Chen, Jicheng Gong, Junfeng(Jim) Zhang, Ian M. Adcock, Kian Fan Chung, Xin Zhou

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inflammation and lung injury in an ovine model of fluid resuscitated endotoxemic shock

Margaret R. Passmore, Liam Byrne, Nchafatso G. Obonyo, Louise E. See Hoe, Ai-Ching Boon, Sara D. Diab, Kimble R. Dunster, Kavita Bisht, John-Paul Tung, Mohd H. Fauzi, Monica Narula, Sanne E. Pedersen, Arlanna Esguerra-Lallen, Gabriela Simonova, Annette Sultana, Chris M. Anstey, Kiran Shekar, Kathryn Maitland, Jacky Y. Suen, John F. Fraser

01.12.2018 | Editorial | Ausgabe 1/2018 Open Access

Thank you and farewell after 15 years editing Respiratory Research

Jan Lotvall, Reynold A. Panettieri Jr

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inflammatory pathways are upregulated in the nasal epithelium in patients with idiopathic pulmonary fibrosis

Marc A. Sala, Yalbi Itzel Balderas-Martínez, Ivette Buendía-Roldan, Hiam Abdala-Valencia, Kiwon Nam, Manu Jain, Sangeeta Bhorade, Ankit Bharat, Paul A. Reyfman, Karen M. Ridge, Annie Pardo, Jacob I. Sznajder, G. R. Scott Budinger, Alexander V. Misharin, Moises Selman

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Airway epithelial cells exposed to wildfire smoke extract exhibit dysregulated autophagy and barrier dysfunction consistent with COPD

Eugene Roscioli, Rhys Hamon, Susan E. Lester, Hubertus P. A. Jersmann, Paul N. Reynolds, Sandra Hodge

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Downregulation of exosomal let-7a-5p in dust exposed- workers contributes to lung cancer development

Lin Zhang, Changfu Hao, Ruonan Zhai, Di Wang, Jianhui Zhang, Lei Bao, Yiping Li, Wu Yao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Soluble epoxide hydrolase derived lipid mediators are elevated in bronchoalveolar lavage fluid from patients with sarcoidosis: a cross-sectional study

Marcus O. D. Sjödin, Antonio Checa, Mingxing Yang, Sven-Erik Dahlén, Åsa M. Wheelock, Anders Eklund, Johan Grunewald, Craig E. Wheelock

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Use and inhalation technique of inhaled medication in patients with asthma and COPD: data from a randomized controlled trial

Claudia Gregoriano, Thomas Dieterle, Anna-Lisa Breitenstein, Selina Dürr, Amanda Baum, Sabrina Maier, Isabelle Arnet, Kurt E. Hersberger, Jörg D. Leuppi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Cellular and acellular ex vivo lung perfusion preserve functional lung ultrastructure in a large animal model: a stereological study

Jasmin Steinmeyer, Simon Becker, Murat Avsar, Jawad Salman, Klaus Höffler, Axel Haverich, Gregor Warnecke, Christian Mühlfeld, Matthias Ochs, Anke Schnapper-Isl

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Women with COPD by biomass show different serum profile of adipokines, incretins, and peptide hormones than smokers

Oliver Pérez-Bautista, Martha Montaño, Rogelio Pérez-Padilla, Joaquín Zúñiga-Ramos, Mariana Camacho-Priego, Tonatiuh Barrientos-Gutiérrez, Ivette Buendía-Roldan, Yadira Velasco-Torres, Carlos Ramos

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Dihydrotestosterone is a predictor for mortality in males with community-acquired pneumonia: results of a 6-year follow-up study

Seline Zurfluh, Manuela Nickler, Manuel Ottiger, Christian Steuer, Alexander Kutz, Mirjam Christ-Crain, Werner Zimmerli, Robert Thomann, Claus Hoess, Christoph Henzen, Luca Bernasconi, Andreas Huber, Beat Mueller, Philipp Schuetz, for the proHOSP study group

01.12.2018 | Research | Ausgabe 1/2018 Open Access

SOX30 specially prevents Wnt-signaling to suppress metastasis and improve prognosis of lung adenocarcinoma patients

Fei Han, Ming-qian Zhang, Wen-bin Liu, Lei Sun, Xiang-lin Hao, Li Yin, Xiao Jiang, Jia Cao, Jin-yi Liu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Pneumonia in patients with cirrhosis: risk factors associated with mortality and predictive value of prognostic models

Lichen Xu, Shuangwei Ying, Jianhua Hu, Yunyun Wang, Meifang Yang, Tiantian Ge, Chunhong Huang, Qiaomai Xu, Haihong Zhu, Zhi Chen, Weihang Ma

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Lipoxin A4 receptor agonist BML-111 induces autophagy in alveolar macrophages and protects from acute lung injury by activating MAPK signaling

Huaizheng Liu, Kefu Zhou, Liangkan Liao, Tianyi Zhang, Mingshi Yang, Chuanzheng Sun

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Cytotoxic lymphocytes in COPD airways: increased NK cells associated with disease, iNKT and NKT-like cells with current smoking

Jonas Eriksson Ström, Jamshid Pourazar, Robert Linder, Anders Blomberg, Anne Lindberg, Anders Bucht, Annelie F. Behndig

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study

Daphnée Lamarche, Jennie Johnstone, Nicole Zytaruk, France Clarke, Lori Hand, Dessi Loukov, Jake C. Szamosi, Laura Rossi, Louis P. Schenck, Chris P. Verschoor, Ellen McDonald, Maureen O. Meade, John C. Marshall, Dawn M. E. Bowdish, Tim Karachi, Diane Heels-Ansdell, Deborah J. Cook, Michael G. Surette, for the PROSPECT Investigators, Canadian Critical Care Trials Group, Canadian Critical Care Translational Biology Group

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The impact of outdoor air pollutants on outpatient visits for respiratory diseases during 2012–2016 in Jinan, China

Shanshan Wang, Yifan Li, Aimin Niu, Yao Liu, Lili Su, Wanmei Song, Jinyue Liu, Yunxia Liu, Huaichen Li

01.12.2018 | Letter to the Editor | Ausgabe 1/2018 Open Access

Pleural effusion as an initial manifestation in a patient with primary pulmonary monoclonal B-cell lymphocyte proliferative disease

Qin Du, Lili Fan, Hongyu Zhou

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Identification of deleterious and regulatory genomic variations in known asthma loci

Matthew D. C. Neville, Jihoon Choi, Jonathan Lieberman, Qing Ling Duan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The effect of changes to GOLD severity stage on long term morbidity and mortality in COPD

Robert W. V. Flynn, Thomas M. MacDonald, James D. Chalmers, Stuart Schembri

01.12.2018 | Research | Ausgabe 1/2018 Open Access

GLI 2012 equations define few spirometric anomalies in the general population: the PneumoLaus study

Alexandra Lenoir, Jean-William Fitting, Pedro-Manuel Marques-Vidal, Peter Vollenweider, Laurent P. Nicod

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Spirometric changes during exacerbations of COPD: a post hoc analysis of the WISDOM trial

Henrik Watz, Kay Tetzlaff, Helgo Magnussen, Achim Mueller, Roberto Rodriguez-Roisin, Emiel F. M. Wouters, Claus Vogelmeier, Peter M. A. Calverley

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Effects of smoking on the lower respiratory tract microbiome in mice

Rui Zhang, Ling Chen, Lei Cao, Kang-jie Li, Yao Huang, Xiao-qian Luan, Ge Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

LncRNA H19 promotes the proliferation of pulmonary artery smooth muscle cells through AT1R via sponging let-7b in monocrotaline-induced pulmonary arterial hypertension

Hua Su, Xiaoling Xu, Chao Yan, Yangfeng Shi, Yanjie Hu, Liangliang Dong, Songmin Ying, Kejing Ying, Ruifeng Zhang

01.12.2018 | Letter to the Editor | Ausgabe 1/2018 Open Access

Pulmonary aspiration in preschool children with cystic fibrosis

D. Clarke, I. Gorman, F. Ringholz, M. McDermott, DW. Cox, P. Greally, B. Linnane, P. Mc Nally

01.12.2018 | Letter to the Editor | Ausgabe 1/2018 Open Access

Predictors of clinical response to extrafine and non-extrafine particle inhaled corticosteroids in smokers and ex-smokers with asthma

Fajri Gafar, Ilse M. Boudewijn, Claire A. Cox, Judith M. Vonk, Siebrig Schokker, Anne J. Lexmond, Henderik W. Frijlink, Paul Hagedoorn, Dirkje S. Postma, Maarten van den Berge

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Centrilobular emphysema and coronary artery calcification: mediation analysis in the SPIROMICS cohort

Surya P. Bhatt, Hrudaya P. Nath, Young-il Kim, Rekha Ramachandran, Jubal R. Watts, Nina L. J. Terry, Sushil Sonavane, Swati P. Deshmane, Prescott G. Woodruff, Elizabeth C. Oelsner, Sandeep Bodduluri, MeiLan K. Han, Wassim W. Labaki, J. Michael Wells, Fernando J. Martinez, R. Graham Barr, Mark T. Dransfield, for the SPIROMICS investigators

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Right ventricular size and function under riociguat in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension (the RIVER study)

Alberto M. Marra, Michael Halank, Nicola Benjamin, Eduardo Bossone, Antonio Cittadini, Christina A. Eichstaedt, Benjamin Egenlauf, Satenik Harutyunova, Christine Fischer, Henning Gall, Hossein Ardeschir Ghofrani, Marius M. Hoeper, Tobias J. Lange, Karen M. Olsson, Hans Klose, Ekkehard Grünig

01.12.2018 | Research | Ausgabe 1/2018 Open Access

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